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Integrin beta1 mediates hepatocellular carcinoma cells chemotaxis to laminin

Hepatobiliary and Pancreatic Diseases International 2004年第4期3卷 548-551页

作者： Fu, Bian-Hong Wu, Ze-Zhi Dong, Cheng College of Bioengineering Key Lab. Biomech./Tissue Engineering Chongqing University Chongqing 400044 China Coll. of Res./Environmental Science Chongqing University Chongqing 400044 China Bioengineering Program Pennsylvania State University University Park PA 16802-6804 205 Hallowell Building United States

Background: Chemotaxis is an important step during the invasion of carcinoma cells. And integrins are most important receptors mediating interaction between cells and extracellular matrix (ECM). This study was designed to study integrin beta1 mediating chemotaxis of hepatocellular carcinoma (HCC) cells to laminin (LN). Methods: A micropipette technique was adopted to investigate the effect of blockade of integrin beta1 on pseudopod protrusion of HCC cells in response to LN stimulation. Chemotactic pseudopod protrusion of a HCC cell was evaluated using a dual-pipette set-up, in which two pipettes filled with LN solution were positioned in close contact with the same cell, and pseudopod protrusion into each pipette was viewed dynamically and recorded with a tape recorder. The lengths of pseudopods were measured and plotted against time to obtain a pseudopod growth curve. The integrin beta1 subunit on the surfaces of HCC cells were analyzed by flow cytometry. Results: In dual pipette chemotaxis experiment, when the two pipettes were filled with LN (50 μg/ml, 200 μg/ml), pseudopods extended from the HCC cell into each of the pipettes nearly symmetrically, ie, with nearly identical maximum pseudopod length and similar pseudopod growth curves. Upon addition of anti-CD29 (20 μg/ml) to one of the pipettes, pseudopod protrusion was blocked nearly completely while protrusion into the opposite pipette became more evidently, with a larger maximum length. Expression of integrin beta1 was up to 95.78% to cells chosen in the experiment. Conclusion: Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of HCC cell to LN. © 2004, Hepatobiliary Pancreat Dis Int. All rights reserved.

关键词： Chemotaxis Hepatocellular carcinoma Integrins Laminin Micropipette aspiration technique

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A Universal Calibration Curve for the TSI Aerodynamic Particle Sizer

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Journal of Aerosol science 2004年 35卷 S843-S844页

作者： Chuen-Jinn Tsai Sheng-Chieh Chen Cheng-Hsiung Huang Da-Ren Chen Institute of Environmental Engineering National Chiao Tung University No. 75 Poai St. Hsin Chu Taiwan Department of Environmental Engineering and Health Yuanpei University of Science and Technology University of Washington in St. Louis St. Louis MO 63130 USA Department of Mechanical Engineering Joint Program in Environmental Engineering University of Washington in St. Louis St. Louis MO 63130 USA

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Fishery management and culling (multiple letters)

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science 2004年第5703期306卷 1891-1892页

作者： Corkeron, Peter J. Pikitch, Ellen K. Santora, Christine Babcock, Elizabeth Bakun, Andrew Bonfil, Ramon Conover, David Dayton, Paul Doukakis, Phaedra Fluharty, David Heneman, Burr Houde, Ed Livingston, Pat Mangel, Marc McAllister, Murdoch Pope, John Salnsbury, Keith Norwegian Inst. of Marine Research Pb 6404 N-9294 Tromsø Norway Pew Institute for Ocean Science Rosenstiel Sch. Mar. Atmosph. Sci. University of Miami 126 East 56th Street New York NY 10022 United States Pew Institute for Ocean Science RSMAS University of Miami 4600 Rickenbacker Causeway Miami FL 33149-1098 United States RSMAS University of Miami Miami FL 33149-1098 United States Wildlife Conservation Society 2300 Southern Boulevard Bronx NY 10460 United States Marine Sciences Research Center Stony Brook University Stony Brook NY 11794-5000 United States Scripps Institution of Oceanography San Diego CA 92093-0227 United States School of Marine Affairs University of Washington Seattle WA 98105 United States Commonweal Ocean Policy Program Bolinas CA 94924 United States University of Maryland Center for Environmental Science Chesapeake Biological Laboratory Solomons MD 20688 United States Alaska Fisheries Science Center Seattle WA 98115 United States Dept. of Appl. Math. and Statistics Jack Baskin School of Engineering University of California Santa Cruz CA 95064 United States Dept. of Environ. Sci. and Technol. Imperial College Royal School of Mines Building Prince Consort Road London SW7 2BP United Kingdom National Research Council Ltd. Norfolk NR34 OBT United Kingdom Division of Marine Research CSIRO Hobart Tasmania 7001 Australia

