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CIS controls the functional polarization of GM-CSF-derived macrophages

Cellular & Molecular Immunology 2023年第1期20卷 65-79页

作者： Shengbo Zhang Jai Rautela Naiara G.Bediaga Tatiana B.Kolesnik Yue You Junli Nie Laura F.Dagley Justin Bedo Hanqing Wang Li Sun Robyn Sutherland Elliot Surgenor Nadia Iannarella Rhys Allan Fernando Souza-Fonseca-Guimaraes Yi Xie Qike Wang Yuxia Zhang Yuekang Xu Stephen L.Nutt Andrew M.Lew Nicholas D.Huntington Sandra E.Nicholson Michaël Chopin Yifan Zhan Walter and Eliza Hall Institute of Medical Research ParkvilleVICAustralia Department of Medical Biology University of MelbourneParkvilleVICAustralia Department of Biochemistry and Molecular Biology Biomedicine Discovery InstituteMonash UniversityClaytonVICAustralia oNKo-Innate Pty Ltd Moonee PondsVICAustralia Department of Computing and Information Systems University of MelbourneParkvilleVICAustralia Department of Respiratory Medicine Guangzhou Institute of PediatricsGuangzhou Women and Children’s Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical UniversityGuangzhouGuangdongChina College of Biological Science Anhui Normal UniversityHefeiChina University of Queensland Diamantina Institute University of QueenslandTranslational Research InstituteBrisbaneQLDAustralia Program in Cardiovascular and Metabolic Disorders Duke-NUS Medical SchoolDukeSingapore Drug Discovery Shanghai Huaota BiopharmShanghaiChina

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite the importance of these opposing biological outcomes, the intrinsic mechanism that regulates the functional polarization of MØs under GM-CSF signaling remains elusive. Here, we showed that GM-CSF-induced MØ polarization resulted in the expression of cytokine-inducible SH2-containing protein (CIS) and that CIS deficiency skewed the differentiation of monocytes toward immunosuppressive M2-like MØs. CIS deficiency resulted in hyperactivation of the JAK-STAT5 signaling pathway, consequently promoting downregulation of the transcription factor Interferon Regulatory Factor 8 (IRF8). Loss- and gain-of-function approaches highlighted IRF8 as a critical regulator of the M1-like polarization program. In vivo, CIS deficiency induced the differentiation of M2-like macrophages, which promoted strong Th2 immune responses characterized by the development of severe experimental asthma. Collectively, our results reveal a CIS-modulated mechanism that clarifies the opposing actions of GM-CSF in MØ differentiation and uncovers the role of GM-CSF in controlling allergic inflammation.

关键词： CIS GM-CSF Macrophage M2 M1

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A deep learning system for predicting time to progression of diabetic retinopathy

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NATURE MEDICINE 2024年第2期30卷 358-359页

作者： [Anonymous] Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Huadong Sanatorium Wuxi China Department of Ophthalmology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong China Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Medical Records and Statistics Office Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Tech

We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

关键词： Diabetes complications Machine learning Predictive markers

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SocialNLP EmotionGIF 2020 challenge overview: Predicting reaction GIF categories on social media

arXiv

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arXiv 2021年

作者： Shmueli, Boaz Ku, Lun-Wei Ray, Soumya Social Networks and Human-Centered Computing Taiwan International Graduate Program Taiwan Institute of Information Science Academia Sinica Taiwan Institute of Service Science National Tsing Hua University Taiwan

We present an overview of the EmotionGIF 2020 Challenge, held at the 8th International Workshop on Natural Language Processing for Social Media (SocialNLP), in conjunction with ACL 2020. The challenge required predicting affective reactions to online texts, and includes the EmotionGIF dataset, with tweets labeled for the reaction categories. The novel dataset included 40K tweets with their reaction GIFs. Due to the special circumstances of year 2020, two rounds of the competition were conducted. A total of 84 teams registered for the task. Of these, 25 teams successfully submitted entries to the evaluation phase in the first round, while 13 teams participated successfully in the second round. Of the top participants, five teams presented a technical report and shared their code. The top score of the winning team using the Recall@K metric was 62.47%. Copyright © 2021, The Authors. All rights reserved.

