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作者： Nelson, Andrew W. Knight, Andrew W. May, Dustin Eitrheim, Eric S. Schultz, Michael K. Interdisciplinary Human Toxicology Program University of Iowa Iowa CityIA52242 United States Department of Chemistry University of Iowa Iowa CityIA52242 United States State Hygienic Laboratory University of Iowa CoralvilleIA52241 United States Department of Radiology Medical Scientist Training Program University of Iowa 500 Newton Road ML B180 FRRB Iowa CityIA52242 United States

ISBN: (纸本)9780841231221

As unconventional drilling has emerged as a major industry in the U.S. and around the world, many environmental health and pollution risks have surfaced. One emerging concern is the risk of environmental contamination arising from unconventional wastes that are enriched in naturally-occurring radioactive materials (NORM). Although NORM has been a well-documented contaminant of oil and gas wastes for decades, there are new challenges associated with unconventional drilling. This chapter will present the origin of NORM in black shale formations. In addition, we present the fundamentals of radioactive decay and ingrowth, so as to provide a foundation for a discussion of the potential for environmental impact of NORM. Finally, within this context, we highlight key-relatively-unexplored aspects of unconventional drilling that point to the need for further environmental radiochemistry research. © 2015 American Chemical Society.

关键词： Health risks

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Intracranial arterial four-dimensional flow is associated with metrics of brain health and Alzheimer's disease

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 2015年第4期1卷 420-428页

作者： Berman, Sara E. Rivera-Rivera, Leonardo A. Clark, Lindsay R. Racine, Annie M. Keevil, Jon G. Bratzke, Lisa C. Carlsson, Cynthia M. Bendlin, Barbara B. Rowley, Howard A. Blennow, Kaj Zetterberg, Henrik Asthana, Sanjay Turski, Patrick Johnson, Sterling C. Wieben, Oliver Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI United States Neuroscience Training Program University of Wisconsin-Madison Madison WI United States Medical Scientist Training Program University of Wisconsin-Madison Madison WI United States Department of Medical Physics University of Wisconsin School of Medicine and Public Health Madison WI United States Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI United States Department of Radiology University of Wisconsin School of Medicine and Public Health Madison WI United States Department of Medicine University of Wisconsin School of Medicine and Public Health Madison WI United States School of Nursing University of Wisconsin-Madison Madison WI United States Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI United States Clinical Neurochemistry Laboratory Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden Department of Molecular Neuroscience University College London Institute of Neurology London United Kingdom Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI United States

Introduction: Although cerebrovascular disease has long been known to co-occur with Alzheimer's disease (AD), recent studies suggest an etiologic contribution to AD pathogenesis. We used four dimensional (4D)-flow magnetic resonance imaging (MRI) to evaluate blood flow and pulsatility indices in the circle of Willis. We hypothesized decreased mean blood flow and increased pulsatility, metrics indicative of poor vascular health, would be associated with cerebral atrophy and an AD cerebrospinal fluid (CSF) profile. Methods: A total of 312 patients along the AD continuum (172 middle aged, 60 cognitively healthy older, 44 mild cognitive impairment, and 36 AD) underwent MRI, CSF, and medical examinations. Regression was used to predict CSF biomarkers and atrophy from 4D-flow and analysis of covariance to compare vascular health between groups. Results: Decreased mean flow in the middle cerebral artery (MCA) and superior portion of the internal carotid artery (sICA) and increased pulsatility in the MCA were associated with greater brain atrophy. Decreased mean flow in the sICA was associated with lower amyloid beta 1-42 (Aβ₄₂) in the CSF, a pathologic biomarker profile associated with AD. Interestingly, although metrics of flow and pulsatility differed markedly across the AD spectrum, there were no significant differences in cardiovascular risk score, mean arterial pressure, and pulse pressure across the three age-matched older cohorts. Discussion: By measuring intracranial arterial health directly with 4D-flow MRI, these data suggest that intracranial arterial health is compromised in symptomatic AD. Even after accounting for disease stage, cerebral artery health is associated with atrophy and an AD Aβ₄₂ profile, suggesting neurovascular health may contribute to the etiopathogenesis of AD. © 2015.

