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A genetically engineered neuronal membrane-based nanotoxoid elicits protective immunity against neurotoxins

Bioactive Materials 2024年第8期38卷 321-330页

作者： Zhongyuan Guo Audrey T.Zhu Xiaoli Wei Yao Jiang Yiyan Yu Ilkoo Noh Weiwei Gao Ronnie H.Fang Liangfang Zhang Department of NanoEngineering Chemical Engineering ProgramShu and K.C.Chien and Peter Farrell CollaboratoryUniversity of California San DiegoLa JollaCA92093USA Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA92093USA

Given their dangerous effects on the nervous system,neurotoxins represent a significant threat to public *** therapeutic approaches,including chelating agents,receptor decoys,and toxin-neutralizing antibodies,have been *** prophylactic vaccines are desirable,it is oftentimes difficult to effectively balance their safety and efficacy given the highly dangerous nature of *** address this,we report here on a nanovaccine against neurotoxins that leverages the detoxifying properties of cell membrane-coated nanoparticles.A genetically modified cell line with constitutive overexpression of theα7 nicotinic acetylcholine receptor is developed as a membrane source to generate biomimetic nanoparticles that can effectively and irreversibly bind toα-bungarotoxin,a model *** abrogates the biological activity of the toxin,enabling the resulting nanotoxoid to be safely delivered into the body and processed by the immune *** co-administered with an immunological adjuvant,a strong humoral response againstα-bungarotoxin is generated that protects vaccinated mice against a lethal dose of the ***,this work highlights the potential of using genetic modification strategies to develop nanotoxoid formulations against various biological threats.

关键词： Antivirulence vaccine Cell membrane-coated nanoparticle Genetic engineering α-bungarotoxin Nanotoxoid

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Evaluating Urban Runoff in a Catchment of Güzelyurt: A Comparative Analysis of Traditional and LID Approaches 15th

Evaluating Urban Runoff in a Catchment of Güzelyurt: A Comp...

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15th International Congress on Advances in Civil engineering, ACE 2023

作者： Baig, Mirza Mohammed Abdul Basith Akıntuğ, Bertuğ Sustainable Environment and Energy Systems Graduate Program Middle East Technical University Kalkanlı Güzelyurt99738 Turkey Civil Engineering Program Middle East Technical University Northern Cyprus Campus Kalkanlı Mersin 10 Güzelyurt99738 Turkey

ISBN: (纸本)9789819717804

Global warming and climate change have become pressing environmental challenges, primarily caused by human activities such as burning fossil fuels and deforestation. These activities release greenhouse gases into the atmosphere, disrupting the natural balance of radiation and leading to rising global temperatures. The consequences of global warming include more frequent and severe heatwaves, changes in precipitation patterns, and increased risks of urban flooding. This research focuses on sustainable stormwater management as a strategy to mitigate urban flooding and adapt to climate change. The study area is the city of Güzelyurt in Northern Cyprus, characterized by a flat topography and limited stormwater infrastructure. The existing stormwater network is insufficient and prone to failures during rainfall events. The research compares the effectiveness and efficiency of two approaches: a traditional approach that involves resizing conduits, and a sustainable approach that implements Low-Impact Development (LID) strategies. LID strategies aim to mimic natural hydrological processes and include measures such as green infrastructure, permeable pavements, rainwater harvesting systems, and vegetative swales. By implementing these strategies, stormwater runoff can be controlled, mitigating the risk of flooding, improving water quality, promoting groundwater recharge, and reducing the demand for freshwater resources. The study utilizes the Storm Water Management Model (SWMM) software to design the existing stormwater management network and simulate different scenarios. Through the evaluation of performance and analysis of results, the research results demonstrate that the implementation of LID strategies effectively doubled the existing rainfall handling capacity of the stormwater drainage system from 20 mm/h to 40 mm/h. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Deforestation

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

作者： Hao, Senyue Adkins, Aaron J. Zhang, Yitian Zhou, Chao Department of Electrical & Systems Engineering Washington University Saint Louis United States Imaging Science PhD Program Washington University Saint Louis United States Department of Biomedical Engineering Washington University Saint Louis United States

To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a... 详细信息

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

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engineering EDUCATION PROJECTS: THERMAL IMAGING FOR ROBOTIC JOINING OPERATIONS

ENGINEERING EDUCATION PROJECTS: THERMAL IMAGING FOR ROBOTIC ...

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ASME 2023 International Mechanical engineering Congress and Exposition, IMECE 2023

作者： Mauk, Michael G. Kavitha, Arjuna Karthikeyan Senthilvel Vasudevan, Nijanthan Tseng, Tzu-Liang Bill Chiou1, Richard Y. Department of Engineering Leadership and Society Engineering Technology Program Drexel University PhiladelphiaPA United States Department of Industrial Manufacturing and Systems Engineering University of Texas at El Paso El PasoTX United States

ISBN: (纸本)9780791887653

We describe an undergraduate engineering project to give students hands-on experience and integrate diverse knowledge and skills in robotics, thermal imaging, rapid prototyping, machine learning and artificial intelligence, and plastics engineering, and materials testing. A robot is programmed for ultrasonic welding of 3D-printed or laser-machined plastic parts or soldering of components to printed circuit boards. The process is monitored with a thermal camera, and the infrared images and video are analyzed by machine learning and artificial intelligence algorithms for process optimization, based on criteria tensile strength and pressure leak tests. A pre-trained machine learning model can monitor and analyze the thermal joining processes. © 2023 by ASME.

