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第八届高分子化学国际学术研讨会

作者： Yuanzhe Piao Graduate School of Convergence Science and Technology Seoul National University

Lithium-ion batteries are widely used as power sources for portable electronic devices such as digital cameras,notebooks,and digital communication *** efforts have been made to further improve the electrochemical performance of lithium-ion *** application of nanocellulose-based scaffolds as precursors for electrode materials can result in cost-effective *** this work,

关键词： PYROLYSIS OF THREE-DIMENSIONAL WOOD-BASED LIGNOCELLULOSIC MATERIALS FOR LITHIUM ION BATTERY ELECTRODES

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High performance optically isotropic liquid crystal display using twisted liquid crystals for flexible LCDs

High performance optically isotropic liquid crystal display ...

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SID Symposium, Seminar, and Exhibition 2018, Display Week 2018

作者： Song, Seong Min Pagidi, Srinivas Yoo, Hyesun Lee, Chang Suk Lim, Young Jin Manda, Ramesh Seo, Eo Jin Kim, Tae Hyung Lee, Gi-Dong Lee, Seung Hee Applied Materials Institute for BIN Convergence Department of BIN Convergence Technology and Department of Polymer Nano-Science and Technology Chonbuk National University JeonjuJeonbuk54896 Korea Republic of Graduate School of Flexible & Printable Electronics Chonbuk National University JeonjuJeonbuk54896 Korea Republic of Department of Electronics Engineering Dong-A University Busan49315 Korea Republic of

ISBN: (纸本)9781510867659

Optically isotropic polymer/liquid crystal (OILC) composite film in which nano-sized liquid crystal droplets are embedded in a polymer matrix with minimal scattering is proposed for flexible LCDs with high contrast ratio, fast response time and wide-viewing-angle. Feeble light scattering in conventional OILC is overcome utilizing cholesteric LC but limiting its pitch larger than LC droplets, giving rise to higher contrast ratio. In this paper, we reports on electro-optic studies of OILC cells having various pitch sizes, exhibiting an outstanding dark state and improved transmittance. © 2018, Blackwell Publishing Ltd. All rights reserved.

关键词： Liquid crystal displays

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Development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management

The journal of liquid biopsy

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The journal of liquid biopsy 2024年 6卷 100167页

作者： Min-Yi Liao Yun-Jie Hao Ching-Shan Luo Ching-Mei Chen Po-Hao Feng Hsin-Yu Yang Da-Jeng Yao Kang-Yun Lee Fan-Gang Tseng Department of Power Mechanical Engineering National Tsing Hua University Hsinchu 30013 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan. International Ph.D. Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. TMU Research Center of Thoracic Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Nano Science and Technology Program National Tsing Hua University Hsinchu 30013 Taiwan. Institute of Nano Engineering and Micro Systems (NEMS) National Tsing Hua University Hsinchu 30013 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan.

Objectives:Many cancer biomarkers such as the circulating tumor cells/microemboli (CTCs/CTM) have been reported significant associations with clinical outcomes. However, different biomarkers have different sensitivities and specificities for cancer types and cohort patients, and synergistic effects between certain biomarkers have also been observed, leading to the inaccurate, fluctuating, and even controversial results when multiple biomarkers are analyzed together. In this paper, a novel combinational index, P-score, was developed for monitoring and predicting the disease condition of lung cancer patients during follow-up visits. Materials and methods:There were totally 13 return patients with 54 blood samples involved in this study to examine the number of CTC and CTM. Information from one group of 7 patients including 27 blood samples with published clinical data was employed to develop while those from another group of 4 patients containing 14 blood samples with unpublished clinical data were used to validate the P score in prediction. Enumerations were based on immunofluorescent staining images. Distributions of CTC/CTM and their frequencies in stratified patients were carefully examined and analyzed the ROC curve and AUC value to develop the P score and P score-based prediction model. Results and conclusion:We found that the predictive power of P-score was not only comparable to the traditional cancer marker, in comparison with individual CTC/CTM, more false positives could be corrected by using P-score, thereby to improve the accuracy of analysis. From our preliminary validation tests, the prognosis and disease progression monitored longitudinally by P-score were further confirmed by clinical outcome data from physicians and its sensitivity was even better than those from individual biomarkers. We believe that this novel combinational indicator could be a promising tool to interpret clinical outcomes more accurately from multiple factors, particularly useful