关键词： Alzheimer's disease Cardiovascular risk Circle of Willis Mean blood flow Pulsatility index

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EVIDENCE FOR EARLY DETECTION OF CSF BETA-AMYLOID AND TAU AND EFFECT ON LONGITUDINAL COGNITIVE PERFORMANCE IN INDIVIDUALS AT RISK FOR ALZHEIMER’S DISEASE

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Alzheimer's & Dementia 2017年第7期13卷 P213-P214页

作者： Lindsay R. Clark Sara Elizabeth Berman Cynthia M. Carlsson Derek L. Norton Rebecca L. Koscik Henrik Zetterberg Kaj Blennow Sanjay Asthana Sterling C. Johnson Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health: Medical Scientist Training Program Madison WI USA Geriatric Research Education and Clinical Center W.S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden Institute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden University College London London United Kingdom Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Mölndal Sweden Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA

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26th Annual Computational neuroscience Meeting (CNS*2017) of the Organization for Computational neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC neuroscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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FOUR-DIMENSIONAL ARTERIAL BLOOD FLOW METRICS IN THE INTERNAL CAROTID ARTERY PREDICT COGNITIVE PERFORMANCE AND ARE ASSOCIATED WITH CSF BIOMARKERS IN PATIENTS WITH MCI

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Alzheimer's & Dementia 2016年第7期12卷 P548-P549页

作者： Sara Elizabeth Berman Leonardo A. Rivera Annie M. Racine Lindsay R. Clark Christopher R. Nicholas Cynthia M. Carlsson Barbara B. Bendlin Howard A. Rowley Kaj Blennow Henrik Zetterberg Sanjay Asthana Patrick Turski Oliver Wieben Sterling C. Johnson University of Wisconsin School of Medicine and Public Health: Medical Scientist Training Program Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin-Madison Madison WI USA Institute on Aging University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden University College London Institute of Neurology London United Kingdom Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA

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DISTINCT COGNITIVE TRAJECTORIES IN LATE MIDDLE-AGE AND THEIR ASSOCIATIONS WITH BRAIN STRUCTURE AND ALZHEIMER'S DISEASE BIOMARKERS: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION

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Alzheimer's & Dementia 2016年第7期12卷 P306-P307页

作者： Lindsay R. Clark Rebecca L. Koscik Sara Elizabeth Berman Annie M. Racine Kimberly D. Mueller Cynthia M. Carlsson Christopher R. Nicholas Sanjay Asthana Kaj Blennow Henrik Zetterberg Sterling C. Johnson Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health: Medical Scientist Training Program Madison WI USA Neuroscience Training Program University of Wisconsin Madison WI USA Institute on Aging University of Wisconsin Madison WI USA Neuroscience and Public Policy Program University of Wisconsin Madison WI USA Department of Communication Sciences and Disorders University of Wisconsin-Madison Madison WI USA Geriatric Research Education and Clinical Center Wm. S. Middleton Veterans Hospital Madison WI USA Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden University College London Institute of Neurology London United Kingdom Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin-Madison Madison WI USA

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MODIFIABLE RISK FACTORS MODERATE THE RELATIONSHIP BETWEEN BETA-AMYLOID AND LONGITUDINAL COGNITIVE TRAJECTORIES IN THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION STUDY

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Alzheimer's & Dementia 2017年第7期13卷 P485-P485页

作者： Lindsay R. Clark Rebecca L. Koscik Sara Elizabeth Berman Cynthia M. Carlsson Derek L. Norton Barbara B. Bendlin Sanjay Asthana Sterling C. Johnson Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health: Medical Scientist Training Program Madison WI USA Geriatric Research Education and Clinical Center W.S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA

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Erratum to: Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome

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Molecular autism 2017年第1期8卷 38页

