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arXiv 2022年

作者： Chichura, P.M. Foster, A. Patel, C. Ossa-Jaen, N. Ade, P.A.R. Ahmed, Z. Anderson, A.J. Archipley, M. Austermann, J.E. Avva, J.S. Balkenhol, L. Barry, P.S. Thakur, R. Basu Beall, J.A. Benabed, K. Bender, A.N. Benson, B.A. Bianchini, F. Bleem, L.E. Bouchet, F.R. Bryant, L. Byrum, K. Carlstrom, J.E. Carter, F.W. Cecil, T.W. Chang, C.L. Chaubal, P. Chen, G. Chiang, H.C. Cho, H.-M. Chou, T.-L. Citron, R. Cliche, J.-F. Crawford, T.M. Crites, A.T. Cukierman, A. Daley, C.M. Denison, E.V. Dibert, K. Ding, J. Dobbs, M.A. Dutcher, D. Everett, W. Feng, C. Ferguson, K.R. Fu, J. Galli, S. Gallicchio, J. Gambrel, A.E. Gardner, R.W. George, E.M. Goeckner-Wald, N. Gualtieri, R. Guns, S. Gupta, N. Guyser, R. de Haan, T. Halverson, N.W. Harke-Hosemann, A.H. Harrington, N.L. Henning, J.W. Hilton, G.C. Hivon, E. Holder, G.P. Holzapfel, W.L. Hood, J.C. Howe, D. Hrubes, J.D. Huang, N. Hubmayr, J. Irwin, K.D. Jeong, O.B. Jonas, M. Jones, A. Khaire, T.S. Knox, L. Kofman, A.M. Korman, M. Kubik, D.L. Kuhlmann, S. Kuo, C.-L. Lee, A.T. Leitch, E.M. Li, D. Lowitz, A. Lu, C. Marrone, D.P. McMahon, J.J. Meyer, S.S. Michalik, D. Millea, M. Mocanu, L.M. Montgomery, J. Moran, C. Corbett Nadolski, A. Natoli, T. Nguyen, H. Nibarger, J.P. Noble, G. Novosad, V. Omori, Y. Padin, S. Pan, Z. Paschos, P. Patil, S. Pearson, J. Phadke, K.A. Posada, C.M. Prabhu, K. Pryke, C. Quan, W. Rahlin, A. Reichardt, C.L. Riebel, D. Riedel, B. Rouble, M. Ruhl, J.E. Saliwanchik, B.R. Sayre, J.T. Schaffer, K.K. Schiappucci, E. Shirokoff, E. Sievers, C. Smecher, G. Sobrin, J.A. Springmann, A. Stark, A.A. Stephen, J. Story, K.T. Suzuki, A. Tandoi, C. Thompson, K.L. Thorne, B. Tucker, C. Umilta, C. Vale, L.R. Veach, T. Vieira, J.D. Wang, G. Whitehorn, N. Wu, W.L.K. Yefremenko, V. Yoon, K.W. Young, M.R. Department of Physics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Kavli Institute for Cosmological Physics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Department of Physics Case Western Reserve University ClevelandOH44106 United States Department of Physics University of Illinois Urbana-Champaign 1110 West Green Street UrbanaIL61801 United States Department of Physics University of Redlands 1267 East Colton Ave RedlandsCA92374 United States School of Physics and Astronomy Cardiff University CardiffCF24 3YB United Kingdom Kavli Institute for Particle Astrophysics and Cosmology Stanford University 452 Lomita Mall StanfordCA94305 United States SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo ParkCA94025 United States Fermi National Accelerator Laboratory MS209 P.O. Box 500 BataviaIL60510 United States Department of Astronomy University of Illinois at Urbana-Champaign 1002 West Green Street UrbanaIL61801 United States Center for AstroPhysical Surveys National Center for Supercomputing Applications UrbanaIL61801 United States NIST Quantum Devices Group 325 Broadway Mailcode 817.03 BoulderCO80305 United States Department of Physics University of Colorado BoulderCO80309 United States Department of Physics University of California BerkeleyCA94720 United States School of Physics University of Melbourne ParkvilleVIC3010 Australia High-Energy Physics Division Argonne National Laboratory 9700 South Cass Avenue. ArgonneIL60439 United States California Institute of Technology 1200 East California Boulevard. PasadenaCA91125 United States Institut d'Astrophysique de Paris UMR 7095 CNRS Sorbonne Université 98 bis boulevard Arago Paris75014 France Department of Astronomy and Astrophysics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Department of Physics Stanford University 382 Via Pueblo Mall StanfordCA94305 United St

