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SAT0588 Early Cerebral Volume Reduction and Regional Improvement of Prefrontal Gray Matter Volume with Reduced Lupus Disease Activity in Patients with Newly-Diagnosed Non-Neuropsychiatric Systemic Lupus Erythematosus (SLE)

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Annals of the Rheumatic Diseases 2015年 74卷 874-874页

作者： A. Mak R.C. Ho H.Y. Tng H.L. Koh J.S. Chong J.H. Zhou 1Medicine 2Psychological Medicine National University of Singapore 3Center for Cognitive Neuroscience Neuroscience and Behavioral Disorders Program Duke-National University of Singapore Graduate Medical School Singapore Singapore

Background Cerebral volume loss is evident in patients within 9 months of the diagnosis of SLE. As potentially neurotoxic autoantibodies can be present many years before SLE symptoms emerge, cerebral volume loss would theoretically commence even much earlier before the clinical onset of SLE. Also, while it has been suggested that SLE-related inflammation negatively impacts on brain volume, whether reducing SLE disease activity can improve cerebral volume in SLE patients is unknown. Objectives We evaluated if the volumes of the gray matter (GMV) and white matter (WMV) of the brains of newly-diagnosed SLE patients would be reduced as compared to those of age-, sex- and IQ-matched healthy controls (HC). We also investigated for potential regional improvement of GMV and WMV after SLE patients achieved low disease activity (SLEDAI<4). If so, we would further address if reducing disease activity early in the course of SLE would correlate with enhanced cerebral volumes in SLE patients. Methods T1-weighted MRI brain images acquired by a 1.5T Siemens Symphony MRI scanner were obtained from 14 HC and 14 SLE patients within 5 months of their diagnosis (S1) and after attaining low disease activity (S2) with ≥6 months of immunosuppressive therapy. Whole brain voxel-based morphometry was used to detect differences in the GMV and WMV between SLE patients and HC and those between the SLE group at S1 and S2. To examine GMV and WMV changes within the SLE group between S1 and S2, whole brain voxelwise paired t-tests between subject-level GMV (and WMV) probabilistic maps in SLE patients at S1 and S2 was performed at p<0.001 with a minimum cluster size of 980 voxels. Patients with neuropsychiatric symptoms, traditional cardiovascular risk factors, anti-cardiolipin antibodies and lupus anticoagulant were excluded as these factors may engender cerebral volume loss independent of SLE. Results The mean ± SD age of the SLE patients and HC was 39.38±13.9 and 34.07±14.4 years respectively, wit

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Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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Nature communications 2019年第1期10卷 2068页

作者： Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Sim Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology School of Philosophy Psychology and Language Sciences The University of Edinburgh Edinburgh EH8 9JZ UK. Institute of Mental Health Singapore 539747 Singapore. Medical Genetics Section Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Edinburgh EH4 2XU UK. BrainWorkup LLC Los Angeles 90033 CA USA. Department of Psychiatry and Behavioral Sciences Keck School of Medicine University of Southern California Los Angeles 90033 CA USA. Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology & Neuroscience King's College London De Crespigny Park Denmark Hill London SE5 8AF UK. Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku 20520 Finland. Department of Internal Medicine Satakunta Central Hospital Pori 28100 Finland. Centre for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh Teviot Place Edinburgh EH8 9AG Scotland. Max Planck Institute for Molecular Genetics Berlin 14195 Germany. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle 98101 Washington USA. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York 10029 NY USA. Mental Illness Research Education and Clinical Center (VISN 3) James J. Peters VA Medical Center Bronx 10468 NY USA. Department of Psychiatry Brigham and Women's Hospital Harvard Medical School Boston 02115 MA USA. NORMENT K.G. Jebsen Centre for Psychosis Research Department of Clinical Science University of Bergen Bergen 5021 Norway. Dr. Einar Martens Research Group for Biological Psychiatry Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen 5020 Norway. Center for Psychiatric Neuroscience Feinstein Institute for Medical Resea

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions...

