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Incidental melanoma and thyroid cancer lead to diagnosis of Lynch syndrome and endometrial cancer: A case report

JAAD Case Reports 2024年 51卷 66-68页

作者： Kuo, Molly E. Smith, Emily H. Plotzke, Jaclyn Chan, May Else, Tobias Cha, Kelly B. Medical Scientist Training Program University of Michigan Departments of Dermatology and Dermatopathology Saint Louis University Department of Dermatology University of Michigan Department of Pathology University of Michigan Division of Metabolism Endocrinology and Diabetes Department of Internal Medicine University of Michigan

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Analysis of Postoperative Distal Radius Fracture Outcomes in the Setting of Osteopenia and Osteoporosis for Patients with Comorbid Conditions

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Journal of Hand Surgery Global Online 2023年第5期5卷 601-605页

作者： Tuaño, Krystle R. Fisher, Marlie H. Lee, Nayun Khatter, Neil J. Le, Elliot Washington, Kia M. Iorio, Matthew L. Division of Plastic and Reconstructive Surgery University of Colorado Hospital Denver CO United States Medical Scientist Training Program University of Colorado Anschutz Medical Campus Aurora CO United States University of Colorado School of Medicine Anschutz Medical Campus Aurora CO United States

Purpose: Distal radius fractures (DRFs) are among the most common orthopedic injuries, especially in the elderly. A wide variety of approaches have been advocated as successful treatment modalities;yet, there remains variability in practice patterns of DRF in patients with osteoporosis and osteopenia. Using large data set analysis, we sought to determine the risk profile of operative fixation of DRF in patients with low bone mineral density. Methods: A commercially available health care database, PearlDiver, was queried for all patients who underwent open reduction internal fixation of DRFs between 2010 and 2020. The study population was divided into groups based on the presence or absence of osteopenia or osteoporosis and was further classified by patients who were receiving bisphosphonate therapy. Complication rates were calculated, including rates of malunion, surgical site infection, osteomyelitis, hardware failure, and hardware removal. Five-year future fragility fractures were defined in hip, vertebrae, humerus, and wrist fractures. Chi-square analysis and logistic regression were performed to determine an association between these comorbidities and various postoperative complications. Results: A total of 152,926 patients underwent open reduction internal fixation of a DRF during the study period. Chi-square analysis of major complications at 3 months showed a statistically significant increase in malunion in patients with osteopenia (P = .05) and patients with osteoporosis (P = .05) who underwent open reduction internal fixation. Logistic regression analysis at 12 months after surgery demonstrated that osteopenia was associated with an increased risk of hardware failure (P < .0001), hardware removal (P < .0001), surgical site infection (P < .0001), and malunion (P = .004). Osteoporosis was associated with a significantly increased risk of hardware failure (P = .01), surgical site infection (P < .0001), and malunion (P < .0001). Conclusions: We demonstrated, u

关键词： Distal radius Fragility fracture ORIF Osteopenia Osteoporosis

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Confocal imaging of calcium microdomains and calcium extrusion in turtle hair cells

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NEURON 1995年第6期15卷 1323-1335页

作者： Tucker, T Fettiplace, R Department of Neurophysiology Neuroscience Training Program University of Wisconsin Medical School Madison Wisconsin 53706 USA

We have studied spatial Ca2+ distribution in hair cells filled with the low affinity fluorescent indicator Calcium Green 5N using real-time confocal microscopy and whole-cell recording. During depolarizations lasting several hundred milliseconds, Ca2+ fluorescence increased at a number of hotspots around the base of the cell but changed little near the hair bundle. The hotspots required influx of Ca2+ through voltage-dependent channels, and they expanded during the pulse from an initial diameter of <1 mu m. Strong Ca2+ buffers like BAPTA slowed their growth rate. On repolarization, the fluorescence decayed with two time constants: similar to 0.1 s, which may represent Ca2+ diffusion away from the entry sites, and 10 s, probably reflecting Ca2+ extrusion. Extrusion occurs mainly via a CaAT-Pase that can be blocked by vanadate. We suggest the hotspots are microdomains of Ca2+ attaining a concentration of at least 85 mu M near assemblies of synaptic release sites.

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Angiotensin AT 1 R Expressing Cells Within the Ventral Hypothalamus Modulate Integrative Control of Cardiometabolic Functions

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iScience 2025年

作者： Jhonatan Pasos Valerie A. Wagner Samuel B.R. Lawton Alyssa M. Madison Kush Nandani Natalia M. Mathieu Connie C. Grobe John J. Reho Bonnie P. Freudinger Alexander J. Sherman Daniel T. Brozoski Lisa L. Morselli Colin M.L. Burnett Jeffrey L. Segar Pablo Nakagawa Curt D. Sigmund Justin L. Grobe Department of Physiology Medical College of Wisconsin Milwaukee WI 53226 USA Universidad CES Medellin Antioquia Colombia Medical Scientist Training Program Medical College of Wisconsin Milwaukee WI 53226 USA Department of Pediatrics Division of Neonatology Medical College of Wisconsin Milwaukee WI 53226 USA Comprehensive Rodent Metabolic Phenotyping Core Medical College of Wisconsin Milwaukee WI 53226 USA Engineering Core Medical College of Wisconsin Milwaukee WI 53226 USA Department of Medicine / Division of Endocrinology and Molecular Medicine Medical College of Wisconsin Milwaukee WI 53226 USA Cardiovascular Center Medical College of Wisconsin Milwaukee WI 53226 USA Department of Medicine / Division of Cardiovascular Medicine Medical College of Wisconsin Milwaukee WI 53226 USA Department of Biomedical Engineering Medical College of Wisconsin Milwaukee WI 53226 USA Neuroscience Research Center Medical College of Wisconsin Milwaukee WI 53226 USA

