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Chronic radiation-associated dysphagia in oropharyngeal cancer survivors: Towards age-adjusted dose constraints for deglutitive muscles

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CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY 2019年 18卷 16-22页

作者： Christopherson, Kaitlin M. Ghosh, Alokananda Sherif, Abdallah Mohamed, Radwan Kamal, Mona Fuller, David Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX United States Department of Biostatistics and Data Science University of Texas School of Public Health Houston TX United States Department of Clinical Oncology University of Alexandria Alexandria Egypt Department of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston TX United States Baylor College of Medicine Houston TX United States Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA United States Department of Radiation Oncology The University of Texas Medical Branch Galveston TX United States Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX United States Department of Thoracic & Head and Neck Oncology The University of Texas MD Anderson Cancer Center Houston TX United States Medical Physics Program The University of Texas Graduate School of Biomedical Sciences Houston TX United States Department of Computer Science University of Illinois at Chicago Chicago IL United States Department of Electrical and Computer Engineering The University of Iowa Iowa City IA United States

Objectives: We sought to model chronic radiation-associated dysphagia (RAD) in patients given intensity-modulated radiation therapy (IMRT) for oropharyngeal squamous cell cancer (OPSCC) as a function of age and dose to non-target swallowing muscles. Methods: We reviewed 300 patients with T1-T4 N0-3 M0 OPSCC given definitive IMRT with concurrent chemotherapy. Chronic RAD was defined as aspiration or stricture on videoflouroscopy/endoscopy, gastrostomy tube, or aspiration pneumonia at >= 12 months after IMRT. Doses to autosegmented regions of interest (ROIs;inferior, middle and superior constrictors, anterior and posterior digastrics, mylo/geniohyoid complex, intrinsic tongue, and gengioglossus) were obtained from DICOM-RT plans and dose-volume histograms. The probability of chronic RAD as a function of mean ROI dose, stratified by age (<50, 50-59, 60-69, or >70 years), was estimated with logistic probability models and subsequent unsupervised nonlinear curves. Results: Chronic RAD was observed in 34 patients (11%). Age was a significant correlate of chronic RAD, both independently and with dose for all muscle groups examined. Distinct muscle-specific dose-response profiles were observed as a function of age (e.g., 5% of patients in their 50 s [but 20% of those 70 +] who received 60 Gy to the superior constrictor had chronic RAD). This effect was stable across all observed muscle ROIs, with a false discovery rate-corrected p < 0.05, for all dose/muscle/age models, suggesting that including age as a covariate improves modeling of chronic RAD. Conclusions: Age at treatment moderates the probability of chronic RAD after chemo-IMRT for OPSCC, with aging muscles showing lower dose thresholds. Uniform dose constraints may not predict toxicity in older patients. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

关键词： Oropharynx IMRT Radiation Toxicity Presbyphagia

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The Raman Spectrum of Janus Transition Metal Dichalcogenide Monolayers WSSe and MoSSe

arXiv

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arXiv 2020年

作者： Petrić, Marko M. Kremser, Malte Barbone, Matteo Qin, Ying Sayyad, Yasir Shen, Yuxia Tongay, Sefaattin Finley, Jonathan J. Botello-Méndez, Andrés R. Müller, Kai Walter Schottky Institut Department of Electrical and Computer Engineering Technische Universität München Am Coulombwall 4 Garching85748 Germany Schellingstr. 4 Munich80799 Germany Walter Schottky Institut and Physik Department Technische Universität München Am Coulombwall 4 Garching85748 Germany Materials Science and Engineering School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85287 United States Universidad Nacional Autónoma de México Institute of Physics 20-364 MéxicoD.F.01000 Mexico

Janus transition metal dichalcogenides (TMDs) lose the horizontal mirror symmetry of ordinary TMDs, leading to the emergence of additional features, such as native piezoelectricity, Rashba effect, and enhanced catalytic activity. While Raman spectroscopy is an essential non-destructive, phase- and composition-sensitive tool to monitor the synthesis of materials, a comprehensive study of the Raman spectrum of Janus monolayers is still missing. Here, we discuss the Raman spectra of WSSe and MoSSe measured at room and cryogenic temperatures, near- and off-resonance. By combining Raman data with calculations of the phonon dispersion and using symmetry considerations, we identify the four first-order Raman modes and higher-order two-phonon modes. Moreover, we observe defect-activated phonon processes, which provide a route toward a quantitative assessment of the defect concentration and, thus, the crystal quality of the materials synthesized. Our work establishes a solid background for future research on material synthesis, study and application of Janus TMD monolayers. Copyright © 2020, The Authors. All rights reserved.