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Proceedings of the 14th annual conference of INEBRIA

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Addiction Science & Clinical Practice 2017年第1期12卷 1-24页

作者： Aisha S. Holloway Sarah Landale Laura Cariola Jennifer Ferguson Dorothy Newbury-Birch Amy Flynn John R. Knight Lon Sherritt Sion K. Harris Amy J. O’Donnell Eileen Kaner Barbara Hanratty Denise Howel Elaine McColl Ruth McGovern Stephanie Scott Elaine Stamp Ellen Lynch Amy M. Loree Steve Martino Amy C. Justice Kimberly A. Yonkers Kate Gilstead-Hayden Steven J. Ondersma Joy Scheidell Angeline Adam Jennifer McNeely Robert P. Schwartz Li-Tzy Wu Geetha Subramaniam Gaurav Sharma Anne H. Berman Karoline Kolaas Elisabeth Petersén Erik Hedman Kristina Sinadinovic Anna Thurang Sven Andréasson Ingvar Rosendahl Mikael Gajecki Preben Bendtsen Catharina Linderoth Ulrika Müssener Fredrik Spak Ida Gremyr Ann M. Mitchell Brayden N. Kameg Deborah Finnell Christine L. Savage Khadejah F. Mahmoud Benjamin C. Riordan Tamlin S. Conner Jayde A. M. Flett Damian Scarf Bonnie McRee Janice Vendetti Karen Steinberg Gallucci Kate Robaina Brendan J. Clark Kathryne D. Reed Rachel M. Hodapp Ivor Douglas Ellen L. Burnham Jacqueline Jones Laura Aagaard Paul F. Cook Brett R. Harris Jiang Yu Margaret Wolff Meighan Rogers Carolina Barbosa Brendan J. Wedehase Laura J. Dunlap Shannon G. Mitchell Kristi A. Dusek Jan Gryczynski Arethusa S. Kirk Marla T. Oros Colleen Hosler Kevin E. O’Grady Barry S. Brown Colin Angus Sidney Sherborne Duncan Gillespie Petra Meier Alan Brennan Divane de Vargas Janaina Soares Donna Castelblanco Ian Wittman Ryan P. McCormack Mirelis Gonzalez Kelly M. Doran Donna Shelley John Rotrosen Lillian Gelberg E. Jennifer Edelman Christopher J. Cutter Lynn E. Fiellin Patrick G. O’Connor David A. Fiellin Nathan B. Hansen Stephen A. Maisto Yanhong Deng James Dziura Roger Bedimo Cynthia Gibert Vincent C. Marconi David Rimland Maria C. Rodriguez-Barradas Michael S. Simberkoff Kendall J. Bryant Emma L. Giles Grant J. McGeechan Simon Coulton Nadine Hendrie Paolo Deluca Colin Drummond Sadie Boniface Amy Ramsey Harry Sumnall Luke Vale Viviana Alabani Amanda Atkinson Grant Stanley Jo Frankham Eilish Gilvarry Nicola Howe Justine Clephane David Gar Nursing Studies School of Health in Social Science The University of Edinburgh Edinburgh UK Health and Social Care Institute School of Health and Social Care Teesside University Middlesbrough Tees Valley UK School of Health and Social Care Teesside University Middlesbrough Tees Valley UK Alcohol and Public Health Team School of Health and Social Care Middlesbrough Teesside UK Department of Pediatrics Harvard Medical School Boston MA USA Center for Adolescent Substance Abuse Research Boston Children’s Hospital Boston MA USA Institute of Health and Society Newcastle University Baddiley-Clark Building Richardson Road Newcastle Upon Tyne Northumberland UK VA Connecticut Healthcare System Veterans Aging Cohort Study West Haven CT USA Department of Psychiatry Yale University School of Medicine New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare System West Haven CT USA Yale University School of Medicine New Haven CT USA Merrill-Palmer Skillman Institute and Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit MI USA Department of Psychiatry and Behavioral Neurosciences Merrill-Palmer Skillman Institute Detroit MI USA Department of Psychiatry and Behavioral Neurosciences and Merrill-Palmer Skillman Institute Wayne State University Detroit MI USA Department of Population Health NYU School of Medicine New York NY USA Friends Research Institute Inc Baltimore MD USA Department of Psychiatry and Behavioral Sciences Department of Medicine and Duke Clinical Research Institute Duke University Medical Center Durham NC USA Center for the Clinical Trials Network National Institute on Drug Abuse National Institutes of Health Bethesda MD USA The EMMES Corporation Rockville MD USA Department of Clinical Neuroscience Center for Psychiatry Research Karolinska Institutet Stockholm Sweden

