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Injectable Artificial Ovary with Xenogeneic Extracellular Matrix Hydrogels: A Proof-of-Concept Study on Preserving and Restoring the Ovarian Function

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SSRN 2024年

作者： Yang, Chungmo Chung, Nanum Song, Chaeyoung Kim, Hyerim Shin, Jungwoo Lee, Kangwon Lee, Jung Ryeol Department of Obstetrics and Gynecology Seoul National University Bundang Hospital Seongnam13620 Korea Republic of Department of Translational Medicine Seoul National University College of Medicine Seoul03080 Korea Republic of Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul03080 Korea Republic of Program in Nanoscience and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Department of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Research Institute for Convergence Science Seoul National University Seoul08826 Korea Republic of

One of the emerging strategies in constructing the artificial ovary is the concern of remaining malignant cells in cryopreserved ovarian tissue, impeding fertility preservation after chemotherapy. The extracellular matrix is an emerging material in tissue engineering due to the contents obtained from "the tissue," easy-to-xenograft potential, and the cost-effectiveness of engineering processes. We fabricated an "injectable artificial ovary" utilizing a xenogeneic extracellular matrix (ECM) hydrogel from bovine ovarian tissues. The ECM hydrogel, obtained through a process of decellularization, milling, and digestion, can be prepared as an injectable thermo-responsible hydrogel. The decellularization process ensures the removal of cellular components while preserving native extracellular matrix structures with no cytotoxicity. Notably, we observed that the in-situ development of ovarian follicles post-injection progressed appropriately, culminating in successful ovulation after injecting hydrogel with isolated ovarian follicles into subcutis. Our results suggest the possibility that our method can be used as a heterotopic artificial ovary. Taken together. Our strategy holds promise in advancing artificial ovary technologies that provide a potential solution for patients who cannot undergo conventional treatments with high metastasis potential cancer, offering new perspectives for fertility preservation and reproductive health interventions. © 2024, The Authors. All rights reserved.

关键词： Hydrogels

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Step-growth polymerization of traptavidin-DNA conjugates for plasmonic nanostructures

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Chinese Chemical Letters 2020年第5期31卷 1137-1140页

作者： Young-Youb Kim Yongbin Bang Dayoung Lee Mingyu Kang Yoon-Kyu Song Graduate School of Convergence Science and Technology Seoul National UniversitySeoul 08826Republic of Korea Advanced Institutes of Convergence Technology.Gyeonggi-do 16229 Republic of Korea

Here,we use two important biomaterials,protein and DNA,to construct self-assembled linear nanostructures through Watson-Crick base-paring of *** apply a simple magnetic separation method to purify traptavidin-DNA co njugates,and demonstrate synthesis of linear arrays of traptavidinDNA conjugates via the step-growth polymerization approach with pre-determined DNA *** the traptavidin-DNA array as a template,we assemble gold nanoparticles to form linear plasmonic nanostructures in a programmable *** traptavidin-DNA conjugates thus provide a convenient platform for one-dimensional assembly of biotinylated nanomaterials for many biomedical applications from drug delivery to bio-sensing.

关键词： Protein-DNA conjugate DNA nanostructure Supramolecular assembly Traptavidin Plasmonic nanostructure

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A dual plasmonic core-shell Pt/[TiN@TiO_(2)]catalyst for enhanced photothermal synergistic catalytic activity of VOCs abatement

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nano Research 2022年第8期15卷 7071-7080页

作者： Anqi Li Qianpeng Zhang Shuaiqi Zhao Yanan Chong Peng Wu Yifei Li Xiaojing Jin Guangxu Chen Yongcai Qiu Shihe Yang Daiqi Ye Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control School of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Guangzhou HKUST Fok Ying Tung Research Institute NanshaGuangzhou 511458China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China Guangdong Key Lab of Nano-Micro Material Research School of Chemical Biology and Biotechnology Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China

Volatile organic compounds(VOCs)are ubiquitous organic pollutants affecting atmospheric environment and human *** development of new efficient and environmentally friendly materials utilizing photothermal synergistic catalysis for purification of VOCs is still ***,we design and prepare a core–shell TiN@TiO_(2)nanostructure integrating with nanoscaled Pt(Pt/[TiN@TiO_(2)])by an attractive quenching *** strong light-harvesting capability of Pt and TiN components improve light-to-heat utilization efficiency by their intrinsic surface plasmon resonance *** TiO_(2)component upon the surface and the coexisting coupling effect of Pt0 and Pt2+enhance the photocatalytic effect of the *** a result,the catalytic performance is significantly improved with toluene(120 ppm)conversion of 100%under the gas hourly space velocity of 72,000 mL·g^(−1)·h^(−1)and light illumination of 500 mW·cm^(−2).The desired catalyst thus achieves highly efficient coupling effect of photocatalysis and light-to-heat conversion for promoting VOCs abatement.

