Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional (3D) structure of proteins and other biologically significant complexes at near-atomic resol...
Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional (3D) structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging method that does not require crystallization and can capture molecules in their native states. In single-particle cryo-EM, the 3D molecular structure needs to be determined from many noisy 2D tomographic projections of individual molecules, whose orientations and positions are unknown. The high level of noise and the unknown pose parameters are two key elements that make reconstruction a challenging computational problem. Even more challenging is the inference of structural variability and flexible motions when the individual molecules being imaged are in different conformational states. This review discusses computational methods for structure determination by single-particle cryo-EM and their guiding principles from statistical inference, machine learning, and signal processing, which also play a significant role in many other data science applications.
This volume contains the papers selected for presentation at IPCO 2002, the NinthInternationalConferenceonIntegerprogrammingandCombinatorial- timization, Cambridge, MA (USA), May 27–29, 2002. The IPCO series of c- fe...
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ISBN:
(数字)9783540478676
ISBN:
(纸本)9783540436768
This volume contains the papers selected for presentation at IPCO 2002, the NinthInternationalConferenceonIntegerprogrammingandCombinatorial- timization, Cambridge, MA (USA), May 27–29, 2002. The IPCO series of c- ferences highlights recent developments in theory, computation, and application of integer programming and combinatorial optimization. IPCO was established in 1988 when the ?rst IPCO program committee was formed. IPCO is held every year in which no International Symposium on Ma- ematical programming (ISMP) takes places. The ISMP is triennial, so IPCO conferences are held twice in every three-year period. The eight previous IPCO conferences were held in Waterloo (Canada) 1990, Pittsburgh (USA) 1992, Erice (Italy) 1993, Copenhagen (Denmark) 1995, Vancouver (Canada) 1996, Houston (USA) 1998, Graz (Austria) 1999, and Utrecht (The Netherlands) 2001. In response to the call for papers for IPCO 2002, the program committee received 110 submissions, a record number for IPCO. The program committee met on January 7 and 8, 2002, in Aussois (France), and selected 33 papers for inclusion in the scienti?c program of IPCO 2002. The selection was based on originality and quality, and re?ects many of the current directions in integer programming and combinatorial optimization research.
This IMA Volume in mathematics and its Applications MULTIDIMENSIONAL HYPERBOLIC PROBLEMS AND COMPUTATIONS is based on the proceedings of a workshop which was an integral part ofthe 1988-89 IMA program on NONLINEAR WAV...
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ISBN:
(数字)9781461391210
ISBN:
(纸本)9781461391234
This IMA Volume in mathematics and its Applications MULTIDIMENSIONAL HYPERBOLIC PROBLEMS AND COMPUTATIONS is based on the proceedings of a workshop which was an integral part ofthe 1988-89 IMA program on NONLINEAR WAVES. We are grateful to the Scientific Commit tee: James Glimm, Daniel Joseph, Barbara Keyfitz, Andrew Majda, Alan Newell, Peter Olver, David Sattinger and David Schaeffer for planning and implementing an exciting and stimulating year-long program. We especially thank the Work shop Organizers, Andrew Majda and James Glimm, for bringing together many of the major figures in a variety of research fields connected with multidimensional hyperbolic problems. A vner Friedman Willard Miller PREFACE A primary goal of the IMA workshop on Multidimensional Hyperbolic Problems and Computations from April 3-14, 1989 was to emphasize the interdisciplinary nature of contemporary research in this field involving the combination of ideas from the theory of nonlinear partial differential equations, asymptotic methods, numerical computation, and experiments. The twenty-six papers in this volume span a wide cross-section of this research including some papers on the kinetic theory of gases and vortex sheets for incompressible flow in addition to many papers on systems of hyperbolic conservation laws. This volume includes several papers on asymptotic methods such as nonlinear geometric optics, a number of articles applying numerical algorithms such as higher order Godunov methods and front tracking to physical problems along with comparison to experimental data, and also several interesting papers on the rigorous mathematical theory of shock waves.
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