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Wavelet-Based System for Classification of Airborne Laser Scanner Data

Wavelet-Based System for Classification of Airborne Laser Sc...

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2003 IGARSS: Learning From Earth's Shapes and Colours

作者： Vu, T. Thuy Yokoyama, Ryuzo Yamazaki, Fumio Tokunaga, Mitsuharu STAR Program Asian Institute of Technology Pathumthani Thailand Institute of Industrial Science University of Tokyo Tokyo Japan Environmental System Engineering Kanazawa Institute of Technology Ishikawa Japan

A new semi-automatic processing system for classification of airborne laser scanner cloud points is developed. To mitigate the difficulty caused by the complex distribution of objects on earth's surface, wavelet was adopted in size-based clustering of laser points. A hybrid method of processing laser scanner data in both grid and raw formats was also adopted to speed up the processing time and adjust the smoothing effect of interpolation. The processing focused on processing the data acquired over urban area. This paper presents and explains the components of the system using the test data acquired over Shinjuku area, Tokyo, Japan.

关键词： Remote sensing

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Collection and Characteritzation of Ultra-Fine Airborne Particulates

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Microscopy and Microanalysis 2003年第S2期9卷 790-791页

作者： J. J. Bang L. E. Murr M. A. Chaney Environmental Science & Engineering Program The University of Texas at El Paso TX 7996 Dept. of Metallurgical and Materials Engineering The University of Texas at El Paso 500 S. University M-201 El Paso TX 79968

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Wavelet-based system for classification of airborne laser scanner data

Wavelet-based system for classification of airborne laser sc...

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IEEE International Symposium on Geoscience and Remote Sensing (IGARSS)

作者： T. Thuy Vu R. Yokoyama F. Yamazaki M. Tokunaga STAR Program Asian Institute of Technology Pathum Thani Thailand Institute of Industrial Science University of Tokyo Tokyo Japan Environmental System Engineering Kanazawa Institute of Technology Ishikawa Japan

A new semi-automatic processing system for classification of airborne laser scanner cloud points is developed. To mitigate the difficulty caused by the complex distribution of objects on Earth's surface, wavelet was adopted in size-based clustering of laser points. A hybrid method of processing laser scanner data in both grid and raw formats was also adopted to speed up the processing time and adjust the smoothing effect of interpolation. The processing focused on processing the data acquired over urban area. This paper presents and explains the components of the system using the test data acquired over Shinjuku area, Tokyo, Japan.

关键词： Interpolation Laser theory Clouds Filtering Equations Low pass filters Data engineering Systems engineering and theory Surface waves Surface emitting lasers

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Management of hazardous waste in Thailand: present situation and future prospects

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Journal of Material Cycles and Waste Management 2003年第1期5卷 0031-0038页

作者： H. Ozaki K. Sharma C. Phanuwan K. Fukushi C. Polprasert Department of Civil Engineering Osaka Sangyo University 3-1-1 Nakagaito Daito Osaka 574-8530 Japan Tel. +81-72-875-3001 (ext. 3718) Fax +81-72-875-5044 e-mail: ozaki@ce.osaka-sandai.ac.jp JP Urban Environmental Engineering and Management Program School of Environment Resources and Development Asian Institute of Technology Pathumthani Thailand TH Environmental Science Center The University of Tokyo Tokyo Japan JP