关键词： core-shell Pt/[TiN@TiO_(2)]catalyst volatile organic compounds(VOCs)abatement photothermal synergistic catalysis full spectrum sunlight utilization

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Nationwide human biomonitoring strategy in Korea: Prioritization of novel contaminants using GC/TOF-MS with suspect and non-target screening

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Chemosphere 2024年 369卷 143814页

作者： Mok, Sori Lee, Sunggyu Lee, Nahyun Kim, Sungkyoon Choi, Kyungho Park, Jeongim Kho, Younglim Moon, Hyo-Bang Department of Marine Science and Convergence Technology College of Science and Convergence Technology Hanyang University Ansan15588 Korea Republic of Graduate School of Public Health Seoul National University Seoul08826 Korea Republic of Department of Environmental Health Sciences Soonchunhyang University Asan31538 Korea Republic of Department of Health Environment & Safety Eulji University Gyeonggi-do Seongnam13135 Korea Republic of

According to global regulations on hazardous chemicals, numerous alternatives have been manufactured and used in various consumer products. Suspect and non-target analyses are advanced analytical techniques used for identifying novel contaminants. In the present study, suspect and non-target analytical approaches using a gas chromatography coupled to a time-of-flight mass spectrometer were applied to identify novel contaminants in 40 pooled serum samples from a sub-population (n = 400) of the 2015–2017 national biomonitoring program. Suspect screening analysis was performed using an in-house library based on retention times and quantifier and qualifier ions for 222 contaminants, including persistent organic pollutants and emerging contaminants. Non-target analysis was performed by matching deconvoluted mass spectra to the spectral library from the National Institute of Standards and technology. The suspect screening analysis identified organochlorinated pesticides, organophosphate esters, phthalate esters, and alternative plasticizers. Among the 68 compounds identified in the non-target analysis, siloxanes, novel organophosphate esters, and UV ink photoinitiators were considered candidates for future inclusion in the biomonitoring program based upon significant human exposure. Our findings demonstrate the feasibility of suspect and non-target analysis to identify novel contaminants to prioritize for inclusion within a national human biomonitoring program. © 2024 Elsevier Ltd

关键词： Gas chromatography

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Monitoring Disease-Implicated Hydrogen Sulfide in Blood Using a Facile Deproteinization-Based Electrochemiluminescence Chemosensor System

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SSRN 2023年

作者： Bak, Yecheol Anjong, Tikum Florence Kim, Jihwan Jeon, Sang Hyeon Park, Jihwan Lee, Kangwon Shin, Iksoo Kim, Sehoon Seoul02792 Korea Republic of Program in Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Department of Chemistry College of Natural Science Soongsil University Seoul156743 Korea Republic of Korea University Korea Republic of

Hydrogen sulfide (H2S), an antioxidant and cell signaling molecule, plays a critical role in redox reactions in the biological system, and its imbalances in blood levels have been implicated in various diseases. Here, we demonstrate a novel chemosensor-based "turn-on" electrochemiluminescence (ECL) system for the selective and sensitive detection of H2S in a type 1 diabetes rat model. Our luminogenic chemosensor (Probe) is a redox-stable cyclometalating iridium (III) complex with emission-quenching 2,4-dinitrophenyl ether (DNP) that shows a significant enhancement in emission intensity upon cleavage of DNP by selective reaction towards H2S. To achieve robust and reliable ECL emission of Probe for biological analysis, we developed a facile deproteinization protocol based on organic solvent-induced protein precipitation/syringe filtration that eliminates uncontrolled protein adsorption on the electrode surface from protein-rich biological samples. Our deproteinization-assisted ECL chemosensor system showed effectiveness in detecting disease-associated H2S levels in biological media with a linear response in the range of 0-250 µM (R2: 0.992), the limit of detection of 7.2 µM, and average signal-to-noise ratio of ~25. It enables reliable in vitro monitoring of H2S level changes in blood samples of a type 1 diabetes rat model. This strategy to integrate chemosensor-based ECL and facile deproteinization protocol provides a sensitive and rapid disease-monitoring platform for detecting small-molecule biomarkers that cannot be detected by conventional ECL sandwich immunoassays. © 2023, The Authors. All rights reserved.

