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Porous FeAl alloys via powder sintering:Phase transformation,microstructure and aqueous corrosion behavior

Journal of Materials science & technology 2021年第27期86卷 64-69页

作者： Gang Chen Klaus-Dieter Liss Chao Chen Yuehui He Xuanhui Qu Peng Cao Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083PR China Materials and Engineering Science Program Guangdong Technion-Israel Institute of TechnologyShantouGuangdong515063PR China Technion-Israel Institute of Technology Haifa32000Israel School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering&Information SciencesUniversity of WollongongWollongongNSW2522Australia State Key Laboratory for Powder Metallurgy Central South UniversityChangsha410083PR China Department of Chemical and Materials Engineering The University of AucklandPrivate Bag 92019Auckland1142New Zealand MacDiarmid Institute of Advanced Materials and Nanotechnology Victoria University of WellingtonPO Box 600Wellington6140New Zealand

This study investigates the phase transformation and microstructure of porous Fe Al parts sintered from elemental powder mixtures using in-situ neutron diffraction and in-situ thermal dilatometry.A single B2 structured Fe Al phase was determined in the sintered Fe Al *** combined effects of the Kirkendall porosity,transient liquid phase,and phase transformations associated with powder sintering all contribute to the swelling phenomenon of the final sintered *** aqueous corrosion test indicates that the corrosion products include iron oxides in the porous Fe Al *** accumulation of corrosion products blocks the pore channel and decreases pore size and permeability over the soaking time.

关键词： Powder sintering Intermetallic Porous Corrosion Neutron diffraction

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High-quality reference genome and annotation aids understanding of berry development for evergreen blueberry(Vaccinium darrowii)

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Horticulture Research 2021年第1期8卷 3321-3336页

作者： Jiali Yu Amanda M.Hulse-Kemp Ebrahiem Babiker Margaret Staton Genome Science and Technology Program University of TennesseeKnoxvilleTN 37996USA USDA-ARS Gen omics and Bioi nformatics Research Un it RaleighNCUSA Department of Crop and Soil Sciences North Carolina State UniversityRaleighNCUSA USDA-ARS Thad Cochran Southern Horticultural Laboratory PoplarvilleMSUSA Department of Entomology and Plant Pathology University of TennesseeKnoxvilleTN 37996USA

Vaccinium darrowii Camp(2 n=2×=24)is a native North American blueberry species and an important source oftraits such as low chill requirement in commercial southern highbush blueberry breeding(Vaccinium coymbosum,2n=4 ×=48).We present a chromosomal-scale genome of *** generated by the combination of PacBio sequencing and high throughput chromatin conformation capture(Hi-C)scaffolding technologies,yielding a total length of 1.06 Gigabases(Gb).Over 97.8%of the genome sequences are scaffolded into 24 chromosomes representing the two *** primary haplotype assembly of V,darrowii contains 34,809 protein-coding *** to a *** haplotype assembly reveals high collinearity between the two genomes with small intrachromosomal rearrangements in eight chromosome *** small RNA sequencing,the annotation was further expanded to include more than 200,000 small RNA loci and 638 microRNAs expressed in berry *** analysis across fruit development stages indicates that genes involved in photosynthesis are downregulated,while genes involved in flavonoid and anthocyanin biosynthesis are signi ficantly increased at the late stage of berry ripening.A high-quality reference genome and accompanying annotation of *** is a signi ficant new resource for assessing the evergreen blueberry contribution to the breeding of southern highbush blueberries.

关键词： breeding blue bases

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Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance

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Nano Communication Networks 2011年第1期2卷 39-49页

作者： Karig, David K. Siuti, Piro Dar, Roy D. Retterer, Scott T. Doktycz, Mitchel J. Simpson, Michael L. Center for Nanophase Materials Sciences Oak Ridge National Laboratory Bethel Valley Road Oak Ridge TN 37831 United States Biosciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 United States Graduate Program in Genome Science and Technology University of Tennessee Knoxville TN 37996 United States Department of Physics and Astronomy University of Tennessee Knoxville TN 37996-2010 United States Department of Materials Science and Engineering University of Tennessee Knoxville TN 37996-2010 United States Center for Environmental Biotechnology University of Tennessee Knoxville TN 37996-2010 United States

