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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

Plant Communications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn Hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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FDAM: Filter-Dedicated Approximate Multiplier Design for Real-Time CNN Acceleration

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IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 2025年

作者： Nguyen, Kihwan Kim Xuan Truong Jeon, Dongsuk Lee, Hyuk-Jae Korea Republic of program Department of Electrical Engineering Seoul08826 Korea Republic of Inter-University Semiconductor Research Center Seoul National University Graduate School of Convergence Science and Technology Research Institute for Convergence Science Seoul08826 Korea Republic of Department of Electrical and Computer Engineering Seoul08826 Korea Republic of

Video super-resolution (VSR) is widely used in various high-definition applications, such as HDTVs and smartphones, requiring a dedicated upscaling technique for realtime full-HD generation. To reduce on-chip buffers for largesize output feature maps, a streaming VSR accelerator may employ an output stationary dataflow, leading to a large energy consumption caused by frequent filter switching. To mitigate this, we introduce a new filter-dedicated multiplier design for realtime VSR acceleration. We replace costly multipliers with adders, shifters, and multiplexers (MUXes), referred to as unified multiple constant multiplications (UMCM). The conventional UMCM, however, may incur considerable area/power overhead due to the unified topology constraint among different filter sets. To address this problem, we propose a new approximated MCM (AMCM) problem to relax the constraint and an approximate compatible graph synthesis (A-CGS) framework to efficiently solve AMCM by jointly searching for approximated filters and constructing a unified graph. Additionally, we suggest a lightweight finetuning method by freezing approximated filters and only finetuning biases, which can recover the original model’s accuracy within a few epochs. Experimental results with synthetic data demonstrate that AMCM reduces the area by up to 49.8%, 44.8%, and 40.3% when considering constant sets of 2, 4, and 8, respectively. Our designs with SR application achieve up to a 73.3% reduction in energy consumption. Experiments with the Set5 and Set14 datasets show that our model with bias correction achieves similar restoration performance compared to the eightbit models. © 1982-2012 IEEE.

关键词： Acceleration

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Solution-processable electrode-material embedding in dynamically inscribed nanopatterns(SPEEDIN)for continuous fabrication of durable flexible devices

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Microsystems & nanoengineering 2021年第5期7卷 173-181页

作者： Wonseok Lee Hyoungseok Chae Dong Kyo Oh Minyoung Lee Hyunsoo Chun Gyubeom Yeon Jaewon Park Joohoon Kim Hongseok Youn Junsuk Rho Jong G.Ok Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Graduate Program of Energy Technology School of Integrated TechnologyInstitute of Integrated TechnologyGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Mechanical Engineering Hanbat National UniversityDaejeon 34158Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea

A facile and scalable lithography-free fabrication technique,named solution-processable electrode-material embedding in dynamically inscribed nanopatterns(SPEEDIN),is developed to produce highly durable *** uniquely utilizes a single continuous flow-line manufacturing process comprised of dynamic nanoinscribing and metal nanoparticle solution coating with selective ***-and/or micro-trenches are inscribed into arbitrary polymers,and then an Ag nanoparticle solution is dispersed,soft-baked,doctor-bladed,and hard-baked to embed Ag micro-and nanowire structures into the *** to lithographically embossed metal structures,the embedded SPEEDIN architectures can achieve higher durability with comparable optical and electrical properties and are robust and power-efficient even under extreme stresses such as scratching and *** one tangible application of SPEEDIN,we demonstrate a flexible metal electrode that can operate at 5 V at temperatures up to 300℃even under the influence of harsh external *** can be applied to the scalable fabrication of diverse flexible devices that are reliable for heavy-duty operation in harsh environments involving high temperatures,mechanical deformations,and chemical hazards.

