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Communications biology 2020年第1期3卷 676页

作者： Herve Celia Istvan Botos Xiaodan Ni Tara Fox Natalia de Val Roland Lloubes Jiansen Jiang Susan K Buchanan Laboratory of Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 USA. Laboratory of Membrane Proteins and Structural Biology Biochemistry and Biophysics Center National Heart Lung and Blood Institute National Institutes of Health Bethesda MD 20892 USA. Center for Molecular Microscopy Center for Cancer Research National Cancer institute National Institutes of Health Bethesda MD 20892 USA. Cancer Research Technology Program Frederick National Laboratory for Cancer Research Leidos Biomedical Research Inc Frederick MD 21701 USA. Laboratoire d'Ingénierie des Systèmes Macromoléculaires UMR7255 CNRS/Aix-Marseille Université Institut de Microbiologie de la Méditerranée 13402 Marseille Cedex 20 France. Laboratory of Membrane Proteins and Structural Biology Biochemistry and Biophysics Center National Heart Lung and Blood Institute National Institutes of Health Bethesda MD 20892 USA. jiansen.jiang@nih.gov. Laboratory of Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 USA. susan.buchanan2@nih.gov.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

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Nature communications 2022年第1期13卷 7566页

作者： Matthew A Reyna David Haan Marta Paczkowska Lieven P C Verbeke Miguel Vazquez Abdullah Kahraman Sergio Pulido-Tamayo Jonathan Barenboim Lina Wadi Priyanka Dhingra Raunak Shrestha Gad Getz Michael S Lawrence Jakob Skou Pedersen Mark A Rubin David A Wheeler Søren Brunak Jose M G Izarzugaza Ekta Khurana Kathleen Marchal Christian von Mering S Cenk Sahinalp Alfonso Valencia Jüri Reimand Joshua M Stuart Benjamin J Raphael Department of Computer Science Princeton University Princeton NJ 08540 USA. Department of Biomedical Informatics Emory University Atlanta GA 30322 USA. Department of Biomolecular Engineering and UC Santa Cruz Genomics Institute University of California Santa Cruz Santa Cruz CA 95060 USA. Computational Biology Program Ontario Institute for Cancer Research Toronto Ontario Canada. Department of Information Technology IDLab Ghent University IMEC Ghent the Netherlands. Department of Plant Biotechnology and Bioinformatics Ghent University Ghent the Netherlands. Barcelona Supercomputing Center (BSC) Barcelona 08034 Spain. Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim Norway. Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics University of Zurich CH-8057 Zurich Switzerland. Department of Pathology and Molecular Pathology University Hospital Zurich CH-8091 Zurich Switzerland. Department of Physiology and Biophysics Weill Cornell Medicine New York NY 10065 USA. Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H 3Z6 Canada. The Broad Institute of MIT and Harvard Cambridge MA 02124 USA. Massachusetts General Hospital Center for Cancer Research Charlestown MA 02129 USA. Harvard Medical School 250 Longwood Avenue Boston MA 02115 USA. Massachusetts General Hospital Department of Pathology Boston MA 02114 USA. Department of Molecular Medicine (MOMA) Aarhus University Hospital Aarhus Denmark. Bioinformatics Research Centre (BiRC) Aarhus University Aarhus Denmark. Human Genome Sequencing Center Baylor College of Medicine Houston TX 77030 USA. DTU Bioinformatics Department of Bio and Health Informatics Technical University of Denmark Kemitorvet 2800 Kongens Lyngby Denmark. Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences University of Copenhagen 2200 Copenhagen Denmark. De

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Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

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Nature genetics 2023年第6期55卷 1080页

