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25th Annual computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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26th Annual computational Neuroscience Meeting (CNS*2017) of the Organization for computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder (vol 6, 22851, 2016)

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SCIENTIFIC REPORTS 2016年第1期6卷 22851-22851页

作者： Lima, Leandro de Araujo Feio-dos-Santos, Ana Cecilia Belangero, Sintia Iole Gadelha, Ary Bressan, Rodrigo Affonseca Salum, Giovanni Abrahao Pan, Pedro Mario Moriyama, Tais Silveira Graeff-Martins, Ana Soledade Tamanaha, Ana Carina Alvarenga, Pedro Krieger, Fernanda Valle Fleitlich-Bilyk, Bacy Jackowski, Andrea Parolin Brietzke, Elisa Sato, Joao Ricardo Polanczyk, Guilherme Vanoni Mari, Jair de Jesus Manfro, Gisele Gus do Rosario, Maria Conceiao Miguel, Euripedes Constantino Puga, Renato David Tahira, Ana Carolina Souza, Viviane Neri Chile, Thais Gouveia, Gisele Rodrigues Simoes, Sergio Nery Chang, Xiao Pellegrino, Renata Tian, Lifeng Glessner, Joseph T. Hashimoto, Ronaldo Fumio Rohde, Luis Augusto Sleiman, Patrick M. A. Hakonarson, Hakon Brentani, Helena Inter-institutional Grad Program on Bioinformatics University of São Paulo São Paulo SP Brazil Center for Applied Genomics The Children’s Hospital of Philadelphia Philadelphia PA USA Department & Institute of Psychiatry University of São Paulo Medical School São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre RS Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil Department & Institute of Psychiatry University of São Paulo Medical School São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil Department & Institute of Psychiatry University of São Paulo Medical School São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) São Paulo SP Brazil Department of Psychiatry Federal University of São Paulo São Paulo SP Brazil Department & Institute of Psychiatry University of S

Many studies have attempted to investigate the genetic susceptibility of Attention-Deficit/Hyperactivity Disorder (ADHD), but without much success. The present study aimed to analyze both single-nucleotide and copy-number variants contributing to the genetic architecture of ADHD. We generated exome data from 30 Brazilian trios with sporadic ADHD. We also analyzed a Brazilian sample of 503 children/adolescent controls from a High Risk Cohort Study for the Development of Childhood Psychiatric Disorders, and also previously published results of five CNV studies and one GWAS meta-analysis of ADHD involving children/adolescents. The results from the Brazilian trios showed that cases with de novo SNVs tend not to have de novo CNVs and vice-versa. Although the sample size is small, we could also see that various comorbidities are more frequent in cases with only inherited variants. Moreover, using only genes expressed in brain, we constructed two “in silico” protein-protein interaction networks, one with genes from any analysis, and other with genes with hits in two analyses. Topological and functional analyses of genes in this network uncovered genes related to synapse, cell adhesion, glutamatergic and serotoninergic pathways, both confirming findings of previous studies and capturing new genes and genetic variants in these pathways.

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Cooperative networked systems: Multiple graphs, coalitional games, new probabilistic models

Cooperative networked systems: Multiple graphs, coalitional ...

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Mediterranean Conference on Control and Automation

作者： Baras, John S. Applied Mathematics Statistics and Scientific Computation Program Institute for Systems Research University of Maryland College Park United States

ISBN: (纸本)9781457701252

Networked systems are ubiquitous. A taxonomy of networked systems includes infrastructure and communication networks, social and economic networks, biological networks and biological swarms, robotic swarms, and several other categories. Most networked systems include physical components and cyber components implemented in various ways. Thus many networked systems come from the domain of cyberphysical systems (CPS). Cooperative networked systems represent from a certain abstract point of view a distributed and (at least partially) asynchronous implementation of the well known cycle "sense-decide-actuate" of control systems. Yet the interaction of dynamics, sensing, control and decision making, with network structures has created the need for a new scientific basis for the modeling, analysis, design and performance evaluation of such networked systems. For example, efforts to develop a new "Network Science" have emerged. Similarly, efforts to develop new theories of computation that emphasize multiple agents interacting over networks, beyond the conventional concepts and principles of computation and computability, have been also undertaken very recently. In another direction, several efforts have been undertaken very recently to develop models for such systems that integrate continuous and event-triggered dynamics within a framework that permits validation and testing of correctness. Thus the consideration of cooperative networked systems have raised fundamental new questions and challenges. © 2011 IEEE.

关键词： Decision making

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Estimating functional agent-based models: An application to bid shading in online markets format 11

Estimating functional agent-based models: An application to ...

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13th Annual Genetic and Evolutionary computation Conference - Companion Publication, GECCO 2011 Companion

作者： Guo, Wei Jank, Wolfgang Rand, William Applied Mathematics and Statistics and Scientific Computation Program Department of Mathematics University of Maryland College Park MD United States Department of Decision Operations and Information Technology Robert H. Smith School of Business University of Maryland College Park MD United States Department of Marketing Robert H. Smith School of Business University of Maryland College Park MD United States

ISBN: (纸本)9781450306904

Bid shading is a common strategy in online auctions to avoid the "winner's curse". While almost all bidders shade their bids, at least to some degree, it is impossible to infer the degree and volume of shaded bids directly from observed bidding data. In fact, most bidding data only allows us to observe the resulting price process, i.e. whether prices increase fast (due to little shading) or whether they slow down (when all bidders shade their bids). In this work, we propose an agent-based model that simulates bidders with different bidding strategies and their interaction with one another. We calibrate that model (and hence estimate properties about the propensity and degree of shaded bids) by matching the emerging simulated price process with that of the observed auction data using genetic algorithms. From a statistical point of view, this is challenging because we match functional draws from simulated and real price processes. We propose several competing fitness functions and explore how the choice alters the resulting ABM calibration. We apply our model to the context of eBay auctions for digital cameras and show that a balanced fitness function yields the best results. © 2011 ACM.

