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检索条件"机构=Program of Bioinformatics and Computational Biology"
532 条 记 录,以下是21-30 订阅
排序:
Refinement of NMR-determined protein structures with database derived distance constraints
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Journal of bioinformatics and computational biology 2005年 第6期3卷 1315-1329页
作者: Cui, Feng Jernigan, Robert Wu, Zhijun Program on Bioinformatics and Computational Biology Iowa State University Ames IA 50011 United States Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 50011 United States Department of Mathematics Program on Bioinformatics and Computational Biology Iowa State University Ames IA 50011 United States
The protein structures determined by NMR (Nuclear Magnetic Resonance Spectroscopy) are not as detailed and accurate as those by X-ray crystallography and are often underdetermined due to the inadequate distance data a... 详细信息
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Network-based method to infer the contributions of proteins to the etiology of drug side effects
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Frontiers of Electrical and Electronic Engineering in China 2015年 第3期10卷 124-134页
作者: Rui Li (1) Ting Chen (1) (2) Shao Li (1) 1.MOE Key Laboratory of Bioinformatics and Bioinformatics Division TNLIST Department of Automation Tsinghua University Beijing 100084 China 2.Program in Computational Biology and Bioinformatics University of Southern California Los Angeles CA 90089 USA
Studying the molecular mechanisms that underlie the relationship between drugs and the side effects they produce is critical for drug discovery and drug development. Currently, however, computational methods are still... 详细信息
来源: 评论
Characterizing Emergency Department Care for Patients With Histories of Incarceration
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JACEP Open 2025年 第1期6卷 100022-100022页
作者: Huang, Thomas Socrates, Vimig Ovchinnikova, Polina Faustino, Isaac Kumar, Anusha Safranek, Conrad Chi, Ling Wang, Emily A. Puglisi, Lisa Wong, Ambrose H. Wang, Karen H. Taylor, R. Andrew Department of Emergency Medicine Yale School of Medicine New Haven CT United States Department for Biomedical Informatics and Data Science Yale University School of Medicine New Haven CT United States Program of Computational Biology and Bioinformatics Yale University New Haven CT United States SEICHE Center for Health and Justice Yale School of Medicine New Haven CT United States Equity Research and Innovation Center Yale School of Medicine Yale University New Haven CT United States
Objectives: Patients with a history of incarceration experience bias from health care team members, barriers to privacy, and a multitude of health care disparities. We aimed to assess care processes delivered in emerg... 详细信息
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Convergent Usage of Amino Acids in Human Cancers as A Reversed Process of Tissue Development
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Genomics, Proteomics & bioinformatics 2022年 第1期20卷 147-162页
作者: Yikai Luo Han Liang Graduate Program in Quantitative and Computational Biosciences Baylor College of MedicineHoustonTX 77030USA Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA
Genome-and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution,but its characteristics and implication in cancer evolution and therapy remain lar... 详细信息
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A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
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Genome Medicine 2025年 第1期17卷 1-19页
作者: Wang, Jiawei Liu, Yujing Li, Hongyu Nguyen, Tuan P. Soto-Vargas, John Lee Wilson, Rashaun Wang, Weiwei Lam, TuKiet T. Zhang, Chi Lin, Chen Wolf, Erika J. Williamson, Douglas E. Ursano, Robert Stein, Thor DiSano, Krista Schnurr, Paula Scott, William K. Pierce, Meghan Montalvo-Ortiz, Janitza Noller, Crystal Miller, Mark W. Marx, Brian McKee, Ann Logue, Mark W. Keane, Terence M. Labadorf, Adam T. Kaye, Alfred Huber, Bertrand R. Hoffman, Ellen Davis, David A. Cruz, Dianne A. Che, Alicia Benedek, David Alvarez, Victor E. Lewis, David A. Glausier, Jill Holtzheimer, Paul E. Friedman, Matthew J. Williams, Kenneth R. Picciotto, Marina R. Nairn, Angus C. Krystal, John H. Duman, Ronald S. Young, Keith A. Zhao, Hongyu Girgenti, Matthew J. Program of Computational Biology & Bioinformatics Yale University New Haven 06511 CT United States Department of Psychiatry Yale School of Medicine New Haven 06511 CT United States Department of Biostatistics Yale School of Public Health New Haven 06510 CT United States NIDA Neuroproteomics Center Yale School of Medicine New Haven 06511 CT United States Department of Molecular Biophysics and Biochemistry Yale School of Medicine New Haven 06511 CT United States Keck MS & Proteomics Resource Yale School of Medicine New Haven 06510 CT United States Department of Psychiatry University of Pittsburgh Pittsburgh 15213 PA United States Department of Psychiatry Geisel School of Medicine at Dartmouth Lebanon 03756 NH United States Central Texas Veterans Health Care System Research Service Temple 76504 TX United States Department of Psychiatry and Behavioral Sciences Texas A & M University School of Medicine Bryan 77807 TX United States National Center for PTSD United States Department of Veterans Affairs White River Junction 05009 VT United States