作者： Bernardo Rodriguez-Martin Eva G Alvarez Adrian Baez-Ortega Jorge Zamora Fran Supek Jonas Demeulemeester Martin Santamarina Young Seok Ju Javier Temes Daniel Garcia-Souto Harald Detering Yilong Li Jorge Rodriguez-Castro Ana Dueso-Barroso Alicia L Bruzos Stefan C Dentro Miguel G Blanco Gianmarco Contino Daniel Ardeljan Marta Tojo Nicola D Roberts Sonia Zumalave Paul A Edwards Joachim Weischenfeldt Montserrat Puiggròs Zechen Chong Ken Chen Eunjung Alice Lee Jeremiah A Wala Keiran M Raine Adam Butler Sebastian M Waszak Fabio C P Navarro Steven E Schumacher Jean Monlong Francesco Maura Niccolo Bolli Guillaume Bourque Mark Gerstein Peter J Park David C Wedge Rameen Beroukhim David Torrents Jan O Korbel Iñigo Martincorena Rebecca C Fitzgerald Peter Van Loo Haig H Kazazian Kathleen H Burns Peter J Campbell Jose M C Tubio Department of Zoology Genetics and Physical Anthropology Universidade de Santiago de Compostela Santiago de Compostela Spain. Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain. Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Transmissible Cancer Group Department of Veterinary Medicine University of Cambridge Cambridge UK. The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain. Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK. Genome Data Science Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology (BIST) Barcelona Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA) Barcelona Spain. The Francis Crick Institute London UK. Department of Human Genetics University of Leuven Leuven Belgium. Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon South Korea. Cancer Ageing and Somatic Mutation Programme Wellcome Sanger Institute Cambridge UK. Department of Biochemistry Genetics and Immunology University of Vigo Vigo Spain. Galicia Sur Health Research Institute Vigo Spain. Faculty of Science and Technology University of Vic-Central University of Catalonia (UVic-UCC) Vic Spain. Barcelona Supercomputing Center (BSC) Barcelona Spain. Experimental Cancer Genetics Wellcome Sanger Institute Cambridge UK. Oxford Big Data Institute University of Oxford Oxford UK. DNA Repair and Genome Integrity Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Department of Biochemistry and Molecular Biology Universidade de Santiago de Compostela Santiago de Compostela Spain. Medical R

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LifeTime and improving European healthcare through cell-based interceptive medicine (vol 587, pg 377, 2020)

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NATURE 2021年第7852期592卷 E8-E8页

作者： Rajewsky, Nikolaus Almouzni, Genevieve Gorski, Stanislaw A. Aerts, Stein Amit, Ido Bertero, Michela G. Bock, Christoph Bredenoord, Annelien L. Cavalli, Giacomo Chiocca, Susanna Clevers, Hans De Strooper, Bart Eggert, Angelika Ellenberg, Jan Fernandez, Xose M. Figlerowicz, Marek Gasser, Susan M. Hubner, Norbert Kjems, Jorgen Knoblich, Jurgen A. Krabbe, Grietje Lichter, Peter Linnarsson, Sten Marine, Jean-Christophe Marioni, John C. Marti-Renom, Marc A. Netea, Mihai G. Nickel, Dorthe Nollmann, Marcelo Novak, Halina R. Parkinson, Helen Piccolo, Stefano Pinheiro, Ines Pombo, Ana Popp, Christian Reik, Wolf Roman-Roman, Sergio Rosenstiel, Philip Schultze, Joachim L. Stegle, Oliver Tanay, Amos Testa, Giuseppe Thanos, Dimitris Theis, Fabian J. Torres-Padilla, Maria-Elena Valencia, Alfonso Vallot, Celine van Oudenaarden, Alexander Vidal, Marie Voet, Thierry Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany Charité-Universitätsmedizin Berlin Germany Berlin Institute of Health (BIH) Berlin Germany German Center for Cardiovascular Research (DZHK) Partner Site Berlin Berlin Germany Institute for Biology Humboldt University of Berlin Berlin Germany Cardiovascular and Metabolic Sciences Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany Department of Pediatric Oncology/Hematology Charité-Universitätsmedizin Berlin Berlin Germany Institut Curie CNRS PSL Research University Sorbonne Université Nuclear Dynamics Unit Equipe Labellisée Ligue contre le cancer Paris France VIB Center for Brain and Disease Research Leuven Belgium Department of Human Genetics KU Leuven Leuven Belgium Department of Neurosciences KU Leuven Leuven Belgium UK Dementia Research Institute at UCL University College London London UK Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK Department of Immunology Weizmann Institute of Science Rehovot Israel Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology Barcelona Spain CNAG-CRG Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain Universitat Pompeu Fabra Barcelona Spain ICREA Barcelona Spain CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Department of Laboratory Medicine Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases Vienna Austria Department of Medical Humanities Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands Institute of Human Genetics UMR 9002 CNRS and University of Montpellier Montpellier France Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy Department of Oncology and Hemato

