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检索条件"机构=Program in Structural and Computational Biology and Molecular Biophysics"
257 条 记 录,以下是101-110 订阅
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SARS-CoV-2 identified through crystallographic screening and computational docking
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Science Advances 2021年 第16期7卷
作者: Schuller, Marion Correy, Galen J. Gahbauer, Stefan Fearon, Daren Wu, Taiasean Díaz, Roberto Efraín Young, Iris D. Martins, Luan Carvalho Smith, Dominique H. Schulze-Gahmen, Ursula Owens, Tristan W. Deshpande, Ishan Merz, Gregory E. Thwin, Aye C. Biel, Justin T. Peters, Jessica K. Moritz, Michelle Herrera, Nadia Kratochvil, Huong T. Aimon, Anthony Bennett, James M. Neto, Jose Brandao Cohen, Aina E. Dias, Alexandre Douangamath, Alice Dunnett, Louise Fedorov, Oleg Ferla, Matteo P. Fuchs, Martin R. Gorrie-Stone, Tyler J. Holton, James M. Johnson, Michael G. Krojer, Tobias Meigs, George Powell, Ailsa J. Rack, Johannes Gregor Matthias Rangel, Victor L. Russi, Silvia Skyner, Rachael E. Smith, Clyde A. Soares, Alexei S. Wierman, Jennifer L. Zhu, Kang O Brien, Peter Jura, Natalia Ashworth, Alan Irwin, John J. Thompson, Michael C. Gestwicki, Jason E. Von Delft, Frank Shoichet, Brian K. Fraser, James S. Ahel, Ivan Sir William Dunn School of Pathology University of Oxford South Parks Road OxfordOX1 3RE United Kingdom Department of Bioengineering and Therapeutic Sciences University of California San Francisco San FranciscoCA94158 United States Department of Pharmaceutical Chemistry University of California San Francisco San FranciscoCA94158 United States Diamond Light Source Ltd. Harwell Science and Innovation Campus DidcotOX11 0DE United Kingdom Institute for Neurodegenerative Disease University of California San Francisco San FranciscoCA94158 United States Chemistry and Chemical Biology Graduate Program University of California San Francisco San FranciscoCA94158 United States Tetrad Graduate Program University of California San Francisco San FranciscoCA94158 United States Coronavirus Research Group Structural Biology Consortium University of California San Francisco San FranciscoCA94158 United States Biochemistry Department Institute for Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil Helen Diller Family Comprehensive Cancer University of California San Francisco San FranciscoCA94158 United States Centre for Medicines Discovery University of Oxford South Parks Road HeadingtonOX3 7DQ United Kingdom Stanford Synchrotron Radiation Lightsource Slac National Accelerator Center Menlo ParkCA94025 United States Wellcome Centre for Human Genetics University of Oxford Old Road Campus OxfordOX3 7BN United Kingdom National Synchrotron Light Source Ii Brookhaven National Laboratory UptonNY11973 United States Department of Biochemistry and Biophysics University of California San Francisco San FranciscoCA94158 United States Department of Molecular Biophysics and Integrated Bioimaging Lawrence Berkeley National Laboratory BerkeleyCA94720 United States ChemPartner Corporation South San FranciscoCA94080 United States Structural Genomics Consortium University of Oxford Old Road Campus HeadingtonOX3 7DQ United Kingdom School of
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate ribosylation signaling. This enzyme is a promis... 详细信息
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From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis
Osteoarthritis and Cartilage Open
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Osteoarthritis and Cartilage Open 2025年 第3期7卷 100621-100621页
作者: Roberts, Jack B. Rockel, Jason S. Mulders, Rick Capellini, Terence D. Appleton, C. Thomas Phanstiel, Douglas H. Lories, Rik Geurts, Jeroen Ali, Shabana Amanda Bhutani, Nidhi Stone, Laura Cruz-Almeida, Yenisel Jurisica, Igor Boer, Cindy G. Ramos, Yolande F.M. Rice, Sarah J. Kapoor, Mohit Biosciences Institute Newcastle University Newcastle upon Tyne United Kingdom Division of Orthopedics Osteoarthritis Research Program Schroeder Arthritis Institute University Health Network and Krembil Research Institute University Health Network Toronto ON Canada Department of Medical Biophysics and Computer Science University of Toronto Toronto ON Canada Department of Biomedical Data Sciences Section Molecular Epidemiology Leiden University Medical Center Leiden Netherlands Department of Human Evolutionary Biology Harvard University Cambridge MA United States Bone and Joint Institute and Department of Medicine Schulich School of Medicine and Dentistry Western University London Canada Curriculum in Bioinformatics and Computational Biology University of North Carolina Chapel Hill NC United States Laboratory of Tissue Homeostasis and Disease Skeletal Biology and Engineering Research Centre Department of Development and Regeneration KU Leuven Leuven Belgium Division of Rheumatology University Hospitals Leuven Leuven Belgium Rheumatology Department of Musculoskeletal Medicine Lausanne University Hospital and University of Lausanne (CHUV-UNIL) Lausanne Switzerland Bone and Joint Center Henry Ford Health + Michigan State University Health Sciences Detroit MI United States Department of Orthopaedic Surgery Stanford School of Medicine Stanford CA United States Department of Anesthesiology School of Medicine University of Minnesota Minneapolis MN United States Pain Research and Intervention Center of Excellence (PRICE) at the University of Florida Gainesville FL United States Department of Internal Medicine Genomics Medicine Center Erasmus MC University Medical Center Rotterdam Netherlands Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada Department of Surgery University of Toronto Toronto ON Canada