Cells offer natural examples of highly efficient networks of nanomachines. Accordingly, both intracellular and intercellular communication mechanisms in nature are looked to as a source of inspiration and instruction for engineered nanocommunication. Harnessing biological functionality in this manner requires an interdisciplinary approach that integrates systems biology, synthetic biology, and nanofabrication. Here, we present a model system that exemplifies the synergism between these realms of research. We propose a synthetic gene network for operation in a nanofabricated cell mimic array that propagates a biomolecular signal over long distances using the phenomenon of stochastic resonance. Our system consists of a bacterial quorum sensing signal molecule, a bistable genetic switch triggered by this signal, and an array of nanofabricated cell mimic wells that contain the genetic system. An optimal level of noise in the system helps to propagate a time-varying AHL signal over long distances through the array of mimics. This noise level is determined both by the system volume and by the parameters of the genetic network. Our proposed genetically driven stochastic resonance system serves as a testbed for exploring the potential harnessing of gene expression noise to aid in the transmission of a time-varying molecular signal. © 2011.

关键词： Gene expression

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An integrated genetic-epigenetic analysis shed light on the mechanisms linking coronavirus disease 2019 (COVID-19) and cancer

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Cancer Communications 2021年第4期41卷 349-353页

作者： Zheng Dong Huiguang Yi Centre for Molecular Medicine and Therapeutics British Columbia Children’s Hospital Research InstituteUniversity of British ColumbiaVancouverBritish Columbia V5Z 4H4Canada Genome Science and Technology Graduate Program University of British ColumbiaVancouverBritish Columbia V5Z 4S6Canada Department of Epidemiology and Biostatistics University of GeorgiaAthensGeorgia 30602USA

Dear editor,The Coronavirus disease 2019(COVID-19)is an emerging disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection[1,2].It has spread rapidly across the world and caused a global health *** of 10 February 2021,COVID-19 has caused 2,333,446 deaths *** majority of COVID-19 deaths had comorbidities including cancer[1,2].

关键词： cancer acute respiratory

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Using a literature-based NMF model for discovering gene functional relationships

Using a literature-based NMF model for discovering gene func...

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IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

作者： Elina Tjioe Michael Berry Ramin Homayouni Genome Science and Technology Graduate School University of Tennessee Knoxville TN USA Department of Electrical Engineering and Computer Science University of Tennessee Knoxville TN USA Bioinformatics Program Department of Biology University of Memphis Memphis TN USA

The rapid growth of the biomedical literature and genomic information presents a major challenge for determining the functional relationships among genes. In this study, we develop a Web-based bioinformatics software environment called FAUN or feature annotation using nonnegative matrix factorization (NMF) to facilitate both the discovery and classification of functional relationships among genes. Both the computational complexity and parameterization of NMF for processing gene sets are discussed. We tested FAUN on three manually constructed gene document collections, and then used it to analyze several microarray-derived gene sets obtained from studies of the developing cerebellum in normal and mutant mice. FAUN provides utilities for collaborative knowledge discovery and identification of new gene relationships from text streams and repositories (e.g., MEDLINE). It is particularly useful for the validation and analysis of gene associations suggested by microarray experimentation.

关键词： Bioinformatics Genomics Data mining Matrix decomposition Large scale integration Feature extraction Iterative methods Biological system modeling Computer science Computational biology

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Molecular characterization of an anther-preferential gene from rice

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Journal of Plant Biology 2000年第4期43卷 232-237页

作者： Young -Ju Choi Ayahiko Shomura Takuji Sasaki Gynheung An Yong -Yoon Chung Department of Biology Korea University Seoul Korea Rice Genome Research Program National Institute of Agrobiological Resources Tsukuba Japan National Research Laboratory of Plant Functional Genomics Division of Molecular Life Sciences Pohang University of Science and Technology (POSTECH) Pohang Korea

Expression levels of anther-expressed genes in rice were estimated by plaque hybridization. A total of 33 cDNAs, isolated randomly from an anther-enriched cDNA library, were used as probes to hybridize both anther and leaf cDNAs. The expression level of individual cDNA clones was then estimated by counting the number of plaques hybridized to each probe. Based on abundance patterns that appeared in both anther and leaf cDNA libraries, the clones were classified into three groups. This classification showed that the majority of the clones (one group) exhibited expression in both cDNA libraries at almost equal frequency. The other two groups showed either low or no expression in the leaf cDNA library. Among the cDNA clones,RA1003 (detected only in the anther cDNA library) was selected and further characterized at the molecular level. Consistent with the results of the plaque hybridization experiment, northern blot analysis also revealed no gene expression in vegetative organs, leaves, or roots. However, expression was high in the flowers, especially in the anthers. Detailed molecular studies of the gene are also described and discussed here.

