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Author Correction: A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Nature communications 2024年第1期15卷 8955页

作者： Andrea Cortese Sarah J Beecroft Stefano Facchini Riccardo Curro Macarena Cabrera-Serrano Igor Stevanovski Sanjog R Chintalaphani Hasindu Gamaarachchi Ben Weisburd Chiara Folland Gavin Monahan Carolin K Scriba Lein Dofash Mridul Johari Bianca R Grosz Melina Ellis Liam G Fearnley Rick Tankard Justin Read Ashirwad Merve Natalia Dominik Elisa Vegezzi Ricardo P Schnekenberg Gorka Fernandez-Eulate Marion Masingue Diane Giovannini Martin B Delatycki Elsdon Storey Mac Gardner David J Amor Garth Nicholson Steve Vucic Robert D Henderson Thomas Robertson Jason Dyke Vicki Fabian Frank Mastaglia Mark R Davis Marina Kennerson Ros Quinlivan Simon Hammans Arianna Tucci Melanie Bahlo Catriona A McLean Nigel G Laing Tanya Stojkovic Henry Houlden Michael G Hanna Ira W Deveson Paul J Lockhart Phillipa J Lamont Michael C Fahey Enrico Bugiardini Gianina Ravenscroft Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology London UK. andrea.cortese@ucl.ac.uk. Department of Brain and Behavioral Sciences University of Pavia Pavia Italy. andrea.cortese@ucl.ac.uk. Pawsey Supercomputing Research Centre Kensington WA Australia. Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology London UK. Department of Brain and Behavioral Sciences University of Pavia Pavia Italy. Harry Perkins Institute of Medical Research Nedlands WA Australia. Department of Neurology and Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/Universidad de Sevilla/CSIC Sevilla 41013 Spain. Genomics and Inherited Disease Program Garvan Institute of Medical Research Sydney NSW Australia. Centre for Population Genomics Garvan Institute of Medical Research and Murdoch Children's Research Institute Sydney NSW Australia. School of Computer Science and Engineering University of New South Wales Sydney NSW Australia. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA. Centre for Medical Research University of Western Australia Nedlands WA Australia. Northcott Neuroscience Laboratory ANZAC Research Institute Sydney NSW 2139 Australia. Faculty of Medicine and Health University of Sydney Sydney NSW 2006 Australia. Population Health and Immunity Division The Walter and Eliza Hall Institute of Medical Research 1 G Royal Parade Parkville VIC 3052 Australia. Department of Medical Biology The University of Melbourne 1G Royal Parade Parkville VIC3052 Australia. Department of Mathematics and Statistics Curtin University Perth WA Australia. Bruce Lefroy Centre Murdoch Children's Research Institute Parkville VIC Australia. Department of Paediatrics University of Melbourne Royal Children's Hospital Parkville VIC Australia. Department of Neuropathology National Hospital for Neurology and Neurosurgery London United Kingdom. IRCCS Mondino Foundation

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Euclid: Early Release Observations – A preview of the Euclid era through a galaxy cluster magnifying lens