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Neuroscience needs Network Science

arXiv

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arXiv 2023年

作者： Barabási, Dániel L. Bianconi, Ginestra Bullmore, Ed Burgess, Mark Chung, SueYeon Eliassi-Rad, Tina George, Dileep Kovács, István A. Makse, Hernán Papadimitriou, Christos Nichols, Thomas E. Sporns, Olaf Stachenfeld, Kim Toroczkai, Zoltán Towlson, Emma K. Zador, Anthony M. Zeng, Hongkui Barabási, Albert-László Bernard, Amy Buzsáki, György Biophysics Program Harvard University CambridgeMA United States Department of Molecular and Cellular Biology Center for Brain Science Harvard University CambridgeMA United States School of Mathematical Sciences Queen Mary University of London LondonE1 4NS United Kingdom The Alan Turing Institute The British Library LondonNW1 2DB United Kingdom Department of Psychiatry Wolfson Brain Imaging Centre University of Cambridge Cambridge United Kingdom ChiTek-i AS Oslo Norway Center for Neural Science New York University New YorkNY United States Center for Computational Neuroscience Flatiron Institute Simons Foundation New YorkNY United States Network Science Institute Northeastern University BostonMA United States Khoury College of Computer Sciences Northeastern University BostonMA United States Santa Fe Institute Santa FeNM United States DeepMind United Kingdom Department of Physics and Astronomy Northwestern University 633 Clark Street EvanstonIL60208 United States Northwestern Institute on Complex Systems Chambers Hall Northwestern University 600 Foster St EvanstonIL60208 United States Levich Institute and Physics Department City College of New York New YorkNY10031 United States Columbia University New YorkNY10027 United States Big Data Institute Li Ka Shing Centre for Health Information and Discovery Nuffield Department of Population Health University of Oxford OxfordOX3 7LF United Kingdom Wellcome Centre for Integrative Neuroimaging FMRIB Nuffield Department of Clinical Neurosciences University of Oxford OxfordOX3 9DU United Kingdom Department of Psychological and Brain Sciences Indiana University BloomingtonIN47405 United States Department of Physics University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Department of Computer Science Department of Physics and Astronomy Hotchkiss Brain Institute Children’s Research Hospital University of Calgary CalgaryAB Canada Cold Spring Harbor Laboratory

The brain is a complex system comprising a myriad of interacting elements, posing significant challenges in understanding its structure, function, and dynamics. Network science has emerged as a powerful tool for studying such intricate systems, offering a framework for integrating multiscale data and complexity. Here, we discuss the application of network science in the study of the brain, addressing topics such as network models and metrics, the connectome, and the role of dynamics in neural networks. We explore the challenges and opportunities in integrating multiple data streams for understanding the neural transitions from development to healthy function to disease, and discuss the potential for collaboration between network science and neuroscience communities. We underscore the importance of fostering interdisciplinary opportunities through funding initiatives, workshops, and conferences, as well as supporting students and postdoctoral fellows with interests in both disciplines. By uniting the network science and neuroscience communities, we can develop novel network-based methods tailored to neural circuits, paving the way towards a deeper understanding of the brain and its functions. © 2023, CC BY-NC-SA.