Objective: Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies...
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structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (vol 14, pg 1059, 2018)
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NATURE CHEMICAL biology 2019年 第2期15卷 205-205页
作者: Masureel, Matthieu Zou, Yaozhong Picard, Louis-Philippe van der Westhuizen, Emma Mahoney, Jacob P. Rodrigues, Joao P. G. L. M. Mildorf, Thomas J. Dror, Ron O. Shaw, David E. Bouvier, Michel Pardon, Els Steyaert, Jan Sunahara, Roger K. Weis, William I. Zhang, Cheng Kobilka, Brian K. Department of Molecular and Cellular Physiology Stanford University School of Medicine Stanford USA Geneus Technologies Ltd Chengdu People’s Republic of China Department of Biochemistry Institute for Research in Immunology and Cancer Université de Montreal Montreal Québec Canada Monash Institute for Pharmaceutical Sciences Monash University Victoria Australia Department of Pharmacology University of Michigan Ann Arbor USA Department of Computer Science Stanford University Stanford USA Department of Structural Biology Stanford University Stanford USA D. E. Shaw Research New York USA Dropbox New York USA Department of Computer Science and Institute for Computational and Mathematical Engineering Stanford University Stanford USA Department of Biochemistry and Molecular Biophysics Columbia University New York USA Structural Biology Brussels Vrije Universiteit Brussel Brussels Belgium Structural Biology Research Center VIB Brussels Belgium Department of Pharmacology University of California San Diego School of Medicine La Jolla USA Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh USA
In the version of this paper originally published, the structure for epinephrine shown in Figure 1a was redrawn with an extra carbon. The structure has been replaced in the HTML and PDF versions of the article. The or... 详细信息
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Going Deeper in Cryo Electron Tomography with Neural Networks
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Microscopy and Microanalysis 2017年 第S1期23卷 814-815页
作者: Muyuan Chen Wei Dai Stella Y. Sun Michael F. Schmid Wah Chiu Steven J. Ludtke Graduate Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX Verna Marrs and McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX
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Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease
npj metabolic health and disease
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npj metabolic health and disease 2024年 第1期2卷 15页
作者: Annalise Schweickart Richa Batra Bryan J Neth Cameron Martino Liat Shenhav Anru R Zhang Pixu Shi Naama Karu Kevin Huynh Peter J Meikle Leyla Schimmel Amanda Hazel Dilmore Kaj Blennow Henrik Zetterberg Colette Blach Pieter C Dorrestein Rob Knight Suzanne Craft Rima Kaddurah-Daouk Jan Krumsiek Tri-Institutional Program in Computational Biology & Medicine Weill Cornell Medicine New York NY USA. Department of Physiology and Biophysics Weill Cornell Medicine Institute for Computational Biomedicine Englander Institute for Precision Medicine New York NY USA. Department of Neurology Mayo Clinic Rochester MN USA. Department of Pediatrics University of California San Diego La Jolla CA USA. Department of Microbiology New York University Grossman School of Medicine New York NY USA. Department of Biostatistics and Bioinformatics Duke University Durham NC USA. Tasmanian Independent Metabolomics and Analytical Chemistry Solutions (TIMACS) Hobart TAS Australia. Baker Heart and Diabetes Institute 75 Commercial Road Melbourne VIC Australia. Baker Department of Cardiovascular Research Translation and Implementation La Trobe University Bundoora VIC Australia. Department of Psychiatry and Behavioral Sciences Duke University Durham NC USA. Department of Psychiatry and Neurochemistry University of Gothenburg Gothenburg Sweden. Duke Molecular Physiology Institute Duke University Durham NC USA. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. Departments of Pediatrics Computer Science and Engineering Bioengineering University of California San Diego La Jolla CA USA. Department of Gerontology and Geriatric Medicine Wake Forest University School of Medicine Winston Salem NC USA. Duke Institute of Brain Sciences Duke University Durham NC USA. Department of Medicine Duke University Durham NC USA.