作者： Lauren E Ethridge Stormi P White Matthew W Mosconi Jun Wang Ernest V Pedapati Craig A Erickson Matthew J Byerly John A Sweeney Department of Pediatrics Section on Developmental and Behavioral Pediatrics University of Oklahoma Health Sciences Center 1100 NE 13th Street Nicholson Tower Suite 4900 Oklahoma City OK 73104 USA. Department of Psychology University of Oklahoma Norman OK USA. Department of Psychiatry University of Texas Southwestern Medical Center Dallas TX USA. Schiefelbusch Institute for Life Span Studies and Clinical Child Psychology Program University of Kansas Lawrence KS USA. Kansas Center for Autism Research and Training (KCART) Kansas City KS USA. Department of Psychology Zhejiang University of Technology Hangzhou Zhejiang China. Division of Child and Adolescent Psychiatry Cincinnati Children's Hospital Medical Center Cincinnati OH USA. Department of Psychiatry and Behavioral Neuroscience University of Cincinnati Cincinnati OH USA. Division of Child Neurology Cincinnati Children's Hospital Medical Center Cincinnati OH USA. Center for Mental Health Research and Recovery Montana State University Bozeman MT USA.

[This corrects the article DOI: 10.1186/s13229-017-0140-1.].

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Informed consent in the psychiatric application of deep brain stimulation technology

Informed consent in the psychiatric application of deep brai...

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IEEE International Symposium on Ethics in Science, Technology and Engineering

作者： Andrew Koivuniemi Medical Scientist Training Program Indiana University School of Medicine Indianapolis IN

Deep brain stimulation offers a promising new therapeutic option for individuals with treatment resistant psychiatric illness. Prior to surgery, patients and their surgeons discuss the procedure in a practice known as informed consent. During this discussion, patients are educated about how the surgery will be performed, the possible risks of an adverse event, and the likelihood of a therapeutic benefit. However, while these elements of discussion are appropriate and sufficient for traditional surgeries of the body, they are likely inadequate for surgeries of the mind because they fail to establish a definition of “mind” for the patient and treatment team. This paper seeks to demonstrate some of the issues that might arise when the term “mind” is not adequately defined prior to deep brain stimulation and proposes a framework definition of “mind” to help facilitate addressing this topic during informed consent.

关键词： Satellite broadcasting Neurosurgery Brain stimulation Hemorrhaging Educational institutions

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Kayexalate (Sodium Polystyrene Sulfonate) as a Hallmark and Cause of Gastrointestinal Tract Injury: Two Case Reports and a Review of the Literature

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Academic Forensic Pathology 2014年第2期4卷 235-239页

作者： Palte, Michael J. Barasch, Samuel P. Mandal, Rakesh Brooks, Erin G. University of Wisconsin School of Medicine and Public Health - Medical Scientist Training Program Madison WI United States University of Wisconsin Hospital and Clinics - Pathology and Laboratory Medicine Madison WI United States

Kayexalate (sodium polystyrene sulfonate) is a cation exchange resin that is commonly used for the treatment for hyperkalemia. With the increasing prevalence of type II diabetes mellitus in developed nations, there has been a concordant rise in renal disease and hyperkalemic patients receiving Kayexalate therapy. Gastrointestinal necrosis is a rare but major complication associated with Kayexalate use that has not been previously well characterized in the forensic literature. Kayexalate crystals have a distinctive “mosaic” appearance on hematoxylin and eosin stained sections and a characteristic coloration with periodic acid-Schiff (PAS) and acid-fast stains. As they are relatively easily identified in histologic sections, and may represent a primary or contributory cause of death, it is suggested that forensic pathologists become familiar with these features. We present two cases in which Kayexalate crystals were detected at autopsy. In one case, the crystals were located within the intestinal lumen and mucosa in areas of mucosal ulceration, while in the other, crystals were located on the intestinal serosal surface without apparent mucosal ulceration. We discuss how to interpret the significance of Kayexalate crystals, review prior literature on Kayexalate therapy-related gastrointestinal necrosis, and explain how to notify the Food and Drug Administration of an adverse Kayexalate reaction detected at autopsy. © 2014 Academic Forensic Pathology International.

关键词： Forensic pathology Gastrointestinal necrosis Hyperkalemia Kayexalate Sodium polystyrene sulfonate Therapeutic complication

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