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191 Dose prescription variability in Oropharynx Cancer Radiotherapy

Radiotherapy and Oncology 2024年 192卷 S225-S228页

作者： Christian R Hansen Tony Tadic Andrea McNiven Jens Petersen Sharma Manju Gareth Price Mohamed A Naser Pernille Lassen Jens Overgaard Lachlan McDowell Clifton David Fuller David Thomsen Sue S Yom J⊘rgen Johansen Jeppe Friborg Andrew Hope Laboratory of Radiation Physics Odense University Hospital Odense Denmark. Institute of Clinical Research University of Southern Denmark Odense Denmark. Danish Center of Particle Therapy Aarhus University Hospital Aarhus Denmark. Department of Medical Physics Princess Margaret Cancer Centre Toronto Canada. Department of Oncology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark. Department of Computer Science University of Copenhagen Copenhagen Denmark. Department of Radiation Oncology University of California San Francisco San Francisco USA. Division of Cancer Sciences University of Manchester The Christie NHS Foundation Trust Manchester United Kingdom. Department of Radiation Oncology Baylor College of Medicine Houston USA. Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston USA. Medical Physics Program The University of Texas Graduate School of Biomedical Sciences Houston USA. Department of Experimental Clinical Oncology Aarhus University Hospital Aarhus Denmark. Department of Oncology Aarhus University Hospital Aarhus Denmark. Department of Radiation Oncology Princess Alexandra Hospital Brisbane Australia. Department of Oncology Odense University Hospital Odense Denmark. Department of Otolaryngology-Head Neck Surgery Princess Margaret Cancer Centre Toronto Canada

Purpose/Objective Radiotherapy treatment planning hinges on a critical factor: the prescribed dose. Surprisingly, no consistent, standardised global approach to interpreting this prescription exists. This study aimed to examine and illustrate the variations in prescribed doses for the same treatment across North European and North American centres. Material/Methods The study analysed consecutively treated oropharynx cancer patients from six globally recognised radiotherapy departments. The criteria for inclusion encompassed curative IMRT or VMAT radiotherapy administered in 2017 or later. These centres were divided into three North American and three North European centres. Dose-volume histogram (DVH) data were extracted from the local treatment planning system for the Gross Tumour Volume (GTV), the high-dose Clinical Target Volume (CTV), and Planning Target Volume (PTV) for each patient. The DVH was sampled in 1 cGy dose bins across the 0 to 100 Gy range. All DVHs were scaled to a standard prescription of 70 Gy delivered in 35 fractions to facilitate straightforward comparisons across centres. No biological corrections were applied. For the three target volumes (GTV, CTV, PTV), we extracted and compared metrics such as D95% (Dose to 95% of the volume), D98%, D99%, V95% (Volume receiving 95% of the prescription dose), V105%, and V107%. We visually compared these metrics and conducted statistical testing using the Mann-Whitney U-test. Results Our study encompassed 1,375 patients treated across six centres, revealing a spectrum of 38 different dose prescriptions, ranging from 55 Gy in 20 to 70 Gy in 35 fractions. When normalised to 70 Gy, the median mean CTV dose exhibited a 4% difference, ranging from 70.12 Gy to 72.93 Gy across centres. Notably, the three European centres showed a high consistency, deviating by only 0.4%, while the three North American centres showed a slight variation within 2%. Figure 1 presents the mean CTV dose and the D98% boxplots. The interqu

关键词： HPV or EBV related cancers Dose prescription Treatment planning Trials

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Probing the universality of topological defect formation in a quantum annealer: Kibble-Zurek mechanism and beyond

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Physical Review Research 2020年第3期2卷 033369-033369页

作者： Yuki Bando Yuki Susa Hiroki Oshiyama Naokazu Shibata Masayuki Ohzeki Fernando Javier Gómez-Ruiz Daniel A. Lidar Sei Suzuki Adolfo del Campo Hidetoshi Nishimori Institute of Innovative Research Tokyo Institute of Technology Nagatsuta-cho Midori-ku Yokohama 226-8503 Japan Institute of Innovative Research Tokyo Institute of Technology Oh-okayama Meguro-ku Tokyo 152-8550 Japan Department of Physics Tohoku University Sendai 980-8578 Japan Graduate School of Information Sciences Tohoku University Sendai 980-8579 Japan Sigma-i Co. Ltd. Konan Minato-ku Tokyo 108-0075 Japan Donostia International Physics Center E-20018 San Sebastián Spain Departments of Electrical and Computer Engineering Chemistry and Physics University of Southern California Los Angeles California 90089 USA Center for Quantum Information Science & Technology University of Southern California Los Angeles California 90089 USA Department of Liberal Arts Saitama Medical University Moroyama Saitama 350-0495 Japan IKERBASQUE Basque Foundation for Science E-48013 Bilbao Spain Department of Physics University of Massachusetts Boston 100 Morrissey Boulevard Boston Massachusetts 02125 USA RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS) Wako Saitama 351-0198 Japan