arXiv

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arXiv 2024年

作者： Atek, Hakim Gavazzi, R. Weaver, J.R. Diego, J.M. Schrabback, T. Hatch, N.A. Aghanim, N. Dole, H. Hartley, W.G. Taamoli, S. Congedo, G. Jimenez-Teja, Y. Cuillandre, J.-C. Bañados, E. Belladitta, S. Bowler, R.A.A. Franco, M. Jauzac, M. Mahler, G. Richard, J. Rocci, P.-F. Serjeant, S. Toft, S. Abriola, D. Bergamini, P. Biviano, A. Dimauro, P. Ezziati, M. Golden-Marx, J.B. Grillo, C. Hughes, A.C.N. Kang, Y. Kneib, J.-P. Lombardi, M. Mamon, G.A. McPartland, C.J.R. Meneghetti, M. Miyatake, H. Montes, M. Mortlock, D.J. Oesch, P.A. Okabe, N. Rosati, P. Taylor, A.N. Tarsitano, F. Weller, J. Kluge, M. Laureijs, R. Paltani, S. Saifollahi, T. Schirmer, M. Stone, C. Mora, A. Altieri, B. Amara, A. Andreon, S. Auricchio, N. Baldi, M. Balestra, A. Bardelli, S. Basset, A. Bender, R. Bodendorf, C. Bonino, D. Branchini, E. Brescia, M. Brinchmann, J. Camera, S. Candini, G.P. Capobianco, V. Carbone, C. Cardone, V.F. Carretero, J. Casas, S. Castander, F.J. Castellano, M. Cavuoti, S. Cimatti, A. Conselice, C.J. Conversi, L. Copin, Y. Corcione, L. Courbin, F. Courtois, H.M. Da Silva, A. Degaudenzi, H. Di Giorgio, A.M. Dinis, J. Douspis, M. Dubath, F. Dupac, X. Dusini, S. Ealet, A. Farina, M. Farrens, S. Ferriol, S. Fotopoulou, S. Frailis, M. Franceschi, E. Galeotta, S. Gillard, W. Gillis, B. Giocoli, C. Gómez-Alvarez, P. Grazian, A. Grupp, F. Guzzo, L. Hailey, M. Haugan, S.V.H. Hoar, J. Hoekstra, H. Holliman, M.S. Holmes, W. Hook, I. Hormuth, F. Hornstrup, A. Hudelot, P. Jahnke, K. Jhabvala, M. Keihänen, E. Kermiche, S. Kiessling, A. Kitching, T. Kohley, R. Kubik, B. Kuijken, K. Kümmel, M. Kunz, M. Kurki-Suonio, H. Lahav, O. Le Mignant, D. Ligori, S. Lilje, P.B. Lindholm, V. Lloro, I. Maino, D. Maiorano, E. Mansutti, O. Marggraf, O. Markovic, K. Martinet, N. Marulli, F. Massey, R. Maurogordato, S. McCracken, H.J. Mei, S. Mellier, Y. Merlin, E. Meylan, G. Moresco, M. Moscardini, L. Nakajima, R. Nichol, R.C. Institut d’Astrophysique de Paris UMR 7095 CNRS Sorbonne Université 98 bis boulevard Arago Paris75014 France Aix-Marseille Université CNRS CNES LAM Marseille France Department of Astronomy University of Massachusetts AmherstMA01003 United States Instituto de Física de Cantabria Edificio Juan Jordá Avenida de los Castros Santander39005 Spain Universität Innsbruck Institut für Astro- und Teilchenphysik Technikerstr. 25/8 Innsbruck6020 Austria School of Physics and Astronomy University of Nottingham University Park NottinghamNG7 2RD United Kingdom Université Paris-Saclay CNRS Institut d’astrophysique spatiale Orsay91405 France Department of Astronomy University of Geneva ch. d’Ecogia 16 Versoix1290 Switzerland Physics and Astronomy Department University of California 900 University Ave. RiversideCA92521 United States Institute for Astronomy University of Edinburgh Royal Observatory Blackford Hill EdinburghEH9 3HJ United Kingdom Instituto de Astrofísica de Andalucía CSIC Glorieta de la Astronomía Granada18080 Spain Observatorio Nacional Rua General Jose Cristino 77-Bairro Imperial de Sao Cristovao Rio de Janeiro20921-400 Brazil Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-Yvette91191 France Max-Planck-Institut für Astronomie Königstuhl 17 Heidelberg69117 Germany INAF-Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Via Piero Gobetti 93/3 Bologna40129 Italy Jodrell Bank Centre for Astrophysics Department of Physics and Astronomy University of Manchester Oxford Road ManchesterM13 9PL United Kingdom The University of Texas at Austin AustinTX78712 United States Department of Physics Centre for Extragalactic Astronomy Durham University South Road DH1 3LE United Kingdom Department of Physics Institute for Computational Cosmology Durham University South Road DH1 3LE United Kingdom Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban4041 South Africa School of