We present the first measurements of asteroids in millimeter wavelength (mm) data from the South Pole Telescope (SPT), which is used primarily to study the cosmic microwave background (CMB). We analyze maps of two ∼ 270 deg2 sky regions near the ecliptic plane, each observed with the SPTpol camera ∼ 100 times over one month. We subtract the mean of all maps of a given field, removing static sky signal, and then average the mean-subtracted maps at known asteroid locations. We detect three asteroids-(324) Bamberga, (13) Egeria, and (22) Kalliope-with signal-to-noise ratios (S/N) of 11.2, 10.4, and 6.1, respectively, at 2.0 mm (150 GHz);we also detect (324) Bamberga with S/N of 4.1 at 3.2 mm (95 GHz). We place constraints on these asteroids' effective emissivities, brightness temperatures, and light curve modulation amplitude. Our flux density measurements of (324) Bamberga and (13) Egeria roughly agree with predictions, while our measurements of (22) Kalliope suggest lower flux, corresponding to effective emissivities of 0.64±0.11 at 2.0 mm and Copyright © 2022, The Authors. All rights reserved.

关键词： Cameras

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Hearing loss prevalence and years lived with disability, 1990-2019: Findings from the Global Burden of Disease Study 2019

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The Lancet 2021年第10278期397卷 996-1009页

作者： Haile, Lydia M. Kamenov, Kaloyan Briant, Paul Svitil Orji, Aislyn U. Steinmetz, Jaimie D. Abdoli, Amir Abdollahi, Mohammad Abu-Gharbieh, Eman Afshin, Ashkan Ahmed, Haroon Rashid, Tarik Ahmed Akalu, Yonas Alahdab, Fares Alanezi, Fahad Mashhour Alanzi, Turki M. Al Hamad, Hanadi Ali, Liaqat Alipour, Vahid Al-Raddadi, Rajaa M. Amu, Hubert Arabloo, Jalal Arab-Zozani, Morteza Arulappan, Judie Ashbaugh, Charlie Atnafu, Desta Debalkie Babar, Zaheer-Ud-Din Baig, Atif Amin Banik, Palash Chandra Bärnighausen, Till Winfried Barrow, Amadou Bender, Rose G. Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bibi, Sadia Bijani, Ali Burkart, Katrin Cederroth, Christopher R. Charan, Jaykaran Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Dagnew, Amare Belachew Dagnew, Baye Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi Desalew, Assefa Dhamnetiya, Deepak Dhimal, Mandira Lamichhane Dhimal, Meghnath Doyle, Kerrie E. Duncan, Bruce B. Ekholuenetale, Michael Filip, Irina Fischer, Florian Franklin, Richard Charles Gaidhane, Abhay Motiramji Gaidhane, Shilpa Gallus, Silvano Ghamari, Farhad Ghashghaee, Ahmad Ghozali, Ghozali Gilani, Syed Amir Glǎvan, Ionela-Roxana Golechha, Mahaveer Goulart, Barbara Niegia Garcia Gupta, Veer Bala Gupta, Vivek Kumar Hamidi, Samer Hammond, Billy Randall Hay, Simon I. Hayat, Khezar Heidari, Golnaz Hoffman, Howard J. Hopf, Kathleen Pillsbury Hosseinzadeh, Mehdi Househ, Mowafa Hussain, Rabia Hwang, Bing-Fang Iavicoli, Ivo Ibitoye, Segun Emmanuel Ilesanmi, Olayinka Stephen Irvani, Seyed Sina Naghibi Islam, Sheikh Mohammed Shariful Iwagami, Masao Jacob, Louis Jayapal, Sathish Kumar Jha, Ravi Prakash Jonas, Jost B. Kalhor, Rohollah Al-Salihi, Nawzad Kameran Kandel, Himal Kasa, Ayele Semachew Kayode, Gbenga A. Khalilov, Rovshan Khan, Ejaz Ahmad Khatib, Mahalaqua Nazli Kosen, Soewarta Koyanagi, Ai Kumar, G. Anil Landires, Ivan Lasrado, Savita Lim, Stephen S. Liu, Xuefeng Lobo, Stany W. Lugo, Alessandra Makki, Alaa Mendoza, Walter Mersha, Amanual Getnet Mihretie, Kebadnew Mulatu Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Noncommunicable Diseases World Health Organization (WHO) Geneva Switzerland Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran University of Medical Sciences Tehran Iran School of Pharmacy Tehran University of Medical Sciences Tehran Iran Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Department of Biosciences COMSATS Institute of Information Technology Islamabad Pakistan Department of Computer Science and Engineering University of Kurdistan Hewler Erbil Iraq Department of Medical Physiology University of Gondar Gondar Ethiopia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia Health Information Management and Technology Department Dammam Saudi Arabia Geriatric and Long Term Care Department Hamad Medical Corporation Doha Qatar Rumailah Hospital Hamad Medical Corporation Doha Qatar Department of Biological Sciences National University of Medical Sciences (NUMS) Rawalpindi Pakistan Health Management and Economics Research Center Tehran Iran Department of Community Medicine King Abdulaziz University Jeddah Saudi Arabia Department of Population and Behavioural Sciences University of Health and Allied Sciences Ho Ghana Social Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran Department of Maternal and Child Health Sultan Qaboos University Muscat Oman Department of Health System and Health Economics Bahir Dar University Bahir Dar Ethiopia Department of Pharmacy University of Huddersfield Huddersfield United Kingdom Unit of Biochemistry Universiti

