检索结果-内蒙古大学图书馆

76. Validation of Systemic Inflammatory Mediators as Biomarkers for Severity and Adverse Outcomes in Clostridium difficile Infection

引用

Open Forum Infect Dis 2019年第SUPPL 2期6卷 S1-S1页

作者： Michael G Dieterle Rosemary K B Putler Donald A Perry Anitha Menon Lisa Abernathy-Close Naomi Perlman Aline Penkevich Alexandra Standke Micah Keidan Kimberly Vendrov Ingrid L Bergin Vincent B Young Krishna Rao Medical Scientist Training Program (MSTP) Department of Microbiology and Immunology University of Michigan Medical School Ann Arbor Michigan Thermo Fisher Scientific Ann Arbor Michigan University of Michigan Ann Arbor Michigan Department of Internal Medicine Division of Infectious Diseases University of Michigan Ann Arbor Michigan Department of Internal Medicine Infectious Diseases Division University of Michigan Ann Arbor Michigan University of Michigan Medical School Ann Arbor Michigan

BackgroundClostridium difficileinfection (CDI) can result in severe disease and death. We are currently unable to identify patients at risk for developing adverse outcomes. We previously showed multiple inflammatory m...

Background Clostridium difficile infection (CDI) can result in severe disease and death. We are currently unable to identify patients at risk for developing adverse outcomes. We previously showed multiple inflammatory mediators were associated with severity and adverse outcomes. Here, we set out to validate these findings in patients and a murine model of CDI. Methods CDI was diagnosed by the clinical microbiology laboratory. Sera were collected ≤48 hours after diagnosis from pilot (October 2010–November 2012) and validation (January–September 2016) cohorts. Inflammatory mediators were measured with a custom multiplex assay. IDSA severity was defined as serum creatinine >1.5-fold above baseline or white blood cell count >15,000 cells/mL. The 30-day outcomes were all-cause mortality and disease-related complications (DRCs): ICU admission, colectomy, or death attributed to CDI. We sought to validate our patient findings in a murine model of CDI: 67 antibiotic-treated mice were infected with 630 g (37 mice), a low virulence strain, or VPI 10463 (30 mice), a highly virulent strain. Host responses were assessed with a murine version of the multiplex panel. Unadjusted and adjusted models were built using logistic and L1 regression, respectively. Results The pilot cohort had 156 CDI cases; 63 (40%) with IDSA severity. The inflammatory response in IDSA severe cases was distinct based on redundancy analysis of all measured analytes ( P = 0.01). In unadjusted analysis, IL-2R, IL-6, and procalcitonin associated with severity ( P < 0.001, P = 0.003, and P = 0.003, respectively). The same findings were seen in the validation cohort of 272 cases (Figure 1). Unadjusted analyses revealed several predictors of severity and outcomes (Table 1). Adjusted models performed well (Figure 2) with AUCs of 0.74 [0.67–0.81] (IDSA severity), 0.89 [0.83–0.95] (death), and 0.84 [0.74–0.95] (DRCs). Application of each model to the mouse cohort for high vs. low virulence infections revealed AUCs of

来源：评论

Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease

引用

Nature communications 2020年第1期11卷 1065页

作者： Rebecca Aron Pasquale Pellegrini Edward W Green Daniel C Maddison Kwadwo Opoku-Nsiah Ana Osório Oliveira Jinny S Wong Aaron C Daub Flaviano Giorgini Paul Muchowski Steven Finkbeiner Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. San Francisco CA 94158 USA. Taube-Koret Center for Neurodegenerative Disease San Francisco CA 94158 USA. Yumanity Therapeutics Cambridge MA 02139 USA. Department of Genetics and Genome Biology College of Life Sciences University of Leicester Adrian Building University Road Leicester LE1 7RH UK. DKFZ Heidelberg 69120 Germany. Graduate Program in Chemistry and Chemical Biology Department of Pharmaceutical Chemistry University of California-San Francisco San Francisco CA 94158 USA. Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Taube-Koret Center for Neurodegenerative Disease San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Biomedical Sciences University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Neuroscience University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Medical Scientist Training Program University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Department of Neurology and Physiology University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