The number of topological defects created in a system driven through a quantum phase transition exhibits a power-law scaling with the driving time. This universal scaling law is the key prediction of the Kibble-Zurek mechanism (KZM), and testing it using a hardware-based quantum simulator is a coveted goal of quantum information science. Here we provide such a test using quantum annealing. Specifically, we report on extensive experimental tests of topological defect formation via the one-dimensional transverse-field Ising model on two different D-Wave quantum annealing devices. We find that the quantum simulator results can indeed be explained by the KZM for open-system quantum dynamics with phase-flip errors, with certain quantitative deviations from the theory likely caused by factors such as random control errors and transient effects. In addition, we probe physics beyond the KZM by identifying signatures of universality in the distribution and cumulants of the number of kinks and their decay, and again find agreement with the quantum simulator results. This implies that the theoretical predictions of the generalized KZM theory, which assumes isolation from the environment, applies beyond its original scope to an open system. We support this result by extensive numerical computations. To check whether an alternative, classical interpretation of these results is possible, we used the spin-vector Monte Carlo model, a candidate classical description of the D-Wave device. We find that the degree of agreement with the experimental data from the D-Wave annealing devices is better for the KZM, a quantum theory, than for the classical spin-vector Monte Carlo model, thus favoring a quantum description of the device. Our work provides an experimental test of quantum critical dynamics in an open quantum system, and paves the way to new directions in quantum simulation experiments.

关键词： Critical exponents Nonequilibrium statistical mechanics Open quantum systems Quantum computation Quantum master equation Quantum simulation Quantum statistical mechanics Quantum spin models

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Kramers nodal lines in intercalated TaS2 superconductors

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Nature Communications 2025年第1期16卷 1-10页

作者： Zhang, Yichen Gao, Yuxiang Pulkkinen, Aki Guo, Xingyao Huang, Jianwei Guo, Yucheng Yue, Ziqin Oh, Ji Seop Moon, Alex Oudah, Mohamed Gao, Xue-Jian Marmodoro, Alberto Fedorov, Alexei Mo, Sung-Kwan Hashimoto, Makoto Lu, Donghui Rajapitamahuni, Anil Vescovo, Elio Kono, Junichiro Hallas, Alannah M. Birgeneau, Robert J. Balicas, Luis Minár, Ján Hosur, Pavan Law, Kam Tuen Morosan, Emilia Yi, Ming Department of Physics and Astronomy Rice University Houston 77005 TX United States New Technologies Research Center University of West Bohemia Plzen 301 00 Czech Republic Department of Physics Hong Kong University of Science and Technology Clear Water Bay Hong Kong Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston 77005 TX United States Smalley-Curl Institute Rice University Houston 77005 TX United States Department of Physics University of California Berkeley Berkeley 94720 CA United States National High Magnetic Field Laboratory Tallahassee Tallahassee 32310 FL United States Physics Department Florida State University Tallahassee 32306 FL United States Stewart Blusson Quantum Matter Institute University of British Columbia Vancouver Vancouver V6T 1Z4 BC Canada Advanced Light Source Lawrence Berkeley National Laboratory Berkeley Berkeley 94720 CA United States Stanford Synchrotron Radiation Lightsource SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park 94025 CA United States National Synchrotron Light Source II Brookhaven National Lab Upton 11973 NY United States Rice Center for Quantum Materials Rice University Houston 77005 TX United States Department of Electrical and Computer Engineering Rice University Houston 77005 TX United States Department of Materials Science and NanoEngineering Rice University Houston 77005 TX United States Department of Physics & Astronomy University of British Columbia Vancouver Vancouver V6T 1Z1 BC Canada Canadian Institute for Advanced Research Toronto Toronto M5G 1M1 ON Canada Materials Science Division Lawrence Berkeley National Laboratory Berkeley Berkeley 94720 CA United States Department of Physics and Texas Center for Superconductivity University of Houston Houston 77204 TX United States

Kramers degeneracy is one fundamental embodiment of the quantum mechanical nature of particles with half-integer spin under time reversal symmetry. Under the chiral and noncentrosymmetric achiral crystalline symmetries, Kramers degeneracy emerges respectively as topological quasiparticles of Weyl fermions and Kramers nodal lines (KNLs), anchoring the Berry phase-related physics of electrons. However, an experimental demonstration for ideal KNLs well isolated at the Fermi level is lacking. Here, we establish a class of noncentrosymmetric achiral intercalated transition metal dichalcogenide superconductors with large Ising-type spin-orbit coupling, represented by InxTaS2, to host an ideal KNL phase. We provide evidence from angle-resolved photoemission spectroscopy with spin resolution, angle-dependent quantum oscillation measurements, and ab-initio calculations. Our work not only provides a realistic platform for realizing and tuning KNLs in layered materials, but also paves the way for exploring the interplay between KNLs and superconductivity, as well as applications pertaining to spintronics, valleytronics, and nonlinear transport. © The Author(s) 2025.

