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EUROTEC 2011 Conference, in Conjunction with EQUIPLAST

作者： Sun, Shih-Po Charles, Lyndon Peng, Fei Olson, James R. Shaw, Montgomery T. Wei, Mei Polymer Program Institute of Materials Science University of Connecticut Storrs CT United States Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs CT United States Teleflex Medical Inc. Coventry CT United States

Orthopedic procedures often require repair materials that can carry large loads without excessive deformation or failure. To this end, we designed composites using two biocompatible/bioabsorbable polymers, poly(L-lactic acid) (PLLA) and polycaprolactone (PCL). The latter was filled with nano-needles of hydroxyapatite (HA), while the PLLA was used in long-fiber form. Theory advises that the HA nano-needles must be of high aspect ratio and be aligned in the matrix to gain sufficient stiffness. We have explored several processing techniques for accomplishing this task, and have successfully made composites in the 8-to 10-GPa range. Variations of this structure will also be described.

关键词： Hydroxyapatite

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PEG-POSS Hybrid Polyurethanes: Mechanically Robust Nanostructured Hydrogels

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MRS Online Proceedings Library (OPL) 2011年第1期1060卷 1060-LL03-10-1060-LL03-10页

作者： Jian Wu Qing Ge Patrick T Mather wujian@mail.pse.umass.edu University of Connecticut Chemical Engineering DepartmentPolymer Program Institute of Materials Science 97 North Eagleville Road Storrs CT 06269 United States Qing@*** University of Connecticut Chemical Engineering Departmentand Polymer ProgramInstitute of Materials Sciece Storrs CT 06269 United States ptmather@syr.edu University of Connecticut Chemical Engineering Departmentand Polymer ProgramInstitute of Materials Sciece Storrs CT 06269 United States

A series of unique hybrid thermoplastic polyurethanes (TPUs) was synthesized using PEG as soft segment and incorporating an isobutyl-functionalized POSS diol (TMP POSS diol) in the hard segment. The molecular weight of PEG was systematically varied to include 10, 20, and 35 kDa, while the mole ratio of POSS diol (as chain extender) to PEG was in range from 3:1 to 8:1 with samples featuring a PEG molecular weight of 10 kDa. The diisocyanate employed for TPU polymerization was 4,4'-methylenebis(phenyl-isocyanate) (MDI). We found that the hydrophobic hard segments (POSS) can form crystalline structures driven by micro-phase separation, this being due to significant thermodynamic incompatibility between POSS and ethylene oxide units. The POSS nano-crystals thus formed serve as physical crosslinking sites within an inorganic-organic hybrid network. This affords a new hybrid organic-inorganic hydrogel in the water-swollen state. The equilibrium swelling ratio increased monotonically with PEG loading and ranged from ∼70% to ∼600%. The shear modulus, G, of the hybrid hydrogels was observed to span 0.3 < G < 4.0 MPa – C values commonly found for elastomers, not hydrogels. Indeed, the hydrogel stiffness can be finely tuned through the POSS:PEG molar ratio, as this predictably controls swelling in water.

关键词： biomaterial nanostructure polymer

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polymeric foams for oral drug delivery. A review

Polymeric foams for oral drug delivery. A review

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9th International Conference on Foam Processing and Technology, FOAMS 2011

作者： Terife, Graciela Faridi, Niloufar Wang, Peng Gogos, Costas G. Materials Science and Engineering Program New Jersey Institute of Technology Newark NJ 07102 United States Polymer Processing Institute Newark NJ 07102 United States Department of Chemical Engineering University of Rhode Island Kingston RI 02881 United States Otto York Department of Chemical Biological and Pharmaceutical Engineering New Jersey Institute of Technology Newark NJ 07102 United States

Manufacturing of drug delivery systems through the extrusion process is of great interest in academia and pharmaceutical industry alike. Even though significant amount of research has been conducted in this field, there are still many challenges to be addressed such as: thermal stability of drugs, difficult downstream handling of extrudates and high density of the extrudates. Recently, the foaming process is being seen as an answer for some of these problems. This paper reviews the role of polymeric foams in the manufacture of oral drug delivery systems. A case study analyzing the influence of foaming on the dissolution profile of a polymeric excipient in water is discussed in more detail.

