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第九届海内外华人神经科学家研讨会

作者： Joseph Cichon Lianyan Huang Guang Yang Medical Scientist Training Program at New York University School of Medicine Department of Anesthesiology Perioperative Care and Pain Medicine New York University School of Medicine

Neuropathic pain involves long-lasting modifications of pain transmission pathways that result in increased cortical activity. How the cortical circuits are modified and become hyperactive is unclear. Using in vivo two-photon microscopy, we performed structural and functional imaging of fluorescently labeled neurons in the cortex of a mouse model of neuropathic pain. Our studies show that the development of neuropathic pain is accompanied by an increased remodeling of postsynaptic dendritic spines in layer V(L5) pyramidal neurons in the somatosensory cortex. Concomitantly, these pyramidal neurons exhibit a persistent elevation of neuronal activity over weeks to months during the maintenance phase of neuropathic pain. Furthermore, local inhibitory interneuron networks shift their activities in favor of hyperactivity of L5 pyramidal neurons. In addition, we find that pharmacogenetic activation of certain types of interneurons reduces L5 pyramidal neuronal hyperactivity and reverses pain hypersensitivity. Together, our findings reveal cell type-specific changes during the development of neuropathic pain and provide a rationale for the treatment of chronic pain by targeting specific subtypes of interneurons.

关键词： in vivo imaging dendritic spine interneuron neuropathic pain

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Continuous attractor-based clocks are unreliable phase estimators

arXiv

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arXiv 2017年

作者： Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J. Murugan, Arvind Department of Physics James Franck Institute University of Chicago ChicagoIL United States Department of Chemistry James Franck Institute University of Chicago ChicagoIL United States Medical Scientist Training Program Pritzker School of Medicine University of Chicago ChicagoIL United States Department of Molecular Genetics and Cell Biology University of Chicago ChicagoIL United States Department of Physics University of Chicago ChicagoIL United States

Statistical estimation theory determines the optimal way of estimating parameters of a fluctuating noisy signal. However, if the estimation is performed on unreliable hardware, a sub-optimal estimation procedure can outperform the previously optimal procedure. Here, we compare classes of circadian clocks by viewing them as phase estimators for the periodic day-night light signal. We find that continuous attractor-based free running clocks, such as those found in the cyanobacterium Synechococcus elongatus and humans, are nearly optimal phase estimators since their flat attractor directions efficiently project out light intensity fluctuations due to weather patterns ('external noise'). However, such flat directions also make these continuous limit cycle attractors highly vulnerable to diffusive'internal noise'. Given such unreliable biochemical hardware, we find that point attractor-based damped clocks, such as those found in a smaller cyanobacterium with low protein copy number, Prochlorococcus marinus, outperform continuous attractor-based clocks. By interpolating between the two types of clocks found in these organisms, we demonstrate a family of biochemical phase estimation strategies that are best suited to different relative strengths of external and internal noise. Copyright © 2017, The Authors. All rights reserved.

关键词： Clocks

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Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

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Current Treatment Options in Allergy 2017年第1期4卷 71-97页

作者： Amritwar, Ameya U. Lowry, Christopher A. Brenner, Lisa A Hoisington, Andrew J. Stiller, John W. Hamilton, Robert Postolache, Teodor T. Mood and Anxiety Program University of Maryland School of Medicine Baltimore MD United States Saint Elizabeths Hospital-DBH Psychiatry Residency Training Program Washington DC United States Department of Integrative Physiology and Center for Neuroscience University of Colorado Boulder Boulder CO United States Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE) Denver CO United States Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC) Denver CO United States Department of Psychiatry Physical medicine and Rehabilitation and Neurology University of Colorado Anschutz Medical Campus Aurora CO United States Department of Civil and Environmental Engineering US Air Force Academy 2354 Fairchild Dr. Suite 6H-161 Colorado Springs CO United States Division of Allergy and Clinical Immunology Department of Medicine Johns Hopkins Asthma and Allergy Center Baltimore MD United States VISN 5 Capitol Health Care Network Mental Illness Research Education and Clinical Center (MIRECC) Baltimore MD United States

A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience. In summary, we suggest: (1) inquiring among patients with allergies about personal and family history of depression, substance use disorders, suicidal ideation, and attempts;(2) increased mindfulness regarding the potential effects of allergy medications on mood and behavior;and (3) for people identified with certain types of depression or increased suicide risk, a systematic multilevel collaborative approach. While, for practical reasons the majority of patients with depression will continue to be treated by general or family practitioners, the allergy-treating provider should always consider integrated care for bipolar, psychotic, or suicidal depression and incomplete remission, or relapsing and highly recurrent course. While awaiting results of a much needed basic and clinical research to guide the clinical approach to patients with comorbid allergic rhinitis and depression, the simple steps recommended here are expected to lead to improved clinical outcomes in depression, and, perhaps, contributing to lowering the highly resilient suicide *** objectives: a) Present overlaps between allergy, allergen exposure, depression, and suicidal behavior in adults and b) Familiarize allergists with the principles of diagnosis and treatment of depression in adults and importance to mon