We present the first analysis of the Euclid Early Release Observations (ERO) program that targets fields around two lensing clusters, Abell 2390 and Abell 2764. We use VIS and NISP imaging to produce photometric catalogs for a total of ∼ 500 000 objects. The imaging data reach a 5 σ typical depth in the range 25.1–25.4 AB in the NISP bands, and 27.1–27.3 AB in the VIS band. Using the Lyman-break method in combination with photometric redshifts, we search for high-redshift galaxies. We identify 30 Lyman-break galaxy (LBG) candidates at z > 6 and 139 extremely red sources (ERSs), most likely at lower redshift. The deeper VIS imaging compared to NISP means we can routinely identify high-redshift Lyman breaks of the order of 3 magnitudes, which reduces contamination by brown dwarf stars and low-redshift galaxies. The difficulty of spatially resolving most of these sources in 0′′ . 3 pix−1 imaging makes the distinction between galaxies and quasars more challenging. Spectroscopic followup campaigns of such bright sources will help constrain both the bright end of the ultraviolet galaxy luminosity function and the quasar luminosity function at z > 6, and constrain the physical nature of these objects. Additionally, we have performed a combined strong lensing and weak lensing analysis of A2390, and demonstrate how Euclid will contribute to better constraining the virial mass of galaxy clusters. From these data, we also identify optical and near-infrared counterparts of known z > 0.6 clusters, which exhibit strong lensing features, establishing the ability of Euclid to characterize high-redshift clusters. Finally, we provide a glimpse of Euclid’s ability to map the intracluster light out to larger radii than current facilities, enabling a better understanding of the cluster assembly history and mapping of the dark matter distribution. This initial dataset illustrates the diverse spectrum of legacy science that will be enabled by the Euclid survey. © 2024, CC BY.

关键词： Galaxies

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Proceedings of the 8th Annual Conference on the Science of Dissemination and Implementation : Washington, DC, USA. 14-15 December 2015

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Implementation science : IS 2016年第2期11 Suppl 2卷 100页

作者： Chambers, David Simpson, Lisa Hill-Briggs, Felicia Neta, Gila Vinson, Cynthia Beidas, Rinad Marcus, Steven Aarons, Gregory Hoagwood, Kimberly Schoenwald, Sonja Evans, Arthur Hurford, Matthew Rubin, Ronnie Hadley, Trevor Barg, Frances Walsh, Lucia Adams, Danielle Mandell, David Martin, Lindsey Mignogna, Joseph Mott, Juliette Hundt, Natalie Kauth, Michael Kunik, Mark Naik, Aanand Cully, Jeffrey McGuire, Alan White, Dominique Bartholomew, Tom McGrew, John Luther, Lauren Rollins, Angie Salyers, Michelle Cooper, Brittany Funaiole, Angie Richards, Julie Lee, Amy Lapham, Gwen Caldeiro, Ryan Lozano, Paula Gildred, Tory Achtmeyer, Carol Ludman, Evette Addis, Megan Marx, Larry Bradley, Katharine VanDeinse, Tonya Wilson, Amy Blank Stacey, Burgin Powell, Byron Bunger, Alicia Cuddeback, Gary Barnett, Miya Stadnick, Nicole Brookman-Frazee, Lauren Lau, Anna Dorsey, Shannon Pullmann, Michael Mitchell, Shannon Schwartz, Robert Kirk, Arethusa Dusek, Kristi Oros, Marla Hosler, Colleen Gryczynski, Jan Barbosa, Carolina Dunlap, Laura Lounsbury, David O’Grady, Kevin Brown, Barry Damschroder, Laura Waltz, Thomas Ritchie, Mona Atkins, David Imel, Zac E. Xiao, Bo Can, Doğan Georgiou, Panayiotis Narayanan, Shrikanth Berkel, Cady Gallo, Carlos Sandler, Irwin Brown, C. Hendricks Wolchik, Sharlene Mauricio, Anne Marie Mehrotra, Sanjay Chandurkar, Dharmendra Bora, Siddhartha Das, Arup Tripathi, Anand Saggurti, Niranjan Raj, Anita Hughes, Eric Jacobs, Brian Kirkendall, Eric Loeb, Danielle Trinkley, Katy Yang, Michael Sprowell, Andrew Nease, Donald Lyon, Aaron Lewis, Cara Boyd, Meredith Melvin, Abigail Nicodimos, Semret Liu, Freda Jungbluth, Nathanial Flynn, Allen Landis-Lewis, Zach Sales, Anne Baloh, Jure Ward, Marcia Zhu, Xi Bennett, Ian Unutzer, Jurgen Mao, Johnny Proctor, Enola Vredevoogd, Mindy Chan, Ya-Fen Williams, Nathaniel Green, Phillip Bernstein, Steven Rosner, June-Marie DeWitt, Michelle Tetrault, Jeanette Dziura, James Hsiao, Allen Sussman, Scott O’Connor, Patrick Toll, Benjamin Jones, Michael Gassaway, Julie Tobin, Jonathan Zatzic Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville USA AcademyHealth Washington USA Department of Medicine and Welch Center for Prevention Epidemiology and Clinical Research Johns Hopkins Medical Institutions Baltimore USA Psychiatry University of Pennsylvania Philadelphia USA Family Medicine and Community Health University of Pennsylvania Philadelphia USA School of Social Policy and Practice University of Pennsylvania Philadelphia USA Psychiatry UC San Diego La Jolla USA Child & Adolescent Psychiatry The Child Study Center at NYU Langone Medical Center New York NY New York USA Psychiatry and Behavioral Sciences MUSC Charleston USA DBHIDS City of Philadelphia Philadelphia USA CBH City of Philadelphia Philadelphia USA Psychiatry University of Pennsylvania Perelman School of Medicine Philadelphia USA Health Services Research & Development Department of Veterans Affairs & Baylor College of Medicine Houston USA Treatment Core Department of Veterans Affairs Waco USA National Center for PTSD Executive Division Department of Veterans Affairs White River Junction USA HSR&D HSR&D Center for Health Information and Communication Roudebush VA Medical Center Indianapolis USA Psychology Indiana University Purdue University Indianapolis Indianapolis USA Department of Psychiatric Rehabilitation and Counseling Rutgers University Newark USA Health Services Research & Development Richard L. Roudebush VAMC Indianapolis USA IUPUI Department of Psychology ACT Center of Indiana Indianapolis USA Human Development Washington State University Pullman USA Prevention Science Washington State University Pullman USA Group Health Research Institute Group Health Seattle USA Behavioral Health Services Group Health Seattle USA Preventive Care Group Health Seattle USA Health Services Research & Development Primary and Specialty Medical Care Service VA Puget Sound Seattle USA School of Social Work Un