Background: Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability. Methods: We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested meta-regression models for severity-specific prevalence, accounting for hearing aid coverage, cause, and the presence of tinnitus. We also forecasted the prevalence of hearing loss until 2050. Findings: An estimated 1·57 billion (95% uncertainty interval 1·51–1·64) people globally had hearing loss in 2019, accounting for one in five people (20·3% [19·5–21·1]). Of these, 403·3 million (357·3–449·5) people had hearing loss that was moderate or higher in severity after adjusting for hearing aid use, and 430·4 million (381·7–479·6) without adjustment. The largest number of people with moderate-to-complete hearing loss resided in the Western Pacific region (127·1 million people [112·3–142·6]). Of all people with a hearing impairment, 62·1% (60·2–63·9) were older than 50 years. The Healthcare Access and Quality (HAQ) Index explained 65·8% of the variation in national age-standardised rates of years lived with disability, because countries with a low HAQ Index had higher rates of years lived with disability. By 2050, a projected 2·45 billion (2·35–2·56) people will have hearing loss, a 56·1% (47·3–65·2) increase from 2019, despite stable age-standardised prevalence. Interpretation: As populations age, the number of people with hearing loss will increase. Interventions such as childhood screening, hearing aids, effective management of otitis media and meningitis, and cochlear implants have the potential to ameliorate this burden. Because the burden of moderate-to-complete hearing loss is concentrated in countries with low health-ca

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Quantum computing at the frontiers of biological sciences

arXiv

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arXiv 2019年

作者： Emani, Prashant S. Warrell, Jonathan Anticevic, Alan Bekiranov, Stefan Gandal, Michael McConnell, Michael J. Sapiro, Guillermo Aspuru-Guzik, Alán Baker, Justin Bastiani, Matteo McClure, Patrick Murray, John Sotiropoulos, Stamatios N. Taylor, Jacob Senthil, Geetha Lehner, Thomas Gerstein, Mark B. Harrow, Aram W. Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Department of Molecular Biophysics and Biochemistry Yale University New HavenCT06520 United States Yale School of Medicine Department of Psychiatry New HavenCT06511 United States University of Virginia School of Medicine Department of Biochemistry and Molecular Genetics CharlottesvilleVA22903 United States Department of Psychiatry Semel Institute David Geffen School of Medicine University of California–Los Angeles 695 Charles E. Young Drive South Los AngelesCA90095 United States Univ. of Virginia School of Medicine Department of Neuroscience CharlottesvilleVA22903 United States Department of Electrical and Computer Engineering Duke University DurhamNC27708 United States Department of Chemistry University of Toronto 80 St. George Street TorontoONM5S 3H6 Canada TorontoONM5S 1M1 Canada CIFAR Artificial Intelligence Research Chair Vector Institute TorontoONM5S 1M1 Canada Department of Computer Science University of Toronto 40 St. George Street TorontoONM5S 2E4 Canada Schizophrenia and Bipolar Disorder Program McLean Hospital BelmontMA02478 United States Department of Psychiatry Harvard Medical School BostonMA02114 United States Sir Peter Mansfield Imaging Centre School of Medicine University of Nottingham NottinghamNG7 2RD United Kingdom Machine Learning Team National Institute of Mental Health BethesdaMD20892 United States Section on Functional Imaging Methods National Institute of Mental Health BethesdaMD20892 United States Department of Psychiatry Yale University School of Medicine New HavenCT06511 United States Department of Physics Yale University New HavenCT06511 United States Joint Center for Quantum Information and Computer Science University of Maryland College ParkMD20742 United States National Institute of Standards and Technology GaithersburgMD20899 United States Office of Genomics Research Coordination N