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including a person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affe... 详细信息
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TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (vol 50, pg 83, 2017)
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NATURE GENETICS 2018年 第5期50卷 764-764页
作者: Verma, Nipun Pan, Heng Dore, Louis C. Shukla, Abhijit Li, Qing V. Pelham-Webb, Bobbie Teijeiro, Virginia Gonzalez, Federico Krivtsov, Andrei Chang, Chan-Jung Papapetrou, Eirini P. He, Chuan Elemento, Olivier Huangfu, Danwei Developmental Biology Program Sloan Kettering Institute New York NY USA Weill Graduate School of Medical Sciences at Cornell University/The Rockefeller University/Sloan Kettering Institute Tri-Institutional MD-PhD Program New York NY USA Department of Physiology and Biophysics Englander Institute for Precision Medicine Institute for Computational Biomedicine Weill Cornell Medical College New York NY USA Weill Cornell Graduate School of Medical Sciences Weill Cornell Medical College New York NY USA Department of Chemistry Department of Biochemistry and Molecular Biology Institute for Biophysical Dynamics Howard Hughes Medical Institute University of Chicago Chicago IL USA Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA Cancer Biology and Genetics Program Sloan Kettering Institute New York NY USA Department of Oncological Sciences and Black Family Stem Cell Institute Icahn School of Medicine at Mount Sinai New York NY USA
TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output are diff... 详细信息
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Structuring stress for active materials control
arXiv
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arXiv 2019年
作者: Zhang, Rui Redford, Steven A. Ruijgrok, Paul V. Kumar, Nitin Mozaffari, Ali Zemsky, Sasha Dinner, Aaron R. Vitelli, Vincenzo Bryant, Zev Gardel, Margaret L. de Pablo, Juan J. Pritzker School of Molecular Engineering University of Chicago ChicagoIL60637 United States The graduate program in Biophysical Sciences University of Chicago ChicagoIL60637 United States James Franck Institute University of Chicago ChicagoIL60637 United States Department of Bioengineering Stanford University StanfordCA94305 United States Program in Biophysics Stanford University StanfordCA94305 United States Department of Chemistry University of Chicago ChicagoIL60637 United States Department of Physics University of Chicago ChicagoIL60637 United States Department of Structural Biology Stanford University Medical Center StanfordCA94305 United States Center for Molecular Engineering Argonne National Laboratory LemontIL60439 United States
Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essential functions. Controlling those dyna... 详细信息
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Analyses of protein cores reveal fundamental differences between solution and crystal structures
arXiv
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arXiv 2019年
作者: Mei, Zhe Treado, John D. Grigas, Alex T. Levine, Zachary A. Regan, Lynne O'Hern, Corey S. Integrated Graduate Program in Physical & Engineering Biology Yale University New HavenCT06520 United States Department of Chemistry Yale University New HavenCT06520 United States Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Graduate Program in Computational Biology & Bioinformatics Yale University New HavenCT06520 United States Department of Pathology Yale University New HavenCT06520 United States Department of Molecular Biophysics and Biochemistry Yale University New HavenCT06520 United States Institute of Quantitative Biology Biochemistry and Biotechnology Center for Synthetic and Systems Biology School of Biological Sciences University of Edinburgh Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
There have been several studies suggesting that protein structures solved by NMR spectroscopy and x-ray crystallography show significant differences. To understand the origin of these differences, we assembled a datab... 详细信息
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Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study (vol 15, pg 984, 2018)