A1 Introduction to the 8th Annual Conference on the Science of Dissemination and Implementation: Optimizing Personal and Population Health David Chambers, Lisa Simpson D1 Discussion forum: Population health D&I research Felicia Hill-Briggs D2 Discussion forum: Global health D&I research Gila Neta, Cynthia Vinson D3 Discussion forum: Precision medicine and D&I research David Chambers S1 Predictors of community therapists’ use of therapy techniques in a large public mental health system Rinad Beidas, Steven Marcus, Gregory Aarons, Kimberly Hoagwood, Sonja Schoenwald, Arthur Evans, Matthew Hurford, Ronnie Rubin, Trevor Hadley, Frances Barg, Lucia Walsh, Danielle Adams, David Mandell S2 Implementing brief cognitive behavioral therapy (CBT) in primary care: Clinicians' experiences from the field Lindsey Martin, Joseph Mignogna, Juliette Mott, Natalie Hundt, Michael Kauth, Mark Kunik, Aanand Naik, Jeffrey Cully S3 Clinician competence: Natural variation, factors affecting, and effect on patient outcomes Alan McGuire, Dominique White, Tom Bartholomew, John McGrew, Lauren Luther, Angie Rollins, Michelle Salyers S4 Exploring the multifaceted nature of sustainability in community-based prevention: A mixed-method approach Brittany Cooper, Angie Funaiole S5 Theory informed behavioral health integration in primary care: Mixed methods evaluation of the implementation of routine depression and alcohol screening and assessment Julie Richards, Amy Lee, Gwen Lapham, Ryan Caldeiro, Paula Lozano, Tory Gildred, Carol Achtmeyer, Evette Ludman, Megan Addis, Larry Marx, Katharine Bradley S6 Enhancing the evidence for specialty mental health probation through a hybrid efficacy and implementation study Tonya VanDeinse, Amy Blank Wilson, Burgin Stacey, Byron Powell, Alicia Bunger, Gary Cuddeback S7 Personalizing evidence-based child mental health care within a fiscally mandated policy reform Miya Barnett, Nicole Stadnick, Lauren Brookman-Frazee, Anna Lau S8 Leveraging an existing

关键词： Veteran Affair Motivational Interview Qualitative Comparative Analysis Community That Care Supplemental Nutrition Assistance program

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Getting Undergraduates Ready for China’s Belt and Road Initiative (BRI) Through an Overseas Experiential Learning Project

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China and the World 2021年第3期4卷