关键词： Machine learning

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SPLORT: Evaluation of a Web-based Approach for Descriptive and Exploratory Analysis of Multivariate Spatio-temporal Data 21

SPLORT: Evaluation of a Web-based Approach for Descriptive a...

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14th International Symposium on Visual Information Communication and Interaction, VINCI 2021

作者： Feijóo-García, Miguel Alfonso Hernández-Peñalosa, José Tiberio Program of Systems and Computing Engineering Universidad de Los Andes Colombia and Program of Systems Engineering Universidad El Bosque Colombia Program of Systems and Computing Engineering Universidad de Los Andes Colombia

ISBN: (纸本)9781450386470

The multivariate Spatiooral data challenges the analysts along the navigation and exploration of the information, using Data Analytics techniques. We present SPLORT, as a user-centered web-based solution for segmented Visual Analytics. The tool involves a "What-Where-When"pyramidal paradigm to drive Spatiooral analysis towards the findings of new insights. It features multi-layered coordinated views to help the analyst navigate and explore multivariate data simultaneously. We evaluated this web-based tool, and reported the findings and results, considering users' performance and perceptions, basing our analysis on their Likert scale (0-5) responses, regarding their experience and the tool's usability, and the sentiment of their feedback, by using Natural Language Processing (NLP) techniques. Our findings from the pilot study held, suggest that SPLORT successfully allows the users to visually query, explore and analyze contextless multi-scale attributes within space and time, which quickly drives them to new insights and to support easier decision-making processes. Moreover, the tool's flexibility, due to its multi-layered GUI, supports better and more friendly visual analytics. © 2021 ACM.

关键词： Data Analytics

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Surface modification techniques of membranes to improve their antifouling characteristics:recent advancements and developments

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Frontiers of Chemical Science and engineering 2023年第12期17卷 1837-1865页

作者： Muhammad Tawalbeh Haya Aljaghoub Muhammad Qasim Amani Al-Othman Sustainable and Renewable Energy Engineering Department University of SharjahSharjah 27272United Arab Emirates Sustainable Energy&Power Systems Research Centre RISEUniversity of SharjahSharjah 27272United Arab Emirates Industrial Engineering and Engineering Management Department University of SharjahSharjah 27272United Arab Emirates Department of Chemical and Biological Engineering American University of SharjahSharjah 26666United Arab Emirates Materials Science and Engineering Program College of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates

Extensive research efforts are currently devoted to developing and improving conventional technologies for water treatment. Membrane-based water treatment technologies are among the most preferred options due to their commercial success, simple operation, low energy and space requirements, and high separation efficiency. Despite the advances made in membrane-based technologies, fouling remains a critical challenge. Fouling occurs upon the accumulation of unwanted impurities on the membrane surface and within the membrane pores which results in a significant decline in the membrane permeate flux. To alleviate the operational challenges from fouling, surface modification to develop antifouling membranes appears to be an effective technique. A comprehensive review of the surface modification techniques for the development of antifouling membranes is provided in this paper. Chemical surface modification techniques (grafting and plasma treatment), physical modification techniques (blending, coating, adsorption, and thermal treatment), and combined physical and chemical modification techniques have been discussed. Moreover, the challenges related to surface modification and the future research directions are addressed.

关键词： fouling antifouling membrane surface modification membrane pretreatment

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Homogenization Technique of Magnetostriction Calculation in Laminated Iron Core 26

Homogenization Technique of Magnetostriction Calculation in ...

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26th International Conference on Electrical Machines and systems, ICEMS 2023

作者： Gao, Yanhui Fujita, Hiroki Guan, Weimin Muramatsu, Kazuhiro Oita University Intelligent Mechanical Systems Program Oita Japan Wuhan University School of Electrical Engineering and Automation Wuhan China Saga University Department of Electrical and Electronic Engineering Saga Japan

ISBN: (纸本)9798350317589

Accurate displacement calculation in the laminated iron cores of electric machines is important for the accurate prediction of noise generation in the electric machines. The authors proposed a modeling method of displacements due to magnetostriction in the laminated iron core using a homogenization model with equivalent anisotropic magnetic and elastic parameters. The calculated displacements obtained from the homogenization model are compared with those of the real laminated iron core model, and the solid core model neglecting the laminated structure. The homogenization model shows good agreement with the real model. © 2023 IEEE.

