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检索条件"机构=Program in Neuroscience and Medical Scientist Training Program"
513 条 记 录,以下是191-200 订阅
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An inexpensive microscopy system for microfluidic studies in budding yeast
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Translational Medicine of Aging 2019年 3卷 52-56页
作者: Chen, Kenneth L. Ven, Toby N. Crane, Matthew M. Chen, Dexter E. Feng, Yen-Chi Suzuki, Nozomi Russell, Adam E. de Moraes, Diogo Kaeberlein, Matt Department of Pathology School of Medicine University of Washington Seattle WA United States Department of Genome Sciences School of Medicine University of Washington Seattle WA United States Medical Scientist Training Program School of Medicine University of Washington Seattle WA United States
Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high cost of the motori... 详细信息
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Cooperation among an anonymous group protected Bitcoin during failures of decentralization
arXiv
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arXiv 2022年
作者: Blackburn, Alyssa Huber, Christoph Eliaz, Yossi Shamim, Muhammad S. Weisz, David Seshadri, Goutham Kim, Kevin Hang, Shengqi Aiden, Erez Lieberman The Center for Genome Architecture Baylor College of Medicine HoustonTX77030 United States Department of Molecular and Human Genetics Baylor College of Medicine HoustonTX United States Center for Theoretical Biological Physics Rice University HoustonTX77030 United States Institute for Markets and Strategy WU Vienna University of Economics and Business Vienna Austria Department of Physics University of Houston HoustonTX77204 United States Medical Scientist Training Program Baylor College of Medicine HoustonTX United States Department of Computer Science Rice University HoustonTX77030 United States
Bitcoin is a digital currency designed to rely on a decentralized, trustless network of anonymous agents. Using a pseudonymous-address-linking procedure that achieves >99% sensitivity and >99% specificity, we re... 详细信息
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Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression
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Cell Reports 2023年 第6期42卷 112642页
作者: Campbell, Amy E. Dyle, Michael C. Albanese, Roberto Matheny, Tyler Sudheendran, Kavitha Cortázar, Michael A. Forman, Thomas Fu, Rui Gillen, Austin E. Caruthers, Marvin H. Floor, Stephen N. Calviello, Lorenzo Jagannathan, Sujatha Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora 80045 CO United States Functional Genomics Research Centre Human Technopole Milan 20157 Italy Computational Biology Research Centre Human Technopole Milan 20157 Italy RNA Bioscience Initiative University of Colorado Anschutz Medical Campus Aurora 80045 CO United States Department of Biochemistry University of Colorado Boulder Boulder 80309 CO United States Department of Craniofacial Biology University of Colorado Anschutz Medical Campus Aurora 80045 CO United States Medical Scientist Training Program University of Colorado Anschutz Medical Campus Aurora 80045 CO United States Department of Cell and Tissue Biology University of California San Francisco San Francisco 94143 CA United States Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco 94143 CA United States
Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread pro... 详细信息
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Proliferative and metastatic roles for Phospholipase D in mouse models of cancer
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Advances in Biological Regulation 2018年 67卷 134-140页
作者: Roth, Eric Frohman, Michael A. The Graduate Program in Molecular and Cellular Pharmacology The Medical Scientist Training Program the Department of Pharmacological Sciences Stony Brook University New York 11794 United States
Phospholipase D (PLD) activity has been proposed to facilitate multiple steps in cancer progression including growth, metabolism, angiogenesis, and mobility. The canonical enzymes PLD1 and PLD2 enact their diverse eff... 详细信息
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Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma
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CNS Oncology 2024年 第1期13卷 2415285页
作者: Oshima, Sonoko Yao, Jingwen Bobholz, Samuel Nagaraj, Raksha Raymond, Catalina Teraishi, Ashley Guenther, Anna-Marie Kim, Asher Sanvito, Francesco Cho, Nicholas S C Eldred, Blaine S Connelly, Jennifer M Nghiemphu, Phioanh L Lai, Albert Salamon, Noriko Cloughesy, Timothy F LaViolette, Peter S Ellingson, Benjamin M UCLA Brain Tumor Imaging Laboratory (BTIL) Center for Computer Vision & Imaging Biomarkers University of California Los Angeles Los Angeles 90024 CA United States Department of Radiological Sciences David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States Department of Bioengineering Henry Samueli School of Engineering & Applied Science University of California Los Angeles Los Angeles 90024 CA United States Department of Radiology Medical College of Wisconsin Milwaukee 53226 WI United States Medical Scientist Training Program David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States UCLA Neuro-Oncology Program David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States Department of Neurology Medical College of Wisconsin Milwaukee 53226 WI United States Department of Neurology David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States Department of Biophysics Medical College of Wisconsin Milwaukee 53226 WI United States Department of Biomedical Engineering Medical College of Wisconsin Milwaukee 53226 WI United States Department of Psychiatry & Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States Department of Neurosurgery David Geffen School of Medicine University of California Los Angeles Los Angeles 90024 CA United States