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovation in massively parallel, classical computing hardware and algorithms continues to address many of these challenges, but there is a need to simultaneously consider new paradigms to circumvent current barriers to processing speed. Accordingly, we articulate a view towards quantum computation and quantum information science, where algorithms have demonstrated potential polynomial and exponential computational speedups in certain applications, such as machine learning. The maturation of the field of quantum computing, in hardware and algorithm development, also coincides with the growth of several collaborative efforts to address questions across length and time scales, and scientific disciplines. We use this coincidence to explore the potential for quantum computing to aid in one such endeavor: the merging of insights from genetics, genomics, neuroimaging and behavioral phenotyping. By examining joint opportunities for computational innovation across fields, we highlight the need for a common language between biological data analysis and quantum computing. Ultimately, we consider current and future prospects for the employment of quantum computing algorithms in the biological sciences. Copyright © 2019, The Authors. All rights reserved.

关键词： Machine learning

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Correction to: Does CO2 emissions-economic growth relationship reveal EKC in developing countries? Evidence from Kazakhstan

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Environmental science and pollution research international 2019年第34期26卷 35282页

作者： Fakhri J Hasanov Jeyhun I Mikayilov Shahriyar Mukhtarov Elchin Suleymanov King Abdullah Petroleum Studies and Research Center P.O. Box 88550 Riyadh 11672 Saudi Arabia. Research Program on Forecasting Economics Department The George Washington University 2115 G Street NW Washington DC 20052 USA. Institute of Control Systems B. Vahabzade Street 9 AZ1141 Baku Azerbaijan. Department of Statistics and Econometrics Azerbaijan State University of Economics Istiqlaliyyat Str. 6 AZ1001 Baku Azerbaijan. Institute for Scientific Research on Economic Reforms 88a Hasan Bey Zardabi Avenue AZ1011 Baku Azerbaijan. Department ofWorld Economy Baku Engineering University Hasan Aliyev 120 AZ0101 Khirdalan Azerbaijan. smuxtarov@beu.edu.az. UNEC Empirical Research Center Azerbaijan State University of Economics (UNEC) Istiqlaliyyat Str. 6 AZ1141 Baku Azerbaijan. smuxtarov@beu.edu.az. Department of Finance Baku Engineering University Hasan Aliyev 120 AZ0101 Khirdalan Azerbaijan. The Institute of Economics Azerbaijan National Academy of Sciences H. Javid pr. 115 AZ1001 Baku Azerbaijan.

The article Does CO emissions-economic growth relationship reveal EKC in developing countries? Evidence from Kazakhstan, written by Fakhri J. Hasanov, Jeyhun I.

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Transportation system based summer academy for teachers (RTP, Strand 4) 122

Transportation system based summer academy for teachers (RTP...

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2015 122nd ASEE Annual Conference and Exposition

作者： Nambisan, Shashi S. Richards, Jennifer Li, Wenshu University of Tennessee Department of Civil Engineering KnoxvilleUT United States University of Tennessee Evaluation Statistics and Measurement Program United States

