BackgroundPelvic floor muscle training (PFMT) is widely used for pelvic floor muscle (PFM) weakness in women;however, it has no prolonged *** evaluate the effect of Transcranial Direct Current Stimulation (tDCS) assoc...
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BackgroundPelvic floor muscle training (PFMT) is widely used for pelvic floor muscle (PFM) weakness in women;however, it has no prolonged *** evaluate the effect of Transcranial Direct Current Stimulation (tDCS) associated with PFMT on PFM contraction, sexual function and quality of life (QoL) in healthy *** Design32 nulliparous women, aged 22.7 +/- 0.42 years, were randomized into two groups: G1 (active tDCS combined with PFMT) and G2 (sham tDCS combined with PFMT). The treatment was performed three times a week for 4 weeks, totaling 12 sessions. PFM function was assessed using the PERFECT scheme (P = power, E = endurance, R = repetitions, F = rapid contractions, ECT = each timed contraction) and the perineometer (cmH2O). Sexual function was assessed by The Female Sexual Function Index, and QoL by the SF-36 questionnaire. These assessments were performed before and after the 12nd treatment session and after 30-day *** was a significant increase (p = 0.037) in the power of G2 compared to G1;repetitions and fast contraction increased in the G1 group, and the resistance increased in both groups, however, without statistical difference between the groups. ECT increased in the G1 group (p = 0.0).ConclusionActive tDCS combined with PFMT did not potentiate the effect of the PFMT to increase the PFM function, QoL, and sexual function in healthy women. However, adjunctive tDCS to PFMT improved the time of contractions, maintaining it during follow-up.
Under the increasingly complex and interconnected world we live in, data has become extremely valuable. Nevertheless, exploring even a simple database is not a trivial task, as it requires technical knowledge which ma...
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PurposeThis systematic review aimed to identify and synthesize evidence on hospital readmissions among pediatric oncology patients, focusing on the indications, risk factors, and proposed strategies to prevent *** rev...
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PurposeThis systematic review aimed to identify and synthesize evidence on hospital readmissions among pediatric oncology patients, focusing on the indications, risk factors, and proposed strategies to prevent *** review followed PRISMA 2020 guidelines. Databases including Embase, Medline, Scopus, Mendeley, and Google Scholar were searched. Studies examining hospital readmission as a main outcome in pediatric cancer patients, including those undergoing surgical oncology procedures or receiving hematopoietic cell transplantation, were included. Quality assessment was undertaken using the Newcastle-Ottawa Scale and PROBAST *** total of 18 studies met the inclusion criteria. The studies spanned from 2008 to 2023, with an increase in publications from 2020 onward (61%). Fever and infection were the most common readmission indications. Statistically significant risk factors reported included younger age, specific cancer types (e.g., acute lymphoblastic leukemia), and socioeconomic factors. Prevention strategies proposed included early follow-up, tailored anticipatory guidance, discharge education, and specialized care at pediatric oncology *** systematic review highlights the multifaceted nature of hospital readmissions in pediatric oncology patients and the need for standardized definitions, additional studies, and comprehensive interventions. Future research should focus on high-quality prospective studies, integration of predictive analytics, and addressing socioeconomic disparities to improve patient outcomes.
Badminton is a very popular subject in Physical Education (PE). Many students enroll badminton courses in every semester which pose a tremendous teaching load to the instructors. The one-on-one guiding/feedback time p...
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The patient's infusion fluid will only be changed if the nurse changes it or based on information from the patient's family. The research method used in terms of fluid volume utilizes the function of the Ardui...
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A common assumption is that upward mobility produces positive psychological outcomes. However, status-based identity framework and social class worldview model propose that perceived social mobility in either directio...
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A common assumption is that upward mobility produces positive psychological outcomes. However, status-based identity framework and social class worldview model propose that perceived social mobility in either direction will lead to increased distress. Based on this claim, we examined relations among subjective social mobility, life satisfaction, and mental health using polynomial regression with response surface mapping. In Study 1, groups that experienced both subjective downward and upward mobility reported more depressive symptomatology than groups that remained in middle or upper social statuses in a sample of 567 adults. We did not find significant relations between subjective social mobility and life satisfaction. In Study 2, both groups that experienced subjective downward and upward mobility reported more depressive and academic distress symptomatology than groups that remained in middle or upper social social statuses in a sample of 7,598 clients from college counseling center data. The results provide insights relevant to multicultural counseling and training.
Objective: A Virtual Patient Tour (VPT) was developed to inform cardiac surgery patients about their hospitalization from the admission to their postoperative stay on the ward. The objective of our study was to assess...
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Objective: A Virtual Patient Tour (VPT) was developed to inform cardiac surgery patients about their hospitalization from the admission to their postoperative stay on the ward. The objective of our study was to assess the feasibility and acceptability of this VPT following the framework of the Virtual Reality Clinical Outcomes Research Experts Committee. Methods: In this single-centre cross-sectional study, adult patients admitted to the hospital for elective cardiac surgery were included. Acceptability, usability, and tolerability were measured by the validated questionnaires Unified Theory of Acceptance and Use of Technology (acceptability), System Usability Scale (usability), and Virtual Reality Sickness Questionnaire (tolerability). Descriptive statistics were used for the analysis. Results: Twenty-eight participants used the VPT. Results showed high acceptability (mean 16.7 +/- 1.5), acceptable usability (mean 86.7 +/- 9.3), and high tolerability (sickness score, median 7.1 % [0-17.1 %]). Conclusion: The use of the VPT is a feasible and promising technique. The next step is to optimize the content and technique of the VPT based on the suggestions of the participants. Practice implications: We recommend incorporating the VPT into preoperative patient education in addition to the routine information in cardiac surgery patients.
作者:
Xerxa, ElenaBajorath, JuergenRhein Friedrich Wilhelms Univ
Lamarr Inst Machine Learning & Artificial Intellig Dept Life Sci Informat & Data Sci B ITLIMES Program Unit Chem Biol & Med Chem Friedrich Hirzebruch Allee 5-6 D-53115 Bonn Germany
The continued growth of data from biological screening and medicinal chemistry provides opportunities for datadriven experimental design and decision making in early-phase drug discovery. Approaches adopted from data ...
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The continued growth of data from biological screening and medicinal chemistry provides opportunities for datadriven experimental design and decision making in early-phase drug discovery. Approaches adopted from data science help to integrate internal and public domain data and extract knowledge from historical in-house data. Protein kinase (PK) drug discovery is an exemplary area where large amounts of data are accumulating, providing a valuable knowledge base for discovery projects. Herein, the evolution of PK drug discovery and development of small molecular PK inhibitors (PKIs) is reviewed, highlighting milestone developments in the field and discussing exemplary studies providing a basis for increasing data orientation of PK discovery efforts.
Banking service transformation from traditional services to bank digitalization has several advantages for both banks and customers. This study aims to examine several theories, including UTAUT, Meta UTAUT and TAM plu...
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In-service teachers’ professional development regarding technology adoption in education is often focused on only one specific technology. To maximize the utilization of technologies, teachers need to be able to leve...
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