This paper deals with the present scenario of hazardous waste management practices in Thailand, and gives some insights into future prospects. Industrialization in Thailand has systematically increased the generation of hazardous waste. The total hazardous waste generated in 2001 was 1.65 million tons. It is estimated that over 300 million kg/year of hazardous waste is generated from nonindustrial, community sources (e.g., batteries, fluorescent lamps, cleansing chemicals, pesticides). No special facilities are available for handling these wastes. There are neither well-established systems for separation, storage, collection, and transportation, nor the effective enforcement of regulations related to hazardous wastes management generated from industrial or nonindustrial sectors. Therefore, because of a lack of treatment and disposal facilities, these wastes find their way into municipal wastewaters, public landfills, nearby dump sites, or waterways, raising serious environmental concern. Furthermore, Thailand does not have an integrated regulatory framework regarding the monitoring and management of hazardous materials and wastes. In addition to the absence of a national definition of hazardous wastes, limited funding has caused significant impediments to the effective management of hazardous waste. Thus, current waste management practices in Thailand present significant potential hazards to humans and the environment. The challenging issues of hazardous waste management in Thailand are not only related to a scarcity of financial resources (required for treatment and disposal facilities), but also to the fact that there has been no development of appropriate technology following the principles of waste minimization and sustainable development. A holistic approach to achieving effective hazardous waste management that integrates the efforts of all sectors, government, private, and community, is needed for the betterment of human health and the environment.

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Patents Commentary

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CATTECH 2002年第1期6卷 9-10页

作者： Turaga, Uday Fuel Science Program Department of Energy and Geo-Environmental Engineering and Clean Fuels and Catalysis Program The Energy Institute The Pennsylvania State University University Park

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Monitoring the navy's strategic reserve of ozone-depleting substances

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NAVAL ENGINEERS JOURNAL 2002年第4期114卷 95-104页

作者： Smith, DE Breslin, DA Toms, GS Norton, P DENNIS E. SMITH PH.D. is currently a statistical consultant for GEO-CENTERS INC. He received a B.A. in Mathematics (magna cum laude)from Wabash College and an M.S. in mathematics an M.S. in statistics and a Ph.D. in statistics from the University of Wisconsin. From November 1973 until February 1999 he was president and principal statistician at Desmatics Inc. where he participated in a number of studies involving the application of statistical methods to various technical problems in the Navy's environmental-protection and auxiliary-machinery programs. Dr. Smith was instrumental in developing the statistical procedures underlying the Navy's ODS reserve monitoring plan. DAVID A. BRESLIN P.E. is the director of technical operations for the Naval Surface Warfare Center and chairs the ASNE/SNAME Joint Committee on Environmental Engineering. He received a master of science in aerospace engineering from Virginia Tech a master of engineering administration in industrial and systems engineering from Virginia Tech and a bachelor of engineering in mechanical engineering from Stevens Institute of Technology. From 1993 to 1997 he was the program manager of the Naval Sea Systems Command's CFC and Halon Elimination Program and played a critical role in establishing the Navy's strategic reserve of ozone-depleting substances. Because of his many efforts he received a Stratospheric Ozone Protection Award in 1995 from the U.S. Environmental Protection Agency in recognition of “exceptional contributions to global environmental protection”. GREGORY S. TOMS P.E. is the CFC &Halon Elimination Program Manager for the Naval Sea Systems Command (NAVSEA). He received a master of science degree in mechanical engineering from the University of Maryland and a B.S. degree in mechanical engineering from West Virginia University. From 1984 to 1997 he was employed at the Naval Surface Warfare Center Carderock Division Annapolis Detachment (formerly David Taylor Research Center)where he worked on the development of advanced cent