关键词： Selenium compounds

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electrically driven hot-carrier generation and above-threshold light emission in plasmonic tunnel junctions

arXiv

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arXiv 2019年

作者： Cui, Longji Zhu, Yunxuan Abbasi, Mahdiyeh Ahmadivand, Arash Gerislioglu, Burak Nordlander, Peter Natelson, Douglas Department of Physics and Astronomy Rice University HoustonTX77005 Smalley-Curl Institute Rice University HoustonTX77005 Department of Electrical and Computer Engineering Rice University HoustonTX77005 Department of Materials Science and Nanoengineering Rice University HoustonTX77005

Localized surface plasmons (LSPs) in metal nanostructures have attracted much attention for their role in generating non-equilibrium hot carriers (HCs) for photochemistry1-3, photodetection4,5 and photoluminescence6. In addition to optical excitation, LSPs and HC dynamics can be driven electrically via inelastic tunneling. LSP-mediated light emission in tunnel junctions7-13 commonly features photon energies below the threshold set by the applied voltage bias. Recent work14-18 has reported photon energies significantly above that threshold, while the underlying physical origin remains elusive. Proposed mechanisms include higher-order electron-plasmon and electron-electron interactions15,17-20, and blackbody radiation of hot electrons16,21. We report measurements of light emission in tunnel junctions of different plasmonic materials and reveal that HCs generated by nonradiative decay of electrically excited plasmons play a key role in above-threshold light emission. We observed the crossover from above- to below-threshold light emission regime by controlling the tunneling current. There is a giant material dependence of the photon yield, as much as four orders of magnitude, much greater than the plasmon-enhanced radiative efficiency of the tunneling gap. The spectral features of light emission are consistent with a proposed mechanism that incorporates the plasmonic field enhancement and a non-equilibrium HC distribution parametrized by a bias-dependent Boltzmann factor. The effective temperatures of HCs are found to correlate with the bias voltage, rather than the dissipated electrical power. electrically driven HC generation (above 2000 K under modest voltage) and plasmon-enhanced light emission could open new strategies for chemistry, optoelectronics and quantum optics. Copyright © 2019, The Authors. All rights reserved.

关键词： Light emission

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Adsorption-Controlled growth of Ga2O3 by suboxide molecular-beam epitaxy

arXiv

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arXiv 2020年

作者： Vogt, Patrick Hensling, Felix V.E. Azizie, Kathy Chang, Celesta S. Turner, David Park, Jisung McCandless, Jonathan P. Paik, Hanjong Bocklund, Brandon J. Hoffman, Georg Bierwagen, Oliver Jena, Debdeep Xing, Huili G. Mou, Shin Muller, David A. Shang, Shun-Li Liu, Zi-Kui Schlom, Darrell G. Department of Materials Science and Engineering Cornell University IthacaNY14853 United States School of Applied and Engineering Physics Cornell University IthacaNY14853 United States Air Force Research Laboratory Materials and Manufacturing Directorate Wright Patterson AFB OH45433 United States Azimuth Corporation 2970 Presidential Drive Suite 200 FairbornOH45324 United States School of Electrical and Computer Engineering Cornell University IthacaNY14853 United States Cornell University IthacaNY14853 United States Department of Materials Science and Engineering Pennsylvania State University University ParkPA16802 United States Paul-Drude-Institut für Festkörperelektronik Leibniz-Institut im Forschungsverbund Berlin e.V. Hausvogteiplatz 5–7 Berlin10117 Germany Kavli Institute at Cornell for Nanoscale Science IthacaNY14853 United States Leibniz-Institut für Kristallsüchtung Max-Born-Str. 2 Berlin12489 Germany