关键词： Iron

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Evaluation of the performance of demand control ventilation system for school buildings located in the hot climate of Saudi Arabia

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Building Simulation 2022年第6期15卷 1067-1082页

作者： Alaa Alaidroos Ayad Almaimani Moncef Krarti Ammar Dahlan Rahif Maddah Architectural Engineering Department King Abdulaziz UniversityRabighSaudi Arabia Faculty of Architecture and Planning King Abdulaziz UniversityJeddahSaudi Arabia Building Systems Program University of Colorado BoulderBoulderCOUSA

The advantages of the demand control ventilation system(DCV)have been widely discussed in previous research ***,the literature has not addressed the benefits of DCV on controlling indoor CO_(2)concentration and minimizing cooling energy consumption for school buildings located in extremely hot ***,this paper contributes to the development of DCV and mechanical ventilation systems through a comprehensive evaluation of these systems to maintain acceptable indoor air quality(IAQ)while minimizing cooling energy demands for school buildings located in the harsh hot climate of Saudi *** evaluation is based on a calibrated whole-building energy model and validated IAQ predictions using field data obtained from a school case study in *** results of this research study confirm that hourly and sub-hourly monitoring of indoor CO_(2)concentration is required to ensure optimal design and operation of the ventilation systems in *** addition,the analyses indicate that a 13%increase in cooling energy end-use can result for any additional 0.1 students/m^(2)density increase in the ***,the energy penalties related to ventilation needs can be reduced by up to 25%using DCV instead of conventional mechanical ventilation systems for school buildings located in Saudi Arabia’s hot climate.

关键词： mechanical ventilation demand control ventilation(DCV) indoor air quality(IAQ) CO_(2)concentration energy efficiency school buildings

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Modeling of an external force estimator for an end-effector of a robot by neural networks

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Journal of the Chinese Institute of Engineers, Transactions of the Chinese Institute of Engineers,Series A 2023年第8期46卷 895-904页

作者： Junplod, Goragod Kornmaneesang, Woraphrut Chen, Shyh-Leh Wongsa, Sarawan Department of Control Systems and Instrumentation Engineering King Mongkut’s University of Technology Thonburi Bangkok Thailand International Bachelor Program in Engineering Yuan Ze University Taoyuan Taiwan Department of Mechanical Engineering National Chung Cheng University Chiayi Taiwan Advanced Institute of Manufacturing with High-Tech Innovations National Chung Cheng University Chiayi Taiwan

This paper proposes a method to estimate external forces at the tip of a robot end-effector by using a neural network model. In order to avoid the use of an expensive force sensor in the training purpose, the proposed method implements the indirect training method by including the inverse dynamic model of the robot manipulator to the training algorithm with available information from a default robot system. In this method, the robot dynamics equations are necessary for the training, therefore a disturbance observer is adopted to deal with the existing uncertainties and errors. The performance of the proposed estimation method is evaluated through experiments of a 5-DOF robotic experimental platform, comparing to another existing estimation method using recurrent neural network with a type-1 disturbance observer for the external force estimation. The estimation results show that the behavior of the estimated external forces strongly correlates with the applied external forces and the proposed method is superior to the other method. © 2023 The Chinese Institute of Engineers.

关键词： Recurrent neural networks

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One-step flow synthesis of size-controlled polymer nanogels in a fluorocarbon microfluidic chip

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RSC Advances 2024年第16期14卷 11258-11265页

作者： Montalbo, Reynaldo Carlos K. Wu, Meng-Jie Tu, Hsiung-Lin Institute of Chemistry Academia Sinica Taipei11529 Taiwan Nanoscience and Technology Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan Department of Engineering and System Science National Tsing-Hua University Hsinchu300044 Taiwan Department of Chemistry National Cheng-Kung University Tainan70101 Taiwan Genome and Systems Biology Degree Program Academia Sinica and National Taiwan University Taiwan

Synthetic polymer nanoparticles (NPs) with biomimetic properties are ideally suited for different biomedical applications such as drug delivery and direct therapy. However, bulk synthetic approaches can suffer from poor reproducibility and scalability when precise size control or multi-step procedures are required. Herein, we report an integrated microfluidic chip for the synthesis of polymer NPs. The chip could sequentially perform homopolymer synthesis and subsequent crosslinking into NPs without intermediate purification. This was made possible by fabrication of the chip with a fluorinated elastomer and incorporation of two microfluidic mixers. The first was a long channel with passive mixing features for the aqueous RAFT synthesis of stimuli-responsive polymers in ambient conditions. The polymers were then directly fed into a hydrodynamic flow focusing (HFF) junction that rapidly mixed them with a crosslinker solution to produce NPs. Compared to microfluidic systems made of PDMS or glass, our chip had better compatibility and facile fabrication. The polymers were synthesized with high monomer conversion and the NP size was found to be influenced by the flow rate ratio between the crosslinker solution and polymer solution. This allowed for the size to be predictably controlled by careful adjustment of the fluid flow rates. The size of the NPs and their stimuli-responses were studied using DLS and SEM imaging. This microfluidic chip design can potentially streamline and provide some automation for the bottom-up synthesis of polymer NPs while offering on-demand size control. © 2024 The Royal Society of Chemistry.

关键词： Microfluidic chips

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