The domestic production of the most powerful ozone-depleting substances (ODSs) has permanently ceased and the abundant supplies of a number of refrigerants, fire-fighting agents, and solvents, once taken for granted, are now a thing of the past. The Navy has adopted a successful strategy for addressing the threat posed by the unavailability of ODSs. That strategy includes relying on a strategic reserve of ODSs. Considering that the strategic reserve will play a critical role in sustained Fleet operations into the middle of the century, it is important to record the history of the reserve and to document lessons learned in order to educate future generations that may face similar challenges. This is the third of three papers that cover all aspects of the Navy's strategic reserve of ODSs. Breslin (1999) documented the history of the Navy's effort to size, establish, and monitor a reserve designed to support Fleet operations until the middle of the century. Breslin, Smith, and Toms (2000) addressed in detail the process used to estimate the required size of the reserve, including the survey method, statistical analyses, and sizing algorithms. This paper discusses the Navy's plan for monitoring the Navy's strategic reserves of ODSs and describes the methods used in the monitoring process. In particular it discusses the underlying assumptions and statistical techniques associated with the Navy's prediction of the expected drawdown of the reserves. A comparison of actual data, collected since the strategic reserves began operations in 1995, with the predicted reserve drawdown, is included in the paper.

关键词： Marine engineering

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A statistical method for estimating the life expectancy of certain shipboard equipment

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NAVAL ENGINEERS JOURNAL 2002年第1期114卷 27-32页

作者： Smith, DE Breslin, DA Toms, GS DENNIS E. SMITH PH.D. is a statistical consultant for Geo-Centers Inc. He received a B.A. in mathe-matics (magna cum laude) from Wabash College and an M.S. in mathematics an M.S. in statistics and a Ph.D. in statistics from the University of Wisconsin. From November 1973 until February 1999 he was President and Principal Statistician at Desmatics Inc. where he participated in a number of studies involving the application of statistical methods to various technical problems in the Navy's environmental-protection and auxiliary-machinery programs. Dr. Smith was instrumental in developing the statistical procedures underlying the Navy's ODS reserve monitoring plan. DAVID A. BRESLIN P.E. is the Director of Technical Operations for the Naval Surface Warfare Center and is the chairperson of ASNE's Committee on Environmental Engineering. He received a master of science degree in aerospace engineering from Virginia Tech a master of engineering administration in indus-trial & systems engineering from Virginia Tech and a bachelor of engineering in mechanical engineering from Stevens Institute of Technology. From 1993 to 1997 he was the program manager of the Naval Sea Systems Command's CFC & Halon Elimination Program and played a critical role in establishing the Navy's strategic reserve of ozone-depleting substances. Because of his many efforts he received a Stratospheric Ozone Protection Award in 1995 from the U.S. Environmental Protection Agency in recogni-tion of “exceptional contributions to global environmental protection”. GREGORY S. TOMS P.E. is the CFC & Halon Elimination Program Manager for the Naval Sea Systems Command (NAVSEA). He received a master of science degree in mechanical engineering from the University of Maryland and a B.S. degree in mechanical engineering from West Virginia University. From 1984 to 1997 he was employed at the Naval Surface Warfare Center Carderock Division Annapolis Detachment (formerly David Taylor Research Center) where he worked on the development of advanced cent

This paper reviews an inexpensive statistical-sampling methodology that can be used to determine the attrition rates of certain types of shipboard equipment. The methodology relies on surveys that are conducted in conjunction with regularly scheduled ship visits over a period of time and a statistical analysis of the survey results. The statistical technique allows for reasonably accurate estimates to be made of attrition rates. The specific example cited in this paper is related to galley-type refrigeration equipment, such as salad chillers, beverage dispensers, et cetera. In the case of galley-type refrigeration equipment, the Navy needs to know whether the Fleet's inventory of equipment relying on Class I Ozone-Depleting Substances (ODSs) will be replaced through natural attrition by the end of fiscal year (FY) 2005, at which time supplies of ODS-based refrigerants will no longer be available for use by ship galleys. This paper outlines the process used to gather data, the analysis of the data, and concludes that the Navy's inventory of galley equipment using Class I ODSs will be replaced through natural attrition by the end of FY05. The methodology reviewed by this paper has wider applications. For various types of shipboard equipment, the methodology can also be used to estimate with reasonable accuracy life expectancies, configurations, conditions, and other items of interest.

关键词： Ship equipment

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