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Regulatory considerations for the clinical and research use of transcranial direct current stimulation (tDCS): Review and recommendations from an expert panel

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Clinical Research and Regulatory Affairs 2015年第1期32卷 22-35页

作者： Fregni, F. Nitsche, M.A. Loo, C.K. Brunoni, A.R. Marangolo, P. Leite, J. Carvalho, S. Bolognini, N. Caumo, W. Paik, N.J. Simis, M. Ueda, K. Ekhtiari, H. Luu, P. Tucker, D.M. Tyler, W.J. Brunelin, J. Datta, A. Juan, C.H. Venkatasubramanian, G. Boggio, P.S. Bikson, M. Spaulding Neuromodulation Center Spaulding Rehabilitation Hospital Harvard Medical School Boston MA United States Department of Clinical Neurophysiology Georg-August-University Göttingen Germany School of Psychiatry Black Dog Institute University of New South Wales Sydney Australia Service of Interdisciplinary Neuromodulation Department and Institute of Psychiatry University of São Paulo São Paulo Brazil Department of Experimental and Clinical Medicine University Politecnica Delle Marche Ancona IRCCS Fondazione Santa Lucia Rome Italy School of Psychology (EPsi) University of Minho Campus de Gualtar Braga Portugal Department of Psychology University of Milano Bicocca Milan Italy Laboratory of Neuropsychology IRCC Instituto Auxologico Italiano Milan Italy Laboratory of Pain and Neuromodulation Hospital de Clínicas de Porto Alegre UFRGS Porto Alegre Brazil Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Seoul South Korea Institute of Physical Medicine and Rehabilitation Clinics Hospital University of Sao Paulo Medical School Sao Paolo Brazil Division of Neurology Santa Casa Medical School Sao Paulo Brazil National Cardiovascular Center Osaka Japan Translational Neuroscience Program Institute for Cognitive Science Studies Tehran Iran Neurocognitive Laboratory Iranian National Center for Addiction Studies Tehran University of Medical Sciences Tehran Iran Electrical Geodesics Inc. University of Oregon Eugene OR United States Virginia Tech Carilion Research Institute Department of Psychiatry and Behavioral Medicine School of Biomedical Engineering and Sciences Roanoke VA United States EA 4615 Centre Hospitalier le Vinatier Université de Lyon Bron F-69003 France Department of Biomedical Engineering Neural Engineering Laboratory City College of the City University of New York New York NY United States Institute of Cognitive Neuroscience National Central University Taiw

The field of transcranial electrical stimulation (tES) has experienced significant growth in the past 15 years. One of the tES techniques leading this increased interest is transcranial direct current stimulation (tDCS). Significant research efforts have been devoted to determining the clinical potential of tDCS in humans. Despite the promising results obtained with tDCS in basic and clinical neuroscience, further progress has been impeded by a lack of clarity on international regulatory pathways. Therefore, a group of research and clinician experts on tDCS were convened to review the research and clinical use of tDCS. This report reviews the regulatory status of tDCS and summarizes the results according to research, off-label, and compassionate use of tDCS in the following countries: Australia, Brazil, France, Germany, India, Iran, Italy, Portugal, South Korea, Taiwan, and the US. Research use, off label treatment, and compassionate use of tDCS are employed in most of the countries reviewed in this study. It is critical that a global or local effort is organized to pursue definite evidence to either approve and regulate or restrict the use of tDCS in clinical practice on the basis of adequate randomized controlled treatment trials. © 2014 Informa Healthcare USA, Inc. All rights reserved.