关键词： Social networking (online)

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Learning Pairwise Preferences from Movie Ratings 7

Learning Pairwise Preferences from Movie Ratings

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7th International Conference on ICT for Smart Society, ICISS 2020

作者： Qomariyah, Nunung Nurul Fajar, Ahmad Nurul Bina Nusantara University Faculty of Computing and Media Computer Science Department Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program-Master of Information Systems Management Information Systems Management Department Jakarta11480 Indonesia

ISBN: (纸本)9781665404228

Preference Elicitation is now considered a crucial stage in recommender system. That is the stage where we collect and query preferences of the users as part of interactive decision support system. Preference elicitation can be performed using many ways, such as asking the user explicitly to give ratings or feedbacks for some products, or implicitly observing their behaviour. Once this preference has been collected by the system, it can then be used to generate item recommendation. Using explicit feedback itself, such as rating only, has several drawbacks. Using ratings is very subjective. Two users with similar taste might give different rating to the same item. A user also may not be consistent in giving number to express their liking. In other case, a user may like an item more than the other items, but feels difficult to give lower rating on the other item, because it means that the particular item is just as bad as the one he/she does not like. By showing two different items as a pair, it will be easier for the users to pick which one is the best. In this paper, we show the result of our experiment in predicting user pairwise preferences by using their movie ratings data. We evaluated five different machine learning algorithms to predict the data in pairwise preference format. The result shows that K-Nearest Neighbour and Random Forest outperformed the other algorithms. © 2020 IEEE.

关键词： Recommender systems

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Fine-Tuned MobileNetV2 and VGG16 Algorithm for Fish Image Classification

Fine-Tuned MobileNetV2 and VGG16 Algorithm for Fish Image Cl...

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International Conference on Informatics, Multimedia, Cyber and information System (ICIMCIS)

作者： Devi Fitrianah Kristien Margi Suryaningrum Noviyanti Tri Maretta Sagala Vina Ayumi Siew Mooi Lim Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia Mathematics Statistics Department School of Computer Science Bina Nusantara University Jakarta Indonesia Informatics Engineering Program Faculty of Computer Science Universitas Mercu Buana Jakarta Indonesia Computer Science Department Faculty of Computing and Information Technology Tunku Abdul Rahman University College Kuala Lumpur Malaysia

ISBN: (纸本)9781665473286

Study on the identification and classification of fish is challenging and valuable because of its role in advancing the marine and agricultural fields. This research has benefits interms of monitoring fish populations and ecosystems in a particular area. Furthermore, this research helps monitor fish that are considered threatened or endangered so that it makes iteasier to map prohibited areas for fishing. This research aims to know performance of MobileNetV2 and VGG16 with parameter tuning process by identifying the value of batch size, epoch, learning rate, and optimizer for fish image dataset. The proposed research phase consists of five main stages, including experimental setup, dataset construction, dataset preprocessing, dataset training and modelling and evaluation. As the result, VGG16 obtained the highest accuracy value. For VGG16 without fine-tuning, the testing accuracy is 98.07%. For VGG16 with fine-tuning, the testing accuracy is 96.56%.

关键词： Training Biological system modeling Sociology Ecosystems Fish Statistics Monitoring

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LOCI: A Mobile QA System with Multimodal Motivation Scheme for Local Intent Questions in Dynamic Social Networks 91

LOCI: A Mobile QA System with Multimodal Motivation Scheme f...