作者： Andrew Min Han Chin Thomas Menkhoff Hans-Dieter Evers Hoong Hui Daniel Gn Kevin Koh Chester Wey Lee Patrick H. M. Loh Linda Low Sebastian Tan Teng Seng Teo Natalie Yap Lee Kong Chian School of Business Singapore Management University (SMU) 81 Victoria Street Singapore 188065 Singapore Andrew Chin Min Han graduated from Tsinghua University in Beijing China with a Tsinghua–MIT Sloan International Master of Business Administration degree under the Singapore Government’s Asian Business Fellowship (ABF) scholarship program. He is the Program Director of Singapore Management University (SMU) Executive Certificate in China Business and of the SMU Internationalisation Series. He teaches as an Adjunct Faculty of Strategy and Organisation at the SMU Lee Kong Chian School of Business since January 2017. He teaches effectively in English and Chinese. With over 23 years of experience in education and publishing industry in Asia Andrew Chin’s multi-sector career has enabled him to experience the full spectrum of the education industry in his roles as the Singapore EDB Officer handling the World-Class University portfolio and the Specialist Information and Publishing Industry portfolio Chief Representative and Country Manager (China) at Thomson Learning (Fortune 500 company) and Co-founder and CEO for an early childhood education business. Andrew was a Business Development Director (Universities) at Sodexo Group (Fortune 500 company) for the Asia-Pacific region. After working 10 years in Beijing China Andrew returned to Singapore in 2012 to work closely with the top leadership at Singapore Management University on the SMU China & East Asia Initiatives. Thomas Menkhoff is the Professor of Organisational Behaviour & Human Resources (Education) at the Lee Kong Chian School of Business Singapore Management University (SMU). Two of his recent publications include: (i) Menkhoff Thomas Ning Kan Siew Evers Hans-Dieter and Chay Yue Wah eds. Living in Smart Cities: Innovation and Sustainability (New Jersey: World Scientific Publishing 2018) and (ii) Chay Yue Wah Menkhoff Thomas and Low Linda eds. China’s Belt and Road Initiative — Understanding the Dynamics of a Global Transfor

In this paper, we explain how an experiential learning course and study tour to Gansu Province (People’s Republic of China) enabled undergraduates at the Singapore Management University (SMU) to acquire 21st-century competencies and higher-order thinking skills by analyzing and evaluating specific aspects of China’s Belt and Road Initiative (BRI) and China–Singapore (Chongqing) Connectivity Initiative — New International Land–Sea Trade Corridor (CCI-ILSTC) with emphasis on developing viable Go-To-Market (GTM) strategies aimed at selling Gansu produce in four Southeast Asian markets. We share how the course was designed to support the attainment of key learning goals and discuss how we turned pedagogical aspirations into concrete learning outcomes. We introduce key aspects of the so-called “SMU-XO” project that the students conducted in partnership with an industry partner, Pacific International Lines (PIL), and discuss how the project work helped learners to gain global competency by (i) examining critical issues related to BRI such as multi-modal infrastructure connectivity, (ii) appreciating the local perspectives of project stakeholders in Lanzhou and Shanghai and (iii) successfully interacting with people from different cultures, namely China, Indonesia, Vietnam, Malaysia and Thailand.

关键词： Experiential learning Singapore China Belt and Road Initiative (BRI)

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Erratum

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Canadian Journal of Anaesthesia 1992年第7期39卷 749-749页

