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Testing the What Matters to Me workbook in a diverse sample of seriously ill patients and caregivers

PEC Innovation 2023年 3卷 100216-100216页

作者： Fromme, Erik K. Nisotel, Lauren Mendoza, Kimberly Thacker, Ayush Lowery, Kurt Sihlongonyane, Bukiwe DeBartolo, Katherine O. Roessner, Jane Margo, Judy N. Serious Illness Care Program Ariadne Labs Boston MA United States Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer Institute Boston MA United States American Cancer Society Atlanta GA United States Harvard T.H Chan School of Public Health Boston MA United States Brandeis University Waltham MA United States Boston University School of Public Health Boston MA United States The Conversation Project Institute for Healthcare Improvement Boston MA United States Science & Technology Platform Ariadne Labs Boston MA United States

Objectives: We evaluated the What Matters to Me Workbook, a patient-facing version of the Serious Illness Conversation Guide co-created by Ariadne Labs and The Conversation Project. Methods: We purposively recruited diverse seriously ill patients and caregivers in the US. Participants completed the Workbook, a survey, and a semi-structured in-depth interview about their experience. Qualitative analysis of interviews and notes was employed to extract themes. Simple descriptive statistics were employed to analyze eight investigator authored questions. Results: Twenty-nine study participants completed twenty-one interviews and twenty-five surveys. Ratings for safety (3.87/4, SD = 0.43) and acceptability (3.59/4, SD = 0.956) were higher than ratings for ease of use (3.30/4, SD = 0.97) and usefulness (3.24/4, SD = 0.80). Qualitative analysis identified that while the workbook was safe, acceptable, easy to use, and useful, it is more important who is recommending it and how they are explaining it. Conclusion: If presented in the right way by a trustworthy person, the What Matters to Me Workbook can be an easy to use, useful, and safe resource for patients with serious illness and their caregivers. Innovation: The Workbook focuses on serious illness rather than end-of-life and meshes with a clinician-facing conversation guide and a health-system level intervention. © 2023

关键词： Advance care planning Caregivers Communication Goal concordant care Patient education Serious illness

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Author Correction: Regional patterns of wild animal hunting in African tropical forests (Nature Sustainability, (2025), 10.1038/s41893-024-01494-5)

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Nature Sustainability 2025年 1页

作者： Ingram, Daniel J. Froese, Graden Z. L. Carroll, Daire Bürkner, Paul C. Maisels, Fiona Abugiche, Ajonina S. Allebone-Webb, Sophie Balmford, Andrew Cornelis, Daniel Dethier, Marc Dounias, Edmond Ekodeck, Herbert G. Emogor, Charles A. Fa, Julia E. Fonteyn, Davy Ghiurghi, Andrea Greengrass, Elizabeth Kümpel, Noëlle F. Lupo, Karen Muhindo, Jonas Ngandjui, Germain Ngohouani, Gracia Dorielle Sandrin, François Schleicher, Judith Schmitt, Dave N. Vanegas, Liliana Vanthomme, Hadrien P. A. van Vliet, Nathalie Willcox, Adam S. Midoko Iponga, Donald Kemalasari, Della Muchlish, Usman Nasi, Robert Sampurna, Yahya Tarla, Francis Nchembi Willis, Jasmin Scharlemann, Jӧrn P. W. Abernethy, Katharine Coad, Lauren Faculty of Natural Sciences University of Stirling Stirling United Kingdom School of Natural Sciences University of Kent Canterbury United Kingdom School of Life Sciences University of Sussex Brighton United Kingdom Nsombou Abalghe-Dzal Association Makokou Gabon Institut de Recherche en Ecologie Tropicale Centre National de la Recherche Scientifique et Technologique Libreville Gabon Nicholas School of the Environment Duke University DurhamNC United States Department of Biology and Environmental Sciences University of Gothenburg Gothenburg Sweden Gothenburg Global Biodiversity Centre Gothenburg Sweden Department of Statistics TU Dortmund University Dortmund Germany Global Conservation Program Wildlife Conservation Society BronxNY United States Canada-Cameroon Ape Network TorontoON Canada Ecosec Montpellier France Conservation Science Group Department of Zoology and Conservation Research Institute University of Cambridge Cambridge United Kingdom UPR Forêts et Sociétés Campus International de Baillarguet CIRAD Montpellier France Forêts et Sociétés Université de Montpellier CIRAD Montpellier France Consultant Sahara Conservation N’Djaména Chad CEFE Université de Montpellier CNRS EPHE IRD Montpellier France CAR Program Wildlife Conservation Society Bangui Central African Republic Department of Computer Science and Technology University of Cambridge Cambridge United Kingdom Nigeria Program Wildlife Conservation Society Calabar Nigeria Bogor Indonesia Department of Natural Sciences School of Science and the Environment Manchester Metropolitan University Manchester United Kingdom AGRECO G.E.I.E Brussels Belgium Independent researcher London United Kingdom BirdLife International Cambridge United Kingdom Department of Anthropology Southern Methodist University DallasTX United States Independent consultant Yaoundé Cameroon Environmental Change Institute University of Oxford Oxford United Kingdom School of Natural Resources University