关键词： Chemosensor

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Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

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Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： Jeongho Yang Woongbeom Heogh Hogi Ju Sukhyun Kang Tae-Sik Jang Hyun-Do Jung Mohammad Jahazi Seung Chul Han Seong Je Park Hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas Jr Sang Hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed *** is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid *** study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive *** strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid ***,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional *** outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

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Synthesis of functionalized mesoporous silica nanoparticles for colorimetric and fluorescence sensing of selective metal (Fe³⁺) ions in aqueous solution

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Methods 2024年 223卷 26-34页

作者： Santhamoorthy, Madhappan Mohan, Anandhu Mani, Kailasam Saravana Devendhiran, Tamiloli Periyasami, Govindasami Kim, Seong-Cheol Lin, Mei-Ching Kumarasamy, Keerthika Huang, Po-Jui Ali, Asif School of Chemical Engineering Yeungnam University Gyeongsan 38541 South Korea Department of Nano Science and Technology Convergence General Graduate School Gachon University 1342 Seongnam-Daero Sujeong-Gu Gyeonggi-Do Seongnam-Si 13120 South Korea Centre for Material Chemistry Department of Chemistry Karpagam Academy of Higher Education Tamil Nadu Coimbatore 641021 India Department of Chemistry National Changhua University of Education Changhua 500 Taiwan Department of Chemistry College of Science King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung Taiwan Department of Nutrition Chung Shan Medical University Taichung 40203 Taiwan

The fabrication of red fluorescent hybrid mesoporous silica-based nanosensor materials has promised the bioimaging and selective detection of toxic pollutants in aqueous solutions. In this study, we present a hybrid mesoporous silica nanosensor in which the propidium iodide (PI) was used to conveniently integrate into the mesopore walls using bis(trimethoxysilylpropyl silane) precursors. Various characterization techniques including X-ray diffraction (XRD), Fourier-transform infrared (FTIR), N₂ adsorption–desorption, zeta potential, particle size analysis, thermogravimetric, and UV–visible analysis were used to analyze the prepared materials. The prepared PI integrated mesoporous silica nanoparticles (PI-MSNs) selective metal ion sensing capabilities were tested with a variety of heavy metal ions (100 mM), including Ni²⁺, Cd²⁺, Co²⁺, Zn²⁺, Cr³⁺, Cu²⁺, Al³⁺, Mg²⁺, Hg²⁺ and Fe³⁺ ions. Among the investigated metal ions, the prepared PI-MSNs demonstrated selective monitoring of Fe³⁺ ions with a significant visible colorimetric pink color change into orange and quenching of pink fluorescence in an aqueous suspension. The selective sensing behavior of PI-MSNs might be due to the interaction of Fe³⁺ ions with the integrated PI functional fluorophore present in the mesopore walls. Therefore, we emphasize that the prepared PI-MSNs could be efficient for selective monitoring of Fe³⁺ ions in an aqueous solution and in the biological cellular microenvironment. © 2024

关键词： Colorimetric sensor Fe3+ ion sensing Mesoporous silica nanoparticles nanosensors Recyclability

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Field-response of polymer microemulsions based on reactive mesogens

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Journal of Molecular Liquids 2025年 420卷

作者： Manda, Ramesh Dhara, Surajit Kim, Tae Hyung Lim, Young Jin Lee, Seung Hee Kim, MinSu School of Physics University of Hyderabad Telangana Hyderabad500046 India Department of Nano Convergence Engineering Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of Department of JBNU-KIST Industry-Academia Convergence Research Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of Department of Polymer Nano Science and Technology Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of