来源：评论

Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease

引用

Nature communications 2020年第1期11卷 2374页

作者： Rebecca Aron Pasquale Pellegrini Edward W Green Daniel C Maddison Kwadwo Opoku-Nsiah Ana Osório Oliveira Jinny S Wong Aaron C Daub Flaviano Giorgini Paul Muchowski Steven Finkbeiner Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. San Francisco CA 94158 USA. Taube-Koret Center for Neurodegenerative Disease San Francisco CA 94158 USA. Yumanity Therapeutics Cambridge MA 02139 USA. Department of Genetics and Genome Biology College of Life Sciences University of Leicester Adrian Building University Road Leicester LE1 7RH UK. DKFZ Heidelberg 69120 Germany. Graduate Program in Chemistry and Chemical Biology Department of Pharmaceutical Chemistry University of California-San Francisco San Francisco CA 94158 USA. Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Taube-Koret Center for Neurodegenerative Disease San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Biomedical Sciences University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Neuroscience University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Medical Scientist Training Program University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu. Department of Neurology and Physiology University of California-San Francisco San Francisco CA 94158 USA. sfinkbeiner@gladstone.ucsf.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

来源：评论

Correction to: Neurological Symptoms in Hypophosphatasia

引用

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2019年第2期30卷 535页

作者： J M Colazo J R Hu K M Dahir J H Simmons Vanderbilt University School of Medicine Vanderbilt University Medical Center Nashville TN 37232 USA. Medical Scientist Training Program Vanderbilt University School of Medicine Nashville TN 37232 USA. Department of Medicine Division of Diabetes Endocrinology and Metabolism Vanderbilt University Medical Center Nashville TN 37232 USA. Department of Pediatrics Division of Diabetes Endocrinology and Metabolism Vanderbilt University Medical Center Nashville TN 37232 USA. jill.h.simmons@vanderbilt.edu.

Due to a typesetting error the title of the article was published wrongly.

来源：评论

Author Correction: TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

引用

Scientific reports 2019年第1期9卷 17502页

作者： Amy L Whillock Nurbek Mambetsariev Wai W Lin Laura L Stunz Gail A Bishop Department of Microbiology & Immunology University of Iowa Iowa City IA USA. Immunology Graduate Program University of Iowa Iowa City IA USA. Medical Scientist Training Program University of Iowa Iowa City IA USA. Holden Comprehensive Cancer Center University of Iowa Iowa City IA USA. Northwestern Memorial Hospital Chicago IL USA. Sanford-Burnham-Prebys Medical Discovery Institute La Jolla CA USA. Department of Microbiology & Immunology University of Iowa Iowa City IA USA. gail-bishop@uiowa.edu. Internal Medicine University of Iowa Iowa City IA USA. gail-bishop@uiowa.edu. Immunology Graduate Program University of Iowa Iowa City IA USA. gail-bishop@uiowa.edu. Medical Scientist Training Program University of Iowa Iowa City IA USA. gail-bishop@uiowa.edu. Holden Comprehensive Cancer Center University of Iowa Iowa City IA USA. gail-bishop@uiowa.edu. VA Medical Center Iowa City IA USA. gail-bishop@uiowa.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

来源：评论

Correction to: SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/bioconductor‑powered RNA‑seq analyses

引用

BMC bioinformatics 2021年第1期22卷 381页

作者： Nicholas J Eagles Emily E Burke Jacob Leonard Brianna K Barry Joshua M Stolz Louise Huuki BaDoi N Phan Violeta Larios Serrato Everardo Gutiérrez-Millán Israel Aguilar-Ordoñez Andrew E Jaffe Leonardo Collado-Torres Lieber Institute for Brain Development Johns Hopkins Medical Campus Baltimore MD 21205 USA. Winter Genomics Salaverry 874 int 100 Lindavista CDMX 07300 Mexico. QuestBridge Scholar Palo Alto CA 94303 USA. Department of Neuroscience Johns Hopkins School of Medicine Baltimore MD 21205 USA. Computational Biology Department School of Computer Science Carnegie Mellon University Pittsburgh PA 15213 USA. Medical Scientist Training Program School of Medicine University of Pittsburgh Pittsburgh PA 15213 USA. Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas Mexico City CDMX 11340 Mexico. Department of Supercomputing Instituto Nacional de Medicina Genómica (INMEGEN) Mexico City CDMX 14610 Mexico. Center for Computational Biology Johns Hopkins University Baltimore MD 21205 USA. Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA. Department of Genetic Medicine McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine Baltimore MD 21205 USA. Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA. Lieber Institute for Brain Development Johns Hopkins Medical Campus Baltimore MD 21205 USA. lcolladotor@***. Center for Computational Biology Johns Hopkins University Baltimore MD 21205 USA. lcolladotor@***.