Correction to: Nature Sustainabilityhttps://***/10.1038/s41893-024-01494-5, published online 6 January 2025. In the version of the article initially published, the second affiliation for Daniel Ingram, Durrell Institute of Conservation and Ecology (DICE), School of Natural sciences, University of Kent, Canterbury, UK, was mistakenly listed as a present address and has now been amended in the HTML and PDF versions of the article. © The Author(s) 2025.

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The evolution of lithium-ion battery recycling

Nature Reviews Clean Technology

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Nature Reviews Clean technology 2025年第1期1卷

作者： Xiaotu Ma Zifei Meng Yan Wang Marilena Velonia Bellonia Jeffrey Spangenberger Gavin Harper Eric Gratz Elsa Olivetti Renata Arsenault Mechanical and Materials Engineering Department Worcester Polytechnic Institute Worcester MA USA Technology and Policy Program Institute for Data Systems and Society Massachusetts Institute of Technology Cambridge MA USA ReCell Center Argonne National Laboratory Lemont IL USA School of Metallurgy and Materials University of Birmingham Birmingham UK The Faraday Institution Harwell Science and Innovation Campus Didcot UK Ascend Elements Inc. Westborough MA USA Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA USA Ford Ion Park Battery Center of Excellence Romulus MI USA

Demand for lithium-ion batteries (LIBs) is increasing owing to the expanding use of electrical vehicles and stationary energy storage. Efficient and closed-loop battery recycling strategies are therefore needed, which will require recovering materials from spent LIBs and reintegrating them into new batteries. In this Review, we outline the current state of LIB recycling, evaluating industrial and developing technologies. Among industrial technologies, pyrometallurgy can be broadly applied to diverse electrode materials but requires operating temperatures of over 1,000 °C and therefore has high energy consumption. Hydrometallurgy can be performed at temperatures below 200 °C and has material recovery rates of up to 93% for lithium, nickel and cobalt, but it produces large amounts of wastewater. Developing technologies such as direct recycling and upcycling aim to increase the efficiency of LIB recycling and rely on improved pretreatment processes with automated disassembly and cleaner mechanical separation. Additionally, the range of materials recovered from spent LIBs is expanding from the cathode materials recycled with established methods to include anode materials, electrolytes, binders, separators and current collectors. Achieving an efficient recycling ecosystem will require collaboration between recyclers, battery manufacturers and electric vehicle manufacturers to aid the design and automation of battery disassembly lines.

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The unseen invaders: Tracking phylogeographic dynamics and genetic diversity of cryptic Pomacea canaliculata and P. maculata (Golden apple snails) across Taiwan

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Ecology and Evolution 2024年第4期14卷 e11268页

作者： Banerjee, Pritam Dey, Gobinda Maity, Jyoti Prakash Stewart, Kathryn A. Sharma, Raju Kumar Chan, Michael W. Y. Lee, Kuanhsuen Chen, Chien-Yen Department of Environmental Science Policy and Management University of California Berkeley CA United States Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Environmental Science Laboratory Department of Chemistry Biological Laboratory School of Applied Sciences KIIT Deemed to be University Odisha Bhubaneswar India Institute of Environmental Sciences Leiden University Leiden Netherlands Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Earth and Environmental Sciences National Chung Cheng University Chiayi County Min-Hsiung Taiwan Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University Chiayi Taiwan