作者： Michèle, Saiah Alain, Borgeat Oliver, Wilder-Smith Hung, Orlando R. Hope, Charles E. Laney, Geoffrey Whynot, Sara C. Coonan, Thomas J. Malloy, David S. Patterson, S. Gelb, A. Manninen, P. Strum, D. Glosten, B. Spellman, M. J. Eger, E. I. Craen, R. A. Gelb, A. W. Murkin, J. M. Chong, K. Y. Penning, D. H. El-Behairy, H. Brien, J. F. Coh, J. W. Arellano, R. Correa, J. Fedorko, L. Liu, Z. Boylan, J. F. Sandler, A. N. Nierenberg, H. Sheiner, P. A. Greig, P. D. O’Leary, G. M. Teasdale, S. J. Glynn, M. F. X. Orser, B. A. Wang, L. -Y. MacDonald, J. F. Loomis, C. W. Arunachalam, K. D. Vyas, D. Milne, B. Gagnon, Daniel Lavoie, Josée Dupuis, Jean-Yves Miller, D. R. Martineau, R. J. Greenway, D. Olivaris, L. Hull, K. Tierney, R. N. M. Wynands, J. E. Martineau, R. St-Jean, B. Kitts, J. Miller, D. Lindsay, P. Curran, M. Allen, G. C. Crossan, M. L. Wise, Richard Donati, François Bevan, David R. Hardy, J. F. Desroches, J. Perrault, J. Carrier, M. Robitaille, D. Ansley, D. M. O’Connor, J. P. Dolman, J. Townsend, G. E. Ricci, D. Liepert, D. J. Browne, P. M. Hertz, T. Rooney, M. Yip, R. W. Code, W. Phillips, A. A. McLean, R. F. Devitt, J. H. Harrington, E. M. Byrick, R. J. Wong, P. Y. Wigglesworth, D. Kay, J. C. Sinclair, L. A. Koch, J. P. Deemar, K. A. Christakis, G. K. Belo, S. Angle, P. Cheng, D. Boylan, J. Sandler, A. Feindel, C. Carmichael, F. Boylen, P. DeLima, L. G. R. Nathan, H. J. Hynes, M. S. Bourke, M. E. Russell, G. N. Seyone, C. Chung, F. Chartrand, Daniel Roux, Lucie Dain, S. L. Smith, B. D. Webster, A. C. Wigglesworth, D. F. Rose, D. K. Caskennette, G. Mechetuk, C. Doyle, D. John DeMajo, Wilfred van den Bosch, Frank Lee, Mark McClenaghan, K. M. Mazer, C. D. Preston, R. Crosby, E. T. Kotarba, D. Dudas, H. Elliott, R. D. Enns, J. Manninen, P. H. Farrar, J. K. Huzyka, David L. Lin, L. Philip Fossey, Susan Finucane, Brendan T. Stockwell, M. Lozanoff, S. Lang, S. Hyssen, J. Campbell, D. C. Douglas, M. J. Pavy, T. J. G. Flanagan, M. L. McMorland, G. H. Bands, Colin Ffaracs, Ch. B. Lipsett, Catherine Drover, David Stafford- Department of Anesthesiology University Hospital of Geneva Genève 4 Switzerland Departments of Anaesthesia and Neurosurgery Dalhousie University and Victoria General Hospital Halifax Departments of Anaesthesia and Medicine Dalhousie University Halifax Department of Anaesthesia Victoria General Hospital Dalhousie University Halifax Department of Anaesthesia Dalhousie University and Victoria General Hospital Halifax Department of Anaesthesia University Hospital London Departments of Anesthesia at U of Pittsburgh UC San Francisco U of Chicago USA Departments of Physiology and Anaesthesia The University of Western Ontario and The John. P. Roberts Research Institute London Department of Anaesthesia and Program in Critical Care University Hospital London Department of Anaesthesia/Critical Care University Hospital University of Western Ontario London Department of Anaesthesia Queen’s University Kingston Canada Department of Pharmacology & Toxicology Queen’s University Kingston Canada Department of Anaesthesia University of Toronto Toronto Departments of Anaesthesia Surgery and Haematology The Toronto Hospital Toronto The Acute Pain Research Unit Department of Anaesthesia and The Department of Psychology The Toronto Hospital (General Division) Toronto Departments of Anaesthesia and Psychology Toronto General Division The Toronto Hospital University of Toronto Toronto Departments of Anaesthesia and Behavioral Science University of Toronto Toronto The Toronto Hospital General Division University of Toronto Toronto Dept. Anaesthesia Sunnybrook Health Science Center Canada Dept. Physiology University of Toronto Toronto School of Pharmacy Memorial University of Newfoundland St. John’s Department of Anaesthesia Faculty of Medicine The University of British Columbia & Grace Hospital Vancouver Centre Hospitalier Universitaire de Sherbrooke N. Fleurimont Department of Anesthesia University of Ottawa Heart Institute Ottawa Civic Hospital Ottawa Department of Anaesthesia

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Abstracts

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Canadian Journal of Anaesthesia 1992年第1期39卷 A3-A151页