关键词： Circulating tumor cells/microemboli Combinational index Disease monitoring and prognosis Drug screening Lung cancer

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One-pot synthesis of benzo[: B] fluorenones via a cobalt-catalyzed MHP-directed [3+2] annulation/ring-opening/dehydration sequence

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Chemical Communications 2019年第29期55卷 4206-4209页

作者： Qiu, Shuxian Zhai, Shengxian Wang, Huifei Chen, Xiaoming Zhai, Hongbin State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical Genomics Shenzhen Engineering Laboratory of Nano Drug Slow-Release Shenzhen Graduate School Peking University Shenzhen 518055 China College of Chemistry and Environmental Engineering Anyang Institute of Technology Anyang 455000 China School of Materials Science and Chemical Engineering Ningbo University Ningbo 315211 China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300071 China

We have developed a one-pot synthesis of benzo[b]fluorenones via a cobalt-catalyzed [3+2] annulation of oxabicyclic alkenes followed by a ring-opening/dehydration sequence in good to excellent yields. With the use of 2-(1-methylhydrazinyl)pyridine (MHP), first explored by our group as the bidentate directing group in C-H functionalization of benzoic hydrazides, the new reaction sequence proceeded smoothly and tolerated a wide range of functional groups, featuring facile scalability. Notably, oxygen served as the green oxidant in the reaction system. Careful tuning of the reaction parameters assured the direct synthesis of benzo[b]fluorenones through aromatization of the dihydroepoxybenzofluorenone intermediate. © The Royal Society of Chemistry.

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Significance of the in vivo endocannabinoid level to predict effectiveness of lifestyle multidomain intervention: The SUPERBRAIN study

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Alzheimer's & Dementia 2021年第S5期17卷

作者： Sun Min Lee Sun Ah Park Joonseok Kim Sue Min Kim Song Mi Han Hong-sun Song Buong-O Chun Muncheong Choi Chang Hyung Hong Yoo Kyoung Park Hae Ri Na Byeong C. Kim Kyung Won Park Hee Kyung Park Jee Hyang Jeong Seong Hye Choi So Young Moon Ajou University School of Medicine Suwon Korea Korea Polytechnics Bundang Convergence Technology Education Center Seongnam Korea Neuroscience Graduate Program Ajou University Graduate School of Medicine Suwon Korea Korea Institute of Sports Science Seoul Korea Exercowork Hanam Korea College of Physical Education and Sports Science Kookmin University Seoul Korea Graduate School of East-West Medical Science Kyung Hee University Yong-in South Korea Bobath Memorial Hospital Seongnam South Korea Department of Neurology Chonnam National University Medical School Gwangju Korea Dong-A University Busan Korea University College London London United Kingdom Ewha Womans University School of Medicine Seoul Korea Inha University College of Medicine Inchon Korea