关键词： Regulatory Safety TDCS

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Dissecting the Thermodynamics of Branched Peptides-Lipopolysaccharide Interactions

Dissecting the Thermodynamics of Branched Peptides-Lipopolys...

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第十三届中国国际多肽大会

作者： Rajamani Lakshminarayanan Muruganandham Nandhakumar Eunice Goh Tze Leng Liu Shouping Roger W Beuerman Singapore Eye Research Institute The Academia20 College RoadDiscovery Tower Level 6Singapore 169856 Neuroscience & Behavioral Disorders Program Duke-NUS Graduate Medical School8 College RoadSingapore 169857 Singapore Eye Research InstituteThe Academia20 College RoadDiscovery Tower Level 6Singapore 169856

The outer membrane of Gram-negative bacteria is composed of an asymmetric bilayer of lipopolysaccharide(LPS)and *** presence of LPS in the outer membrane in Gram-negative pathogens provides a formidable barrier for other *** have a designed branched peptide(B2088,(RGRKVVRR)2kK,where k is a branched lysine core)that displayed excellent antibacterial activities against various Gram-negative pathogens(MIC = 1.4 – 5.5 μM).The peptide disrupts the supramolecular organization of LPS and targets the cytoplasmic *** studies showed that the two valine residues in each copy play an important role in the binding of the peptide to *** understand the role of two valine residues,we replaced the later by glycine residues(B2088_99,(RGRKVGGRR)2kK)and investigated their antimicrobial and LPS binding properties.

关键词： Isothermal Titration Calorimetry Branched Peptides Lipopolysaccharide Synergism Binding enthalpy

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Response conflicts cannot be resolved unconsciously

Response conflicts cannot be resolved unconsciously

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The 9th Asia-Pacific Conference on Vision(第九届亚太视觉会议)

作者： Yu-Feng Huang Chun Siong Soon Po-Jang Hsieh Department of Psychology Technical University Dresden Neuroscience and Behavioral Disorders Program Duke-NUS Graduate Medical School Neuroscience and Behavioral Disorders ProgramDuke-NUS Graduate Medical School

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Local activity in dendrites controls STDP by altering NMDA receptor kinetics

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BMC neuroscience 2013年第1期14卷 1-2页

作者： Rajeev V Rikhye Xulin Tan Antonius MJ Van Dongen Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA Program in Neuroscience and Behavioral Disorders Duke-NUS Graduate Medical School Singapore 169857 Singapore

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Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science : Seattle, WA, USA. 24-26 September 2015

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Implementation science : IS 2016年第1期11 Suppl 1卷 85页