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NATURE METHODS 2018年 第11期15卷 984-984页
作者: Hellenkamp, Bjorn Schmid, Sonja Doroshenko, Olga Opanasyuk, Oleg Kuhnemuth, Ralf Adariani, Soheila Rezaei Ambrose, Benjamin Aznauryan, Mikayel Barth, Anders Birkedal, Victoria Bowen, Mark E. Chen, Hongtao Cordes, Thorben Eilert, Tobias Fijen, Carel Gebhardt, Christian Gotz, Markus Gouridis, Giorgos Gratton, Enrico Ha, Taekjip Hao, Pengyu Hanke, Christian A. Hartmann, Andreas Hendrix, Jelle Hildebrandt, Lasse L. Hirschfeld, Verena Hohlbein, Johannes Hua, Boyang Hubner, Christian G. Kallis, Eleni Kapanidis, Achillefs N. Kim, Jae-Yeol Krainer, Georg Lamb, Don C. Lee, Nam Ki Lemke, Edward A. Levesque, Brie Levitus, Marcia McCann, James J. Naredi-Rainer, Nikolaus Nettels, Daniel Thuy Ngo Qiu, Ruoyi Robb, Nicole C. Rocker, Carlheinz Sanabria, Hugo Schlierf, Michael Schroder, Tim Schuler, Benjamin Seidel, Henning Streit, Lisa Thurn, Johann Tinnefeld, Philip Tyagi, Swati Vandenberk, Niels Vera, Andres Manuel Weninger, Keith R. Wunsch, Bettina Yanez-Orozco, Inna S. Michaelis, Jens Seidel, Claus A. M. Craggs, Timothy D. Hugel, Thorsten Institute of Physical Chemistry University of Freiburg Freiburg im Breisgau Germany Engineering and Applied Sciences Columbia University New York NY USA Department of Bionanoscience Kavli Institute of Nanoscience Delft Delft University of Technology Delft the Netherlands Molecular Physical Chemistry Heinrich-Heine-Universität Düsseldorf Düsseldorf Germany Department of Physics and Astronomy Clemson University Clemson SC USA Department of Chemistry University of Sheffield Sheffield UK Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry Aarhus University Aarhus Denmark Physical Chemistry Department of Chemistry Nanosystems Initiative Munich (NIM) Center for Integrated Protein Science Munich (CiPSM) and Center for Nanoscience (CeNS) Ludwig-Maximilians-Universität München Munich Germany Department of Physiology & Biophysics Stony Brook University Stony Brook NY USA Department of Biomedical Engineering University of California Irvine Irvine CA USA Molecular Microscopy Research Group Zernike Institute for Advanced Materials University of Groningen Groningen the Netherlands Physical and Synthetic Biology Faculty of Biology Ludwig-Maximilians-Universität München Planegg-Martinsried Germany Institute for Biophysics Ulm University Ulm Germany Laboratory of Biophysics Wageningen University & Research Wageningen the Netherlands Department of Biomedical Engineering John Hopkins University Baltimore MD USA Department of Physics North Carolina State University Raleigh NC USA B CUBE—Center for Molecular Bioengineering TU Dresden Dresden Germany Laboratory for Photochemistry and Spectroscopy Department of Chemistry University of Leuven Leuven Belgium Dynamic Bioimaging Lab Advanced Optical Microscopy Center and Biomedical Research Institute Hasselt University Hasselt Belgium Institute of Physics University of Lübeck Lübeck Germany Microspectroscopy Research Facility Wageningen Wageningen University & Research Wageningen the Netherla
Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However, generalized protocols and FRET... 详细信息
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Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
arXiv
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arXiv 2018年
作者: Bepler, Tristan Morin, Andrew Brasch, Julia Shapiro, Lawrence Noble, Alex J. Berger, Bonnie Computational and Systems Biology MIT CambridgeMA United States Computer Science and Artificial Intelligence Laboratory MIT CambridgeMA United States Department of Mathematics MIT CambridgeMA United States Department of Biochemistry and Molecular Biophysics Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University NY United States National Resource for Automated Molecular Microscopy Simons Electron Microscopy Center New York Structural Biology Center NY United States
Cryo-electron microscopy (cryoEM) is an increasingly popular method for protein structure determination. However, identifying a sufficient number of particles for analysis (often >100,000) can take months of manual... 详细信息
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