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91st IEEE Vehicular Technology Conference, VTC Spring 2020

作者： Ali, Imad Chang, Ronald Y. Hsu, Cheng-Hsin Lee, Chi-Han Institute of Information Science Academia Sinica Taiwan International Graduate Program Social Networks and Human-Centered Computing Taipei Taiwan Research Center for Information Technology Innovation Academia Sinica Taipei Taiwan National Tsing Hua University Department of Computer Science Hsinchu Taiwan

ISBN: (纸本)9781728152073

Recent research has shown that people are frequently searching for information with local intent. The existing systems fail to answer this class of questions as they are not mainly designed to handle it. In this paper, we propose LOCI, a mobile question answer system with a multimodal motivation scheme for local intent questions where users provide timely and accurate answers in a dynamic social network. LOCI mines users' shared and contextual information to identify the most relevant users for each question. The proposed multimodal motivation scheme exploits users' social ties and monetary rewards to raise their basic motivation levels. LOCI assigns questions to the best answerers via our three proposed algorithms: (i) LOCI-RT, which immediately assigns newly arrived questions/users to available users/questions, (ii) LOCI-LO, which uses short-time batches for locally optimal questions-users assignment, and (iii) LOCI-AD, which assigns short- and long-deadline questions immediately and via batching, respectively. We conduct: (i) a survey to support our assumptions regarding the proposed multimodal motivation scheme, and (ii) trace-driven experiments to evaluate the performance of the three proposed LOCI's algorithms. © 2020 IEEE.

关键词： Motivation

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Integration of Artificial Intelligence in Software Defined Networking Technology through Developing Machine Learning Algorithms

Integration of Artificial Intelligence in Software Defined N...

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Advance computing and Innovative Technologies in Engineering (ICACITE), International Conference on

作者： Lamhot Naibaho Pulkit Raj Saxena Kuldeep Sharma Badria Sulaiman Alfurhood L. Pallavi Bhasker Pant English Language Education Study Program Faculty of Letters and Languages Christian University of Indonesia College of Computing Science and Information Technology Teer Thanker Mahaveer University Moradabad Uttar Pradesh India Department of Computer Science and Engineering Lovely Professional University Phagwara Jalandhar Punjab India Department of Computer Sciences College of Computer Information Sciences Princess Nourah Bint Abdulrahman University Saudi Arabia CSE B V Raju Institute of Technology Narsapur Telangana India Computer Science & Engineering Graphic Era Deemed to be University Dehradun Uttarakhand India

A future networking design called "software-defined networking" combines network programmability with centralized administration (SDN). Network administration is currently handled by SDN, which, at the regulator, which acts as the cable network processor and divides the data plane into a control plane and a data aircraft. Recent breakthroughs in artificial intelligence (Al) have shown a stronger inclination for the science community to benefit from their ability to give learning capabilities and enhance Indicator. The author of this research provides a comprehensive analysis of initiatives underway to incorporate Al with SDN. The study concluded that the three primary Al thread where scientific research was centered were computer science, conceptual, and fuzzy reasoning systems. The authors of this paper explore the several fields in which these approaches may be used, their potential future applications, and the innovations made possible by the integration of AI-based methods into the SDN paradigm. By choosing the right SDN controller, any large organization may lower network complexity, implementation expenses, and maintenance costs. The focus of this article is software defined networking's benefits and downsides (SDN). Following is a basic explanation of artificial intelligence and a list of some of its most significant applications in SDN.

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Diamond-shaped quantum circuit for real-time quantum dynamics in one dimension

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Physical Review Research 2024年第4期6卷 043318-043318页

作者： Shohei Miyakoshi Takanori Sugimoto Tomonori Shirakawa Seiji Yunoki Hiroshi Ueda Center for Quantum Information and Quantum Biology Osaka University Toyonaka Osaka 560-8531 Japan Computational Materials Science Research Team RIKEN Center for Computational Science (R-CCS) Kobe Hyogo 650-0047 Japan Advanced Science Research Center Japan Atomic Energy Agency Tokai Ibaraki 319-1195 Japan Quantum Computational Science Research Team RIKEN Center for Quantum Computing (RQC) Wako Saitama 351-0198 Japan Computational Condensed Matter Physics Laboratory RIKEN Cluster for Pioneering Research (CPR) Wako Saitama 351-0198 Japan RIKEN Interdisciplinary Theoretical and Mathematical Science Program (iTHEMS) Wako Saitama 351-0198 Japan Computational Quantum Matter Research Team RIKEN Center for Emergent Matter Science (CEMS) Wako Saitama 351-0198 Japan