Background In the South Korean study to prevent cognitive impairment and protect brain health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we explored changes of in endocannabinoid after 24-week intervention and impact of baseline endocannabinoid on cognitive and physical effects of intervention. Method A total of 152 participants, aged 60-79 years without dementia but with ? 1 modifiable dementia risk factor, were randomly assigned to the facility-based multidomain intervention (FMI), and home-based MI (HMI), or control groups. Among them, 125 participants (43 FMI, 44 HMI, and 38 control) took measurement for their levels of cortisol, anandamide (N-arachidonoylethanolamine; AEA), and 2-AG (2-arachidonoylglycerol). Plasma levels were determined by liquid chromatography-selected reaction monitoring quantification using a QTrap5500 mass spectrometer (ABSciex, Foster City, CA, USA). We compared changes of compound levels between intervention and control groups. In addition, we analyzed whether the baseline level of the compound was independent predictor for changes in clinical measures after intervention. Result Neither the ratios, cortisol to AEA + 2-AG, cortisol to AEA, and cortisol to 2-AG nor the levels in AEA, 2-AG, and cortisol showed noteworthy differences before and after the SUPERBRAIN program, between control and intervention groups. Some changes in the physical fitness and cognitive function variables were associated with the baseline AEA and cortisol, especially in the intervention group: Figure-8-walks ( p <0.05),and ‘pre-contemplation stage’ score of the readiness to change questionnaire for motivational enhancement ( p <0.05) for cortisol; Prospective Retrospective Memory Questionnaire (PRMQ) by caregiver ( p <0.05), and total scale index score of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS, p <0.05) for AEA; ‘Confirmed control’ score of the questionnaire for motivational enhancement ( p <0.05) for

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Skeletal Muscle Regeneration: Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury (Adv. Mater. 14/2021)

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Advanced Materials 2021年第14期33卷

作者： Yoonhee Jin Dena Shahriari Eun Je Jeon Seongjun Park Yi Sun Choi Jonghyeok Back Hyungsuk Lee Polina Anikeeva Seung-Woo Cho Department of Biotechnology Yonsei University Seoul 03722 Republic of Korea Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge MA 02139 USA McGovern Institute for Brain Research Cambridge MA 02139 USA Department of Biomaterials Science and Engineering Yonsei University Seoul 03722 Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea School of Mechanical Engineering Yonsei University Seoul 03722 Republic of Korea Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA Center for Nanomedicine Institute for Basic Science (IBS) Seoul 03722 Republic of Korea Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul 03722 Republic of Korea

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PI-less IPS/FFS Liquid Crystal Displays Utilizing Reactive LC with Cinnamate Moiety

PI-less IPS/FFS Liquid Crystal Displays Utilizing Reactive L...

引用

SID Symposium, Seminar, and Exhibition 2018, Display Week 2018

作者： He, Rui Wen, Pushan Lee, Chang Suk Kim, Yulki Kang, Shin-Woong Lee, Seung Hee Lee, Myong-Hoon Graduate School of Flexible and Printable Electronics Chonbuk National University Jeonbuk Jeonju54896 Korea Republic of Department of Chemistry and Chemical Engineering Zunyi Normal College Guizhou Zunyi563006 China Department of BIN Convergence Technology Department of Polymer Nano-Science and Technology Chonbuk National University Jeonbuk Jeonju54896 Korea Republic of

ISBN: (纸本)9781510867659

Uniaxial alignment of LC molecules is achieved by irradiating polarized UV at clearing temperature to the mixture of LC and new reactive mesogen having cinnamate moiety without using any conventional alignment layer. The IPS/FFS cell fabricated by the proposed technology showed excellent electro-optic characteristics and robust reliability, which could contribute to the low-cost and green LCDs. © 2018 SID.

关键词： Alignment

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Observation of anti-parity-time-symmetry, phase transitions and exceptional points in an optical fibre

arXiv

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arXiv 2020年

作者： Bergman, Arik Duggan, Robert Sharma, Kavita Tur, Moshe Zadok, Avi Alù, Andrea Faculty of Engineering Institute for Nano-Technology and Advanced Materials Bar-Ilan University Ramat-Gan5290002 Israel Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Department of Electrical and Computer Engineering University of Texas at Austin AustinTX78712 United States School of Electrical Engineering Tel-Aviv University Tel-Aviv6997801 Israel Physics Program Graduate Center City University of New York New YorkNY10026 United States