This paper summarized efforts related to and results from the development and implementation of a 3-day long transportation systems based summer academy (workshop) for 20 teachers. The Academy included brief "in-class" overviews of transportation systems, logistics and supply chain management, and how these related to key STEM concepts followed by 2 days of "site" visits to a variety of transportation system settings. These were combined with seminar style discussions of how teachers experiences on these field trips related to STEM content standards. The participating teachers were each provided a $200 stipend. A pre-test and a post-test were administered to the participants in the Academy to assess the extent of their awareness and knowledge of key concepts about transportation systems. Nine teachers were selected from the summer Academy participants to develop transportation themed lesson plans, implement them in their classes, and evaluate them. This is to help refine the lesson plans for online publication to make them accessible globally. These participants were each offered an additional stipend of $300 for completing this process. While the goal was for the teachers to complete their efforts by December 2014, many of them have experienced problems in completing their work. The revised schedule now coincided with the end of the school year. Feedback from participants in the Academy strongly indicate that the summer Academy provided them real-world contexts to not only to help their students better understand theoretical concepts, but also to help the teachers themselves to gain a broader and deeper understanding and knowledge of transportation systems and how they could adopt the same in fostering deeper learning amongst their students, especially in STEM disciplines. These were validated by the statistical analyses of the data from the tests used to evaluate the same. Efforts are underway to offer a similar summer Academy in June 2015. However, this year's pr

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Optimal CMB lensing reconstruction and parameter estimation with SPTpol data

arXiv

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arXiv 2020年

作者： Millea, Marius Daley, C.M. Chou, T.-L. Anderes, E. Ade, P.A.R. Anderson, A.J. Austermann, J.E. Avva, J.S. Beall, J.A. Bender, A.N. Benson, B.A. Bianchini, F. Bleem, L.E. Carlstrom, J.E. Chang, C.L. Chaubal, P. Chiang, H.C. Citron, R. Corbett Moran, C. Crawford, T.M. Crites, A.T. de Haan, T. Dobbs, M.A. Everett, W. Gallicchio, J. George, E.M. Goeckner-Wald, N. Guns, S. Gupta, N. Halverson, N.W. Henning, J.W. Hilton, G.C. Holder, G.P. Holzapfel, W.L. Hrubes, J.D. Huang, N. Hubmayr, J. Irwin, K.D. Knox, L. Lee, A.T. Li, D. Lowitz, A. McMahon, J.J. Meyer, S.S. Mocanu, L.M. Montgomery, J. Natoli, T. Nibarger, J.P. Noble, G. Novosad, V. Omori, Y. Padin, S. Patil, S. Pryke, C. Reichardt, C.L. Ruhl, J.E. Saliwanchik, B.R. Schaffer, K.K. Sievers, C. Smecher, G. Stark, A.A. Thorne, B. Tucker, C. Veach, T. Vieira, J.D. Wang, G. Whitehorn, N. Wu, W.L.K. Yefremenko, V. Department of Physics University of California BerkeleyCA94720 United States Astronomy Department University of Illinois at Urbana-Champaign 1002 W. Green Street UrbanaIL61801 United States Kavli Institute for Cosmological Physics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Department of Physics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Department of Statistics University of California One Shields Avenue DavisCA95616 United States Cardiff University CardiffCF10 3XQ United Kingdom Fermi National Accelerator Laboratory MS209 P.O. Box 500 BataviaIL60510 United States NIST Quantum Devices Group 325 Broadway Mailcode 817.03 BoulderCO80305 United States Department of Physics University of Colorado BoulderCO80309 United States High Energy Physics Division Argonne National Laboratory 9700 S. Cass Avenue ArgonneIL60439 United States Department of Astronomy and Astrophysics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States School of Physics University of Melbourne ParkvilleVIC3010 Australia Enrico Fermi Institute University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Department of Physics McGill University 3600 Rue University MontrealQCH3A 2T8 Canada School of Mathematics Statistics & Computer Science University of KwaZulu-Natal Durban South Africa University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States Jet Propulsion Laboratory PasadenaCA91109 United States Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St George St TorontoONM5S 3H4 Canada Department of Astronomy & Astrophysics University of Toronto 50 St George St TorontoONM5S 3H4 Canada Physics Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Canadian Institute for Advanced Research CIFAR Program in Gravity Extreme Universe TorontoONM5G 1Z8 Canada Department of Astrophysical and Pla