The cryptic invasion of golden apple snails (Pomacea canaliculata and P. maculata) in Taiwan has caused significant ecological and economical damage over the last few decades, however, their management remains difficult due to inadequate taxonomic identification, complex phylogeny, and limited population genetic information. We aim to understand the current distribution, putative population of origin, genetic diversity, and potential path of cryptic invasion of Pomacea canaliculata and P. maculata across Taiwan to aid in improved mitigation approaches. The present investigation conducted a nationwide survey with 254 samples collected from 41 locations in 14 counties or cities across Taiwan. We identified P. canaliculata and P. maculata based on mitochondrial COI and compared their genetic diversity across Taiwan, as well as other introduced and native countries (based on publicly available COI data) to understand the possible paths of invasion to Taiwan. Based on mitochondrial COI barcoding, sympatric and heterogeneous distributions of invasive P. canaliculata and P. maculata were noted. Our haplotype analysis and mismatch distribution results suggested multiple introductions of P. canaliculata in Taiwan was likely originated directly from Argentina, whereas P. maculata was probably introduced from a single, or a few, introduction event(s) from Argentina and Brazil. Our population genetic data further demonstrated a higher haplotype and genetic diversity for P. canaliculata and P. maculata in Taiwan compared to other introduced regions. Based on our current understanding, the establishment of P. canaliculata and P. maculata is alarming and widespread beyond geopolitical borders, requiring a concerted and expedited national and international invasive species mitigation program. © 2024 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.

关键词： agricultural pest biological invasion DNA barcoding golden apple snails mitochondrial COI Pomacea population genetics

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Refining concept maps as method to assess learning outcomes among engineering students 125

Refining concept maps as method to assess learning outcomes ...

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125th ASEE Annual Conference and Exposition

作者： Ferguson, Sean Michael Foley, Rider W. Eshirow, John Kofi Pollack, Catherine Claire University of Virginia Department of Engineering and Society United States Science Technology and Society Program Department of Engineering and Society University of Virginia United States

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Characterization of halotolerant phosphate-solubilizing rhizospheric bacteria from mangrove (Avicennia sp.) with biotechnological potential in agriculture and pollution mitigation

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Biocatalysis and Agricultural Biotechnology 2024年 55卷

作者： Dey, Gobinda Maity, Jyoti Prakash Banerjee, Pritam Sharma, Raju Kumar Etesami, Hassan Bastia, Tapan Kumar Rath, Prasanta Sukul, Uttara Huang, Hsien-Bin Huang, Kuo-Wei Chen, Chien-Yen Department of Agricultural Chemistry National Taiwan University Taipei 106319 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Chiayi County Ming-Shung 62102 Taiwan Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Rd. Chiayi County Min-Hsiung 62102 Taiwan Environmental Science Laboratory Department of Chemistry Biological Laboratory School of Applied Sciences KIIT Deemed to Be University Odisha Bhubaneswar 751024 India Department of Environmental Science Policy and Management University of California Berkeley CA United States Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Chiayi County Min-Hsiung 62102 Taiwan Department of Soil Science University of Tehran Tehran 31587-77871 Iran Environmental Science Laboratory Department of Chemistry School of Applied Sciences KIIT Deemed to Be University Odisha Bhubaneswar 751024 India Department of Otolaryngology Ditmanson Medical Foundation Chia-Yi Christian Hospital Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University Chiayi 62102 Taiwan