This paper introduces a growth method—suboxide molecular-beam epitaxy (S-MBE)—which enables the growth of Ga2O3 and related materials at growth rates exceeding 1 μm hr−1 with excellent crystallinity in an adsorption-controlled regime. Using a Ga + Ga2O3 mixture with an oxygen mole fraction of x(O) = 0.4 as an MBE source, we overcome kinetic limits that had previously hampered the adsorption-controlled growth of Ga2O3 by MBE. We present growth rates up to 1.6 μm hr−1 for Ga2O3/Al2O3 heterostructures with unprecedented crystalline quality and also at unparalleled low growth temperature for this level of perfection. We combine thermodynamic knowledge of how to create molecular-beams of targeted suboxides with a kinetic model developed for the S-MBE of III-VI compounds to identify appropriate growth conditions. Using S-MBE we demonstrate the growth of phase-pure, smooth, and high-purity homoepitaxial Ga2O3 films that are thicker than 4 μm. With the high growth rate of S-MBE we anticipate a significant improvement to vertical Ga2O3-based devices. We describe and demonstrate how this growth method can be applied to a wide-range of oxides. S-MBE rivals leading synthesis methods currently used for the production of Ga2O3-based devices. Copyright © 2020, The Authors. All rights reserved.

关键词： Molecular beam epitaxy

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Claimed detection of PH3 in the clouds of Venus is consistent with mesospheric SO2

arXiv

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arXiv 2021年

作者： Lincowski, Andrew P. Meadows, Victoria S. Crisp, David Akins, Alex B. Schwieterman, Edward W. Arney, Giada N. Wong, Michael L. Steffes, Paul G. Parenteau, M. Niki Domagal-Goldman, Shawn Department of Astronomy and Astrobiology Program University of Washington Box 351580 SeattleWA98195 United States NASA Nexus for Exoplanet System Science Virtual Planetary Laboratory Team University of Washington Box 351580 SeattleWA98195 United States Jet Propulsion Laboratory California Institute of Technology Earth and Space Sciences Division PasadenaCA91011 United States Jet Propulsion Laboratory California Institute of Technology Instruments Division PasadenaCA91011 United States Department of Earth and Planetary Sciences University of California RiversideCA92521 United States Blue Marble Space Institute of Science SeattleWA United States NASA/Goddard Space Flight Center GreenbeltMD20771 United States School of Electrical and Computer Engineering Georgia Institute of Technology AtlantaGA30332-0250 United States MS 239-4 Space Science Division NASA Ames Research Center Moffett FieldCA United States

The observation of a 266.94 GHz feature in the Venus spectrum has been attributed to PH3 in the Venus clouds, suggesting unexpected geological, chemical or even biological processes. Since both PH3 and SO2 are spectrally active near 266.94 GHz, the contribution to this line from SO2 must be determined before it can be attributed, in whole or part, to PH3. An undetected SO2 reference line, interpreted as an unexpectedly low SO2 abundance, suggested that the 266.94 GHz feature could be attributed primarily to PH3. However, the low SO2 and the inference that PH3 was in the cloud deck posed an apparent contradiction. Here we use a radiative transfer model to analyze the PH3 discovery, and explore the detectability of different vertical distributions of PH3 and SO2. We find that the 266.94 GHz line does not originate in the clouds, but above 80 km in the Venus mesosphere. This level of line formation is inconsistent with chemical modeling that assumes generation of PH3 in the Venus clouds. Given the extremely short chemical lifetime of PH3 in the Venus mesosphere, an implausibly high source flux would be needed to maintain the observed value of 20±10 ppb. We find that typical Venus SO2 vertical distributions and abundances fit the JCMT 266.94 GHz feature, and the resulting SO2 reference line at 267.54 GHz would have remained undetectable in the ALMA data due to line dilution. We conclude that nominal mesospheric SO2 is a more plausible explanation for the JCMT and ALMA data than PH3 © 2021, CC BY.

关键词： Radiative transfer

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Weak antilocalization in quasi-two-dimensional electronic states of epitaxial LuSb thin films

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Physical Review B 2019年第12期99卷 125134-125134页

作者： Shouvik Chatterjee Shoaib Khalid Hadass S. Inbar Aranya Goswami Felipe Crasto de Lima Abhishek Sharan Fernando P. Sabino Tobias L. Brown-Heft Yu-Hao Chang Alexei V. Fedorov Dan Read Anderson Janotti Christopher J. Palmstrøm Department of Electrical & Computer Engineering University of California Santa Barbara California 93106 USA Department of Physics and Astronomy University of Delaware Newark Delaware 19716 USA Department of Materials Science and Engineering University of Delaware Newark Delaware 19716 USA Materials Department University of California Santa Barbara California 93106 USA Advanced Light Source Lawrence Berkeley National Laboratory Berkeley California 94720 USA School of Physics and Astronomy Cardiff University Cardiff CF24 3AA United Kingdom