来源：评论

Using Different Time Operationalizations To Investigate Relationships Among Amyloid PET, White Matter Hyperintensities, And Cognition In A Cognitively Unimpaired Sample

引用

Alzheimer's & Dementia 2023年第S24期19卷

作者： Rebecca E Langhough Lianlian Du Karly Alex Cody Erin M. Jonaitis Bruce P Hermann Nathaniel A. Chin Leonardo A. Rivera-Rivera Robert V. Cadman Christian C. Pompa Sarah Hudson Bradley T. Christian Laura B. Eisenmenger Tobey J Betthauser Sterling C Johnson Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Department of Medicine University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Rebecca ELanghough Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA. University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Department of Biostatistics and Medical Informatics School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Neuroscience Training Program School of Medicine and Public Health (SMPH) University of Wisconsin-Madison Madison WI USA University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Department of Neurology School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA VA Geriatric Research Education and Clinical Center (GRECC) William S. Middleton Memorial Veterans Hospital Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin SMPH Madison WI USA School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA Waisman Center University of Wisconsin-Madison Madison WI USA Department of Medical Physics University of Wisconsin-Madison Madison WI USA Geriatric Research Education and Clinical Center (GRECC) William S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Disease Research Center School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA

Background Amyloid-PET and white matter hyperintensities (WMH) associations in older adults have variously been interpreted as separate or dependent processes. In this study, we examine evidence for a temporal relatio...

Background Amyloid-PET and white matter hyperintensities (WMH) associations in older adults have variously been interpreted as separate or dependent processes. In this study, we examine evidence for a temporal relationship between amyloid-PET and WMH and investigate how both contribute to cognitive decline in a baseline cognitively unimpaired (CU) sample. Method We analyzed longitudinal WMH and PACC3 cognition in n = 240 Wisconsin Registry for Alzheimer’s Prevention participants who were CU at cognitive baseline with ≥1 amyloid-PET and T2-FLAIR scan. Amyloid burden was assessed using [C-11]Pittsburgh Compound B (PiB) PET and a multi-ROI DVR value; DVR>1.19 = PiB+. WMH lesion volume was segmented and summed by the Lesion Segmentation Tool (LST) version 1.2.3 in SPM12 from T1-weighted and T2-weighted FLAIR scans; TIV-adjusted WMH >2.06 = WMH+. Sampled iterative local approximation (SILA) modeling aligned biomarker levels to positivity duration scale (years = 0 at biomarker+ threshold). To investigate how amyloid burden relates to WMH trajectories, time at each WMH scan was operationalized four ways: age, ∼WMH+ duration, years_since_baseline_scan, and ∼PiB+ duration. We compared model fits and interaction effects for the various PiB status*time interactions (mixed effects models; retaining significant quadratic time terms; random slopes and intercepts). We also examined whether PACC3 age-related trajectories differed by PiB/WMH +/- groups (at last scan). Result More women were WMH+ and APOE4 was more common among PiB+ (see also Table1). Significant interactions using age or years_since_baseline_scan suggested slightly faster WMH accumulation in PiB+ vs PiB- at older ages. In parallel models, WMH+ duration*PiB status and PiB+ duration*PiB status did not show differences between PiB+ and PiB- WMH trajectories. Time operationalized as WMH+ duration yielded the best fitting model (see Table2 and Fig1A-D). PACC3 decline was fastest in the PiB+/WMH+ group, followed by PiB+/W

来源：评论

IMMU-12. T-CELL THERAPIES DEMONSTRATE EFFICACY WITHOUT TOXICITY IN IMMUNOCOMPETENT MODELS OF BRAINSTEM TUMORS

引用

Neuro-Oncology 2018年第SUPPL_2期20卷 i101-i101页

作者： Schuelke, Matt Evgin, Laura Wongthida, Phonphimon Thompson, Jill Kottke, Tim Sanchez-Perez, Luis Sampson, John Vile, Richard Mayo Clinic Medical Scientist Training Program Rochester MN USA Mayo Clinic Department of Molecular Medicine Rochester MN USA Duke University Department of Neurosurgery Durham NC USA

Diffuse intrinsic pontine glioma (DIPG) is a pediatric brainstem tumor with a dismal prognosis and no curative treatments. Immunotherapy has been considered as a treatment for these tumors because of its ability to pr...