关键词： electrode process embedding

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High-Resolution Hydrogen Molecule Detection Utilizing a nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： nanoclay

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Brain physiome:A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

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Bioactive Materials 2022年第7期7卷 135-148页

作者： Yoojin Seo Seokyoung Bang Jeongtae Son Dongsup Kim Yong Jeong Pilnam Kim Jihun Yang Joon-Ho Eom Nakwon Choi Hong Nam Kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Next&Bio Inc. Seoul02841Republic of Korea Medical Device Research Division National Institute of Food and Drug Safety EvaluationCheongju28159Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea

In the last few decades,adverse reactions to pharmaceuticals have been evaluated using 2D in vitro models and animal ***,with increasing computational power,and as the key drivers of cellular behavior have been identified,in silico models have *** models are time-efficient and cost-effective,but the prediction of adverse reactions to unknown drugs using these models requires relevant experimental ***,the physiome concept has emerged to bridge experimental datasets with in silico *** brain physiome describes the systemic interactions of its components,which are organized into a multilevel *** of the limitations in obtaining experimental data corresponding to each physiome component from 2D in vitro models and animal models,3D in vitro brain models,including brain organoids and brain-on-a-chip,have been *** this review,we present the concept of the brain physiome and its hierarchical organization,including cell-and tissue-level *** also summarize recently developed 3D in vitro brain models and link them with the elements of the brain physiome as a guideline for dataset *** connection between in vitro 3D brain models and in silico modeling will lead to the establishment of cost-effective and time-efficient in silico models for the prediction of the safety of unknown drugs.

关键词： Brain physiome In vitro 3D platform Brain organoid Brain-on-a-chip In silico model

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Major strategies for improving the performance of perovskite solar cells

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iEnergy 2023年第3期2卷 172-199页

作者： Lixiu Zhang Hang Li Kai Zhang Wenzhe Li Chuantian Zuo George Omololu Odunmbaku Jingde Chen Cong Chen Luozheng Zhang Ru Li Yuping Gao Baomin Xu Jiangzhao Chen Yongsheng Liu Yang Wang Yanlin Song Jianxin Tang Feng Gao Qing Zhao Yong Peng Mingzhen Liu Lei Tao Yuelong Li Zhimin Fang Ming Cheng Kuan Sun Dewei Zhao Yixin Zhao Shihe Yang Chenyi Yi Liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Materials Science and Engineering&Engineering Research Center of Alternative Energy Materials&Devices Sichuan UniversityChengdu 610065China School of Energy&Power Engineer-ing Chongqing UniversityChongqing 400044China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Institute of New Energy Technology Department of Electronic EngineeringCollege of Information Science and TechnologyJinan UniversityGuangzhou 510631China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China College of Optoelectronic Engineering Chongqing UniversityChongqing 400044China College of Chemistry Nankai UniversityTianjin 300071China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China State Key Lab for Mesoscopic Physics and Frontiers Science Center for Nano-optoelec-tronics School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Photoelectronic Thin Film Devices and Technology Nankai UniversityTianjin 300350China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119China

Metal halide perovskite solar cell(PSC)has successfully distinguished itself in optoelectronic field by virtue of the sharp rise in power conversion efficiency over the past *** remarkable efficiency breakthrough at such a fast speed can be mainly attributed to the comprehensive study on film deposition techniques,especially the effective management of surface and interfacial defects in recent ***,we summarized the current trends in performance enhancement for PSCs,with a focus on the generally applicable strategies in high-performance works,involving deposition methods,compositional engineering,additive engineering,crystallization manipulation,charge transport material selection,interfacial passivation,optical coupling effect and constructing tandem solar *** directions and perspectives are also provided.

关键词： Perovskite solar cells efficiency improvement strategies milestones

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Metal‐organic frameworks‐derived novel nanostructured electrocatalysts for oxygen evolution reaction

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Carbon Energy 2021年第1期3卷 66-100页

作者： Xinyu Qin Dongwon Kim Yuanzhe Piao Department of Transdisciplinary Studies Graduate School of Convergence Science and TechnologySeoul National UniversitySuwon‐siGyeonggi‐doRepublic of Korea Advanced Institutes of Convergence Technology Seoul National UniversitySuwon‐siGyeonggi‐doRepublic of Korea