The exotic physics emerging in non-Hermitian systems with balanced distributions of gain and loss has drawn a great deal of attention in recent years. These systems exhibit phase transitions and exceptional point singularities in their spectra, at which eigen-values and eigen-modes coalesce and the overall dimensionality is reduced. Among several peculiar phenomena observed at exceptional points, an especially intriguing property, with relevant practical potential, consists in the inherently enhanced sensitivity to small-scale perturbations. So far, however, these principles have been implemented at the expenses of precise fabrication and tuning requirements, involving tailored nano-structured devices with controlled distributions of optical gain and loss. In this work, anti-parity-time symmetric phase transitions and exceptional point singularities are demonstrated in a single strand of standard single-mode telecommunication fibre, using a setup consisting of entirely of off-the-shelf components. Two propagating signals are amplified and coupled through stimulated Brillouin scattering, which makes the process non-Hermitian and enables exquisite control over gain and loss. Singular response to small variations around the exceptional point and topological features arising around this singularity are experimentally demonstrated with large precision, enabling robustly enhanced spectral response to small-scale changes in the Brillouin frequency shift. Our findings open exciting opportunities for the exploration of non-Hermitian phenomena over a table-top setup, with straightforward extensions to higher-order Hamiltonians and applications in quantum optics, nanophotonics and sensing. Copyright © 2020, The Authors. All rights reserved.

关键词： Optical fibers

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Entanglement properties of disordered quantum spin chains with long-range antiferromagnetic interactions

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Physical Review B 2020年第21期102卷 214201-214201页

作者： Y. Mohdeb J. Vahedi N. Moure A. Roshani Hyun-Yong Lee R. N. Bhatt Stefan Kettemann Stephan Haas Department of Physics and Earth Sciences Jacobs University Bremen Bremen 28759 Germany Technische Universität Braunschweig Institut für Mathematische Physik Mendelssohnstr. 3 38106 Braunschweig Germany Department of Physics Sari Branch Islamic Azad University Sari 48164-194 Iran Department of Physics and Astronomy University of Southern California Los Angeles California 90089-0484 USA Department of Applied Physics Graduate School Korea University Sejong 30019 Korea Division of Display and Semiconductor Physics Korea University Sejong 30019 Korea Interdisciplinary Program in EċICT-Culture-Sports Convergence Korea University Sejong 30019 Korea Department of Electrical Engineering Princeton University Princeton New Jersey 08544 USA School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08540 USA Division of Advanced Materials Science Pohang University of Science and Technology (POSTECH) Pohang 790-784 Korea

Entanglement measures are useful tools in characterizing otherwise unknown quantum phases and indicating transitions between them. Here we examine the concurrence and entanglement entropy in quantum spin chains with random long-range couplings, spatially decaying with a power-law exponent α. Using the strong disorder renormalization group (SDRG) technique, we find by analytical solution of the master equation a strong disorder fixed point, characterized by a fixed point distribution of the couplings with a finite dynamical exponent, which describes the system consistently in the regime α>12. A numerical implementation of the SDRG method yields a power-law spatial decay of the average concurrence, which is also confirmed by exact numerical diagonalization. However, we find that the lowest-order SDRG approach is not sufficient to obtain the typical value of the concurrence. We therefore implement a correction scheme which allows us to obtain the leading-order corrections to the random singlet state. This approach yields a power-law spatial decay of the typical value of the concurrence, which we derive both by a numerical implementation of the corrections and by analytics. Next, using numerical SDRG, the entanglement entropy (EE) is found to be logarithmically enhanced for all α, corresponding to a critical behavior with an effective central charge c=ln(2), independent of α. This is confirmed by an analytical derivation. Using numerical exact diagonalization (ED), we confirm the logarithmic enhancement of the EE and a weak dependence on α. For a wide range of partition size l, the EE fits a critical behavior with a central charge close to c=1, which is the same as for the clean Haldane-Shastry model with a power-law-decaying interaction with α=2. Only for small l≪L, in a range which increases with the number of spins N, we find deviations which are rather consistent with the strong disorder fixed point central charge c=ln(2). Furthermore, we find using ED that the conc

关键词： Magnetism Quantum entanglement Disordered systems Doped semiconductors Density matrix methods Exact diagonalization Renormalization group Tensor network methods

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