关键词： Complex networks

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Mechanismusabhängige Regulation der ultraschnellen Dynamik von Wasser an Grenzflächen in Komplexen mit intrinsisch ungeordneten Proteinen

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Angewandte Chemie 2019年第14期131卷

作者： Aritra Chowdhury Sergey A. Kovalenko Iker Valle Aramburu Piau Siong Tan Nikolaus P. Ernsting Edward A. Lemke Structural and Computational Biology Unit Cell Biology and Biophysics Unit EMBL Meyerhofstraße 1 69117 Heidelberg Deutschland Humboldt Universität Berlin Institut für Chemie Brook-Taylor-Str. 2 12489 Berlin Deutschland Biocenter Mainz Institut für Biologie and Chemie Johannes Gutenberg University Hanns-Dieter-Hüsch-Weg 15 55128 Mainz Deutschland Institute of Molecular Biology 55128 Mainz Deutschland

In diesem Beitrag wird das Zusammenspiel von Dynamik und Molekülerkennung bei intrinsisch ungeordneten Proteinen (IDPs) durch die Anwendung von zeitauflösenden Messtechniken im fs‐ bis ns‐Bereich beleuchtet. Die Konformations‐ und Wasserdynamik an Grenzflächen sowie deren Abschwächung durch die Bindung an ein Partnermolekül wurde anhand zweier IDPs, IBB und Nup153FG, untersucht. Beide Proteine binden an denselben Transportrezeptor (Importinβ), jedoch durch grundlegend verschiedene Bindungsmechanismen. Die Fluktuation des Lösungsmittels an der dynamischen Grenzfläche des Nup153FG‐Importinβ‐Komplexes blieb weitgehend ungestört und beschleunigte sich leicht im Vergleich zum ungebundenen Zustand. Im Gegensatz dazu wurde im IBB‐Importinβ‐Komplex eine beträchtliche relative Verlangsamung der Wasserdynamik an der starreren Grenzfläche beobachtet. Die Ergebnisse zeigen eine Korrelation zwischen der Hydratationsdynamik an Grenzflächen und der Plastizität von IDP‐Komplexen, was eine funktionelle Relevanz einer solchen Regulation impliziert, insbesondere auch für den nukleozytoplasmatischen Transport.

关键词： Intrinsisch ungeordnete Proteine Kernporentransport Protein-Protein-Wechselwirkungen Solvatationsdynamik Zeitaufgelöste Spektroskopie

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Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

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Nature immunology 2025年第4期26卷 635页

作者： Jiacheng He Xiaolei Chai Qiansen Zhang Yang Wang Yijie Wang Xinyu Yang Jingbo Wu Bo Feng Jing Sun Weiwei Rui Shuyin Ze Yuanyuan Fu Yumiao Zhao Ying Zhang Yao Zhang Meizhen Liu Chuang Liu Meifu She Xiangfei Hu Xueyun Ma Huaiyu Yang Dawei Li Senlin Zhao Guichao Li Zhen Zhang Zhonghui Tian Yanlin Ma Lingyan Cao Bo Yi Dali Li Ruth Nussinov Charis Eng Timothy A Chan Eytan Ruppin J Silvio Gutkind Feixiong Cheng Mingyao Liu Weiqiang Lu Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai China. Department of Urology and Department of Pathology The Fifth People's Hospital of Shanghai Fudan University Shanghai China. Department of General Surgery and Department of Pathology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China. Research Center for Complexity Sciences Hangzhou Normal University Hangzhou China. Department of Colorectal Surgery Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China. School of Life Sciences Fudan University Shanghai China. Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research Hainan Provincial Clinical Research Center for Thalassemia Department of Reproductive Medicine Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University) Ministry of Education The First Affiliated Hospital of Hainan Medical University Haikou China. Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University Shanghai China. Department of Gastrointestinal Surgery The Third Xiangya Hospital Central South University Changsha China. Computational Structural Biology Section Basic Science Program Frederick National Laboratory for Cancer Research National Cancer Institute at Frederick Frederick MD USA. Department of Human Molecular Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel Aviv Israel. Genomic Medicine Institute Lerner Research Institute Cleveland Clinic Cleveland OH USA. Department of Molecular Medicine Cleveland Clinic Lerner College of Medicine Case Western Reserve University Cleveland OH USA. Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland OH USA. Center for Immunotherapy and Precision Immuno-Oncology Cleveland Clini

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Correction: Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group's clinical trial E3999

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Blood cancer journal 2023年第1期13卷 103页