Observation of large nonsaturating magnetoresistance in rare-earth monopnictides has raised enormous interest in understanding the role of its electronic structure. Here, by a combination of molecular-beam epitaxy, low-temperature transport, angle-resolved photoemission spectroscopy, and hybrid density functional theory we have unveiled the band structure of LuSb, where electron-hole compensation is identified as a mechanism responsible for large magnetoresistance in this topologically trivial compound. In contrast to bulk single crystal analogues, quasi-two-dimensional behavior is observed in our thin films for both electron and holelike carriers, indicative of dimensional confinement of the electronic states. Introduction of defects through growth parameter tuning results in the appearance of quantum interference effects at low temperatures, which has allowed us to identify the dominant inelastic scattering processes and elucidate the role of spin-orbit coupling. Our findings open up possibilities of band structure engineering and control of transport properties in rare-earth monopnictides via epitaxial synthesis.

关键词： Density of states Electronic structure Fermi surface First-principles calculations Phonons Spin-orbit coupling Topological materials

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Success Factors of the Blockchain Adoption for Smart Manufacture

Success Factors of the Blockchain Adoption for Smart Manufac...

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2018 International Seminar on Research of Information Technology and Intelligent Systems, ISRITI 2018

作者： Surjandy Fernando, Erick Meyliana Kosala, Raymond Warnars, Harco Leslie Hendric Spits Abdurachman, Edi Supangkat, Suhono Harso Computer Science Department BINUS Graduate Program - Doctor of Computer Science Information Systems Audit Program Information Systems Department School of Information Systems Bina Nusantara University Jakarta11480 Indonesia Information Systems Department School of Information Systems Bina Nusantara University Jakarta11480 Indonesia School of Electrical Engineering and Informatics Institut Teknologi Bandung Bandung Indonesia

ISBN: (纸本)9781538674222

Currently, the discussion about smart city becomes a trend topic in which the development of the Internet of Thing (IoT) is used in various sectors including in the manufacturing sector where the Indonesian government is intensively increasing the capacity and production quality. The use of IoT in both smart manufacture and smart city become an interesting thing topic for research and the combination of the new technology Blockchain, may proof the reliability of data. Trust, transparent, secure, real time online process as a new phenomenon to merge IoT with Blockchain technology into smart manufacturing technology. However, for maintaining quality and sustainability, required technology governance so the achievement of implementation can be done well. This research uses the method called Systematic Literature Review (SLR) find the Blockchain adoption factors for Smart Manufacturing Technology Governance and the research conducted on several reputable publications. The result found, there are 35 adoption success factors found from the adoption of blockchain technology into smart manufacture industry. The influence of the technology governance process in smart manufacture industry increase sustainability, realtime and accurate decision making for the industry. © 2018 IEEE.

关键词： Manufacture

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From 3D to 4D: Integration of 3D printed structures for fabrication of multifunctional 4D biological microsensors for lab-on-a-chip and wearable applications 22

From 3D to 4D: Integration of 3D printed structures for fabr...

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22nd International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2018

作者： Didier, Charles Kundu, Avra Rajaraman, Swaminathan University of Central Florida OrlandoFL32828 United States Department of Materials Science and Engineering University of Central Florida OrlandoFL32828 United States Department of Electrical and Computer Engineering University of Central Florida OrlandoFL32828 United States

ISBN: (纸本)9781510897571

We present a novel method for the integration of 3D printed, dynamic, stretchable, packaged structures to realize 4D multifunctional biosensors for lab-on-a-chip and wearable sensor applications. The device incorporates 3D printed serpentine designs, with various out-of-plane structures, integrated on to a flexible Kapton® package with micromolded PDMS insulation. The flexibility of the printed design can be tuned by different resins, and structural design changes. Integration of 3D structures, LEDs, and helices followed by bending/twisting analysis depict the capability of the device to return naturally to its resting state (and hence 4D functionality). 3D microelectrode impedance measurements are additionally demonstrated. Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.