We perform the first simultaneous Bayesian parameter inference and optimal reconstruction of the gravitational lensing of the cosmic microwave background (CMB), using 100 deg2 of polarization observations from the SPTpol receiver on the South Pole Telescope. These data reach noise levels as low as 5.8 µK-arcmin in polarization, which are low enough that the typically used quadratic estimator (QE) technique for analyzing CMB lensing is significantly sub-optimal. Conversely, the Bayesian procedure extracts all lensing information from the data and is optimal at any noise level. We infer the amplitude of the gravitational lensing potential to be Aφ = 0.949 ±0.122 using the Bayesian pipeline, consistent with our QE pipeline result, but with 17% smaller error bars. The Bayesian analysis also provides a simple way to account for systematic uncertainties, performing a similar job as frequentist "bias hardening," and reducing the systematic uncertainty on Aφ due to polarization calibration from almost half of the statistical error to effectively zero. Finally, we jointly constrain Aφ along with AL, the amplitude of lensing-like effects on the CMB power spectra, demonstrating that the Bayesian method can be used to easily infer parameters both from an optimal lensing reconstruction and from the delensed CMB, while exactly accounting for the correlation between the two. These results demonstrate the feasibility of the Bayesian approach on real data, and pave the way for future analysis of deep CMB polarization measurements with SPT-3G, Simons Observatory, and CMB-S4, where improvements relative to the QE can reach 1.5 times tighter constraints on Aφ and 7 times lower effective lensing reconstruction noise. Copyright © 2020, The Authors. All rights reserved.

关键词： Cosmology

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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020)

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LANCET 2020年第10239期395卷 1762-1762页

作者： Reiner, R. C., Jr. Hay, S., I Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health School of Medicine University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States College of Health and Medical Sciences Haramaya University Harar Ethiopia Department of Epidemiology and Biostatistics Haramaya University Harar Ethiopia Department of Medical Laboratory Sciences Haramaya University Harar Ethiopia School of Nursing and Midwifery Haramaya University Harar Ethiopia School of Pharmacy Haramaya University Harar Ethiopia School of Public Health Haramaya University Harar Ethiopia Haramaya University Harar Ethiopia Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Biology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Research Institute Tehran University of Medical Sciences Tehran Iran Department of Economics and Management Sciences for Health Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Department of Microbiology Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran Iran National Institute of Health Research Tehran University of Medical Sciences Tehran Iran Metabolomics and

Summary Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood *** We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor *** The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy *** By co-analysing geospatial trends in d

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A demonstration of improved constraints on primordial gravitational waves with delensing

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Physical Review D 2021年第2期103卷 022004-022004页