来源：评论

Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

引用

npj Genomic Medicine 2024年第1期9卷 49页

作者： Demidov, German Yaldiz, Burcu Garcia-Pelaez, José de Boer, Elke Schuermans, Nika Van de Vondel, Liedewei Paramonov, Ida Johansson, Lennart F. Musacchia, Francesco Benetti, Elisa Bullich, Gemma Sablauskas, Karolis Beltran, Sergi Gilissen, Christian Hoischen, Alexander Ossowski, Stephan de Voer, Richarda Lohmann, Katja Oliveira, Carla Topf, Ana Vissers, Lisenka E. L. M. Zguro, Kristina Zara, Federico Zaganas, Ioannis Yépez, Vicente A. Wirth, Brunhilde Webb, David Verdin, Hannah Van Nieuwenhove, Erika van Montfrans, Joris van Heurck, Roxane van der Veken, Lars Valle, Laura Uva, Paolo Udd, Bjarne Trimouille, Aurelien Thompson, Rachel Tartaglia, Marco Sznajer, Yves Striano, Pasquale Steinke-Lange, Verena Spilioti, Martha Scudieri, Paolo Schröck, Evelin Schon, Katherine Scala, Marcello Savarese, Marco Santen, Gijs W. E. Rump, Andreas Ruivenkamp, Claudia A. L. Roos, Andreas Rooryck, Caroline Riva, Antonella Renieri, Alessandra Ratnaike, Thiloka Radio, Francesca Clementina Privitera, Flavia De la Paz, Manuel Posada Poppe, Bruce Polavarapu, Kiran Platzer, Konrad Peterlin, Borut Pérez-Dueñas, Belén Pauly, Martje Parrini, Elena Olimpio, Catarina Reghan, Mary O. de Benito, Daniel Natera Osorio, Andrés Nascimento Munell, Francina Münchau, Alexander Moortgat, Stéphanie Monestier, Olivier Molnar, Maria Judit Meunier, Colombine Mertes, Christian Mei, Davide Maystadt, Isabelle May, Patrick Maver, Ales Mathioudakis, Lambros Masclaux, Frédéric Mary, Sandrine Delgado, Beatriz Martínez Marcé-Grau, Anna Malaichamy, Sivasankar Macaya, Alfons Luknárová, Rebeka Martín, Estrella López Lochmüller, Hanns Leitão, Elsa Lederer, Damien Leavis, Helen Laner, Andreas Lacombe, Didier Krass, Leon Korff, Christian Kokosali, Evgenia Karakaya, Mert Karadurmus, Deniz Kapaki, Elisabeth Johari, Mridul Iacomino, Michele Huibers, Manon Horvath, Rita Holinski-Feder, Elke Hoffer, Mariette J. V. Herzog, Rebecca Hemelsoet, Dimitri Bouveret, Eva Hammar Haimel, Matthias Hackman, Peter Guerrini, Renzo Grimbacher, Bodo Greally, Marie Ghani, Hamidah Gagneur, Julien Institute of Medical Genetics and Applied Genomics University of Tübingen Tübingen Germany Institute for Bioinformatics and Medical Informatics (IBMI) University of Tübingen Tübingen Germany Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands Department of Clinical Genetics Maastricht University Medical Center Maastricht Netherlands i3S - Instituto de Investigação e Inovação em Saúde Rua Alfredo Allen 208 Porto 4200-135 Portugal IPATIMUP - Institute of Molecular Pathology and Immunology University of Porto Porto Portugal Faculty of Medicine University of Porto Porto Portugal Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen Netherlands Department of Clinical Genetics Erasmus MC University Medical Center Rotterdam Netherlands Center for Medical Genetics Ghent University Hospital Ghent Belgium Translational Neurosciences Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium Laboratory of Neuromuscular Pathology Institute Born-Bunge University of Antwerp Antwerp Belgium Centro Nacional de Análisis Genómico (CNAG) C/Baldiri Reixac 4 Barcelona 08028 Spain Universitat de Barcelona (UB) Barcelona Spain University of Groningen University Medical Center Groningen Department of Genetics Groningen Netherlands Center for Human Technologies Italian Institute of Technology (IIT) Genova Italy Telethon Institute for Genetics and Medicine Pozzuoli (Napoli) 80078 Italy Department of Medical Biotechnologies Med Biotech Hub and Competence Center University of Siena Siena 53100 Italy Institute of Data Science and Digital Technologies Vilnius University Vilnius Lithuania Departament de Genètica Microbiologia i Estadística Facultat de Biologia Universitat de Barcelona (UB) Barcelona Spain Radboud Institute for Molecular Life Sciences Nijmegen Netherlands Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI) Radboud University Medical Center Nijmegen N

We report the results of a comprehensive copy number variant (CNV) reanalysis of 9171 exome sequencing datasets from 5757 families affected by a rare disease (RD). The data reanalysed was extremely heterogeneous, havi...

来源：评论

Cover Image, Volume 75, Issue 1

引用

Cytoskeleton 2018年第1期75卷

作者： J. Daniel Fenn Christopher M. Johnson Juan Peng Peter Jung Anthony Brown Department of Neuroscience and Medical Scientist Training Program Ohio State University Columbus Ohio 43210 Quantitative Biology Institute and Department of Physics and Astronomy Ohio University Athens Ohio 45701 Center for Biostatistics and Department of Biomedical Informatics Ohio State University Columbus Ohio 43210

来源：评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：