咨询与建议

限定检索结果

文献类型

  • 234 篇 期刊文献
  • 22 篇 会议

馆藏范围

  • 256 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 177 篇 理学
    • 108 篇 生物学
    • 55 篇 化学
    • 25 篇 物理学
    • 15 篇 数学
    • 9 篇 统计学(可授理学、...
    • 2 篇 系统科学
  • 134 篇 工学
    • 44 篇 化学工程与技术
    • 36 篇 生物工程
    • 33 篇 生物医学工程(可授...
    • 26 篇 计算机科学与技术...
    • 18 篇 软件工程
    • 7 篇 光学工程
    • 4 篇 材料科学与工程(可...
    • 4 篇 电子科学与技术(可...
    • 3 篇 机械工程
    • 3 篇 动力工程及工程热...
    • 3 篇 信息与通信工程
    • 3 篇 航空宇航科学与技...
    • 2 篇 力学(可授工学、理...
    • 2 篇 仪器科学与技术
    • 2 篇 电气工程
    • 2 篇 控制科学与工程
    • 2 篇 环境科学与工程(可...
    • 2 篇 食品科学与工程(可...
  • 55 篇 医学
    • 40 篇 基础医学(可授医学...
    • 27 篇 临床医学
    • 14 篇 药学(可授医学、理...
    • 7 篇 公共卫生与预防医...
  • 42 篇 农学
    • 27 篇 作物学
  • 10 篇 管理学
    • 5 篇 管理科学与工程(可...
  • 1 篇 教育学

主题

  • 14 篇 proteins
  • 7 篇 computational bi...
  • 7 篇 rna
  • 6 篇 machine learning
  • 5 篇 dna
  • 5 篇 amino acids
  • 4 篇 bioinformatics
  • 4 篇 molecular dynami...
  • 3 篇 protein engineer...
  • 3 篇 x ray crystallog...
  • 3 篇 structural genom...
  • 3 篇 single-molecule ...
  • 3 篇 mass spectrometr...
  • 3 篇 protein structur...
  • 2 篇 biology computin...
  • 2 篇 lc-ms/ms
  • 2 篇 molecular struct...
  • 2 篇 cancer
  • 2 篇 protein design
  • 2 篇 structure determ...

机构

  • 10 篇 department of in...
  • 7 篇 department of mo...
  • 6 篇 national institu...
  • 6 篇 division of card...
  • 6 篇 department of tw...
  • 6 篇 university of gl...
  • 6 篇 department of mo...
  • 5 篇 atherogenomics l...
  • 5 篇 leeds institute ...
  • 5 篇 center for psych...
  • 5 篇 institute for pa...
  • 5 篇 department of st...
  • 5 篇 university of pi...
  • 5 篇 arnie charbonnea...
  • 5 篇 institute for ca...
  • 5 篇 ilsbio llc bioba...
  • 5 篇 broad genomics b...
  • 5 篇 framingham heart...
  • 5 篇 faculty of biosc...
  • 5 篇 osaka internatio...

作者

  • 7 篇 mark gerstein
  • 6 篇 gerstein mark
  • 6 篇 wah chiu
  • 5 篇 steven j. ludtke
  • 5 篇 eleftheria zeggi...
  • 5 篇 macarthur daniel...
  • 5 篇 warrell jonathan
  • 5 篇 daly mark j.
  • 5 篇 gerstein mark b.
  • 5 篇 alfoldi jessica
  • 5 篇 yingxiao wang
  • 5 篇 karczewski konra...
  • 5 篇 jihye seong
  • 4 篇 timothy m frayli...
  • 4 篇 danish saleheen
  • 4 篇 andrew t hatters...
  • 4 篇 terho lehtimäki
  • 4 篇 andrew r wood
  • 4 篇 veronique vitart
  • 4 篇 caroline hayward