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Noninvasive Glucose Sensor Based on Parity-Time Symmetry

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Physical Review Applied 2019年第4期11卷 044049-044049页

作者： Yun Jing Zhang Hoyeong Kwon Mohammad-Ali Miri Efthymios Kallos Helena Cano-Garcia Mei Song Tong Andrea Alu Department of Electrical and Computer Engineering The University of Texas at Austin Austin 78712 USA Department of Electronic Science and Technology Tongji University Shanghai 201804 China Department of Physics Queens College of the City University of New York Queens New York 11367 USA Physics Program Graduate Center City University of New York New York 10016 USA Medical Wireless Sensing Ltd London E1 2AX UK King’s College London London WC2R 2LS UK Photonics Initiative Advanced Science Research Center City University of New York New York 10031 USA Department of Electrical Engineering City College of The City University of New York New York 10031 USA

We discuss a noninvasive technique to detect glucose changes with enhanced sensitivity based on parity-time (PT) symmetry. We detect glucose level changes within the skin by measuring the frequency shift in the electromagnetic resonance induced within a PT-symmetric system that sandwiches the tissue sample under analysis. Even though the sample itself is lossy, and therefore, resonances would be damped, the introduction of balanced gain and loss enables an efficient sensing mechanism that bypasses the conventional limitations of passive sensing schemes. Our results indicate that the resonance shift can be made fairly linear with respect to the glucose concentration variations, and the expected accuracy is large. We also investigate a realistic system to implement the noninvasive PT-symmetric glucose sensor using loop antennas and negative impedance converters, exploring its sensitivity with respect to design errors and disorder.

关键词： Medical physics Optical parametric oscillators & amplifiers Optoelectronics Metamaterials Solid-state detectors PT-symmetry Microwave techniques Resonance techniques

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Practical and secure outsourcing of discrete log group exponentiation to a single malicious server 8

Practical and secure outsourcing of discrete log group expon...

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8th ACM Cloud Computing Security Workshop, CCSW 2017

作者： Crescenzo, Giovanni Di Khodjaeva, Matluba Kahrobaei, Delaram Shpilrain, Vladimir Vencore Labs Basking RidgeNJ07920 United States CUNY Graduate Center New YorkNY10016 United States PhD Program in Computer Science CUNY Graduate Center New YorkNY10016 United States

ISBN: (纸本)9781450353939

Group exponentiation is an important operation used in many public-key cryptosystems and, more generally, cryptographic protocols. To expand the applicability of these solutions to computationally weaker devices, it has been advocated that this operation is outsourced from a computationally weaker client to a computationally stronger server, possibly implemented in a cloud-based architecture. While preliminary solutions to this problem considered mostly honest servers, or multiple separated servers, some of which honest, solving this problem in the case of a single (logical), possibly malicious, server, has remained open since a formal cryptographic model was introduced in [20]. Several later attempts either failed to achieve privacy or only bounded by a constant the (security) probability that a cheating server convinces a client of an incorrect result. In this paper we solve this problem for a large class of cyclic groups, thus making our solutions applicable to many cryptosystems in the literature that are based on the hardness of the discrete logarithm problem or on related assumptions. Our main protocol satisfies natural correctness, security, privacy and efficiency requirements, where the security probability is exponentially small. In our main protocol, with very limited offline computation and server computation, the client can delegate an exponentiation to an exponent of the same length as a group element by performing an exponentiation to an exponent of short length (i.e., the length of a statistical parameter). We also show an extension protocol that further reduces client computation by a constant factor, while increasing offline computation and server computation by about the same factor.

关键词： Group theory

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Erratum to 'Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)': The American Journal of Cardiology 2019 Nov 15;124(10):1590-1593./ doi: 10.1016/***.2019.08.010

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The American journal of cardiology 2021年 142卷 161页

作者： Shiu-Dong Chung Ju-Chi Liu Tsai-Ning Lou Ben-Chang Shia Herng-Ching Lin Li-Ting Kao Division of Urology Department of Surgery Far Eastern Memorial Hospital Taipei Taiwan Department of Computer Science and Engineering and Graduate Program in Biomedical Informatics College of Informatics Yuan-Ze University Chung-Li Taiwan Sleep Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Cardiovascular Medicine Department of Medicine Medical University Hospital-Shuang Ho Hospital TaipeiTaiwan. School of Health Care Administration Taipei Medical University Taipei Taiwan. Big Data Research Center Taipei Medical University Taipei Taiwan. Sleep Research Center Taipei Medical University Hospital Taipei Taiwan School of Health Care Administration Taipei Medical University Taipei Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Department of Pharmacy Practice Tri-Service General Hospital Taipei Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan.. Electronic address: kaoliting@***.