关键词： Allergic rhinitis Depression Inflammation Suicidal behavior Suicidality

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Publisher Correction: The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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Nature communications 2019年第1期10卷 5257页

作者： Katherine A Michaelis Mason A Norgard Xinxia Zhu Peter R Levasseur Shamilene Sivagnanam Shannon M Liudahl Kevin G Burfeind Brennan Olson Katherine R Pelz Diana M Angeles Ramos H Carlo Maurer Kenneth P Olive Lisa M Coussens Terry K Morgan Daniel L Marks Medical Scientist Training Program Oregon Health & Science University Portland OR USA. Brenden-Colson Center for Pancreatic Care Oregon Health & Science University Portland OR USA. Papé Family Pediatric Research Institute Oregon Health & Science University Portland OR USA. Department of Computational Biology Oregon Health & Science University Portland OR USA. Department of Cell Developmental and Cancer Biology Knight Cancer Institute Oregon Health & Science University Portland OR USA. Departments of Medicine and Pathology and Cell Biology Columbia University Medical Center New York NY USA. Department of Pathology Oregon Health & Science University Portland OR USA. Brenden-Colson Center for Pancreatic Care Oregon Health & Science University Portland OR USA. marksd@ohsu.edu. Papé Family Pediatric Research Institute Oregon Health & Science University Portland OR USA. marksd@ohsu.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

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Nature biotechnology 2020年第11期38卷 1356页

作者： Hyun Min Kang Meena Subramaniam Sasha Targ Michelle Nguyen Lenka Maliskova Elizabeth McCarthy Eunice Wan Simon Wong Lauren Byrnes Cristina M Lanata Rachel E Gate Sara Mostafavi Alexander Marson Noah Zaitlen Lindsey A Criswell Chun Jimmie Ye Department of Biostatistics and Center for Statistical Genetics University of Michigan School of Public Health Ann Arbor Michigan USA. hmkang@umich.edu. Biological and Medical Informatics Graduate Program University of California San Francisco San Francisco California USA. Institute for Human Genetics (IHG) University of California San Francisco San Francisco California USA. Institute for Computational Health Sciences University of California San Francisco San Francisco California USA. Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California USA. Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco California USA. Medical Scientist Training Program (MSTP) University of California San Francisco San Francisco California USA. Department of Microbiology and Immunology University of California San Francisco San Francisco California USA. Diabetes Center University of California San Francisco San Francisco California USA. Innovative Genomics Institute University of California Berkeley Berkeley California USA. Department of Neurology University of California San Francisco San Francisco California USA. Developmental and Stem Cell Biology Graduate Program University of California San Francisco San Francisco California USA. Department of Medicine University of California San Francisco San Francisco California USA. Rosalind Russell/Ephraim P Engleman Rheumatology Research Center University of California San Francisco San Francisco California USA. Department of Statistics University of British Columbia Vancouver British Columbia Canada. UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco California USA. Chan Zuckerberg Biohub San Francisco California USA. Lung Biology Center University of California San Francisco San Francisco California USA. Department of Orofacial Sciences Universi

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Correction to: Dynamic linear models guide design and analysis of microbiota studies within artificial human guts

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Microbiome 2018年第1期6卷 212页

作者： Justin D Silverman Heather K Durand Rachael J Bloom Sayan Mukherjee Lawrence A David Program in Computational Biology and Bioinformatics Duke University CIEMAS Room 2171 101 Science Drive Box 3382 Durham NC 27708 USA. Medical Scientist Training Program Duke University Durham NC 27708 USA. Center for Genomic and Computational Biology Duke University Durham NC 27708 USA. Department of Molecular Genetics and Microbiology Duke University Durham NC 27708 USA. University Program in Genetics and Genomics Duke University Durham NC 27708 USA. Departments of Statistical Science Mathematics Computer Science Biostatistics & Bioinformatics Duke University Durham NC 27708 USA. Program in Computational Biology and Bioinformatics Duke University CIEMAS Room 2171 101 Science Drive Box 3382 Durham NC 27708 USA. lawrence.david@duke.edu. Center for Genomic and Computational Biology Duke University Durham NC 27708 USA. lawrence.david@duke.edu. University Program in Genetics and Genomics Duke University Durham NC 27708 USA. lawrence.david@duke.edu. Department of Molecular Genetics and Microbiology Duke University Durham NC 27708 USA. lawrence.david@duke.edu.

AbstractFollowing publication of the original article [1], the authors noticed an error in the presentation of equations in the PDF version.