Understanding molecular rearrangement of liquid crystals (LC) in microemulsions and manipulating their topology with external stimuli offer significant advantages for applications like sensors, displays, and smart windows. We fabricated monodisperse LC and reactive mesogen (RM)-LC microemulsions using porous glass membrane emulsification and investigated their topological transitions under electric fields. LC microemulsions retained their bipolar axes while responding to electric fields, whereas RM-LC microemulsions displayed a distinct response, where the polymer network rotated due to interfacial anchoring strength with field-responsive LCs, despite the polymer network's minimal dielectric anisotropy. These detailed findings on the RM-LC response highlight the role of interfacial interactions in structural transitions, facilitating the design of optimized topologies for low-power, high-performance optical devices. © 2025

关键词： Liquid crystal displays

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Bio‑imitative Synergistic Color‑Changing and Shape‑Morphing Elastic Fibers with a Liquid Metal Core

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Advanced Fiber Materials 2024年第3期6卷 900-910页

作者： Seonwoo Mun Sangmin Lee Kwak Jin Bae Yejin Bae Hye‑Min Lee Byung‑Joo Kim Jaesang Yu Sungjune Park Department of Nano Convergence Engineering Department of Polymer‑Nano Science and TechnologyJeonbuk National UniversityJeonju 54896Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology(KIST)Chudong‑Ro 92Bongdong‑EupWanju‑Gun 55324JeollabukdoKorea R&BD Group 1 Industrialization DivisionKorea Carbon Industry Promotion AgencyJeonju 54853Republic of Korea Department of Advanced Materials and Chemical Engineering Jeonju UniversityJeonju 55069Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The systematic integration of color-changing and shape-morphing abilities into entirely soft devices is a compelling strategy for creating adaptive camouflage,electronic skin,and wearable healthcare *** this study,we developed soft actuators capable of color change and programmable shape morphing using elastic fibers with a liquid metal *** the hollow elastic fiber with the thermochromic pigment was fabricated,liquid metal(gallium)was injected into the core of the *** has a relatively low melting point(29.8℃);thus,fluidity and metallic conductivity are preserved while *** fiber can change color by Joule heating upon applying a current through the liquid metal core and can also be actuated by the Lorentz force caused by the interaction between the external magnetic field and the magnetic field generated around the liquid metal core when a current is *** on this underlying principle,we demonstrated unique geometrical actuations,including flower-like blooming,winging butterflies,and the locomotion of coil-shaped *** color-changing and shape-morphing elastic fiber actuators presented in this study can be utilized in artificial skin,soft robotics,and actuators.

关键词： Electromagnetic actuator Liquid metal Soft electronic Thermochromic elastic fiber Bio-inspired actuator

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Highly Transparent and Flexible All-nanofiber-Based Piezocomposite Containing BaTiO_(3)-Embedded P(VDF-TrFE)nanofibers for Harvesting and Monitoring Human Kinetic Movements

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Advanced Fiber Materials 2024年第5期6卷 1369-1386页

作者： Kiyong Kim Daekyu Choi Sangmin Ji Freddy Baltazar Iniguez Young Jae Song Sam S.Yoon Junki Kim Seongpil An SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Nano Science and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Semiconductor Convergence Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

We developed kinetic energy-harvestable and kinetic movement-detectable piezoelectric nanogenerators(PENGs)consisting of piezoelectric nanofiber(NF)mats and metal-electroplated microfiber(MF)electrodes using electrospinning and electroplating *** non-woven structure and high flexibility of the NF mats and MF electrodes allowed us to achieve highly transparent and flexible piezocomposites.A viscoelastic solution,mixed with P(VDF-TrFE)and BaTiO_(3),was electrospun into piezoelectric NFs with a piezoelectric coefficient d33 of 21.2 pC/*** addition,the combination of electrospinning and elec-troplating techniques enabled the fabrication of Ni-plated MF-based transparent conductive electrodes(TCEs),contributing to the high transparency of the resulting *** energy-harvesting efficiencies of the BaTiO_(3)-embedded NF-based PENGs with transmittances of 86%and 80%were 200 and 240 V/MPa,respectively,marking the highest values in their ***,the output voltage driven by the coupling effect of piezoelectricity and triboelectricity during finger tapping was 25.7 *** highly efficient energy-harvesting performances,along with the transparent and flexible features of the PENGs,hold great promise for body-attachable energy-harvesting and sensing devices,as demonstrated in this study.

关键词： BaTiO_(3) P(VDF-TrFE) Electrospinning All-nanofiber-based piezoelectric nanogenerator Wearable piezoelectric sensor

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