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Superiorization of preconditioned conjugate gradient algorithms for tomographic image reconstruction

arXiv

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arXiv 2018年

作者： Helou, Elias S. Herman, Gabor T. Lin, Chuan Zibetti, Marcelo V.W. Institute of Mathematical Science and Computation University of São Paulo SP Brazil Department of Computer Science Graduate Center City University of New York NY United States School of Electrical Engineering Southwest Jiaotong University Chengdu China Program in Electrical and Computer Engineering Federal University of Technology PR Brazil

Properties of Superiorized Preconditioned Conjugate Gradient (SupPCG) algorithms in image reconstruction from projections are examined. Least squares (LS) is usually chosen for measuring data-inconsistency in these inverse problems. Preconditioned Conjugate Gradient algorithms are fast methods for finding an LS solution. However, for ill-posed problems, such as image reconstruction, an LS solution may not provide good image quality. This can be taken care of by superiorization. A superiorized algorithm leads to images with the value of a secondary criterion (a merit function such as the total variation) improved as compared to images with similar data-inconsistency obtained by the algorithm without superiorization. Numerical experimentation shows that SupPCG can lead to high-quality reconstructions within a remarkably short time. A theoretical analysis is also provided.15A29, 65F22, 65F10, 94A08 Copyright © 2018, The Authors. All rights reserved.

关键词： Image reconstruction

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Small P values may not yield robust findings:an example using REST-meta-PD

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science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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Inverse-designed photonic circuits for fully passive, bias-free Kerr-based nonreciprocal transmission and routing

arXiv

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arXiv 2019年

作者： Yang, Ki Youl Skarda, Jinhie Cotrufo, Michele Dutt, Avik Ahn, Geun Ho Vercruysse, Dries Fan, Shanhui Alù, Andrea Vucković, Jelena E. L. Ginzton Laboratory Stanford University StanfordCA94305 United States Department of Electrical and Computer Engineering University of Texas at Austin AustinTX78712 United States Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Physics Program Graduate Center City University of New York New YorkNY10016 United States Department of Electrical Engineering City University of New York New YorkNY10031 United States

Nonreciprocal devices such as isolators and circulators are key enabling technologies for communication systems, both at microwave and optical frequencies. While nonreciprocal devices based on magnetic effects are available for free-space and fibre-optic communication systems, their on-chip integration has been challenging, primarily due to the concomitant high insertion loss, weak magneto-optical effects, and material incompatibility. We show that Kerr nonlinear resonators can be used to achieve all-passive, low-loss, bias-free, broadband nonreciprocal transmission and routing for applications in photonic systems such as chip-scale LIDAR. A multi-port nonlinear Fano resonator is used as an on-chip, all-optical router for frequency comb based distance measurement. Since time-reversal symmetry imposes stringent limitations on the operating power range and transmission of a single nonlinear resonator, we implement a cascaded Fano-Lorentzian resonator system that overcomes these limitations and significantly improves the insertion loss, bandwidth and non-reciprocal power range of current state-of-the-art devices. This work provides a platform-independent design for nonreciprocal transmission and routing that are ideally suited for photonic integration. Copyright © 2019, The Authors. All rights reserved.

关键词： Insertion losses

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Hybrid support vector regression in electric load during national holiday season

Hybrid support vector regression in electric load during nat...

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2017 International Conference on Innovative and Creative Information Technology: Computational Intelligence and IoT, ICITech 2017

作者： Caraka, Rezzy Eko Bakar, Sakhinah Abu Pardamean, Bens Budiarto, Arif School of Mathematical Sciences Faculty of Science and Technology National University of Malaysia Malaysia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program-Master of Computer Science Bina Nusantara University Jakarta11480 Indonesia

ISBN: (纸本)9781538640456

This paper studies non-parametric time-series approach to electric load in national holiday seasons based on historical hourly data in state electric company of Indonesia consisting of historical data of the Northern Sumatera also South and Central Sumatra electricity load. Given a baseline for forecasting performance, we apply our hybrid models and computation platform with combining parameter of the kernel. To facilitate comparison to results of our analysis, we highlighted the results around MAPE-based and R2-based techniques. In order to get more accurate results, we need to improve, investigate, also develop the appropriate statistical tools. Electric load forecasting is a fundamental aspect of infrastructure development decisions and can reduce the energy usage of the nation. © 2017 IEEE.

关键词： Time series

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