作者： Saiah Michèle Borgeat Alain Wilder-Smith Oliver Orlando R. Hung Charles E. Hope Geoffrey Laney Sara C. Whynot Thomas J. Coonan David S. Malloy S. Patterson A. Gelb P. Manninen D. Strum B. Glosten M. J. Spellman E. I. Eger R. A. Craen A. W. Gelb J. M. Murkin K. Y. Chong D. H. Penning H. El-Behairy J. F. Brien J. W. Coh R. Arellano J. Correa L. Fedorko Z. Liu J. F. Boylan A. N. Sandler H. Nierenberg P. A. Sheiner P. D. Greig G. M. O’Leary S. J. Teasdale M. F. X. Glynn B. A. Orser L. -Y. Wang J. F. MacDonald C. W. Loomis K. D. Arunachalam D. Vyas B. Milne Daniel Gagnon Josée Lavoie Jean-Yves Dupuis D. R. Miller R. J. Martineau D. Greenway L. Olivaris K. Hull R. N. M. Tierney J. E. Wynands R. Martineau B. St-Jean J. Kitts D. Miller P. Lindsay M. Curran G. C. Allen M. L. Crossan Richard Wise François Donati David R. Bevan J. F. Hardy J. Desroches J. Perrault M. Carrier D. Robitaille D. M. Ansley J. P. O’Connor J. Dolman G. E. Townsend D. Ricci D. J. Liepert P. M. Browne T. Hertz M. Rooney R. W. Yip W. Code A. A. Phillips R. F. McLean J. H. Devitt E. M. Harrington R. J. Byrick P. Y. Wong D. Wigglesworth J. C. Kay L. A. Sinclair J. P. Koch K. A. Deemar G. K. Christakis S. Belo P. Angle D. Cheng J. Boylan A. Sandler C. Feindel F. Carmichael P. Boylen L. G. R. DeLima H. J. Nathan M. S. Hynes M. E. Bourke G. N. Russell C. Seyone F. Chung Daniel Chartrand Lucie Roux S. L. Dain B. D. Smith A. C. Webster D. F. Wigglesworth D. K. Rose G. Caskennette C. Mechetuk D. John Doyle Wilfred DeMajo Frank van den Bosch Mark Lee K. M. McClenaghan C. D. Mazer R. Preston E. T. Crosby D. Kotarba H. Dudas R. D. Elliott J. Enns P. H. Manninen J. K. Farrar David L. Huzyka L. Philip Lin Susan Fossey Brendan T. Finucane M. Stockwell S. Lozanoff S. Lang J. Hyssen D. C. Campbell M. J. Douglas T. J. G. Pavy M. L. Flanagan G. H. McMorland Colin Bands Ch. B. Ffaracs Catherine Lipsett David Drover Mark Stafford-Smith Sarah Stevens Kate Shields Michael J. MacSween J. D. McAllister P. K. Morley-Forster A. K. White M. D. Taylor H. M. Vandenberghe D. Knop Department of Anesthesiology University Hospital of Geneva Genève 4 Switzerland Departments of Anaesthesia and Neurosurgery Dalhousie University and Victoria General Hospital Halifax Departments of Anaesthesia and Medicine Dalhousie University Halifax Department of Anaesthesia Victoria General Hospital Dalhousie University Halifax Department of Anaesthesia Dalhousie University and Victoria General Hospital Halifax Department of Anaesthesia University Hospital London Departments of Anesthesia at U of Pittsburgh UC San Francisco U of Chicago USA Departments of Physiology and Anaesthesia The University of Western Ontario and The John. P. Roberts Research Institute London Department of Anaesthesia and Program in Critical Care University Hospital London Department of Anaesthesia/Critical Care University Hospital University of Western Ontario London Department of Anaesthesia Queen’s University Kingston Canada Department of Pharmacology & Toxicology Queen’s University Kingston Canada Department of Anaesthesia University of Toronto Toronto Departments of Anaesthesia Surgery and Haematology The Toronto Hospital Toronto The Acute Pain Research Unit Department of Anaesthesia and The Department of Psychology The Toronto Hospital (General Division) Toronto Departments of Anaesthesia and Psychology Toronto General Division The Toronto Hospital University of Toronto Toronto Departments of Anaesthesia and Behavioral Science University of Toronto Toronto The Toronto Hospital General Division University of Toronto Toronto Dept. Anaesthesia Sunnybrook Health Science Center Canada Dept. Physiology University of Toronto Toronto School of Pharmacy Memorial University of Newfoundland St. John’s Department of Anaesthesia Faculty of Medicine The University of British Columbia & Grace Hospital Vancouver Centre Hospitalier Universitaire de Sherbrooke N. Fleurimont Department of Anesthesia University of Ottawa Heart Institute Ottawa Civic Hospital Ottawa Department of Anaesthesia

