Given their dangerous effects on the nervous system,neurotoxins represent a significant threat to public *** therapeutic approaches,including chelating agents,receptor decoys,and toxin-neutralizing antibodies,have bee...
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Given their dangerous effects on the nervous system,neurotoxins represent a significant threat to public *** therapeutic approaches,including chelating agents,receptor decoys,and toxin-neutralizing antibodies,have been *** prophylactic vaccines are desirable,it is oftentimes difficult to effectively balance their safety and efficacy given the highly dangerous nature of *** address this,we report here on a nanovaccine against neurotoxins that leverages the detoxifying properties of cell membrane-coated nanoparticles.A genetically modified cell line with constitutive overexpression of theα7 nicotinic acetylcholine receptor is developed as a membrane source to generate biomimetic nanoparticles that can effectively and irreversibly bind toα-bungarotoxin,a model *** abrogates the biological activity of the toxin,enabling the resulting nanotoxoid to be safely delivered into the body and processed by the immune *** co-administered with an immunological adjuvant,a strong humoral response againstα-bungarotoxin is generated that protects vaccinated mice against a lethal dose of the ***,this work highlights the potential of using genetic modification strategies to develop nanotoxoid formulations against various biological threats.
Global warming and climate change have become pressing environmental challenges, primarily caused by human activities such as burning fossil fuels and deforestation. These activities release greenhouse gases into the ...
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To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a...
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We describe an undergraduate engineering project to give students hands-on experience and integrate diverse knowledge and skills in robotics, thermal imaging, rapid prototyping, machine learning and artificial intelli...
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The multivariate Spatiooral data challenges the analysts along the navigation and exploration of the information, using Data Analytics techniques. We present SPLORT, as a user-centered web-based solution for segmented...
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Extensive research efforts are currently devoted to developing and improving conventional technologies for water treatment. Membrane-based water treatment technologies are among the most preferred options due to their...
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Extensive research efforts are currently devoted to developing and improving conventional technologies for water treatment. Membrane-based water treatment technologies are among the most preferred options due to their commercial success, simple operation, low energy and space requirements, and high separation efficiency. Despite the advances made in membrane-based technologies, fouling remains a critical challenge. Fouling occurs upon the accumulation of unwanted impurities on the membrane surface and within the membrane pores which results in a significant decline in the membrane permeate flux. To alleviate the operational challenges from fouling, surface modification to develop antifouling membranes appears to be an effective technique. A comprehensive review of the surface modification techniques for the development of antifouling membranes is provided in this paper. Chemical surface modification techniques (grafting and plasma treatment), physical modification techniques (blending, coating, adsorption, and thermal treatment), and combined physical and chemical modification techniques have been discussed. Moreover, the challenges related to surface modification and the future research directions are addressed.
Accurate displacement calculation in the laminated iron cores of electric machines is important for the accurate prediction of noise generation in the electric machines. The authors proposed a modeling method of displ...
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The advantages of the demand control ventilation system(DCV)have been widely discussed in previous research ***,the literature has not addressed the benefits of DCV on controlling indoor CO_(2)concentration and minimi...
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The advantages of the demand control ventilation system(DCV)have been widely discussed in previous research ***,the literature has not addressed the benefits of DCV on controlling indoor CO_(2)concentration and minimizing cooling energy consumption for school buildings located in extremely hot ***,this paper contributes to the development of DCV and mechanical ventilation systems through a comprehensive evaluation of these systems to maintain acceptable indoor air quality(IAQ)while minimizing cooling energy demands for school buildings located in the harsh hot climate of Saudi *** evaluation is based on a calibrated whole-building energy model and validated IAQ predictions using field data obtained from a school case study in *** results of this research study confirm that hourly and sub-hourly monitoring of indoor CO_(2)concentration is required to ensure optimal design and operation of the ventilation systems in *** addition,the analyses indicate that a 13%increase in cooling energy end-use can result for any additional 0.1 students/m^(2)density increase in the ***,the energy penalties related to ventilation needs can be reduced by up to 25%using DCV instead of conventional mechanical ventilation systems for school buildings located in Saudi Arabia’s hot climate.
This paper proposes a method to estimate external forces at the tip of a robot end-effector by using a neural network model. In order to avoid the use of an expensive force sensor in the training purpose, the proposed...
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Synthetic polymer nanoparticles (NPs) with biomimetic properties are ideally suited for different biomedical applications such as drug delivery and direct therapy. However, bulk synthetic approaches can suffer from po...
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