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检索条件"机构=Program in Neuroscience and Medical Scientist Training Program"
515 条 记 录,以下是511-520 订阅
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The Hippo Pathway in Liver Homeostasis and Pathophysiology
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Pathology: Mechanisms of Disease 1000年 第1期16卷 299-322页
作者: Jordan H. Driskill Duojia Pan 2Medical Scientist Training Program University of Texas Southwestern Medical Center Dallas Texas 75390 USA 1Department of Physiology Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas Texas 75390 USA email: Jordan.Driskill@UTSouthwestern.eduDuojia.Pan@UTSouthwestern.edu
Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular organisms to mammals. Genetic studies of...
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An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology
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Vision Science 1000年 第1期9卷 245-267页
作者: Mutahar Andrabi Brian A. Upton Richard A. Lang Shruti Vemaraju 2Science of Light Center Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA 1The Visual Systems Group Abrahamson Pediatric Eye Institute Division of Pediatric Ophthalmology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA email: richard.lang@***shruti.vemaraju@*** 3Molecular and Developmental Biology Graduate Program College of Medicine University of Cincinnati Cincinnati Ohio USA 4Medical Scientist Training Program College of Medicine University of Cincinnati Cincinnati Ohio USA 5Division of Developmental Biology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA 6Department of Ophthalmology College of Medicine University of Cincinnati Cincinnati Ohio USA
We live on a planet that is bathed in daily and seasonal sunlight cycles. In this context, terrestrial life forms have evolved mechanisms that directly harness light energy (plants) or decode light information for ada...
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Obesity, Inflammation, and Cancer
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Pathology: Mechanisms of Disease 1000年 第1期11卷 421-449页
作者: Tuo Deng Christopher J. Lyon Stephen Bergin Michael A. Caligiuri Willa A. Hsueh 2Department of Medicine Weill Cornell Medical College at Cornell University New York New York 10021 1Diabetes Research Center and Center for Bioenergetics Houston Methodist Research Institute Houston Texas 77030 email: Tdeng@*** 4The Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute The Ohio State University Columbus Ohio 43210 3Medical Scientist Training Program and Biomedical Sciences Graduate Program The Ohio State University Columbus Ohio 43210 5The Diabetes and Metabolism Research Center Division of Endocrinology Diabetes and Metabolism Department of Medicine The Ohio State University Columbus Ohio 43210 email: Willa.Hsueh@osumc.edu
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions, including cancer, and is increasingly recognized as a growing cause of preventable cancer risk. Chronic inflammation, a well-known...
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Extrachromosomal DNA: Biogenesis and Functions in Cancer
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Cancer Biology 1000年 第1期8卷 135-153页
作者: Ellis J. Curtis John C. Rose Paul S. Mischel Howard Y. Chang 2Medical Scientist Training Program University of California San Diego La Jolla California USA 1Department of Pathology Stanford University School of Medicine Stanford California USA email: pmischel@stanford.edu 3Center for Personal Dynamic Regulomes Stanford University Stanford California USA email: howchang@stanford.edu 4Sarafan Chemistry Engineering and Medicine for Human Health (Sarafan ChEM-H) Stanford University Stanford California USA 5Howard Hughes Medical Institute Stanford California USA
In cancer, oncogenes can untether themselves from chromosomes onto circular, extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most aggressive forms of cancer of women and men and of adults and c...
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Genetic Disease and Therapy
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Pathology: Mechanisms of Disease 1000年 第1期16卷 145-166页
作者: Theodore L. Roth Alexander Marson 3Innovative Genomics Institute University of California Berkeley California 94720 USA 1Medical Scientist Training Program University of California San Francisco California 94143 USA email: theodore.roth@ucsf.edu 4Gladstone Institutes San Francisco California 94158 USA 2Department of Microbiology and Immunology and Diabetes Center University of California San Francisco California 94143 USA 6Parker Institute for Cancer Immunotherapy San Francisco California 94129 USA 8Helen Diller Family Comprehensive Cancer Center University of California San Francisco California 94158 USA 5Department of Medicine University of California San Francisco California 94143 USA 7Chan Zuckerberg Biohub San Francisco California 94158 USA
Genetic diseases cause numerous complex and intractable pathologies. DNA sequences encoding each human's complexity and many disease risks are contained in the mitochondrial genome, nuclear genome, and microb...
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