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Biodegradable Microfluidic Scaffolds with Tunable Degradation Properties from Amino Alcohol-based Poly(ester amide) Elastomers

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MRS Online Proceedings Library 2011年第1期1299卷 1-6页

作者： Jane Wang Tatiana Kniazeva Carly F. Campbell Robert Langer Jeffrey S. Ustin Jeffrey T. Borenstein Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge USA Biomedical Engineering Charles Stark Draper Laboratory Cambridge USA Program of Polymer Science and Technology Massachusetts Institute of Technology Cambridge USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge USA Trauma Surgery Cleveland MetroHealth Hospital Cleveland USA

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable; the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements.

关键词： biomaterial microelectro-mechanical (MEMS) polymer

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polymeric foams for oral drug delivery. A review

Polymeric foams for oral drug delivery. A review

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9th International Conference on Foam Processing and technology, FOAMS 2011

作者： Terife, Graciela Faridi, Niloufar Wang, Peng Gogos, Costas G. Materials Science and Engineering Program New Jersey Institute of Technology Newark NJ 07102 United States Polymer Processing Institute Newark NJ 07102 United States Department of Chemical Engineering University of Rhode Island Kingston RI 02881 United States Otto York Department of Chemical Biological and Pharmaceutical Engineering New Jersey Institute of Technology Newark NJ 07102 United States

Manufacturing of drug delivery systems through the extrusion process is of great interest in academia and pharmaceutical industry alike. Even though significant amount of research has been conducted in this field, there are still many challenges to be addressed such as: thermal stability of drugs, difficult downstream handling of extrudates and high density of the extrudates. Recently, the foaming process is being seen as an answer for some of these problems. This paper reviews the role of polymeric foams in the manufacture of oral drug delivery systems. A case study analyzing the influence of foaming on the dissolution profile of a polymeric excipient in water is discussed in more detail.

关键词： Thermodynamic stability

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Studies on Nanostructured M50 Type Steel Using X-Ray Absorption Spectroscopy and NMR

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MRS Online Proceedings Library 2011年第1期351卷 195-199页

作者： Mahalingam Balasubramanian Y. D. Zhang J. I. Budnick K. E. Gonsalves T. D. Xiao Department of Physics University of Connecticut Storrs USA Department of Physics and Connecticut Advanced Technology Center for Precision Manufacturing University of Connecticut Storrs USA Polymer Science Program Institute of Materials Science and Department of Chemistry University of Connecticut Storrs USA Connecticut Advanced Technology Center for Precision Manufacturing University of Connecticut Storrs USA

We have investigated the local structural and magnetic properties of Fe in nanostructured Fe-Cr-Mo-V-C M50 type steel. Experimental techniques which we used include XAFS and NMR. NMR results on as-synthesized M50 type steel shows that the material contains a small amount of bcc Fe plus some other highly disordered phase(s). XAFS measurements indicate that the near neighbor coordinations around Fe are not simply well ordered bcc or fcc Fe and that the sample doesn’t have long range crystalline order. XAFS measurements on the consolidated sample show that Fe is predominantly in the form of bcc Fe with good long range order.

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Surfactant-free colloidal crystal of ZnO quantum dots

Surfactant-free colloidal crystal of ZnO quantum dots

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作者： Zhang, Xi Sun, Dazhi Sue, Hung-Jue Polymer Technology Center Materials Science and Engineering Program College Station TX 77843 United States Polymer Technology Center Mechanical Engineering Texas A and M University College Station TX 77843 United States

ISBN: (纸本)9781617387623

Monodisperse ZnO quantum dots (QDs) with a particle size of about 5 nm have been synthesized. Isopropanol together with hexane were utilized to precipitate ZnO nanoparticles to form condensed phases, ranging from white flocculation, to gel-like fluid, and to transparent solid. The morphology and structure in the transparent ZnO solid was characterized by UV-vis, X-ray diffraction, small-angle X-ray scattering, transmission electron microscopy, and scanning electron microscopy. The mechanisms for the formation of transparent ZnO QDs close-packed structure were monitored via UV-vis spectra, and found likely to be a colloidal crystal. The colloidal crystal is transparent and absorbs UV light efficiently. Possible conditions for the formation of the ZnO QDs colloidal crystal are discussed. © 2010 Materials Research Society.

关键词： ZnO nanoparticles

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Curing behavior of polycardanol by MEKP and cobalt naphthenate using differential scanning calorimetry

Curing behavior of polycardanol by MEKP and cobalt naphthena...

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作者： Zhou, Qun Cho, Donghwan Song, Bong Keun Kim, Hyun-Joong Department of Polymer Science and Engineering Kumoh National Institute of Technology Gumi Gyungbuk 730-701 Korea Republic of Korea Research Institute of Chemical Technology Daejeon 305-343 Korea Republic of Program in Environmental Materials Science Seoul National University Seoul 151-921 Korea Republic of

In this study, polycardanol, which was synthesized by enzymatic oxidative polymerization of thermally treated cashew nut shell liquid (CNSL) using fungal peroxidase, was partially or fully cured using methyl ethyl ketone peroxide (MEKP) as initiator and cobalt naphthenate (Co-Naph) as accelerator. The curing behavior of polycardanol was extensively investigated in terms of curing temperature, curing time, concentration of initiator and accelerator, and the monomer-to-polymer conversion of polycardanol by means of differential scanning calorimetry (DSC). The curing behavior significantly depends on the thermal condition given and it was monitored with the change of the exotherms as a function of temperature. The optimal conditions for fully curing polycardanol are 1 wt% MEKP, 0.2 wt% Co-Naph, curing time 120 min, and curing temperature 200 °C. This study suggests that a polycardanol with high monomer-to-polymer conversion would be useful for processing a polycardanol matrix composite under the optimal conditions of curing. © Akadémiai Kiadó, Budapest, Hungary 2009.