Mangroves represent intricate and ever-changing ecosystems, exhibiting fluctuations in water level, salinity, and nutrient (such as NPK) availability as well as a wide array of unique bacterial communities. Microbial interactions in different components (e.g., tree roots) of the mangrove ecosystem are crucial to understand the ecosystem functioning for potential application in pollution mitigation and agricultural production. This study aimed to isolate phosphate-solubilizing bacteria (PSB) from the rhizosphere sediment of mangrove (Avicennia sp.) in terms of heavy metals (HMs) and salinity tolerance as well as plant growth promoting (PGP) traits, where the effective PSB were used on Brassica chinensis for their seed priming and growth under salinity stress. The effective two PSB isolates were identified by 16S rRNA, where JKD01 and JKD02 were closely related (99%) to Enterobacter cloacae (OQ271412) and Kocuria rhizophila (OQ271413), respectively. Both the strains exhibited phosphate solubilization, IAA, NH_3, and EPS production ability as well as HMs resistant ability where, E. cloacae (OQ271412) and K. rhizophila (OQ271413), are effectively remove the Cu from the water with 33.23% and 27.54%, respectively. The FTIR results showed functional group shifts (carboxyl, phosphate, and amino) in Cu-treated bacterial biomass and intracellular Cu presence, indicating the involvement of Cu in the bio-sorption and intracellular bioaccumulation process, respectively. The findings suggested PSB tolerance to salinity and HMs are present in mangroves, making them a valuable source for isolating effective bacteria to reduce stress in plants, lower HMs accumulation in mangroves, and aid in the bioremediation of HMs-contaminated environments. © 2023

关键词： Bio-priming Copper remediation Heavy metal tolerant Mangrove Phosphate-solubilizing bacteria Salt tolerant

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Computational modeling of potential milciclib derivatives inhibitor-CDK2 binding through global docking and accelerated molecular dynamics simulations

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Informatics in Medicine Unlocked 2022年 33卷

作者： Khanam, Mushira Moin, Abu Tayab Ahmed, Kazi Ahsan Patil, Rajesh B. Ripon Khalipha, Abul Bashar Ahmed, Nafisa Bagchi, Rajat Ullah, Md Asad Ferdoush, Jannatul Islam, Saiful Rudra, Bashudev Department of Genetic Engineering and Biotechnology Faculty of Biological Sciences University of Chittagong Chattogram Bangladesh Department of Biochemistry and Molecular Biology Life Science Faculty Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh Department of Biochemistry and Molecular Biology Faculty of Agriculture Bangladesh Agricultural University Mymensingh Bangladesh Biotechnology Program Department of Mathematics and Natural Sciences School of Data and Sciences BRAC University Dhaka Bangladesh Department of Pharmaceutical Chemistry Sinhgad Technical Education Society's Sinhgad College of Pharmacy Vadgaon (Bk) Maharashtra India Department of Pharmacy Life Science Faculty Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh Department of Biotechnology and Genetic Engineering Faculty of Biological Sciences Jahangirnagar University Savar Dhaka Bangladesh Department of Pharmacology BGC Trust Medical College Chattogram Bangladesh Bangladesh Council of Scientific and Industrial Research (BCSIR) Chattogram Laboratories Chattogram Bangladesh

Hepatocellular carcinoma (HCC) is the most common malignant condition of the liver that occurs as a result of uncontrolled cellular proliferation after a series of disruptions at cell cycle regulatory checkpoints in the normal cell. Due to the lack of appropriate therapeutics or remedial treatment methods, new treatment strategies against HCC need to be developed. Cyclin dependent kinases (CDKs) are required to control the cell cycle and apoptosis, but their overexpressionis critical in the progression of cancer and is often expressed in HCC. Thus, CDKs are considered a promising class of target-defined therapy for HCC. Milciclib is a potential candidate for HCC which exhibits inhibitory activity against CDK2 leading to cell cycle arrest and apoptosis of tumor cells. Herein, we have halogenated the parent drug milciclib to improve its efficacy against CDK2. The primary structure of milciclib (D) was modified with F, Cl and,CF₃ groups. The frontier molecular orbital features, binding affinity, non-bonded interaction and the pharmacokinetic parameters were analyzed for milciclib and its derivatives. We also performed molecular docking and extended molecular dynamics simulation studies to study the binding interactions and binding affinity more closely. Our computational investigation showed the derivatives D-F and D-CF₃ have significant chemical reactivity, the best binding affinity, nonbonding interactions, and improved pharmacokinetic properties compared to the parent drug milciclib. Molecular dynamics analysis and MM-PBSA calculations indicated that D-Cl had a slightly more stable conformation and higher binding affinity compared to D-CF₃. © 2022 The Authors