关键词： Thermodynamic stability

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Biodegradable microfluidic scaffolds with tunable degradation properties from amino alcohol-based poly(ester amide) elastomers

Biodegradable microfluidic scaffolds with tunable degradatio...

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2010 MRS Fall Meeting

作者： Wang, Jane Kniazeva, Tatiana Campbell, Carly F. Langer, Robert Ustin, Jeffrey S. Borenstein, Jeffrey T. Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 United States Biomedical Engineering Charles Stark Draper Laboratory Cambridge MA 02139 United States Program of Polymer Science and Technology Massachusetts Institute of Technology Cambridge MA 02139 United States Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 United States Trauma Surgery Cleveland MetroHealth Hospital Cleveland OH 44106 United States

ISBN: (纸本)9781605112763

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable;the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements. © 2011 Materials Research Society.

关键词： Degradation

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Biodegradable Microfluidic Scaffolds with Tunable Degradation Properties from Amino Alcohol-based Poly(ester amide) Elastomers

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MRS Online Proceedings Library 2011年第1期1299卷 1-6页

作者： Jane Wang Tatiana Kniazeva Carly F. Campbell Robert Langer Jeffrey S. Ustin Jeffrey T. Borenstein Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge USA Biomedical Engineering Charles Stark Draper Laboratory Cambridge USA Program of Polymer Science and Technology Massachusetts Institute of Technology Cambridge USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge USA Trauma Surgery Cleveland MetroHealth Hospital Cleveland USA

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable; the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements.

关键词： biomaterial microelectro-mechanical (MEMS) polymer

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Mechanical and Rheological Characteristics of Micro-Particle Maize Tassel-Filled Polypropylene Micro-Composites

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材料科学与工程（中英文B版） 2011年第2期1卷 131-147页

作者： Emmanuel Rotimi Sadiku Annet Chacko Lekgethile Mable Karabo Kekana Goitseona Phiri Jonathan Okechukwu Okonkwo Caliphs Musa Zvinowanda Mahlatsa Mapula Sekhula Nana Mensah Agyei Department of Mechanical Engineering （Polymer Technology） Tshwane University of Technology CSIR Campus Lynnwoodridge 0400 Rep. of South Africa Department of Environmental Water and Earth Science Faculty of Science Tshwane University of Technology Pretoria 0001 Rep . of South Africa Department of Chemistry University of Limpopo Medunsa 0204 Rep. of South Africa

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Phonon transport and thermoelectricity in defect-engineered InAs nanowires

Phonon transport and thermoelectricity in defect-engineered ...

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2011 MRS Fall Meeting

作者： Weathers, Annie Moore, Arden L. Pettes, Michael T. Salta, Daniel Kim, Jaehyun Dick, Kimberly Samuelson, Lars Linke, Heiner Caroff, Philippe Shi, Li Department of Mechanical Engineering University of Texas at Austin Austin TX United States Material Science and Engineering Graduate Program University of Texas at Austin Austin TX United States Center for Nano and Molecular Science University of Texas at Austin Austin TX United States Division of Solid State Physics Lund University S-22100 Lund Sweden Polymer and Materials Chemistry Lund University S-22100 Lund Sweden Institut d'Electronique de Microelectronique et de Nanotechnologie UMR CNRS 8520 F-59652 Villeneuve d'Ascq France