Subtypes of Agouti-related peptide (AgRP) neurons can be distinguished based upon expression of angiotensin II receptors. The Type 1 subtype, which expresses the angiotensin type 1 receptor ( Agtr1a ), was examined for its role in the integrative control of cardiometabolic functions. Mice expressing Cre-recombinase via the Agtr1a locus received bilateral microinjection of an AAV vector encoding Cre-dependent expression of caspase-3 into the arcuate nucleus of mice housed at 22°C or 30°C. Ablation of Agtr1a + cells caused increased food intake, adiposity, resting metabolic rate and shifts in nutrient partitioning, elevated temperature preference, loss of core temperature defense, and changes in blood pressure and heart rate. Many phenotypes were ameliorated by housing animals at thermoneutrality. Thus, Agtr1a + cells in the ventral hypothalamus (including the Type 1 AgRP neuron) influence cardiometabolic control through modulation of thermoregulatory responses to cold. Some functions of these cells appear to oppose canonical roles of other AgRP neuron subtypes.

关键词： Agouti-related peptide Angiotensin Energy metabolism Thermoregulation

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Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo

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Journal of Pharmacology and Experimental Therapeutics 2024年第1期389卷 51-60页

作者： Radin, Daniel P. Shifman, Sophie Outhwaite, Ian R. Sharma, Aryan Bases, Robert Seeliger, Markus A. Tsirka, Stella E. Department of Pharmacological Sciences Renaissance School of Medicine Stony Brook University Stony Brook NY United States Stony Brook Medical Scientist Training Program Renaissance School of Medicine Stony Brook University Stony Brook NY United States

Glioblastoma (GBM) is the most frequently diagnosed primary central nervous system tumor in adults. Despite the standard of care therapy, which includes surgical resection, temozolomide chemotherapy, radiation and the newly added tumor-treating fields, median survival remains only ∼20 months. Unfortunately, GBM has a ∼100% recurrence rate, but after recurrence there are no Food and Drug Administration-approved therapies to limit tumor growth and enhance patient survival, as these tumors are resistant to temozolomide (TMZ). Recently, our laboratory reported that lucanthone slowsGBMby inhibiting autophagic flux through lysosome targeting and decreases the number of Olig21 glioma stem-like cells (GSC) in vitro and in *** now additionally report that lucanthone efficiently abates stemness in patient-derived GSC and reduces tumor microtube formation in GSC, an emerging hallmark of treatment resistance in GBM. In glioma tumors derived from cells with acquired resistance to TMZ, lucanthone retains the ability to perturb tumor growth, inhibits autophagy by targeting lysosomes, and reduces Olig2 *** also find that lucanthone may act as an inhibitor of palmitoyl protein thioesterase 1. Our results suggest that lucanthone may function as a potential treatment option for GBMtumors that are not amenable to TMZ treatment. © 2024 by The American Society for Pharmacology and Experimental Therapeutics.

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The exploration of N6-deoxyadenosine methylation in mammalian genomes

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Protein & Cell 2021年第10期12卷 756-768页

作者： Xuwen Li Zijian Zhang Xinlong Luo Jacob Schrier Andrew D.Yang Tao P.Wu Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Medical Scientist Training Program Baylor College of MedicineHoustonTX 77030USA Huffington Center on Aging Baylor College of MedicineHoustonTX 77030USA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTX 77030USA

N^(6)-methyladenine(N^(6)-mA,m^(6)dA,or 6mA),a prevalent DNA modification in prokaryotes,has recently been identified in higher eukaryotes,including *** 6mA has been well-studied in prokaryotes,the function and regulatory mechanism of 6mA in eukaryotes are still poorly *** studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes,from transposable-element suppression to environmental stress ***,we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical DNA methylation in eukaryotes,predominantly mammals.