语言

  • 247 篇 英文
  • 4 篇 其他
  • 4 篇 中文
检索条件"机构=Program in Structural and Computational Biology and Molecular Biophysics"
256 条 记 录,以下是11-20 订阅
排序:
Scalable On-Chain Storage and Querying for Biomedical Certificates: A Blockchain Solution for Large Data Handling
SSRN
收藏 引用
SSRN 2024年
作者: Ni, Eric Knight, Elizabeth Gerstein, Mark Program in Computational Biology and Bioinformatics Yale University 100 College Street New HavenCT06511 United States Department of Molecular Biophysics & Biochemistry Yale University 266 Whitney Avenue New HavenCT06511 United States Yale School of Medicine 333 Cedar Street New HavenCT06510 United States
Blockchain technology is gaining increased traction in the biomedical sector due to its ability to improve trust and reduce the risk of fraud and errors in the handling of health data. However, the large volume of bio... 详细信息
来源: 评论
Quantum variational autoencoder utilizing regularized mixed-state latent representations
收藏 引用
Physical Review A 2025年 第4期111卷 042416-042416页
作者: Gaoyuan Wang Jonathan Warrell Prashant S. Emani Mark Gerstein Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut 06520 USA NEC Laboratories America Princeton New Jersey 08540 USA Department of Computer Science Yale University New Haven Connecticut 06520 USA Department of Statistics & Data Science Yale University New Haven Connecticut 06520 USA Department of Biomedical Informatics & Data Science Yale University New Haven Connecticut 06520 USA
A major challenge in near-term quantum computing is its application to large real-world datasets due to scarce quantum hardware resources. One approach to enabling tractable quantum models for such datasets involves f... 详细信息
来源: 评论
Alternatively spliced MAP4 isoforms have key roles in maintaining microtubule organization and skeletal muscle function
收藏 引用
iScience 2024年 第11期27卷 111104页
作者: Lucas, Lathan Nitschke, Larissa Nguyen, Brandon Loehr, James A. Rodney, George G. Cooper, Thomas A. Chemical Physical Structural Biology Graduate Program Baylor College of Medicine Houston TX United States Department of Pathology & Immunology Baylor College of Medicine Houston TX United States Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston TX United States Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX United States University of Otago Te Tari Matai Whaiariaro Department of Physiology Dunedin New Zealand
Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. T... 详细信息
来源: 评论
EspalomaCharge: Machine learning-enabled ultra-fast partial charge assignment
arXiv
收藏 引用
arXiv 2023年
作者: Wang, Yuanqing Pulido, Iván Takaba, Kenichiro Kaminow, Benjamin Scheen, Jenke Wang, Lily Chodera, John D. Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New YorkNY10065 United States Physiology Biophysics and System Biology Ph.D. Program Weill Cornell Medical College Cornell University New YorkNY10065 United States Pharmaceutical Research Center Advanced Drug Discovery Asahi Kasei Pharma Corporation Shizuoka410-2321 Japan Tri-Institutional PhD Program in Computational Biology and Medicine Weill Cornell Medical College Cornell University New YorkNY10065 United States Open Molecular Sciences Foundation DavisCA95618 United States
Atomic partial charges are crucial parameters in molecular dynamics (MD) simulation, dictating the electrostatic contributions to intermolecular energies, and thereby the potential energy landscape. Traditionally, the... 详细信息
来源: 评论
qlty: handling large tensors in scientific imaging deep-learning workflows
arXiv
收藏 引用
arXiv 2024年
作者: Zwart, Petrus H. Center for Advanced Mathematics in Energy Research Applications Lawrence Berkeley National Laboratory 1 Cyclotron Road BerkeleyCA94720 United States Berkeley Synchrotron Infrared Structural Biology program Lawrence Berkeley National Laboratory 1 Cyclotron Road BerkeleyCA94720 United States Molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National Laboratory 1 Cyclotron Road BerkeleyCA94720 United States
In scientific imaging, deep learning has become a pivotal tool for image analytics. However, handling large volumetric datasets, which often exceed the memory capacity of standard GPUs, require special attention when ... 详细信息
来源: 评论
Visualizing cortical blood perfusion after photothrombotic stroke in vivo by needle-shaped beam optical coherence tomography angiography
收藏 引用
PhotoniX 2024年 第1期5卷 605-621页