关键词： 3D printers

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Double resonant tunable second harmonic generation in two-dimensional layered materials through band nesting

arXiv

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arXiv 2021年

作者： Biswas, Sudipta Romen Yu, Jin Wang, Zhenwei da Costa, Diego Rabelo Zhao, Chujun Yuan, Shengjun Low, Tony Department of Electrical & Computer Engineering University of Minnesota MinneapolisMN55455 United States Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering Science Shanghai University Shanghai200444 China Institute for Molecules and Materials Radboud University Heijendaalseweg 135 Nijmegen6525AJ Netherlands Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan430072 China Departamento de Física Universidade Federal do Ceará Campus do Pici CE Fortaleza60455-900 Brazil Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and Electronics Hunan University Changsha410082 China School of Physics and Astronomy University of Minnesota MinneapolisMN55455 United States

We proposed a mechanism to generate giant anisotropic second harmonic nonlinear response via double resonance effect, achieved through band nesting via electronic bandstructure engineering. The ideal band setup would be a triplet of nested bands separated by the fundamental resonance energy, ~ω. We demonstrate theoretically that the proposed phenomenon can be realized in bilayer SnS by band tuning with perpendicular electrical bias, which maximizes the second harmonic susceptibility by several orders of magnitude. Moreover, the tunability of the polarization anisotropy can be useful for realizing novel polarization-sensitive devices. © 2021, CC BY.

关键词： Harmonic generation

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Left ventricular hypertrophy detection using electrocardiographic signal

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Scientific reports 2023年第1期13卷 2556页

作者： Cheng-Wei Liu Fu-Hsing Wu Yu-Lun Hu Ren-Hao Pan Chuen-Horng Lin Yung-Fu Chen Guo-Shiang Tseng Yung-Kuan Chan Ching-Lin Wang Division of Cardiology Department of Internal Medicine Tri-Service General Hospital Songshan Branch National Defense Medical Center Taipei Taiwan. Bachelor Degree Program of Artificial Intelligence National Taichung University of Science and Technology Taichung Taiwan. Department of Management Information Systems National Chung-Hsing University Taichung Taiwan. La Vida Tec. Co. Ltd. Taichung Taiwan. Preventive Medicine Center National Yang Ming Chiao Tung University Taipei Taiwan. Department of Information Management Tunghai University Taichung Taiwan. Department of Computer Science and Information Engineering National Taichung University of Science and Technology Taichung Taiwan. Department of Dental Technology and Materials Science Central Taiwan University of Science and Technology Taichung Taiwan. Division of Cardiology Department of Internal Medicine Taoyuan Armed Force General Hospital Hsinchu Branch Hsinchu Taiwan. Department of Management Information Systems National Chung-Hsing University Taichung Taiwan. ykchan@nchu.edu.tw. Department of Information Management National Chin-Yi University of Technology Taichung Taiwan. clwang@ncut.edu.tw.

Left ventricular hypertrophy (LVH) indicates subclinical organ damage, associating with the incidence of cardiovascular diseases. From the medical perspective, electrocardiogram (ECG) is a low-cost, non-invasive, and easily reproducible tool that is often used as a preliminary diagnosis for the detection of heart disease. Nowadays, there are many criteria for assessing LVH by ECG. These criteria usually include that voltage combination of RS peaks in multi-lead ECG must be greater than one or more thresholds for diagnosis. We developed a system for detecting LVH using ECG signals by two steps: firstly, the R-peak and S-valley amplitudes of the 12-lead ECG were extracted to automatically obtain a total of 24 features and ECG beats of each case (LVH or non-LVH) were segmented; secondly, a back propagation neural network (BPN) was trained using a dataset with these features. Echocardiography (ECHO) was used as the gold standard for diagnosing LVH. The number of LVH cases (of a Taiwanese population) identified was 173. As each ECG sequence generally included 8 to 13 cycles (heartbeats) due to differences in heart rate, etc., we identified 1466 ECG cycles of LVH patients after beat segmentation. Results showed that our BPN model for detecting LVH reached the testing accuracy, precision, sensitivity, and specificity of 0.961, 0.958, 0.966 and 0.956, respectively. Detection performances of our BPN model, on the whole, outperform 7 methods using ECG criteria and many ECG-based artificial intelligence (AI) models reported previously for detecting LVH.

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