关键词： Differential scanning calorimetry

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Surfactant-free Colloidal Crystal of ZnO Quantum Dots

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MRS Online Proceedings Library 2010年第1期1207卷 1-6页

作者： Xi Zhang Dazhi Sun Hung-Jue Sue Polymer Technology Center Materials Science and Engineering Program USA Mechanical Engineering Texas A&M University College Station U.S.A.

关键词： Zn crystal nanostructure

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polymer-clay nanocomposite particles by direct and inverse emulsion polymerization

RSC Nanoscience and Nanotechnology

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RSC Nanoscience and Nanotechnology 2010年 64-77页

作者： Ming, Weihua Voorn, Dirk-Jan Van Herk, Alex M. Nanostructured Polymers Research Center Materials Science Program University of New Hampshire Durham NH 03824 United States Laboratory of Polymer Chemistry Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven Netherlands

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NON-IONIC BLOCK COpolymerS FOR GENE DELIVERY TO THE MYOCARDIUM AND SKELETAL MUSCLE CELLS

NON-IONIC BLOCK COPOLYMERS FOR GENE DELIVERY TO THE MYOCARDI...

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第四届国际高分子化学学术讨论会

作者： Won Jong Kim Ran Namgung Kaushik Singha In-Kyu Park Seongbong Jo Department of Chemistry BK21 Program Polymer Research Institute Pohang University of Science and Technology Department of Biomedical Sciences BK21 Program Chonnam National University Medical School Department of Pharmaceutics School of Pharmacy The University of Mississippi University

The work demonstrates the development of acid-labile temperature-responsive sol–gel reversible polymer for enhanced in vivo myocardium and skeletal muscle gene *** this report,multi-blockcopolymers(MBCPs)synthesized from pluronic and di-(ethylene glycol)divinyl ether(DEGDVE)were used as a delivery vehicle for controlled and sustained release of plasmid DNA(p DNA)in in vitro as well

关键词： NON-IONIC BLOCK COpolymerS FOR GENE DELIVERY TO THE MYOCARDIUM AND SKELETAL MUSCLE CELLS profile

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Preparation of poly(lactic acid) nanoparticles and optimization of the particle size

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International Journal of Green Nanotechnology: Physics and Chemistry 2010年第2期2卷 P100-P109页

作者： Maharana, Tungabidya Mohanty, Bikash Negi, Yuvraj Singh Polymer Science and Technology Program Department of Paper Technology Indian Institute of Technology Roorkee 247667 India Saharanpur 247001 Uttar Pradesh Uttarakhand Saharanpur Campus India Department of Chemical Engineering Indian Institute of Technology Roorkee Roorkee India

This article aims to illustrate an application of the Taguchi method of experimental design (TMED) for the preparation of poly(lactic acid) (PLA) nanoparticles via a nanoprecipitation technique. The effect of four pertinent parameters, such as concentration of PLA, solvent-to-non-solvent (S/NS) volume ratio, molecular weight of PLA, and type of solvent, were studied on the yield and size of nanoparticles. The first two factors were varied at four levels, whereas the last two factors were varied at two levels and sixteen experiments were carried out. The application of TMED for optimization of the essential parameters for nanoprecipitation of PLA nanoparticles has been reported. The optimum condition based on the reduction of sizewas found to be at polymer concentration of 10mg/mL, 0.2 S/NS volume ratio, low-molecular-weight PLA (PLAL), and dimethyl sulfoxide (DMSO) as solvent. The size of PLA nanoparticles obtained was around 100 nm. This case study demonstrates the true power of a well-planned and designed experiment over the traditional varying one-factor-at-a-time approach to experimentation. © Taylor & Francis Group, LLC.

关键词： Nanoprecipitation Polylactic acid Taguchi method Transmission electron microscopy Zeta potential

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SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE-BRANCHED POLYETHYLENIMINE MAGNETOPLEXES FOR GENE TRANSFECTION

SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE-BRANCHED POLYETHYL...

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第四届国际高分子化学学术讨论会

作者： Ran Namgung Kaushik Singha Mi Kyung Yu Sangyong Jon Yong Sook Kim Youngkeun Ahn In-Kyu Park Won Jong Kim Department of Chemistry BK21 Program Polymer Research Institute Pohang University of Science and Technology Department of Life Science GIST Department of Biomedical Sciences Chonnam National University Medical School Centre for Biomedical Human Resources at Chonnam National University

Emergence of gene therapy provides a highly versatile and potent armor in combating various human diseases(1).Irrespective of the vector types,efficient gene transfection demands appreciableconcentration of efficient cell-binding delivery vectors at the target site at the onset of gene *** it is necessary to develop simple,fast and efficient methods or strategies which can expedite

关键词： HUVEC SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE-BRANCHED POLYETHYLENIMINE MAGNETOPLEXES FOR GENE TRANSFECTION

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