关键词： Anticancer drug Halogenated derivatives Hepatocellular carcinoma Milciclib Molecular docking Molecular dynamics simulation Non-bond interactions

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Performance of connection joints of beam-column structure using Ultra-high-performance concrete under full-scale tests

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Developments in the Built Environment 2025年 22卷

作者： Aiamsri, Krairerk Yaowarat, Teerasak Horpibulsuk, Suksun Suddeepong, Apichat Buritatum, Apinun Udomchai, Artit Nitichote, Kirati School of Civil Engineering and Construction Management Suranaree University of Technology 111 University Avenue Muang District Nakhon Ratchasima30000 Thailand Undergraduate Program in Civil and Infrastructure Engineering Suranaree University of Technology Nakhon Ratchasima30000 Thailand Center of Excellence in Innovation for Sustainable Infrastructure Development Suranaree University of Technology Nakhon Ratchasima30000 Thailand School of Civil Engineering Suranaree University of Technology Nakhon Ratchasima30000 Thailand Academy of Science The Royal Society of Thailand Bangkok10300 Thailand Institute of Research and Development Suranaree University of Technology Nakhon Ratchasima30000 Thailand The Concrete and Aggregate Products Co. Ltd. Bangkok10800 Thailand

This study examines the application of Ultra-High Performance Concrete (UHPC) in precast beam-column joints to improve structural performance. The studied joints included both adequately and inadequately reinforced conditions (strong and weak joints), constructed using UHPC and deformed rebars. The strong joints allowed the rebars to reach their yield strength under the design bending moment, effectively transferring loads and maintaining structural integrity during service conditions. These well-detailed joints exhibited ductile failure behavior, which is a desired characteristic in reinforced concrete design. In contrast, the weak joints experienced premature and brittle failures, underscoring the importance of proper detailing and reinforcement length. Finally, a practical design scheme was developed to determine the appropriate rebar lengths in UHPC connections to ensure structural integrity and safety. Overall, the integration of UHPC into precast concrete joints significantly enhanced bond performance, improved load transfer mechanisms, and contributed to more resilient and reliable construction practices. © 2025 The Authors

关键词： Ultra-high performance concrete

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Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation

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Journal of Advanced Research 2025年

作者： Vojdani, Aristo Almulla, Abbas F. Vojdani, Elroy Li, Jing Zhang, Yingqian Maes, Michael Immunosciences Lab Inc. Los Angeles 90035 CA United States Cyrex Laboratories LLC Phoenix 85034 AZ United States Sichuan Provincial Center for Mental Health Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610072 China Key Laboratory of Psychosomatic Medicine Chinese Academy of Medical Sciences Chengdu 610072 China Department of Psychiatry Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital the Thai Red Cross Society Bangkok Thailand Medical Laboratory Technology Department College of Medical Technology The Islamic University Najaf Iraq Regenera Medical Los Angeles CA United States Research and Innovation Program for the Development of MU - PLOVDIV– (SRIPD-MUP) Creation of a Network of Research Higher Schools National Plan for Recovery and Sustainability European Union NextGenerationEU United States Department of Psychiatry Medical University of Plovdiv EU Plovdiv Bulgaria Research Center Medical University of Plovdiv EU Plovdiv Bulgaria Kyung Hee University 26 Kyungheedae-ro Dongdaemun-gu Seoul 02447 South Korea