作者： Franck Rapaport Kenneth Seier Yaseswini Neelamraju Duane Hassane Timour Baslan Daniel T Gildea Samuel Haddox Tak Lee H Moses Murdock Caroline Sheridan Alexis Thurmond Ling Wang Martin Carroll Larry D Cripe Hugo Fernandez Christopher E Mason Elisabeth Paietta Gail J Roboz Zhuoxin Sun Martin S Tallman Yanming Zhang Mithat Gönen Ross Levine Ari M Melnick Maria Kleppe Francine E Garrett-Bakelman Human Oncology and Pathogenesis Program Molecular Cancer Medicine Service Memorial Sloan Kettering Cancer Center New York NY USA. Center for Clinical and Translational Science The Rockefeller University New York NY USA. Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville VA USA. Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medicine New York NY USA. Cancer Biology and Genetics Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. Division of Hematology and Oncology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Simon Cancer Center Indiana University Indianapolis IN USA. Department of Malignant Hematology & Cellular Therapy Moffitt Cancer Center Tampa FL USA. Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA. Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA. The WorldQuant Initiative for Quantitative Prediction Weill Cornell Medicine New York USA. Montefiore Medical Center Bronx NY USA. Weill Cornell Medicine and The New York Presbyterian Hospital New York NY USA. Dana-Farber Cancer Institute Boston MA USA. Memorial Sloan Kettering Cancer Center New York NY USA. Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville VA USA. fg5q@virginia.edu. Division of Hematology and Medical Oncology Department of Medicine Weill Cornell Medicine New York NY USA. fg5q@virginia.edu. Department of Medicine University of Virginia Charlottesville VA USA. fg5q@virginia.edu. University of Virginia Cancer Center Charlottesville VA USA. fg5q@virginia.edu.

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Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

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Nature immunology 2024年第7期25卷 1307页

作者： Torben Schiffner Ivy Phung Rashmi Ray Adriana Irimia Ming Tian Olivia Swanson Jeong Hyun Lee Chang-Chun D Lee Ester Marina-Zárate So Yeon Cho Jiachen Huang Gabriel Ozorowski Patrick D Skog Andreia M Serra Kimmo Rantalainen Joel D Allen Sabyasachi Baboo Oscar L Rodriguez Sunny Himansu Jianfu Zhou Jonathan Hurtado Claudia T Flynn Katherine McKenney Colin Havenar-Daughton Swati Saha Kaitlyn Shields Steven Schultze Melissa L Smith Chi-Hui Liang Laura Toy Simone Pecetta Ying-Cing Lin Jordan R Willis Fabian Sesterhenn Daniel W Kulp Xiaozhen Hu Christopher A Cottrell Xiaoya Zhou Jennifer Ruiz Xuesong Wang Usha Nair Kathrin H Kirsch Hwei-Ling Cheng Jillian Davis Oleksandr Kalyuzhniy Alessia Liguori Jolene K Diedrich Julia T Ngo Vanessa Lewis Nicole Phelps Ryan D Tingle Skye Spencer Erik Georgeson Yumiko Adachi Michael Kubitz Saman Eskandarzadeh Marc A Elsliger Rama R Amara Elise Landais Bryan Briney Dennis R Burton Diane G Carnathan Guido Silvestri Corey T Watson John R Yates James C Paulson Max Crispin Gevorg Grigoryan Andrew B Ward Devin Sok Frederick W Alt Ian A Wilson Facundo D Batista Shane Crotty William R Schief Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA USA. IAVI Neutralizing Antibody Center The Scripps Research Institute La Jolla CA USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD) The Scripps Research Institute La Jolla CA USA. Institute for Drug Discovery Leipzig University Medical Faculty Leipzig Germany. Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla CA USA. The Ragon Institute of Mass General MIT and Harvard Cambridge MA USA. Department of Integrative Structural and Computational Biology The Scripps Research Institute La Jolla CA USA. Howard Hughes Medical Institute Program in Cellular and Molecular Medicine Boston Children's Hospital Boston MA USA. Department of Genetics Harvard Medical School Boston MA USA. School of Biological Sciences University of Southampton Southampton UK. Department of Molecular Medicine The Scripps Research Institute La Jolla CA USA. Department of Biochemistry and Molecular Genetics University of Louisville School of Medicine Louisville KY USA. Moderna Inc. Cambridge MA USA. Department of Computer Science Dartmouth College Hanover NH USA. Division of Microbiology and Immunology Emory National Primate Research Center Emory University Atlanta GA USA. Department of Microbiology and Immunology Emory School of Medicine Atlanta GA USA. Multi-omics Vaccine Evaluation Consortium The Scripps Research Institute La Jolla CA USA. San Diego Center for AIDS Research The Scripps Research Institute La Jolla CA USA. Department of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta GA USA. Department of Biological Sciences Dartmouth College Hanover NH USA. Generate Biomedicines Inc. Somerville MA USA. IAVI Neutralizing Antibody Center The Scripps Research Institute La Jolla CA USA. wilson@scripps.edu. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD) The Scripps Resear