Background : Post-traumatic stress disorder (PTSD) is a common and disabling psychiatric disorder. PTSD involves multiple brain regions and is often comorbid with other psychiatric disorders, such as major depressive ... 详细信息
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Incorporating gene annotations as node metadata to improve network centrality measures for better node ranking  13
Incorporating gene annotations as node metadata to improve n...
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2013 4th ACM Conference on bioinformatics, computational biology and Biomedical Informatics, ACM-BCB 2013
作者: Mistry, Divya Dickerson, Julie Department of Electrical and Computer Engineering Bioinformatics and Computational Biology Program Iowa State University Ames IA United States
Network centrality measures allow ranking of nodes and edges based on their importance to the network topology. Closeness centrality [1] and shortest path betweenness centrality [2] are two of the most popular and wel... 详细信息
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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells  1
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丛书名: Springer Theses
1000年
作者: Iman Tavassoly
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is prop... 详细信息
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Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice
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Mechanisms of Ageing and Development 2025年 225卷 112068页
作者: González, John T. Scharfman, Olivia H. Zhu, Wanling Kasamoto, Jessica Gould, Victoria Perry, Rachel J. Higgins-Chen, Albert T. Department of Pathology Yale University School of Medicine New Haven CT United States Department of Cellular & Molecular Physiology Yale School of Medicine New Haven CT United States Department of Endocrinology & Metabolism Yale School of Medicine New Haven CT United States Program in Computational Biology and Bioinformatics Yale University New Haven CT United States Altos Labs Institute of Computation San Diego 92114 CA United States Department of Psychiatry Yale School of Medicine New Haven CT United States
Age-related declines in insulin sensitivity and glucose metabolism contribute to metabolic disease. Despite the liver's central role in glucose homeostasis, a comprehensive phenotypic characterization and concurre... 详细信息
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Constructing a Boolean implication network to study the interactions between environmental factors and OTUs
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Frontiers of Electrical and Electronic Engineering in China 2014年 第4期9卷 127-141页
作者: Congmin Zhu Rui Jiang Ting Chen MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic & Systems Biology TNLIST/ Department of Automation Tsinghua University Beijing 100084 China Computational and Molecular Biology Program University of Southern California Loa Angles CA 90089 USA
Mining relationships between microbes and the environment they live in are crucial to understand the intrinsic mechanisms that govern cycles of carbon, nitrogen and energy in a microbial community. Building upon next-... 详细信息
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Paralog-divergent Features May Help Reduce Off-target Effects of Drugs:Hints from Glucagon Subfamily Analysis
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Genomics, Proteomics & bioinformatics 2017年 第4期15卷 246-254页
作者: Zhining Sa Jingqi Zhou Yangyun Zou Zhixi Su Xun Gu State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of LifeSciencesFudan UniversityShanghai 200433China Department of Genetics Development and Cell BiologyProgram of Bioinformatics and Computational BiologyIowa State UniversityAmesIA 50011USA
Side effects from targeted drugs remain a serious conccrn. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which arc highly homologous in sequences and have similar struct... 详细信息
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