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检索条件"机构=Program in Structural and Computational Biology and Molecular Biophysics"
263 条 记 录,以下是11-20 订阅
排序:
Analytical strategies for studying stem cell metabolism
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Frontiers in biology 2015年 第2期10卷 141-153页
作者: James M. Arnold William T. Choi Arun Sreekumar Mirjana Maletic-Savatic Department of Molecular and Cell Biology Baylor College of Medicine Houston TX 77030 USA Program in Developmental Biology and Medical Scientist Training Program Baylor College of Medicine Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston TX 77030 USA Departments of Pediatrics-Neurology and Neuroscience and Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX 77030 USA
Owing to their capacity for self-renewal and pluripotency, stem cells possess untold potential for revolutionizing the field of regenerative medicine through the development of novel therapeutic strategies for treatin... 详细信息
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Redesign of high-affinity nonspecific nucleases with altered sequence preference
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Journal of the American Chemical Society 2009年 第47期131卷 17345-17353页
作者: Wang, Yi-Ting Wright, Jon D. Doudeva, Lyudmila G. Jhang, Hua-Ci Lim, Carmay Yuan, Hanna S. Institute of Molecular Biology Academia Sinica Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Institute of Chemical Biology and Molecular Biophysics Taiwan International Graduate Program Academia Sinica Taipei Taiwan Institute of Bioinformatics and Structural Biology Department of Chemistry National Tsing Hua University HsinChu Taiwan Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
It is of crucial importance to elucidate the underlying principles that govern the binding affinity and selectivity between proteins and DNA. Here we use the nuclease domain of Colicin E7 (nColE7) as a model system to... 详细信息
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Biomedical data and AI
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Science China Life Sciences 2025年 第5期68卷 1536-1540页
作者: Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I
The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integratin...
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Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks  25
Graph-based information diffusion method for prioritizing fu...
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25th Pacific Symposium on Biocomputing, PSB 2020
作者: Pham, Minh Lichtarge, Olivier Integrative Molecular and Biomedical Sciences Graduate Program Department of Molecular and Human Genetics Baylor College of Medicine One Baylor Plaza HoustonTX77030 United States Departments of Molecular and Human Genetics Structural and Computational Biology and Molecular Biophysics Biochemistry and Molecular Biology and Pharmacology One Baylor Plaza HoustonTX77030 United States
Shortest path length methods are routinely used to validate whether genes of interest are functionally related to each other based on biological network information. However, the methods are computationally intensive,... 详细信息
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Author Correction: DELE1 oligomerization promotes integrated stress response activation
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Nature structural & molecular biology 2025年 第4期32卷 768页
作者: Jie Yang Kelsey R Baron Daniel E Pride Anette Schneemann Xiaoyan Guo Wenqian Chen Albert S Song Giovanni Aviles Martin Kampmann R Luke Wiseman Gabriel C Lander Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA USA. Department of Molecular Medicine Scripps Research La Jolla CA USA. Institute for Neurodegenerative Diseases and Department of Biochemistry and Biophysics University of California San Francisco CA USA. Department of Genetics and Genome Science University of Connecticut Health Center Farmington CT USA. Department of Molecular Medicine Scripps Research La Jolla CA USA. wiseman@scripps.edu. Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA USA. glander@scripps.edu.
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Transgenic mouse models for studying adult neurogenesis
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Frontiers in biology 2016年 第3期11卷 151-167页
作者: Fatih Semerci Mirjana Maletic-Savatic Program in Developmental Biology Baylor College of Medicine Houston TX 77030 USA Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston TX 77030 USA Department of Pediatrics-Neurology Department of Neuroscience and Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX 77030 USA
The mammalian hippocampus shows a remarkable capacity for continued neurogenesis throughout life. Newborn neurons, generated by the radial neural stem cells (NSCs), are important for learning and memory as well as m... 详细信息
来源: 评论
Phytohormone signaling pathway analysis method for comparing hormone responses in plant-pest interactions
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BMC Research Notes 2012年 第1期5卷 1-7页
作者: Studham, Matthew E. MacIntosh, Gustavo C. Bioinformatics and Computational Biology Program Iowa State University Ames IA 50011 United States Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 50011 United States
Background: Phytohormones mediate plant defense responses to pests and pathogens. In particular, the hormones jasmonic acid, ethylene, salicylic acid, and abscisic acid have been shown to dictate and fine-tune defense... 详细信息
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Refinement of NMR-determined protein structures with database derived distance constraints
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Journal of Bioinformatics and computational biology 2005年 第6期3卷 1315-1329页
作者: Cui, Feng Jernigan, Robert Wu, Zhijun Program on Bioinformatics and Computational Biology Iowa State University Ames IA 50011 United States Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 50011 United States Department of Mathematics Program on Bioinformatics and Computational Biology Iowa State University Ames IA 50011 United States
The protein structures determined by NMR (Nuclear Magnetic Resonance Spectroscopy) are not as detailed and accurate as those by X-ray crystallography and are often underdetermined due to the inadequate distance data a... 详细信息
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Predicting dynamic cellular protein-RNA interactions by deep learning using in vivo RNA structures
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细胞研究(英文版) 2021年 第5期31卷 495-516页
作者: Lei Sun Kui Xu Wenze Huang Yucheng T.Yang Pan Li Lei Tang Tuanlin Xiong Qiangfeng Cliff Zhang MOE Key Laboratory of Bioinformatics Beijing Advanced Innovation Center for Structural Biology and Frontier Research Center for Biological StructureCenter for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Program in Computational Biology and Bioinformatics Yale UniversityNew HavenCT 06520USA Department of Molecular Biophysics and Biochemistry Yale UniversityNew HavenCT 06520USA
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular regulation,and dynamically reflect specific cellular ***,presently available tools for predicting RBP-RNA interactions employ RNA... 详细信息
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structural insights into TDP-43 in nucleic-acid binding and domain interactions
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Nucleic Acids Research 2009年 第6期37卷 1799-1808页
作者: Kuo, Pan-Hsien Doudeva, Lyudmila G. Wang, Yi-Ting Shen, Che-Kun James Yuan, Hanna S. Institute of Bioinformatics and Structural Biology National Tsing Hua University Taipei Taiwan Institute of Molecular Biology National Taiwan University Taipei Taiwan Taiwan International Graduate Program Chemical Biology and Molecular Biophysics National Taiwan University Taipei Taiwan Graduate Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degenera...
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