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International Topical Meeting on Microwave Photonics (MWP)

作者： Chao Wei Yake Chen Yang Sun Zhongming Zeng Jia Ye Xihua Zou Wei Pan Xiaojun Xie Lianshan Yan School of Information Science and Technology Key Laboratory of Photonic-Electric Integration and Communication-Sensing Convergence Southwest Jiaotong University Chengdu China Suzhou Institute of Nano-Tech and Nano-Bionics Key Laboratory of Multifunctional Nanomaterials and Smart Systems Chinese Academy of Sciences Suzhou China

The study presents a demonstration of InP/InGaAs modified uni-traveling carrier (MUTC) photodiode (PD) arrays heterogeneously integrated on the thin-film lithium niobate platform. To divide the input optical power evenly, a 1×N multimode interferometer (MMI) is employed to feed the PDs through N waveguides. The PD arrays, consisting of 2, 3, and 4 PDs, exhibit 3-dB bandwidths of 82 GHz, 67 GHz, and 62 GHz, respectively. The measured output power of the 1 ×4 PD array reaches -2.3 dBm at 30 GHz.

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Amino-functionalized reduced graphene oxide@MoS2@CoS2 heterostructure as a high-rate anode material for ultralong lifespan sodium–sulfur batteries

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New Journal of Chemistry 2025年第24期49卷 10379-10387页

作者： Navid Aslfattahi Maryam Sadat Kiai Nilgun Baydogan Lingenthiran Samylingam Kumaran Kadirgama Chee Kuang Kok Department of Fluid Dynamics and Thermodynamics Faculty of Mechanical Engineering Czech Technical University in Prague Prague 166 07 Czech Republic Nano-Science and Nano-Engineering Program Graduate School of Science Engineering and Technology Istanbul Technical University Istanbul-34469 Turkey Energy Institute Ayazaga Campus Istanbul Technical University Maslak Istanbul Turkey Centre for Advanced Mechanical and Green Technology Center of Excellence for Robotics & Sensing Technologies Faculty of Engineering and Technology Multimedia University Jalan Ayer Keroh Lama Bukit Beruang 75450 Melaka Malaysia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang 26600 Pekan Malaysia Centre for Research in Advanced Fluid and Process University Malaysia Pahang Al-Sultan Abdullah Lebuhraya Tun Razak Gambang Kuantan Pahang Malaysia Centre for Sustainable Materials & Surface Metamorphosis (CSMSM) Chennai Institute of Technology Chennai India

A nanocomposite comprising MoS2@CoS2 amino-functionalized graphene (En-RGO) with a two-dimensional structure has been successfully synthesized using a simple self-assembly technique. The resulting cell with a MoS2@CoS...

A nanocomposite comprising MoS₂@CoS₂ amino-functionalized graphene (En-RGO) with a two-dimensional structure has been successfully synthesized using a simple self-assembly technique. The resulting cell with a MoS₂@CoS₂@En-RGO anode and a sulfur cathode exhibits a superior hierarchical architecture that significantly facilitates ion mobility, cell conductivity, and pseudocapacitance. Consequently, this leads to improved rate performance and extended cycle stability in Na–S batteries. Micron-sized CoS₂ was synthesized by solvothermal growth of MoS₂ nanosheets on its surface. This composite material presents enhanced sodium-ion diffusion kinetics attributed to its heterogeneous interface, reduced ion diffusion pathways and increased exposure of active sites for sodium storage due to its hierarchical nanosheet structure. Additionally, amino functionalized graphene oxide with uniform nitrogen doping could improve electronic conductivity. The cell employing MoS₂@CoS₂@En-RGO with superior ion mobility and enhanced adsorption energy of Na⁺ ions achieves a cycle stability of 541.2 mA h g⁻¹ after 1800 cycles. The increased adsorption energy facilitates a more efficient sodiation process at MoS₂@CoS₂@En-RGO compared to En-RGO. Additionally, the MoS₂@CoS₂@En-RGO anode demonstrates a capacity retention of 95.8% after 1800 cycles at 1 A g⁻¹. The enhanced mobility of Na ions and the effective adsorption of polysulfide chains in MoS₂@CoS₂@En-RGO have been examined through DFT calculations, confirming its potential as a promising anode material for

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nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer

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Journal of Biomedical science 2024年第1期31卷 1页