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A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage

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NPJ vaccines 2025年第1期10卷 107页

作者： Nelson Côrtes Aline Lira Jaqueline D Q Silva Evelyn Carvalho Wasim A Prates-Syed Barbara Hamaguchi Ricardo Durães-Carvalho Andrea Balan Niels O S Câmara Otavio Cabral-Marques Norbert Pardi Ester C Sabino José E Krieger Gustavo Cabral-Miranda Department of Infectious Diseases and Tropical Medicine Laboratory of Medical Investigation 46 Faculty of Medicine University of São Paulo São Paulo Brazil. Department of Immunology Institute of Biomedical Sciences University of São Paulo São Paulo Brazil. Department of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of Sao Paulo São Paulo Brazil. Department of Biophysics São Paulo School of Medicine Federal University of São Paulo São Paulo SP Brazil. Department of Microbiology Immunology and Parasitology São Paulo School of Medicine Federal University of São Paulo (UNIFESP) São Paulo SP Brazil. Department of Morphology and Genetics Federal University of São Paulo São Paulo Brazil. Interunit Bioinformatics Graduate Program Institute of Chemistry University of Sao Paulo Sao Paulo Brazil. Applied Structural Biology Laboratory Institute of Biomedical Sciences University of São Paulo São Paulo Brazil. Department of Medicine Division of Molecular Medicine Laboratory of Medical Investigation 29 Faculty of Medicine University of São Paulo São Paulo Brazil. DO'R Institute for Research São Paulo Brazil. Department of Microbiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Pathology Laboratory of Medical Investigation 46 Faculty of Medicine University of São Paulo São Paulo Brazil. Laboratory of Genetics and Molecular Cardiology Clinical Hospital Faculty of Medicine University of São Paulo Heart Institute São Paulo Brazil. Department of Infectious Diseases and Tropical Medicine Laboratory of Medical Investigation 46 Faculty of Medicine University of São Paulo São Paulo Brazil. gcabral.miranda@usp.br. Department of Immunology Institute of Biomedical Sciences University of São Paulo São Paulo Brazil. gcabral.miranda@usp.br.

Still, Zika virus (ZIKV) infection poses a substantial public health risk, especially for pregnant women and their fetuses, as it can result in congenital abnormalities and fetal mortality during pregnancy. Despite significant advances in understanding and combating ZIKV, considerable challenges remain in the fight against this flavivirus. A crucial component of this effort is the development of vaccines, none of which have yet been licensed for human use. Here, we present a comprehensive study of a novel ZIKV vaccine candidate based on virus-like particles (VLPs), designed to provide broad immunological protection against viral infection combined with safety, without the need for additional adjuvants. A self-adjuvanted VLPs-based vaccine displaying the envelope protein domain III (EDIII) of ZIKV was built. The EDIII protein was expressed in E. coli and chemically conjugated to QβVLPs. Immunization of C57BL/6 mice with two doses of the EDIII-QβVLPs vaccine elicited strong EDIII-specific Th1-based immune response. Notably, the vaccine induced neutralizing antibodies and conferred protection in type I IFN receptor-deficient (G129) mice against ZIKV challenge. Furthermore, vaccinated male mice were protected from ZIKV-induced cerebral and testicular damage, critical concerns for ZIKV pathogenesis. These findings suggest that the EDIII-QβVLP vaccine is a promising candidate for preventing ZIKV infection, with potential applications in combatting this and other emerging flaviviruses.

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