Background: The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). However, the connection between viral reactivation and autoimmune biomarkers has remained unclear. Objectives: To investigate immunoglobulin (Ig)G/IgA/IgM responses targeting myelin-related proteins in association with EBV and HHV-6 replication markers in RRMS. Methods: We recruited 55 patients with RRMS and 63 healthy controls and assessed IgG/IgA/IgM responses against seven myelin-related components, as well as EBV nuclear antigen 1 (EBNA-1) and deoxyuridine-triphosphate nucleotidohydrolase (dUTPases). Disability was evaluated using the Expanded Disability Status Scale (EDSS) and disease progression using the Multiple Sclerosis Severity Score (MSSS). Results: IgG/IgA/IgM levels targeting seven myelin-related proteins were significantly higher in RRMS than in controls. IgG against myelin basic protein (MBP) (IgG-MBP), IgM-myelin-associated glycoprotein (IgM-MAG)-37–60, IgA-MBP, and IgA-myelin-oligodendrocyte-glycoprotein (IgA-MOG-31–55) distinguished RRMS from controls with a predictive accuracy of 96.6 % (sensitivity = 95.7 %, specificity = 95.2 %) and an area under the ROC curve of 0.991. A large part of the variance in the EDSS (around 75 %) and MSSS score (62.8 %) was explained by IgG-MBP, IgM-MBP, IgA-MOG-31–55, and IgM-MAG. Part of the variance (47.4 %) in the IgG/IgA/IgM responses to myelin-related proteins was explained by immune responses to EBNA and dUTPases of EBV and HHV-6. Conclusions: Autoimmune reactivities targeting myelin-related proteins are valuable biomarkers of RRMS and the severity and progression of RRMS. Reactivation of EBV and HHV-6 may trigger or maintain these autoimmune responses thereby impacting disease progression. © 2025

关键词： Autoimmunity Disability Epstein–Barr virus Herpesvirus 6 Inflammation Myelin basic protein

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Skill Assessment of North American Multi-Models Ensemble (NMME) for June-September (JJAS) Seasonal Rainfall over Ethiopia

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Atmospheric and Climate sciences 2022年第1期12卷 54-73页

作者： Asaminew Teshome Jie Zhang Qianrong Ma Stephen E. Zebiak Teferi Demissie Tufa Dinku Asher Siebert Jemal Seid Nachiketa Acharya National Meteorological Agency of Ethiopia Addis Ababa Ethiopia Key Laboratory of Meteorological Disaster Ministry of Education (KLME)/International Joint Research Laboratory of Climate and Environment Change (ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD) Nanjing University of Information Science & Technology (NUIST) Nanjing China International Research Institute for Climate and Society (IRI) The Earth Institute Columbia University New York USA NORCE Norwegian Research Center Bjerknes Center for Climate Research Bergen Norway CGIAR Research Program on Climate Change Agriculture and Food Security (CCAFS) East Africa Addis Ababa Ethiopia Ethiopian Institute of Agricultural Research Addis Ababa Ethiopia Scuola Superiore Sant’Anna Pisa Italy Center for Earth System Modeling Analysis and Data Department of Meteorology and Atmospheric Science Pennsylvania State University University Park PA USA

In recent years, there has been increasing demand for high-resolution seasonal climate forecasts at sufficient lead times to allow response planning from users in agriculture, hydrology, disaster risk management, and health, among others. This paper examines the forecasting skill of the North American Multi-model Ensemble (NMME) over Ethiopia during the June to September (JJAS) season. The NMME, one of the multi-model seasonal forecasting systems, regularly generates monthly seasonal rainfall forecasts over the globe with 0.5 - 11.5 months lead time. The skill and predictability of seasonal rainfall are assessed using 28 years of hindcast data from the NMME models. The forecast skill is quantified using canonical correlation analysis (CCA) and root mean square error. The results show that the NMME models capture the JJAS seasonal rainfall over central, northern, and northeastern parts of Ethiopia while exhibiting weak or limited skill across western and southwestern Ethiopia. The performance of each model in predicting the JJAS seasonal rainfall is variable, showing greater skill in predicting dry conditions. Overall, the performance of the multi-model ensemble was not consistently better than any single ensemble member. The correlation of observed and predicted seasonal rainfall for the better performing models—GFDL-CM2p5-FLOR-A06, CMC2-CanCM4, GFDL-CM2p5-FLOR-B01 and NASA-GMAO-062012—is 0.68, 0.58, 0.52, and 0.5, respectively. The COLA-RSMAS-CCSM4, CMC1- CanCM3 and NCEP-CFSv2 models exhibit less skill, with correlations less than 0.4. In general, the NMME offers

关键词： Ethiopia Ensemble June-September Correlation Coefficient Skill

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