作者： Ou, Da-Liang Liao, Zi-Xian Kempson, Ivan M. Li, Lin Yang, Pan-Chyr Tseng, S.-Ja Graduate Institute of Oncology National Taiwan University College of Medicine Taipei 10051 Taiwan National Taiwan University YongLin Institute of Health National Taiwan University Taipei 10051 Taiwan Institute of Medical Science and Technology National Sun Yat-Sen University Kaohsiung 80424 Taiwan Future Industries Institute University of South Australia Mawson Lakes 5095 SA Australia Department of Internal Medicine National Taiwan University College of Medicine Taipei 10051 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan Program in Precision Health and Intelligent Medicine Graduate School of Advanced Technology National Taiwan University Taipei 10051 Taiwan

Background: As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results for treating unresectable HCC, offering new opportunities. Recombinant adeno-associated viral type 2 (AAV2) virotherapy has been approved for clinical use but it efficacy is stifled through systemic administration. On the other hand, iron oxide nanoparticles (ION) can be cleared via the liver and enhance macrophage polarization, promoting infiltration of CD8⁺ T cells and creating a more favorable tumor microenvironment for immunotherapy. Methods: To enhance the efficacy of virotherapy and promote macrophage polarization towards the M1-type in the liver, ION-AAV2 were prepared through the coupling of ION-carboxyl and AAV2-amine using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC)/N-hydroxysulfosuccinimide (Sulfo-NHS). Efficacy after systemic delivery of ION-AAV2 in an orthotopic HCC model was evaluated. Results: After 28 days, the tumor weight in mice treated with ION-AAV2 was significantly reduced by 0.56-fold compared to the control group. The ION-AAV2 treatment led to an approximate 1.80-fold increase in the level of tumor associated M1-type macrophages, while the number of M2-type macrophages was reduced by 0.88-fold. Moreover, a proinflammatory response increased the population of tumor-infiltrating CD8⁺ T cells in the ION-AAV2 group. This transformation converted cold tumors into hot tumors. Conclusions: Our findings suggest that the conjugation of ION with AAV2 could be utilized in virotherapy while simultaneously exploiting macrophage-modulating cancer immunotherapies to effectively suppress HCC growth. © 2023, The Author(s).

关键词： Adeno-associated virus Immune-promoting effect Iron oxide nanoparticles Macrophage Orthotopic hepatocellular carcinoma Photodynamic virotherapy

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technology Roadmap for Flexible Sensors

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ACS nano 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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Ultrahigh Thermal Conductance across Superlubric Interfaces in Twisted Graphite

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Physical Review Letters 2025年第14期134卷 146302-146302页

作者： Fuwei Yang Wenjiang Zhou Zhibin Zhang Xuanyu Huang Jingwen Zhang Nianjie Liang Wujuan Yan Yuxi Wang Mingchao Ding National Key Laboratory of Advanced MicroNanoManufacture Technology Peking University Beijing 100871 China Department of Engineering Mechanics Tsinghua University Beijing 100084 China Center for Nano and Micro Mechanics Tsinghua University Beijing 100084 China Institute of Superlubricity Technology Research Institute of Tsinghua University in Shenzhen Shenzhen 518057 China College of Engineering Peking University Beijing 100871 China School of Advanced Engineering Great Bay University Dongguan 523000 China State Key Laboratory for Mesoscopic Physics Frontiers Science Centre for Nano-optoelectronics School of Physics Peking University Beijing 100871 China Institute of Materials Research Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China School of Energy and Power Engineering Huazhong University of Science and Technology Wuhan Hubei 430074 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China

Interlayer rotation in van der Waals (vdW) materials offers a unique degree of freedom for manipulating lattice dynamics and leads to an exotic state with vanishing friction called structural superlubricity. Extensive theoretical calculations have also predicted the potential of twisted vdW materials for controlling heat flow in advanced electronics. However, precise experimental measurements have proven extremely challenging with only a handful of efforts to date reporting inconsistent results. Here, we have managed to achieve simultaneous mechanical characterizations and thermal measurements of the intrinsic twisted interfaces in microfabricated graphite mesas. Remarkably, the conductance of superlubric interfaces reaches about 600 MWm−2 K−1 which surpasses the measured values for artificially stacked vdW structures by nearly an order of magnitude. Nonetheless, we successfully resolved over 30-fold variation of thermal conductance as the buried interfaces were rotated to a locked state. Further, atomic simulations revealed the predominant role of the transverse acoustic phonons. Together, our findings highlight a general physical picture that directly correlates interfacial thermal transport with sliding resistance, and lay the foundation for twist-enabled thermal management which are particularly beneficial to twistronics and slidetronics.