Aim: A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. In th... 详细信息
来源: 评论
A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
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Mayo Clinic Proceedings: Innovations, Quality and Outcomes 2020年 第2期4卷 203-210页
作者: Sterner, Rosalie M. Hedin, Karen E. Hayden, Richard E. Nowakowski, Grzegorz S. Wyles, Saranya P. Greenberg-Worisek, Alexandra J. Terzic, Andre Kenderian, Saad S. Mayo Clinic Medical Scientist Training Program Mayo Clinic College of Medicine and Science Rochester MN United States Department of Immunology Mayo Clinic Rochester MN United States Otorhinolaryngology Mayo Clinic Scottsdale AZ United States Division of Hematology Department of Medicine Mayo Clinic Rochester MN United States Department of Dermatology Mayo Clinic Rochester MN United States Center for Regenerative Medicine Mayo Clinic Rochester MN United States Department of Cardiology Mayo Clinic Rochester MN United States
Objective: To evaluate the impact of a novel interdisciplinary graduate-level course in chimeric antigenic receptor-T cell therapy on students’ knowledge and interests in translational science. Materials/Participants... 详细信息
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STING deletion protects against amyloid β-induced Alzheimer's disease pathogenesis
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Alzheimer's & dementia : the journal of the Alzheimer's Association 2025年 第5期21卷 e70305页
作者: Jessica M Thanos Olivia C Campbell Maureen N Cowan Katherine R Bruch Katelyn A Moore Hannah E Ennerfelt Nick R Natale Aman Mangalmurti Nagaraj Kerur John R Lukens Department of Neuroscience Center for Brain Immunology and Glia (BIG) University of Virginia Charlottesville Virginia USA. Neuroscience Graduate Program University of Virginia Charlottesville Virginia USA. Brain Immunology and Glia Graduate Training Program University of Virginia Charlottesville Virginia USA. Department of Neurology Massachusetts General Hospital Boston Massachusetts USA. Department of Neurology and Neurological Sciences Stanford University Palo Alto California USA. Department of Ophthalmology and Visual Sciences the Ohio State University Wexner Medical Center Columbus Ohio USA. Ohio State Havener Eye Institute the Ohio State University Wexner Medical Center Columbus Ohio USA. Department of Microbial Infection and Immunity the Ohio State University Wexner Medical Center Columbus Ohio USA.
INTRODUCTION:While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis using genetic tar... 详细信息
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Development of a Dual-Antigen Targeting CAR-T Therapy Directed Against CD70 and Active Integrin β2 for Acute Myeloid Leukemia
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Blood 2024年 144卷 2037-2037页
作者: Amrik S Kang Haley Johnson Nabeel Razi Nicole Lei Aaron C. Logan Benjamin J Huang Arun P Wiita Department of Laboratory Medicine University of California San Francisco San Francisco CA Medical Scientist Training Program University of California San Francisco San Francisco CA Department of Laboratory Medicine University of California San Francisco San Francisco CA Department of Medicine Division of Hematology and Oncology University of California San Francisco San Francisco CA Department of Pediatrics University of California San Francisco San Francisco CA
Introduction: Acute myeloid leukemia (AML) remains a devastating disease with a great need for new therapies. While CAR-T therapy has achieved remarkable success in B-cell leukemias, lymphomas, and multiple myeloma, s...
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Learning deep attribution priors based on prior knowledge
arXiv
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arXiv 2019年
作者: Weinberger, Ethan Janizek, Joseph Lee, Su-In Paul G. Allen School of Computer Science and Engineering University of Washington Medical Scientist Training Program University of Washington
Feature attribution methods are an essential tool for understanding the behavior of complex deep learning models. However, ensuring that models produce meaningful explanations, rather than ones that rely on noise, is ... 详细信息
来源: 评论
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
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Angewandte Chemie 2024年 第5期137卷
作者: Angela T. Fan Gillian E. Gadbois Hai-Tsang Huang Charu Chaudhry Jiewei Jiang Logan H. Sigua Emily R. Smith Sitong Wu Grace J. Poirier Kara Dunne-Dombrink Pavitra Goyal Andrew J. Tao William R. Sellers Eric S. Fischer Katherine A. Donovan Fleur M. Ferguson Department of Chemistry and Biochemistry University of California San Diego The Broad Institute of Harvard and MIT Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston Discovery Technologies Molecular Pharmacology J&J Innovative Medicine Spring House Pennsylvania 19477 United States Medical Scientist Training Program University of California San Diego Department of Cancer Biology Dana-Farber Cancer Institute Boston Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry... 详细信息
来源: 评论