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Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state

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细胞研究（英文版） 2023年第9期33卷 712-726页

作者： Peng Wang Xupeng Liu Ziyue Yao Yu Chen Lanfang Luo Kun Liang Jun-Hao Elwin Tan Min-Wen Jason Chua Yan-Jiang Benjamin Chua Shilin Ma Liping Zhang Wenwu Ma Shuqing Liu Wenhua Cao Luyao Guo Lu Guang Yuefan Wang He Zhao Na Ai Yun Li Chunwei Li Ruiqi Rachel Wang Bin Tean Teh Lan Jiang Kang Yu Ng Shyh Chang Institute of Zoology Chinese Academy of SciencesBeijingChina Beijing.Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina NUS Graduate School for Integrative Sciences and Engineering National University of SingaporeSingaporeSIngapore institute of Molecular and Cell Biology Genome Institute of SingaporeAgency for Science Technology and ResearchSingaporeSingapore Laboratory of Cancer Therapeutics Program in Cancer and Stem Cell BiologyDuke-National University of Singapore Medical SchoolSingaporeSingapore Laboratory of Cancer Epigenome Division of Medical ScienceNational Cancer Centre SingaporeSingaporeSingapore University of Chinese Academy of Sciences BeijingChina CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina Department of Clinical Nutrition Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina Beijing.Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina Laboratory of Cancer Therapeutics Program in Cancer and Stem Cell BiologyDuke-National University of Singapore Medical SchoolSingaporeSingapore Laboratory of Cancer Epigenome Division of Medical ScienceNational Cancer Centre SingaporeSingaporeSingapore CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina

During homeostasis and after injury,adult muscle stem cells(MuSCs)activate to mediate muscle ***,much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and ***,we show that Lin28a is expressed in embryonic limb bud muscle progenitors,and that a rare reserve subset of Lin28a+Pax7-skeletal MuSCs can respond to injury at adult stage by replenishing the Pax7+MuSC pool to drive muscle *** with adult Pax7+MuSCs,Lin28a+MuSCs displayed enhanced myogenic potency in vitro and in vivo upon *** epigenome of adult Lin28a+MuSCs showed resemblance to embryonic muscle *** addition,RNA-sequencing revealed that Lin28a+MuSCs co-expressed higher levels of certain embryonic limb bud transcription factors,telomerase components and the p53 inhibitor Mdm4,and lower levels of myogenic differentiation markers compared to adult Pax7+MuSCs,resulting in enhanced self-renewal and stress-response ***,conditional ablation and induction of Lin28a+MuSCs in adult mice revealed that these cells are necessary and sufficient for efficient muscle ***,our findings connect the embryonic factor Lin28a to adult stem cell self-renewal and juvenile regeneration.

关键词： Muscle stem cells Regeneration

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Designing a Novel Low-Density, High-Strength Ti27.5zr26.5nb25.5ta8.5al12 Refractory High-Entropy Alloy for High-Temperature Applications

SSRN

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SSRN 2024年

作者： Naseer, Hashim Wang, Yangwei Bao, Jiawei Khan, Muhammad Abubaker Afifi, Mohamed A. School of Materials Science and Engineering Beijing Institute of Technology Beijing100081 China Tangshan Research Institute Beijing Institute of Technology Tangshan063000 China Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and Engineering University of Science and Technology Beijing Beijing100083 China Mechanical Engineering Program School of Engineering and Applied Sciences Nile University Giza12677 Egypt

This study introduces a novel Refractory High-Entropy Alloy (RHEA) with the composition Ti27.5Zr26.5Nb25.5Ta8.5Al12, designed for high-temperature structural applications while addressing the limitations of traditional nickel-based superalloys. The alloy was synthesized using vacuum arc melting and characterized through comprehensive experimental methods including X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). This RHEA demonstrated exceptional mechanical properties, achieving a yield strength of 1356 MPa and a specific yield strength of 197.3 MPa·g⁻¹·cm³ at room temperature, with notable ductility (compressive strain >50%) across a wide temperature range up to 1000°C. The microstructural analysis revealed a two-phase BCC/B2 nanodomain structure that contributes significantly to its strength and ductility. This structure was further refined through controlled thermomechanical treatments, eliminating the need for additional heat treatment. The findings suggest that the Ti27.5Zr26.5Nb25.5Ta8.5Al12 RHEA holds great potential as a low-density, high-performance material for demanding environments, offering a viable alternative to heavier superalloys. © 2024, The Authors. All rights reserved.