关键词： Van der Waals forces

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Deep learning acceleration of multiscale superresolution localization photoacoustic imaging

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Light(science & Applications) 2022年第6期11卷 1166-1177页

作者： Jongbeom Kim Gyuwon Kim Lei Li Pengfei Zhang Jin Young Kim Yeonggeun Kim Hyung Ham Kkim Lihong V.Wang Seungchul Lee Chulhong Kim Departments of Electrical Engineering Mechanical EngineeringConvergence IT Engineeringand Interdisciplinary Bioscience and BioengineeringGraduate School of Artificial IntelligenceMedical Device Innovation CenterPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical EngineeringDepartment of Electrical EngineeringCalifornia Institute of Technology1200 E.California Blvd.MC 138-78PasadenaCA 91125USA School of Precision Instruments and Optoelectronics Engineering Tianjin University92 Weijin RoadNankai DistrictTianjin 300072China Opticho 532CHANGeUP GROUND87 Cheongam-roNam-guPohangGyeongsangbuk 37673Republic of Korea

A superresolution imaging approach that localizes very small targets,such as red blood cells or droplets of injected photoacoustic dye,has significantly improved spatial resolution in various biological and medical imaging ***,this superior spatial resolution is achieved by sacrificing temporal resolution because many raw image frames,each containing the localization target,must be superimposed to form a sufficiently sampled high-density superresolution ***,we demonstrate a computational strategy based on deep neural networks(DNNs)to reconstruct high-density superresolution images from far fewer raw image *** localization strategy can be applied for both 3D label-free localization optical-resolution photoacoustic microscopy(OR-PAM)and 2D labeled localization photoacoustic computed tomography(PACT).For the former,the required number of raw volumetric frames is reduced from tens to fewer than *** the latter,the required number of raw 2D frames is reduced by 12 ***,our proposed method has simultaneously improved temporal(via the DNN)and spatial(via the localization method)resolutions in both label-free microscopy and labeled ***-learning powered localization PA imaging can potentially provide a practical tool in preclinical and clinical studies requiring fast temporal and fine spatial resolutions.

关键词： Deep frames networks

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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

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Recent advances in deep-learning-enhanced photoacoustic imaging

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Advanced Photonics Nexus 2023年第5期2卷 2-32页

作者： Jinge Yang Seongwook Choi Jiwoong Kim Byullee Park Chulhong Kim Pohang University of Science and Technology School of Interdisciplinary Bioscience and BioengineeringGraduate School of Artificial IntelligenceMedical Device Innovation CenterDepartment of Electrical EngineeringConvergence IT Engineeringand Mechanical EngineeringPohangRepublic of Korea Sungkyunkwan University Institute of Quantum BiophysicsDepartment of BiophysicsSuwonRepublic of Korea

Photoacoustic imaging(PAI),recognized as a promising biomedical imaging modality for preclinical and clinical studies,uniquely combines the advantages of optical and ultrasound *** PAI’s great potential to provide valuable biological information,its wide application has been hindered by technical limitations,such as hardware restrictions or lack of the biometric information required for image *** first analyze the limitations of PAI and categorize them by seven key challenges:limited detection,low-dosage light delivery,inaccurate quantification,limited numerical reconstruction,tissue heterogeneity,imperfect image segmentation/classification,and ***,because deep learning(DL)has increasingly demonstrated its ability to overcome the physical limitations of imaging modalities,we review DL studies from the past five years that address each of the seven challenges in ***,we discuss the promise of future research directions in DL-enhanced PAI.

关键词： photoacoustic imaging deep learning biomedical imaging.