作者： P. A. R. Ade Z. Ahmed M. Amiri A. J. Anderson J. E. Austermann J. S. Avva D. Barkats R. Basu Thakur J. A. Beall A. N. Bender B. A. Benson F. Bianchini C. A. Bischoff L. E. Bleem J. J. Bock H. Boenish E. Bullock V. Buza J. E. Carlstrom C. L. Chang J. R. Cheshire, IV H. C. Chiang T-L. Chou R. Citron J. Connors C. Corbett Moran J. Cornelison T. M. Crawford A. T. Crites M. Crumrine A. Cukierman T. de Haan M. Dierickx M. A. Dobbs L. Duband W. Everett S. Fatigoni J. P. Filippini S. Fliescher J. Gallicchio E. M. George T. St. Germaine N. Goeckner-Wald D. C. Goldfinger J. Grayson N. Gupta G. Hall M. Halpern N. W. Halverson S. Harrison S. Henderson J. W. Henning S. R. Hildebrandt G. C. Hilton G. P. Holder W. L. Holzapfel J. D. Hrubes N. Huang J. Hubmayr H. Hui K. D. Irwin J. Kang K. S. Karkare E. Karpel S. Kefeli S. A. Kernasovskiy L. Knox J. M. Kovac C. L. Kuo K. Lau A. T. Lee E. M. Leitch D. Li A. Lowitz A. Manzotti J. J. McMahon K. G. Megerian S. S. Meyer M. Millea L. M. Mocanu L. Moncelsi J. Montgomery A. Nadolski T. Namikawa T. Natoli C. B. Netterfield H. T. Nguyen J. P. Nibarger G. Noble V. Novosad R. O’Brient R. W. Ogburn, IV Y. Omori S. Padin S. Palladino S. Patil T. Prouve C. Pryke B. Racine C. L. Reichardt C. D. Reintsema S. Richter J. E. Ruhl B. R. Saliwanchik K. K. Schaffer A. Schillaci B. L. Schmitt R. Schwarz C. D. Sheehy C. Sievers G. Smecher A. Soliman A. A. Stark B. Steinbach R. V. Sudiwala G. P. Teply K. L. Thompson J. E. Tolan C. Tucker A. D. Turner C. Umiltà T. Veach J. D. Vieira A. G. Vieregg A. Wandui G. Wang A. C. Weber N. Whitehorn D. V. Wiebe J. Willmert C. L. Wong W. L. K. Wu H. Yang V. Yefremenko K. W. Yoon E. Young C. Yu L. Zeng C. Zhang Cardiff University Cardiff CF10 3XQ United Kingdom SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park California 94025 USA Kavli Institute for Particle Astrophysics and Cosmology Stanford University 452 Lomita Mall Stanford California 94305 USA Department of Physics and Astronomy University of British Columbia Vancouver British Columbia V6T 1Z1 Canada Fermi National Accelerator Laboratory MS209 P.O. Box 500 Batavia Illinois 60510 USA NIST Quantum Devices Group 325 Broadway Mailcode 817.03 Boulder Colorado 80305 USA Department of Physics University of Colorado Boulder Colorado 80309 USA Department of Physics University of California Berkeley California 94720 USA Harvard-Smithsonian Center for Astrophysics 60 Garden Street Cambridge Massachusetts 02138 USA California Institute of Technology MS 249-17 1216 E. California Blvd. Pasadena California 91125 USA High Energy Physics Division Argonne National Laboratory 9700 S. Cass Avenue Argonne Illinois 60439 USA Kavli Institute for Cosmological Physics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Astronomy and Astrophysics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA School of Physics University of Melbourne Parkville Victoria 3010 Australia Department of Physics University of Cincinnati Cincinnati Ohio 45221 USA Jet Propulsion Laboratory Pasadena California 91109 USA Department of Physics Harvard University Cambridge Massachusetts 02138 USA Minnesota Institute for Astrophysics University of Minnesota Minneapolis Minnesota 55455 USA Department of Physics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Enrico Fermi Institute University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Physics McGill University 3600 Rue University Montreal Quebec H3A 2T8 Canada School of Mathematics Statistics and Computer Science University of KwaZulu-Natal Dur