ISBN: (纸本)9781627482219

There have been reports of improvements in the thermoelectric figure of merit through the use of nanostructured materials to suppress the lattice thermal conductivity. Here, we report on a fundamental study of the combined effects of defect planes and surface scattering on phonon transport and thermoelectric properties of defect-engineered InAs nanowires. A microfabricated device is employed to measure the thermal conductivity and thermopower of individual suspended indium arsenide nanowires grown by metal organic vapor phase epitaxy. The four-probe measurement device consists of platinum resistance thermometers and electrodes patterned on two adjacent SiNx membranes. A nanowire was suspended between the two membranes, and electrical contact between the nanowire and the platinum electrodes was made with the evaporation of a Ni/Pd film through a shadow mask. The exposed back side of the device substrate allows for characterization of the crystal structure of the suspended nanowire with transmission electron microscopy (TEM) following measurement. The 100-200 nm diameter zincblende (ZB) InAs nanowire samples were grown with randomly spaced twin defects, stacking faults, or phases boundaries perpendicular to the nanowire growth direction, as revealed by transmission electron microscopy (TEM) analysis. Compared to single-crystal ZB InAs nanowires with a similar lateral dimension, the thermal conductivity of the defect-engineered nanowires is reduced by fifty percent at room temperature. © 2012 Materials Research Society.

关键词： Nanowires

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Thermal conductivity of polyacrylate composite sheet with aluminum powders

Thermal conductivity of polyacrylate composite sheet with al...

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International Conference on Clean Energy science 2011年国际清洁能源科学会议(ICCES2011)

作者： Jae Ok Kim Hyeon Ju Ryu Woo SeokNoh Jae Cheol Park Department of Applied Chemistry Kumoh National Institute of Technology1 Yangho-dongGumiGyeongbuk730-701Korea Department of Polymer Science and EngineeringKumoh National Institute of Technology1 Yangho-dongGumiGyeongbuk730-701Korea Department of Environmental EngineeringKumoh National Institute of Technology1 Yangho-dongGumiGyeongbuk730-701Korea

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Phonon Transport and Thermoelectricity in Defect-Engineered InAs Nanowires

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MRS Online Proceedings Library 2011年第1期1404卷 36-43页

作者： Weathers, Annie Moore, Arden L. Pettes, Michael T. Salta, Daniel Kim, Jaehyun Dick, Kimberly Samuelson, Lars Linke, Heiner Caroff, Philippe Shi, Li Department of Mechanical Engineering The University of Texas at Austin Austin USA Center for Nano and Molecular Science The University of Texas at Austin Austin USA Material Science and Engineering Graduate Program The University of Texas at Austin Austin USA The Nanometer Structure Consortium (nmC@LU) and Division of Solid State Physics Lund University Lund Sweden Polymer & Materials Chemistry Lund Sweden Institut d’Electronique de Microelectronique et de Nanotechnologie UMR CNRS 8520 France

关键词： thermoelectric nanostructure thermal conductivity

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Broad‐Spectrum Antimicrobial and Biofilm‐Disrupting Hydrogels: Stereocomplex‐Driven Supramolecular Assemblies†

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Angewandte Chemie 2012年第2期125卷

作者： Yan Li Kazuki Fukushima Daniel J. Coady Amanda C. Engler Shaoqiong Liu Yuan Huang John S. Cho Yi Guo Lloyd S. Miller Jeremy P. K. Tan Pui Lai Rachel Ee Weimin Fan Yi Yan Yang James L. Hedrick Institute of Bioengineering and Nanotechnology 31 Biopolis Way The Nanos Singapore 138669 (Singapore) Department of Pharmacy National University of Singapore 18 Science Drive 4 Singapore 117543 (Singapore) Department of Polymer Science and Engineering Yamagata University Yonezawa Yamagata 992‐8510 (Japan) IBM Almaden Research Center 650 Harry Road San Jose CA 95120 (USA) Program of Innovative Therapeutics The First Affiliated Hospital Zhejiang University College of Medicine 79 Qingchun Road Hangzhou 310003 (China) Division of Dermatology University of California Los Angeles 52‐121 Center for Health Sciences Los Angeles CA 90095 (USA)

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