关键词： DNA N^(6)-methyladenine(6mA) mammalian DNA modification norvcanonical mammalian DNA methylation

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A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH (Jan, 10.1038/s41587-022-01568-9, 2023)

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NATURE BIOTECHNOLOGY 2023年第7期41卷 1027-1027页

作者： Jia, Bojing Blair Jussila, Adam Kern, Colin Zhu, Quan Ren, Bing Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Medical Scientist Training Program University of California San Diego La Jolla CA USA Department of Cellular and Molecular Medicine Center for Epigenomics University of California San Diego La Jolla CA USA Ludwig Institute for Cancer Research La Jolla CA USA Institute of Genomic Medicine Moores Cancer Center School of Medicine University of California San Diego La Jolla CA USA

Multiplexed fluorescence in situ hybridization (FISH) is a widely used approach for analyzing three-dimensional genome organization, but it is challenging to derive chromosomal conformations from noisy fluorescence signals, and tracing chromatin is not straightforward. Here we report a spatial genome aligner that parses true chromatin signal from noise by aligning signals to a DNA polymer model. Using genomic distances separating imaged loci, our aligner estimates spatial distances expected to separate loci on a polymer in three-dimensional space. Our aligner then evaluates the physical probability observed signals belonging to these loci are connected, thereby tracing chromatin structures. We demonstrate that this spatial genome aligner can efficiently model chromosome architectures from DNA FISH data across multiple scales and be used to predict chromosome ploidies de novo in interphase cells. Reprocessing of previous whole-genome chromosome tracing data with this method indicates the spatial aggregation of sister chromatids in S/G2 phase cells in asynchronous mouse embryonic stem cells and provides evidence for extranumerary chromosomes that remain tightly paired in postmitotic neurons of the adult mouse cortex.

关键词： Gene regulation Image processing

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Infectious pseudochromhidrosis in the setting of dupilumab use

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JAAD Case Reports 2022年 25卷 27-29页

作者： Kuo, Molly E. Briones, Naomi F. Helfrich, Yolanda R. Medical Scientist Training Program University of Michigan Ann Arbor MI United States Department of Human Genetics University of Michigan Ann Arbor MI United States Department of Dermatology University of Michigan Ann Arbor MI United States

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Quantitative and qualitative disparities exist between baseball and softball peer-reviewed pitching-related literature: a systematic review from 1990 to 2020

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JSES Reviews, Reports, and Techniques 2023年第4期3卷 499-505页

作者： Gilmer, Gabrielle Lin, Albert Shannon, Michael Mirvish, Asher Aloi, Nicholas Shooster, Forrest Greiner, Justin J. Freddie Fu Sports Medicine Center Department of Orthopaedic Surgery University of Pittsburgh Medical Center Pittsburgh PA United States Medical Scientist Training Program University of Pittsburgh School of Medicine Pittsburgh PA United States University of Nebraska Medical Center Department of Orthopedic Surgery Omaha NE United States

Background: Baseball and softball are popular sports with similar rates of injury, especially among pitchers. However, parity between the two sports is lacking, as baseball receives greater research attention than softball. The purpose of this study was to describe the discrepancy between baseball and softball in terms of quantity and quality of research. We hypothesized baseball literature would outnumber softball literature, be published in higher-impact journals, and be of higher quality. Methods: A systematic review was performed to identify original research articles related to baseball and softball from 1990 to 2020. Articles pertaining to pitching were identified via literature searches of PubMed, the Physiotherapy Evidence Database, the Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Central Register of Controlled Trials and further screened by two independent reviewers. Age group studied, journal impact factor, type of research, and level of evidence were compared between pitching-related baseball and softball articles. Injury-related studies were also subanalyzed, and a meta-analysis was performed to assess rates of shoulder and elbow injuries between baseball and softball pitchers. Results: There were 813 baseball publications and 158 softball publications that met our inclusion criteria. More baseball articles were published per year than softball (5:1, P < .001). Baseball had 368 articles related to pitching, while softball had significantly fewer at 49, and there were more baseball pitching articles published per year than softball pitching articles (7.5:1, P < .001). Pitching-related baseball articles were published in journals with a higher mean impact factor than softball pitching articles (3.1 vs. 2.0, P = .049). There was no difference in methodological index for non-randomized studies criteria for rigorous reporting (P = .678), and among all groups, most articles were level III evidence. Baseball pitching articles inclu

关键词： Bias Elbow Gender disparity Inequality Level IV Rotator cuff Shoulder Systematic Review & Meta-Analysis Title IX

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Visualizing drug actions on dendrites: psilocybin and other classic psychedelics

Visualizing drug actions on dendrites: psilocybin and other ...

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Optics and the Brain, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences 2023

作者： Shao, Ling-Xiao Liao, Clara Gregg, Ian Davoudian, Pasha A. Savalia, Neil K. Delagarza, Kristina Kwan, Alex C. Department of Psychiatry Yale University School of Medicine New HavenCT06511 United States Interdepartmental Neuroscience Program Yale University School of Medicine New HavenCT06511 United States Medical Scientist Training Program Yale University School of Medicine New HavenCT06511 United States Department of Neuroscience Yale University School of Medicine New HavenCT06511 United States Meinig School of Biomedical Engineering Cornell University IthacaNY14853 United States

To determine effects of psychedelics on neuronal architecture, we used two-photon microscopy to image dendritic spines in mouse frontal cortex after administering psilocybin (Neuron, 109, 2535, 2021) and compared with... 详细信息

ISBN: (纸本)9781957171210

关键词： Green fluorescent protein High speed photography Multiphoton microscopy Strain

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