作者： Cara Lewis Doyanne Darnell Suzanne Kerns Maria Monroe-DeVita Sara J. Landes Aaron R. Lyon Cameo Stanick Shannon Dorsey Jill Locke Brigid Marriott Ajeng Puspitasari Caitlin Dorsey Karin Hendricks Andria Pierson Phil Fizur Katherine A. Comtois Lawrence A. Palinkas Patricia Chamberlain Gregory A. Aarons Amy E. Green Mark. G. Ehrhart Elise M. Trott Cathleen E. Willging Maria E. Fernandez Nicholas H. Woolf Shuting Lily Liang Natalia I. Heredia Michelle Kegler Betsy Risendal Andrea Dwyer Vicki Young Dayna Campbell Michelle Carvalho Yvonne Kellar-Guenther Laura J. Damschroder Julie C. Lowery Sarah S. Ono Kathleen F. Carlson Erika K. Cottrell Maya E. O’Neil Travis L. Lovejoy Joanna J. Arch Jill L. Mitchell Cara C. Lewis Brigid R. Marriott Kelli Scott Jennifer Schurer Coldiron Eric J. Bruns Alyssa N. Hook Benjamin C. Graham Katelin Jordan Rochelle F. Hanson Angela Moreland Benjamin E. Saunders Heidi S. Resnick Shannon Wiltsey Stirman Cassidy A. Gutner Jennifer Gamarra Dawne Vogt Michael Suvak Jennifer Schuster Wachen Katherine Dondanville Jeffrey S. Yarvis Jim Mintz Alan L. Peterson Elisa V. Borah Brett T. Litz Alma Molino Stacey Young McCaughan Patricia A. Resick Nancy Pandhi Nora Jacobson Neftali Serrano Armando Hernandez Elizabeth Zeidler- Schreiter Natalie Wietfeldt Zaher Karp Michael D. Pullmann Barbara Lucenko Bridget Pavelle Jacqueline A. Uomoto Andrea Negrete Molly Cevasco Suzanne E. U. Kerns Robert P. Franks Christopher Bory Edward J. Miech Teresa M. Damush Jason Satterfield Derek Satre Maria Wamsley Patrick Yuan Patricia O’Sullivan Helen Best Susan Velasquez Miya Barnett Lauren Brookman-Frazee Jennifer Regan Nicole Stadnick Alison Hamilton Anna Lau Scott Roesch Byron J. Powell Thomas J. Waltz Matthew J. Chinman Laura Damschroder Jeffrey L. Smith Monica M. Matthieu Enola K. Proctor JoAnn E. Kirchner Monica J. Matthieu Craig S. Rosen Sarah C. Walker Asia S. Bishop Mariko Lockhart Allison L. Rodriguez Luisa Manfredi Andrea Nevedal Joel Rosenthal Daniel M. Blonigen Anne M. Mauricio Thomas D. Dishion Jenna Rudo-Stern Department of Psychological and Brain Sciences Indiana University Bloomington USA Department of Psychiatry & Behavioral Sciences University of Washington Seattle USA Psychology Department University of Montana Missoula USA Department of Psychology La Salle University Philadelphia USA Division of Public Behavioral Health and Justice Policy University of Washington Seattle USA National Center for PTSD VA Palo Alto Health Care System Menlo Park USA Department of Psychiatry University of Arkansas for Medical Sciences Little Rock USA Department of Psychology University of Washington Seattle USA Department of Speech and Hearing Sciences University of Washington Seattle USA Department of Psychological Sciences University of Missouri Columbia USA Department of Children Youth and Families School of Social Work University of Southern California Los Angeles USA Oregon Social Learning Center Eugene USA Department of Psychiatry University of California San Diego La Jolla USA Child and Adolescent Services Research Center (CASRC) San Diego USA Department of Psychology San Diego State University San Diego USA Pacific Institute for Research and Evaluation Behavioral Health Research Center of the Southwest Albuquerque USA School of Public Health University of Texas Health Science Center at Houston Houston USA Woolf Consulting Santa Barbara USA Rollins School of Public Health Emory University Atlanta USA University of Colorado Cancer Center at Denver Aurora USA South Carolina Primary Health Care Association Columbia USA Veterans Affairs (VA) Ann Arbor Center for Clinical Management Research Ann Arbor USA Personalizing Options through Veteran Engagement (PROVE) Quality Enhancement Research Initiative (QUERI) Program Ann Arbor USA Center to Improve Veteran Involvement in Care (CIVIC) Veterns Affairs (VA) Portland Health Care System (VAPORHCS) Portland USA Department of Family Medicine Oregon Health & Science University Portland USA Division of General Internal Medi

Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective on adoption, implementation, and sustainment of evidence-based interventions Lawrence A. Palinkas A2: Towards making scale up of evidence-based practices in child welfare systems more efficient and affordable Patricia Chamberlain A3: Mixed method examination of strategic leadership for evidence-based practice implementation Gregory A. Aarons, Amy E. Green, Mark. G. Ehrhart, Elise M. Trott, Cathleen E. Willging A4: Implementing practice change in Federally Qualified Health Centers: Learning from leaders’ experiences Maria E. Fernandez, Nicholas H. Woolf, Shuting (Lily) Liang, Natalia I. Heredia, Michelle Kegler, Betsy Risendal, Andrea Dwyer, Vicki Young, Dayna Campbell, Michelle Carvalho, Yvonne Kellar-Guenther A3: Mixed method examination of strategic leadership for evidence-based practice implementation Gregory A. Aarons, Amy E. Green, Mark. G. Ehrhart, Elise M. Trott, Cathleen E. Willging A4: Implementing practice change in Federally Qualified Health Centers: Learning from leaders’ experiences Maria E. Fernandez, Nicholas H. Woolf, Shuting (Lily) Liang, Natalia I. Heredia, Michelle Kegler, Betsy Risendal, Andrea Dwyer, Vicki Young, Dayna Campbell, Michelle Carvalho, Yvonne Kellar-Guenther A5: Efficient synthesis: Using qualitative comparative analysis and the Consolidated Framework for Implementation Research across diverse studies Laura J. Damschroder, Julie C. Lowery A6: Establishing a veterans engagement group to empower patients and inform Veterans Affairs (VA) health services research Sara

关键词： Veteran Affair Motivational Interview Veteran Health Administration Dialectical Behavior Therapy Qualitative Comparative Analysis

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LG-02 MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM

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Neuro-Oncology 2016年第SUPPL_3期18卷 iii78-iii78页

作者： Bergthold, Guillaume Bandopadhayay, Pratiti Ramkissoon, Lori Jain, Payal Wala, Jeremiah Schumacher, Steven Ramkissoon, Shakti Varlet, Pascale Pages, Mélanie Ducar, Matthew Van Hummelen, Paul Bowers, Daniel Giannini, Caterina Puget, Stephanie Hawkins, Cynthia Tabori, Uri Klekner, Almos Bognar, Laszlo Burger, Peter Eberhart, Charles Rodriguez, Fausto Hill, D. Ashley Muller, Sabine Haas-Kogan, Daphne Phillips, Joanna Santagata, Sandro Stiles, Charles Bradner, James Jabado, Nada Goren, Alon Grill, Jacques Ligon, Azra Goumnerova, Liliana Waanders, Angela Storm, Philip Kieran, Mark Resnick, Adam Ligon, Keith Beroukhim, Rameen Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Department de Cancerologie de l'Enfant et de l'Adolescent & UMR 8203 CNRS Gustave Roussy Universite Paris XI Sud Villejuif France Dana-Farber/Boston Children's Cancer and Blood Disorders Center Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Division of Neurosurgery The Children's Hospital of Philadelphia Philadelphia PA USA Cell & Molecular Biology Graduate Group Gene Therapy and Vaccines Program Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Broad Institute Cambridge MA USA Department of Pathology Brigham and Women's Hospital Boston MA USA Laboratoire de Neuropathologie Hopital Sainte-Anne Universite Paris V Descartes Paris France Center for Cancer Genome Discovery Dana-Farber Cancer Institute Boston MA USA Division of Pediatric Hematology-Oncology UT Southwestern Medical School Dallas TX USA Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA Departement de Neurochirurgie Hopital Necker-Enfants Malades Universite Paris V Descartes Paris France Department of Pathology The Hospital for Sick Children Toronto ON Canada Division of Haematology/Oncology The Hospital for Sick Children Toronto ON Canada Department of Neurosurgery Medical and Health Science Center University of Debrecen Debrecen Hungary Departments of Pathology Ophthalmology and Oncology Johns Hopkins University School of Medicine Baltimore MD USA Brain Tumor Institute Children's National Medical Center Washington DC USA Center for Neuroscience and Behavioral Medicine Brain Tumor Institute Children's National Medical Center Washington DC USA Department of Neurology Neurosurgery and Pediatrics University of California San Francisco School of Medicine San Francisco CA USA Department of Radiation Oncology University of California San Francisco. Helen Diller Family Comprehensive Cancer Center San Francisco C