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Highly efficient and stable solid-state fiber dye-sensitized solar cells with Ag-decorated SiO_(2) nanoparticles

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nano Research 2021年第8期14卷 2728-2734页

作者： Jae Ho Kim Seok-Ju Yoo Daseul Lee Jin Woo Choi Sang-Cheol Han Tae In Ryu Hyung Woo Lee Myunghun Shin Myungkwan Song Materials Center for Energy Convergence Korea Institute of Materials Science(KIMS)797Changwon-daeroSungsan-guChangwonGyeongsangnam-do51508Republic of Korea CEN Nano.Co.Ltd. Nano Convergence CenterMuan-roBuduk-myeonMiryang-siGyeongsangnam-do50404Republic of Korea Accident Coordination and Training Division National Institute of Chemical Safety(NICS)90Gajeongbuk-roYuseong-guDaejeon34114Republic of Korea Department of Nanoenergy Engineering and Research Center of Energy Convergence Technology Pusan National UniversityBusandaehak-ro 63-2Geumjeong-guBusan 46241Republic of Korea School of Electronics and Information Engineering Korea Aerospace University Goyang-cityGyeonggi-do10540Republic of Korea

Fiber-shaped dye-sensitized solar cells(FDSSCs)represent promising futuristic flexible or wearable power sources,owing to their simple fabrication process,light weight,weavability,and *** with strategies on changing the properties of semiconductor materials,the effects of incorporating silver-embedded SiO_(2) nanoparticles(Ag@SiO_(2)NPs)on the photoanodes of solid-state FDSSCs(SS-FDSSCs)are *** power conversion efficiency(PCE)of SS-FDSSCs with Ag@SiO_(2) NPs reaches 5.38%,which is comparable to the reference(3.98%).The PCEs remain at 95%between-16.9 and 91.7℃,indicating the operational stability of SS-FDSSCs within this temperature *** fabricated SS-FDSSCs,whose radii were 2 mm,maintains more than 90%of their efficiency over 500 bending cycles and 10 washing cycles.

关键词： dye-sensitized solar cells fiber-shaped solar cells SiO_(2)nanoparticles plasmonic effect solid-state electrolyte

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Anti-inflammatory, antibacterial, and antioxidative bioactive glass-based nanofibrous dressing enables scarless wound healing

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Smart Materials in Medicine 2023年第1期4卷 407-426页

作者： Yuan, Zhengchao Zhang, Lixiang Jiang, Shichao Shafiq, Muhammad Cai, Youjun Chen, Yujie Song, Jiahui Yu, Xiao Ijima, Hiroyuki Xu, Yuan Mo, Xiumei State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai201620 China Department of Orthopaedics Xinqiao Hospital Army Military Medical University No. 183 Xinqiao Street Shapingba District Chongqing400037 China Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan250021 China Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan250117 China Department of Chemical Engineering Faculty of Engineering Graduate School Kyushu University 744 Motooka Nishi-ku Fukuoka-shi Fukuoka819-0395 Japan Lahore54000 Pakistan

Excessive scar tissue formation along with bacterial infection, hemorrhage, and oxidative wound microenvironment pose adverse physiological and psychological effects on patients, which necessitate the advent of innovative anti-inflammatory, anti-bacterial, and anti-oxidative multifunctional wound dressings. The overarching objective of this study was to exploit bioactive glass (BG) and a natural anti-bacterial component namely "oregano essential oil (OEO)" to impart multifunctionality to poly(L-lactide-co-glycolide)/Gelatin (PLGA/Gel)-based nanofibrous dressings for excisional wound management. We performed a series of structural, morphological, and release studies as well as delineated angiogenic, hemostatic, anti-bacterial, and anti-oxidative properties of these bioactive dressings in vitro, which altogether revealed the beneficial effects of BG and OEO in terms of rapid hemostasis, improved chemotactic response, diminished bacterial colonization, and anti-inflammatory response. Impressively, in multiple injury models, including a rat tail-amputation model, an ear artery injury model, and a liver trauma model in rabbit in vivo, we reported BG-mediated rapid hemostasis. Moreover, dressings containing BG showed improved hemocompatibility and suppressed coagulation as revealed by activated partial thromboplastin assay (APTT) in vitro. In addition, the transplantation of these nanofibrous dressings in a full-thickness excisional wound model in rats showed significant tissue regeneration as evidenced by the more number of blood vessels, glands, and hair follicles, re-epithelialization, diminished inflammatory response, and less fibrotic tissue formation. Taken together our approach of simultaneously harnessing economical BG and OEO to enable multifunctionality to nanofibrous dressings for tissue repair may hold great promise for wound healing as well as other bio-related disciplines. © 2023 The Authors

关键词： Biocompatibility

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