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis (vol 50, pg 1368, 2020)

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PSYCHOLOGICAL MEDICINE 2020年第16期50卷 2816-2816页

作者： Wu, Yin Levis, Brooke Riehm, Kira E. Saadat, Nazanin Levis, Alexander W. Azar, Marleine Rice, Danielle B. Boruff, Jill Cuijpers, Pim Gilbody, Simon Ioannidis, John P. A. Kloda, Lorie A. McMillan, Dean Patten, Scott B. Shrier, Ian Ziegelstein, Roy C. Akena, Dickens H. Arroll, Bruce Ayalon, Liat Baradaran, Hamid R. Baron, Murray Bombardier, Charles H. Butterworth, Peter Carter, Gregory Chagas, Marcos H. Chan, Juliana C. N. Cholera, Rushina Conwell, Yeates de Manvan Ginkel, Janneke M. Fann, Jesse R. Fischer, Felix H. Fung, Daniel Gelaye, Bizu Goodyear-Smith, Felicity Greeno, Catherine G. Hall, Brian J. Harrison, Patricia A. Harter, Martin Hegerl, Ulrich Hides, Leanne Hobfoll, Stevan E. Hudson, Marie Hyphantis, Thomas Inagaki, Masatoshi Jette, Nathalie Khamseh, Mohammad E. Kiely, Kim M. Kwan, Yunxin Lamers, Femke Liu, Shen-Ing Lotrakul, Manote Loureiro, Sonia R. Lowe, Bernd McGuire, Anthony Mohd-Sidik, Sherina Munhoz, Tiago N. Muramatsu, Kumiko Osorio, Flavia L. Patel, Vikram Pence, Brian W. Persoons, Philippe Picardi, Angelo Reuter, Katrin Rooney, Alasdair G. Santos, Ina S. Shaaban, Juwita Sidebottom, Abbey Simning, Adam Stafford, Lesley Sung, Sharon Tan, Pei Lin Lynnette Turner, Alyna van Weert, Henk C. White, Jennifer Whooley, Mary A. Winkley, Kirsty Yamada, Mitsuhiko Benedetti, Andrea Thombs, Brett D. [a1]Lady Davis Institute for Medical Research Jewish General Hospital Montréal Québec Canada [a2]Department of Psychiatry McGill University Montréal Québec Canada [a3]Department of Epidemiology Biostatistics and Occupational Health McGill University Montréal Québec Canada [a4]Department of Psychology McGill University Montréal Québec Canada [a5]Schulich Library of Physical Sciences Life Sciences and Engineering McGill University Montreal Quebec Canada [a6]Department of Clinical Neuro and Developmental Psychology Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam the Netherlands [a7]Hull York Medical School and the Department of Health Sciences University of York Heslington York UK [a8]Department of Medicine Department of Health Research and Policy Department of Biomedical Data Science Department of Statistics Stanford University Stanford California USA [a9]Library Concordia University Montréal Québec Canada [a10]Department of Community Health Sciences University of Calgary Calgary Alberta Canada [a11]Hotchkiss Brain Institute and O’Brien Institute for Public Health University of Calgary Calgary Alberta Canada [a12]Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA [a13]Department of Psychiatry Makerere University College of Health Sciences Kampala Uganda [a14]Department of General Practice and Primary Health Care University of Auckland Auckland New Zealand [a15]Louis and Gabi Weisfeld School of Social Work Bar Ilan University Ramat Gan Israel [a16]Endocrine Research Center Institute of Endocrinology and Metabolism Iran University of Medical Sciences Tehran Iran [a17]Ageing Clinical & Experimental Research Team Institute of Applied Health Sciences School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen Scotland UK [a18]Department of Medicine McGill University Montréal Québec Canada [a19]Department of Rehabilitation Medicine University of Washington S

BackgroundItem 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and *** conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic ***16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (−0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01).ConclusionsPHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.

关键词： Depression diagnostic accuracy individual participant data meta-analysis meta-analysis PHQ-8 PHQ-9 screening systematic review

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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