关键词： Scanning electron microscopy

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Report of two cases of snRNA gene RNU4-2 related syndromic intellectual disability from Southeast Asia

Rare. Open Research in Rare Diseases

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Rare. Open Research in Rare Diseases 2025年 3卷 100054-100054页

作者： Goh, Jeannette Lim, Jiin Ying Simons, Annet Ewans, Lisa Kam, Sylvia Goh, Jasmine Teo, Jing Xian Chan, Sock Hoai Chan, Shermaine Ling, Simon Thomas, Terrence Tan, Gavin Lim, Weng Khong Lai, Angeline Jamuar, Saumya Shekhar Genetics service Department of Paediatrics KK Women’s and Children’s Hospital Singapore SingHealth Duke-NUS Genomic Medicine Centre Singapore Radboud University Nijmegen the Netherlands Centre for Clinical Genetics Sydney Children’s Hospitals Network Randwick NSW Australia Genomics and Inherited Disease Program Garvan Institute of Medical Research University of New South Wales Sydney Sydney NSW Australia School of Clinical Medicine Medicine & Health University of New South Wales Sydney NSW Australia SingHealth Duke-NUS Institute of Precision Medicine Singapore KK Research Centre KK Women’s and Children’s Hospital Singapore Neurology service Department of Paediatrics KK Women’s and Children’s Hospital Singapore Ocular Diagnostic Department Singapore National Eye Centre Singapore Cancer & Stem Cell Biology Program Duke-NUS Medical School Singapore Genome Institute of Singapore Agency for Science Technology and Research Singapore

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Detection of presumed genes encoding beta-lactamases by sequence based screening of metagenomes derived from Antarctic microbial mats

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Frontiers of Environmental science & Engineering 2019年第3期13卷 173-184页

作者： Gaston Azziz Matias Gimenez Hector Romero Patricia M. Valdespino-Castillo Luisa I. Falcon Lucas A. M. Ruberto Walter P. Mac Cormack Silvia Batista Molecular Microbiology Unit Clemente Estable Biological Research Insitute Montevideo 11600 Uruguay Microbiology Laboratory Faculty of Agronomy UdelaR Montevideo 12900 Uruguay Genome Organization and Evolution Laboratory Ecology and Evolution Department Faculty of Sciences UdelaR Montevideo 11400 Uruguay Molecular Biophysics and Integrated Bioimaging BSISB Imaging Program Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Bacteial Ecology Laboratory Ecology Institute National Autonomous University of Mexico CDMX 04510 Mexico UN AM Yucatan Technology and Science Park Merida 97302 Mexico Argentine Antarctic Institute Buenos Aires 1650 Argentina Biotechnology Unit Faculty of Pharmacy and Biochemistry Nanobiotec Institute UBA-CONICET Buenos Aires 1113 Argentina

Analysis of environmental samples for bacterial antibiotic resistance genes may have different objectives and analysis strategies. In some cases, the purpose was to study diversity and evolution of genes that could be grouped within a mechanism of antibiotic resistance. Different protocols have been designed for detection and confirmation that a functional gene was found. In this study, we present a sequence-based screening of candidate genes encoding beta-lactamases in 14 metagenomes of Antarctic microbial mats. The samples were obtained from different sites, representing diverse biogeographic regions of maritime and continental Antarctica. A protocol was designed based on generation of Hidden Markov Models from the four beta-lactamase classes by Ambler classification, using sequences from the Comprehensive Antibiotic Resistance Database (CARD). The models were used as queries for metagenome analysis and recovered contigs were subsequently annotated using RAST. According to our analysis, 14 metagenomes analyzed contain A, B and C beta-lactamase genes. Class D genes, however, were identified in 11 metagenomes. The most abundant was class C (46.8%), followed by classes B (35.5%), A (14.2%) and D (3.5%). A considerable number of sequences formed clusters which included, in some cases, contigs from different metagenomes. These assemblies are clearly separated from reference clusters, previously identified using CARD beta-lactamase sequences. While bacterial antibiotic resistance is a major challenge of public health worldwide, our results suggest that environmental diversity of beta-lactamase genes is higher than that currently reported, although this should be complemented with gene function analysis.

关键词： Beta-lactamases Antibiotic resistance coding genes Metagenomes Antarctic microbial mats

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