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Revision of ICD – status update on feeding and eating disorders

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Advances in Eating disorders 2013年第1期1卷

作者： Samir Al-Adawi Brigita Bax Rachel Bryant-Waugh Angélica M. Claudino Phillipa Hay Palmiero Monteleone Claes Norring Kathleen M. Pike David J. Pilon Cecile Rausch Herscovici Geoffrey M. Reed Per-Anders Rydelius Pratap Sharan Cornelia Thiels Janet Treasure Rudolf Uher Department of Behavioral Medicine College of Medicine and Health Sciences Sultan Qaboos University Muscat Sultanate of Oman Eating Disorders Center University of Vilnius Vilnius Lithuania Feeding and Eating Disorders Service Department of Child and Adolescent Mental Health Great Ormond Street Hospital for Children NHS Foundation Trust London UK Eating Disorders Program Federal University of São Paulo São Paulo SP Brazil James Cook University & Foundation Chair of Mental Health School of Medicine University of Western Sydney Australia Department of Psychiatry University of Naples SUN Naples Italy Centre for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet & Stockholm Centre for Eating Disorders Stockholm Sweden Department of Psychiatry Columbia University New York USA Capital Health Halifax Nova Scotia Canada TESIS Center for Systems Therapies Buenos Aires Argentina Department of Mental Health and Substance Abuse (MSD/MER) World Health Organization Geneva Switzerland Department of Child and Adolescent Psychiatry Karolinska Institutet Stockholm Sweden Department of Psychiatry All India Institute of Medical Sciences Ansari Nagar New Delhi India Department of Social Studies University of Applied Sciences Bielefeld Bielefeld Germany Eating Disorders Unit Institute of Psychiatry King's College London London UK Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada B3H 2E2

The World Health Organization is currently revising the International Classification of Diseases and Related Health Problems (ICD-10). A central goal for the revision of the ICD classification of mental and behavioural disorders is to improve its clinical utility. Global representation and cultural sensitivity and relevance are important across all mental disorders, but are especially critical to advancing our understanding, diagnosis and treatment of feeding and eating disorders (FED). This paper summarises the current status of the Eating disorders Consultation Group (EDCG) considerations regarding diagnostic categories for FEDs in ICD-11 and represents work in progress. The recommendations of the EDCG are informed by relevant research evidence, and the consultation group is striving to find a balance between clinical utility and diagnostic purity. Provisional recommendations of the EDCG include: (1) merger of previous FEDs categories in one group; (2) inclusion of six main FED categories that include anorexia nervosa (AN), bulimia nervosa (BN), pica, regurgitation disorder, binge-eating disorder (BED) and avoidant/restrictive food intake disorder, the last two representing new categories; (3) broadening of categories with the aim of reducing the use of the unspecified ED category (e.g. dropping the amenorrhea requirement, increasing the body mass index cut-off for low weight and rewording the cognitive and behavioural features of AN to be more culturally-sensitive). In line with this last recommendation, one point that require further analysis pertain to frequency and severity of the binge-eating and purging behaviours in BN and BED, as the EDCG is considering reducing or eliminating the frequency criterion and broadening the binge-eating criterion to include ‘subjective’ binge episodes.

关键词： mental disorders classification diagnosis International Classification of Diseases (ICD) Diagnostic and Statistical Manual of Mental disorders (DSM) clinical utility cross-cultural applicability eating disorders feeding disorders

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