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SERUM TRIGLYCERIDES IN ALZHEIMER'S DISEASE: RELATION TO NEUROIMAGING, CSF, AND GENETIC VARIATION

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Alzheimer's & Dementia 2019年第7期15卷 P1320-P1321页

作者： Megan Bernath Sudeepa Bhattacharyya Kwangsik Nho Dinesh Kumar Barupal Oliver Fiehn Rebecca Baillie Shannon L. Risacher Matthias Arnold Tanner Y. Jacobson John Q. Trojanowski Leslie M. Shaw Michael W. Weiner P. Murali Doraiswamy Rima F. Kaddurah-Daouk Andrew J. Saykin Indiana University School of Medicine Indianapolis IN USA Indiana Alzheimer Disease Center Indianapolis IN USA Indiana University Medical Scientist Training Program Indianapolis IN USA Department of Medical and Molecular Genetics Indianapolis IN USA University of Arkansas for Medical Sciences Little Rock AR USA Indiana University School of Informatics and Computing Indianapolis IN USA NIH-West Coast Metabolomics Center Davis CA USA NIH-West Coast Metabolomics Center University of California Davis Davis CA USA Rosa & Co LLC San Carlos CA USA Helmholtz Zentrum Muenchen Oberschleißheim Germany German Center for Diabetes Research (DZD) Neuherberg Germany University of Pennsylvania Philadelphia PA USA Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Perelman School of Medicine University of Pennsylvania Department of Pathology and Laboratory Medicine Philadelphia PA USA Center for Imaging of Neurodegenerative Diseases San Francisco Veterans Affairs Medical Center San Francisco CA USA UCSF Department of Radiology and Biomedical Imaging San Francisco CA USA Duke University Medical Center Durham NC USA Duke Institute of Brain Sciences Duke University Durham NC USA Department of Psychiatry and Behavioral Sciences Duke University Durham NC USA Department of Medicine Duke University Durham NC USA Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN USA

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Analytical strategies for studying stem cell metabolism

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Frontiers in Biology 2015年第2期10卷 141-153页

作者： James M. Arnold William T. Choi Arun Sreekumar Mirjana Maletic-Savatic Department of Molecular and Cell Biology Baylor College of Medicine Houston TX 77030 USA Program in Developmental Biology and Medical Scientist Training Program Baylor College of Medicine Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston TX 77030 USA Departments of Pediatrics-Neurology and Neuroscience and Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX 77030 USA

Owing to their capacity for self-renewal and pluripotency, stem cells possess untold potential for revolutionizing the field of regenerative medicine through the development of novel therapeutic strategies for treating cancer, diabetes, cardiovascular and neurodegenerative diseases. Central to developing these strategies is improving our understanding of biological mechanisms responsible for governing stem cell fate and self-renewal. Increasing attention is being given to the significance of metabolism, through the production of energy and generation of small molecules, as a critical regulator of stem cell functioning. Rapid advances in the field of metabolomics now allow for in-depth profiling of stem cells both in vitro and in vivo, providing a systems perspective on key metabolic and molecular pathways which influence stem cell biology. Understanding the analytical platforms and techniques that are currently used to study stem cell metabolomics, as well as how new insights can be derived from this knowledge, will accelerate new research in the field and improve future efforts to expand our understanding of the interplay between metabolism and stem cell biology.

关键词： stem cell metabolism NMR mass spectrometry MRS flux analysis

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Bleeding Risk Using INR/aPTT PreSurgery: Systemtic Review (BRUISR) (BRUISR)

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BLOOD 2017年 130卷 4654-4654页

作者： Liontos, Larissa Fralick, Michael Longmore, Avery Hicks, Lisa K. Sholzberg, Michelle Department of Laboratory Medicine and Pathobiology The University of Toronto Toronto Canada Brigham and Women's Hospital and Harvard Medical School Boston MA Clinician Scientist Training Program The University of Toronto Toronto Canada Hematology/Oncology St. Michael's Hospital Toronto Canada St. Michael's Hospital Toronto Canada Hematology/Oncology Clinical Research Group St. Michael's Hospital Toronto Canada Hematology-Oncology Clinical Research Group Division of Hematology St. Michael's Hospital and University of Toronto Toronto Canada St. Michael's Hospital University of Toronto Toronto Canada

4654

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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease

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Nature communications 2018年第1期9卷 4333页

作者： Rebecca Aron Pasquale Pellegrini Edward W Green Daniel C Maddison Kwadwo Opoku-Nsiah Jinny S Wong Aaron C Daub Flaviano Giorgini Steven Finkbeiner Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. 94158 San Francisco CA USA. Taube-Koret Center for Neurodegenerative Disease 94158 San Francisco CA USA. Yumanity Therapeutics 02139 Cambridge MA USA. Department of Genetics and Genome Biology College of Life Sciences University of Leicester Adrian Building University Road LE1 7RH Leicester UK. DKFZ 69120 Heidelberg Germany. Graduate Program in Chemistry and Chemical Biology Department of Pharmaceutical Chemistry University of California-San Francisco 94158 San Francisco CA USA. Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Taube-Koret Center for Neurodegenerative Disease 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Biomedical Sciences University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Neuroscience University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Medical Scientist Training Program University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Department of Neurology and Physiology University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu.

The original version of this Article incorrectly gave a publication date of 8 October 2018; this should have been 28 September 2018. This has now been corrected in the PDF and HTML versions of the Article.

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