We present a constraint on the tensor-to-scalar ratio, r, derived from measurements of cosmic microwave background (CMB) polarization B-modes with “delensing,” whereby the uncertainty on r contributed by the sample variance of the gravitational lensing B-modes is reduced by cross-correlating against a lensing B-mode template. This template is constructed by combining an estimate of the polarized CMB with a tracer of the projected large-scale structure. The large-scale-structure tracer used is a map of the cosmic infrared background derived from Planck satellite data, while the polarized CMB map comes from a combination of South Pole Telescope, bicep/Keck, and Planck data. We expand the bicep/Keck likelihood analysis framework to accept a lensing template and apply it to the bicep/Keck dataset collected through 2014 using the same parametric foreground modeling as in the previous analysis. From simulations, we find that the uncertainty on r is reduced by ∼10%, from σ(r)=0.024 to 0.022, which can be compared with a ∼26% reduction obtained when using a perfect lensing template or if there were zero lensing B-modes. Applying the technique to the real data, the constraint on r is improved from r0.05<0.090 to r0.05<0.082 (95% C.L.). This is the first demonstration of improvement in an r constraint through delensing.

关键词： Cosmic microwave background Inflation Large scale structure of the Universe

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Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

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European urology 2018年第3期73卷 322-339页

作者： Shancheng Ren Gong-Hong Wei Dongbing Liu Liguo Wang Yong Hou Shida Zhu Lihua Peng Qin Zhang Yanbing Cheng Hong Su Xiuqing Zhou Jibin Zhang Fuqiang Li Hancheng Zheng Zhikun Zhao Changjun Yin Zengquan He Xin Gao Haiyen E Zhau Chia-Yi Chu Jason Boyang Wu Colin Collins Stanislav V Volik Robert Bell Jiaoti Huang Kui Wu Danfeng Xu Dingwei Ye Yongwei Yu Lianhui Zhu Meng Qiao Hang-Mao Lee Yuehong Yang Yasheng Zhu Xiaolei Shi Rui Chen Yang Wang Weidong Xu Yanqiong Cheng Chuanliang Xu Xu Gao Tie Zhou Bo Yang Jianguo Hou Li Liu Zhensheng Zhang Yao Zhu Chao Qin Pengfei Shao Jun Pang Leland W K Chung Jianfeng Xu Chin-Lee Wu Weide Zhong Xun Xu Yingrui Li Xiuqing Zhang Jian Wang Huanming Yang Jun Wang Haojie Huang Yinghao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai China. Biocenter Oulu Faculty of Biochemistry and Molecular Medicine University of Oulu Oulu Finland. BGI-Shenzhen Shenzhen China China National GeneBank-Shenzhen BGI-Shenzhen Shenzhen China. Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester MN USA. China National GeneBank-Shenzhen BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Division of Genomics and Bioinformatics CUHK-BGI Innovation Institute of Trans-Omics The Chinese University of Hong Kong Hong Kong China. BGI Education Center University of Chinese Academy of Sciences Shenzhen China. BGI-Shenzhen Shenzhen China. School of Biological Science and Medical Engineering Southeast University Nanjing China State Key Laboratory of Bioelectronics Southeast University Nanjing China. Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China. Department of Urology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou China. Uro-Oncology Research Program Department of Medicine Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles CA USA. Vancouver Prostate Centre and Department of Urologic Sciences University of British Columbia Vancouver BC Canada. Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles CA USA. Department of Urology Changzheng Hospital Second Military Medical University Shanghai China. Department of Urology Fudan University Shanghai Cancer Center Shanghai China. Department of Pathology Shanghai Changhai Hospital Second Military Medical University Shanghai China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China Program for Personalized Cancer Care NorthShore University HealthS

BACKGROUND:Global disparities in prostate cancer (PCa) incidence highlight the urgent need to identify genomic abnormalities in prostate tumors in different ethnic populations including Asian men. OBJECTIVE:To systematically explore the genomic complexity and define disease-driven genetic alterations in PCa. DESIGN, SETTING, AND PARTICIPANTS:The study sequenced whole-genome and transcriptome of tumor-benign paired tissues from 65 treatment-naive Chinese PCa patients. Subsequent targeted deep sequencing of 293 PCa-relevant genes was performed in another cohort of 145 prostate tumors. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:The genomic alteration landscape in PCa was analyzed using an integrated computational pipeline. Relationships with PCa progression and survival were analyzed using nonparametric test, log-rank, and multivariable Cox regression analyses. RESULTS AND LIMITATIONS:We demonstrated an association of high frequency of CHD1 deletion with a low rate of TMPRSS2-ERG fusion and relatively high percentage of mutations in androgen receptor upstream activator genes in Chinese patients. We identified five putative clustered deleted tumor suppressor genes and provided experimental and clinical evidence that PCDH9, deleted/loss in approximately 23% of tumors, functions as a novel tumor suppressor gene with prognostic potential in PCa. Furthermore, axon guidance pathway genes were frequently deregulated, including gain/amplification of PLXNA1 gene in approximately 17% of tumors. Functional and clinical data analyses showed that increased expression of PLXNA1 promoted prostate tumor growth and independently predicted prostate tumor biochemical recurrence, metastasis, and poor survival in multi-institutional cohorts of patients with PCa. A limitation of this study is that other genetic alterations were not experimentally investigated. CONCLUSIONS:There are shared and salient genetic characteristics of PCa in Chinese and Caucasian men. Novel genetic alterations i

关键词： AR coactivator mutation Axon guidance pathway CHD1 deletion Chinese prostate cancer Clustered deleted tumor suppressor genes Personalized medicine Prognosis RNA-seq TMPRSS2-ERG fusion Whole genome sequencing

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Corrigendum to "A Gene Module-Based eQTL Analysis Prioritizing Disease Genes and Pathways in Kidney Cancer"

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Computational and structural biotechnology journal 2018年 16卷 196页

作者： M Q Yang D Li W Yang Y Zhang J Liu W Tong Joint Bioinformatics Graduate Program Department of Information Science George W. Donaghey College of Engineering and Information Technology University of Arkansas at Little Rock USA. University of Arkansas for Medical Sciences 2801 S. University Ave Little Rock AR 72204 USA. School of Computer Science Carnegie Mellon University 5000 Forbes Ave Pittsburgh PA 15213 USA. Department of Statistics Harvard University Cambridge MA 02138 USA. Divisions of Bioinformatics and Biostatistics National Center for Toxicological Research US Food and Drug Administration 3900 NCTR Road Jefferson AR 72079 USA.

[This corrects the article DOI: 10.1016/***.2017.09.003.].

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