Engineering cost‐effective catalysts with exceptional performance for theelectrochemical oxygen evolution reaction (OER) remains crucial for theaccelerated development of renewable energy techniques, and especially so,given the pivotal role of OER in water electrolysis. On the basis of the metalnodes (clusters) and organic linkers, metal‐organic frameworks (MOFs) andtheir derivatives are rapidly gaining ground in the fabrication of electrocatalysts,with promising catalytic activity and sound durability in OER, thanksto their controllable pore structures, abundant unsaturated active sites of metalion, extensive specific surface area, as well as easily functionalized/modifiedsurfaces. This review presents an in‐depth understanding of the establishedprogress of MOFs‐derived materials for OER electrocatalysis. The materialdesigning strategies of the pristine, monometallic, and multimetallic MOFsbasedcatalysts are summarized to indicate the infinite possibilities of themorphology and the composition of MOF‐derived materials. While emphasisis laid on the essential features of MOF‐derived materials for the electrocatalysisof the corresponding reactions, insights about the applications in OERare discussed. Finally, this paper is concluded by presenting challengesand perspectives for MOF‐derived materials’ future applications in OERelectrocatalysis.

关键词： electrocatalyst high‐performance metal‐organic frameworks oxygen evolution reaction

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

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Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon Park Honghwan Choi Chowon Kim Jusung An Jungryun Kim Kwang Rok Mun Seungyong Shin Kunyu Zhang Pengchao Zhao Yuri Kim Nayeon Kang Seong-Beom Han Dahee Kim Jiwon Yoon Misun Kang Jihwan Kim Letao Yang Solmaz Karamikamkar Jinjoo Kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee Kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song Woo Young Jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung Kim Yu Shrike Zhang Yongju Kim Ho Seong Jang Sehoon Kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

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Singular topological edge states in locally resonant metamaterials

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science Bulletin 2025年第7期70卷 1080-1086页

作者： Yeongtae Jang Seokwoo Kim Eunho Kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Division of Mechanical System Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Graduate School of Mechanical-Aerospace-Electric Convergence Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea

Band topology has emerged as a novel tool for material design across various domains,including photonic and phononic systems,and metamaterials.A prominent model for band topology is the Su-Schri effer-Heeger(SSH)chain,which reveals topological in-gap states within Bragg-type gaps(BG)formed by periodic *** from classical BGs,another mechanism for bandgap formation in metamaterials involves strong coupling between local resonances and propagating waves,resulting in a local resonance-induced bandgap(LRG).Previous studies have shown the challenge of topological edge state emergence within the ***,we reveal that topological edge states can emerge within an LRG by achieving both topological phase and bandgap transitions *** describe this using a model of inversion-symmetric extended SSH chains for locally resonant ***,this topological state can lead to highly localized modes,comparable to a subwavelength unit cell,when it emerges within the *** experimentally demonstrate distinct differences in topologically protected modesDhighlighted by wave localizationDbetween the BG and the LRG using locally resonant granulebased *** findings suggest the scope of topological metamaterials may be extended via their bandgap nature.

关键词： Band topology Metamaterials Singular topological edge states Local resonance Woodpile metamaterials

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Design of a compact beam transport system for laser-driven proton therapy

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Plasma science and technology 2025年第1期27卷 1-6页

作者： Yangfan LI Xiaofei SHEN Yilin YAO Bin QIAO Graduate School of China Academy of Engineering Physics Beijing 100193People’s Republic of China Center for Applied Physics and Technology HEDPSand SKLNPTSchool of PhysicsPeking UniversityBeijing 100871People’s Republic of China Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang 621000People’s Republic of China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Frontiers Science Center for Nano-optoelectronic Peking UniversityBeijing 100094People’s Republic of China

We put forward a new design of a compact beam transport system for intense laser-driven proton therapy,where instead of using conventional pulsed solenoids,our design relies on a helical coil irradiated by a nanosecond laser pulse to generate strong magnetic fields for focusing protons.A pair of dipole magnets and apertures are employed to further filter protons with large divergences and low *** numerical studies combine particle-in-cell simulations for laser-plasma interaction to generate high-energy monoenergetic proton beams,finite element analysis for evaluating the magnetic field distribution inside the coil,and MonteCarlo simulations for beam transport and energy *** results show that with this design,a spread-out Bragg peak in a range of several centimeters to a deep-seated tumor with a dose of approximately 16.5 cGy and fluctuation around 2% can be *** instantaneous dose rate reaches up to 10^(9)Gy/s,holding the potential for future FLASH radiotherapy research.

关键词： intense laser-plasma interaction laser-driven ion acceleration laser-driven proton acceleration particle-in-cell proton radiotherapy

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