关键词： Calibration

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Parsimonious reconstruction of network evolution

Parsimonious reconstruction of network evolution

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Lecture Notes in Computer Science

作者： Patro, Rob Sefer, Emre Malin, Justin Marçais, Guillaume Navlakha, Saket Kingsford, Carl Center for Bioinformatics and Computational Biology University of Maryland College Park MD 20742 United States Department of Computer Science University of Maryland College Park MD 20742 United States Computational Biology Bioinformatics and Genomics Concentration Biological Sciences Graduate Program University of Maryland College Park MD 20742 United States Program in Applied Mathematics Statistics and Scientific Computation University of Maryland College Park MD 20742 United States School of Computer Science Carnegie Mellon University Pittsburgh PA 15213 United States

ISBN: (纸本)9783642230370

We consider the problem of reconstructing a maximally parsimonious history of network evolution under models that support gene duplication and loss and independent interaction gain and loss. We introduce a combinatorial framework for encoding network histories, and we give a fast procedure that, given a set of duplication histories, in practice finds network histories with close to the minimum number of interaction gain or loss events. In contrast to previous studies, our method does not require knowing the relative ordering of unrelated duplication events. Results on simulated histories suggest that common ancestral networks can be accurately reconstructed using this parsimony approach. © 2011 Springer-Verlag.

关键词： Genes

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Representing GASPEC with the world gas model

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Energy Journal 2009年第SPECIAL ISSUE 1期30卷 97-118页

作者： Egging, Ruud Holz, Franziska Von Hirschhausen, Christian Gabriel, Steven A. 1143 Glenn L. Martin Hall Dept of Civil and Environmental Engineering University of Maryland College Park MD 20742-3021 United States DIW Berlin 10117 Berlin Mohrenstr. 58 Germany Chair of Energy Economics and Public Sector Management TU Dresden 01062 Dresden Germany Applied Mathematics and Scientific Computation Program University of Maryland College Park MD 20742 United States

This paper presents results of simulating a more collusive behavior of a group of natural gas producing and exporting countries, sometimes called GASPEC. We use the World Gas Model, a dynamic, strategic representation of world gas production, trade, and consumption between 2005 and 2030. In particular, we simulate a closer cooperation of the GASPEC countries when exporting pipeline gas and liquefied natural gas;we also run a more drastic scenario where GASPEC countries deliberately hold back production. The results show that compared to our Base Case, a gas cartel would reduce total supplied quantities and induce price increases in gas importing countries up to 22%. There is evidence that the natural gas markets in Europe and North America would be affected more than other parts of the world. Lastly, the vulnerability of gas importers worldwide is further illustrated by the results of a sensitivity case in which price levels are up to 87% higher in Europe and North America. Copyright © 2009 by the IAEE. All rights reserved.

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On the relationship between forecast accuracy and detection performance: An application to biosurveillance

On the relationship between forecast accuracy and detection ...

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IEEE Conference on Technologies for Homeland Security

作者： Thomas Lotze Galit Shmueli Applied Mathematics and Scientific Computation Program University of Maryland College Park MD USA Department of Decision Operations & Information Technologies and Center for Health and Information Decision Systems University of Maryland College Park MD USA

While many methods have been proposed for detecting disease outbreaks from pre-diagnostic data, their performance is usually not well understood. In this paper, we describe the relationship between forecast accuracy and the detection accuracy of a method. We argue that most existing temporal detection methods for biosurveillance can be characterized as a forecasting component coupled with a monitoring/detection component. We show that improved forecasting results in improved detection and we quantify the relationship between forecast accuracy and detection metrics under different scenarios. The forecast accuracy can then be used to rate an algorithm's expected performance in detecting outbreaks. Simulation is used to compare empirical performance with theoretical results; we also show examples with authentic biosurveillance data.

关键词： Control charts Yttrium Educational institutions Diseases Signal generators Bioinformatics Probability Condition monitoring Error correction Statistics

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A family of growth models for representing the price process in online auctions 07

A family of growth models for representing the price process...

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Proceedings of the ninth international conference

作者： Hyde, Valerie Jank, Wolfgang Shmueli, Galit Applied Mathematics and Scientific Computation Program University of Maryland College Park MD 20742 Decision and Information Technologies Department Robert H. Smith School of Business University of Maryland College Park MD 20742

ISBN: (纸本)1595937005

Bids during an online auction arrive at unequally-spaced discrete time points. Our goal is to capture the entire continuous price-evolution function by representing it as a functional object. Various nonparametric smoothing methods exist to recover the functional object from the observed discrete bid data. Previous studies use penalized polynomial and monotone smoothing splines;however, these require the determination and storage of a large number of coefficients and often lengthy computational time. We present a family of parametric growth curves that describe the price-evolution during online auctions. This approach is parsimonious and has an appealing interpretation in the online auction context. We also provide an automated fitting algorithm that is computationally fast. Methods are illustrated using eBay data. Copyright 2007 ACM.

关键词： Cost accounting

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Resonant responses to variance modulation in stochastic integrate-and-fire neurons

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BMC Neuroscience 2007年第2期8卷 1-1页

作者： Joanna Pressley Todd W Troyer Applied Mathematics and Scientific Computation Program University of Maryland College Park MD 20742 USA Neuroscience and Cognitive Science Program University of Maryland College Park MD 20742 USA Department of Psychology University of Maryland College Park MD 20742 USA

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