In recent years, quantum computing has evolved as an exciting frontier, with the development of numerous algorithms dedicated to constructing quantum circuits that adeptly represent quantum many-body states. However, this domain remains in its early stages and requires further refinement to better understand the effective construction of highly entangled quantum states within quantum circuits. Here, we demonstrate that quantum many-body states can be universally represented using a quantum circuit comprising multiqubit gates. Furthermore, we evaluate the efficiency of a quantum circuit constructed with two-qubit gates in quench dynamics for the transverse-field Ising model. In this specific model, despite the initial state being classical without entanglement, it undergoes long-time evolution, eventually leading to a highly entangled quantum state. Our results reveal that a diamond-shaped quantum circuit, designed to approximate the multiqubit gate-based quantum circuit, remarkably excels in accurately representing the long-time dynamics of the system. Moreover, the diamond-shaped circuit follows the volume law behavior in entanglement entropy, offering a significant advantage over alternative quantum circuit constructions employing two-qubit gates.

关键词： Quantum entanglement

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Efficient Bitcoin Address Classification Using Quantum-Inspired Feature Selection

arXiv

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arXiv 2024年

作者： Sie, Ming-Fong Chang, Yen-Jui Lin, Chien-Lung Chang, Ching-Ray Liao, Shih-Wei Department of Computer Science and Information Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Rd. Taipei City10617 Taiwan Master Program in Intelligent Computing and Big Data Chung Yuan Christian University No. 499 Xingzhong N. Rd. Taoyuan City320317 Taiwan Department of Physics National Taiwan University Taiwan Quantum Information Center Chung Yuan Christian University No. 499 Xingzhong N. Rd. Taoyuan City320317 Taiwan

Over 900 million Bitcoin transactions have been recorded, posing considerable challenges for machine learning regarding computation time and maintaining prediction accuracy. We propose an innovative approach using quantum-inspired algorithms implemented with Simulated Annealing and Quantum Annealing to address the challenge of local minima in solution spaces. This method efficiently identifies key features linked to mixer addresses, significantly reducing model training time. By categorizing Bitcoin addresses into six classes—exchanges, faucets, gambling, marketplaces, mixers, and mining pools—and applying supervised learning methods, our results demonstrate that feature selection with SA reduced training time by 30.3% compared to using all features in a random forest model while maintaining a 91% F1-score for mixer addresses. This highlights the potential of quantum-inspired algorithms to swiftly and accurately identify high-risk Bitcoin addresses based on transaction features. © 2024, CC BY.

关键词： Simulated annealing

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Predicting User Preferences with XGBoost Learning to Rank Method 3

Predicting User Preferences with XGBoost Learning to Rank Me...

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3rd International Seminar on Research of information Technology and Intelligent Systems, ISRITI 2020

作者： Qomariyah, Nunung Nurul Kazakov, Dimitar Fajar, Ahmad Nurul Bina Nusantara University Faculty of Computing and Media Computer Science Department Jakarta11480 Indonesia University of York Computer Science Department York United Kingdom Binus Graduate Program-Master of Information Systems Management Bina Nusantara University Information Systems Management Department Jakarta11480 Indonesia

ISBN: (纸本)9781728184067

Learning user preferences become very important as the personalization systems grow rapidly in this current era. Offering special and personal services can be an added value for the companies to maintain their customer loyalty. Building a personalized recommendation requires a good machine learning model to understand the individual preferences. Every user can be presented with a list of items sorted by its score learned from the individual preferences. So the first couple items shown will be the most liked items by the user. We can borrow the Learning to Rank algorithm from information Retrieval to solve this problem. In this paper, we present the implementation of user preferences learning by using XGBoost Learning to Rank method in movie domain. We show the evaluation of three different approaches in Learning to Rank according to their Normalized Discounted Cumulative Gain (NDCG) score. We can conclude that in our case study, the pairwise approach appears to be the best solution to produce a personalized list of recommendation. © 2020 IEEE.

关键词： Recommender systems

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