作者: Xiangyu Guo Jingjing Zhao Liqun Sun Varun Gupta Lin Du Komal Sharma Aidan Van Vleck Kaitlyn Liang Liangcai Cao Lingjie Kong Yuanmu Yang Yong Huang Adam de la Zerda Guofan Jin State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China Department of Structural Biology Stanford University School of MedicineStanford UniversityStanfordCA 94305USA Department of Neurosurgery Stanford University School of MedicineStanford UniversityStanfordCA 94305USA Department of Radiology Stanford University School of MedicineStanford UniversityStanfordCA 94305USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeley 94720USA School of Optics and Photonics Beijing Institute of TechnologyNo.5 South Zhongguancun StreetHaidianBeijing 100081China Biophysics Program Molecular Imaging Programand Bio-X Program at Stanford UniversityStanfordCA 94305USA Chan Zuckerberg Biohub San FranciscoCA 94110USA Institute of Medical Equipment Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China
Optical imaging techniques provide low-cost,non-radiative images with high spatiotemporal resolution,making them advantageous for long-term dynamic observation of blood perfusion in stroke research and other brain stu... 详细信息
来源: 评论
Development of label-free triboelectric nanosensors as screening platforms for anti-tumor drugs
收藏 引用
Nano Energy 2024年 125卷
作者: Cheng, Yu-Ying Ganguly, Anindita Cheng, Yi-Yun Ortiz, Christopher Llynard D. Pal, Arnab Shah, Pramod Kaswan, Kuldeep Yang, Lee-Wei Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Praexisio Taiwan Inc. New Taipei221425 Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu300044 Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Institute of Biological Chemistry Academia Sinica Taipei115 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu300044 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu300044 Taiwan Biomedical Artificial Intelligence PhD Program National Tsing Hua University Hsinchu300044 Taiwan Physics Division National Center for Theoretical Sciences Taipei Taiwan
This study introduces a general label-free drug screening platform with potential to support high-throughput drug screening for any protein target. Its innovation lies in quantifying the affinity of molecule-molecule ... 详细信息
来源: 评论
Variational methods for Learning Multilevel Genetic Algorithms using the Kantorovich Monad
arXiv
收藏 引用
arXiv 2024年
作者: Warrell, Jonathan Alesiani, Francesco Smith, Cameron Mösch, Anja Min, Martin Renqiang NEC Laboratories America Machine Learning Department PrincetonNJ08540 United States Department of Molecular Biophysics and Biochemistry Yale University New HavenCT06520 United States Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States NEC Laboratories Europe Kurfuerstenanlage 36 HeidelbergD-69115 Germany Molecular Pathology Unit Center for Cancer Research Massachusetts General Hospital Research Institute Department of Pathology Harvard Medical School BostonMA United States Broad Institute of MIT and Harvard CambridgeMA United States
Levels of selection and multilevel evolutionary processes are essential concepts in evolutionary theory, and yet there is a lack of common mathematical models for these core ideas. Here, we propose a unified mathemati... 详细信息
来源: 评论
BPS2025 - Sticker strength modulates intrachain vs. interchain tug-of-war in multivalent disordered regions
收藏 引用
Biophysical Journal 2025年 第3期124卷 557a-557a页
作者: David Moses Garrett M. Ginell Alex S. Holehouse Shahar Sukenik Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA USA Department of Biochemistry and Molecular Biophysics Washington University in St. Louis St. Louis MO USA Department of Chemistry Syracuse University Syracuse NY USA
来源: 评论
structural Basis of RNA-Induced Autoregulation of the DExH-type RNA Helicase Maleless
SSRN
收藏 引用
SSRN 2022年
作者: Ankush Jagtap, Pravin Kumar Müller, Marisa Kiss, Anna E. Thomae, Andreas W. Lapouge, Karine Beck, Martin Becker, Peter B. Hennig, Janosch Structural and Computational Biology Unit EMBL Heidelberg Meyerhofstraße 1 Heidelberg69117 Germany Chair of Biochemistry IV Biophysical Chemistry University of Bayreuth Bayreuth Germany Molecular Biology Division Biomedical Center LMU Munich Planegg-Martinsried 82152 Germany Core Facility Bioimaging The Biomedical Center LMU Munich Planegg-Martinsried 82152 Germany Protein Expression and Purification Core Facility EMBL Heidelberg Heidelberg69117 Germany Department of Molecular Sociology Max Planck Institute of Biophysics Frankfurt am Main60438 Germany
Unwinding RNA secondary structures by RNA helicases is essential for RNA metabolism. How the basic unwinding reaction of DExH-type helicases is regulated by their accessory domains is unresolved. Here, we combine stru... 详细信息
来源: 评论