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检索条件"机构=Program of Bioinformatics and Computational Biology"
528 条 记 录,以下是21-30 订阅
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Pitfalls of restriction enzyme analysis in identifying, characterizing,typing, and naming viral pathogens in the era of whole genome data, as illustrated by HAdV type 55
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Virologica Sinica 2016年 第5期31卷 448-453页
作者: Qiwei Zhang Shoaleh Dehghan Donald Seto Biosafety Level-3 Laboratory School of Public HealthSouthern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research) Chemistry Department American University Bioinformatics and Computational Biology Program School of Systems BiologyGeorge Mason University
Restriction endonuclease analysis(REA),or restriction fragment length polymorphism(RFLP),was useful for identifying and determining the relatedness and putative identities of microbial strains(Tang et al.,1997)and for... 详细信息
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Convergent Usage of Amino Acids in Human Cancers as A Reversed Process of Tissue Development
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Genomics, Proteomics & bioinformatics 2022年 第1期20卷 147-162页
作者: Yikai Luo Han Liang Graduate Program in Quantitative and Computational Biosciences Baylor College of MedicineHoustonTX 77030USA Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA
Genome-and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution,but its characteristics and implication in cancer evolution and therapy remain lar... 详细信息
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Incorporating gene annotations as node metadata to improve network centrality measures for better node ranking  13
Incorporating gene annotations as node metadata to improve n...
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2013 4th ACM Conference on bioinformatics, computational biology and Biomedical Informatics, ACM-BCB 2013
作者: Mistry, Divya Dickerson, Julie Department of Electrical and Computer Engineering Bioinformatics and Computational Biology Program Iowa State University Ames IA United States
Network centrality measures allow ranking of nodes and edges based on their importance to the network topology. Closeness centrality [1] and shortest path betweenness centrality [2] are two of the most popular and wel... 详细信息
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Building a unified model for drug synergy analysis powered by large language models
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Nature Communications 2025年 第1期16卷 1-17页
作者: Liu, Tianyu Chu, Tinyi Luo, Xiao Zhao, Hongyu Interdepartmental Program in Computational Biology & Bioinformatics Yale University New Haven CT United States Department of Biostatistics Yale University New Haven CT United States Department of Computer Science University of California Los Angeles Los Angeles CA United States
Drug synergy prediction is a challenging and important task in the treatment of complex diseases including cancer. In this manuscript, we present a unified Model, known as BAITSAO, for tasks related to drug synergy pr...
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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells  1
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丛书名: Springer Theses
1000年
作者: Iman Tavassoly
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is prop... 详细信息
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Developmental systems biology flourishing on new technologies
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Journal of Genetics and Genomics 2008年 第10期35卷 577-584页
作者: Jing-Dong J. Han Yi Liu Huiling Xue Kai Xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng Huang Chunyu Jin Bo Xian Jing Li Lei Hou Yixing Han Chaoqun Niu Timothy C. Alcon Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Machine Perception (Ministry of Education) Peking University Beijing 100871 China Bioinformatics and Computational Biology Graduate Program Iowa State University Ames IA 50011-1040 USA
Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new... 详细信息
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Constructing a Boolean implication network to study the interactions between environmental factors and OTUs
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Frontiers of Electrical and Electronic Engineering in China 2014年 第4期9卷 127-141页
作者: Congmin Zhu Rui Jiang Ting Chen MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic & Systems Biology TNLIST/ Department of Automation Tsinghua University Beijing 100084 China Computational and Molecular Biology Program University of Southern California Loa Angles CA 90089 USA
Mining relationships between microbes and the environment they live in are crucial to understand the intrinsic mechanisms that govern cycles of carbon, nitrogen and energy in a microbial community. Building upon next-... 详细信息
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Paralog-divergent Features May Help Reduce Off-target Effects of Drugs:Hints from Glucagon Subfamily Analysis
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Genomics, Proteomics & bioinformatics 2017年 第4期15卷 246-254页
作者: Zhining Sa Jingqi Zhou Yangyun Zou Zhixi Su Xun Gu State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of LifeSciencesFudan UniversityShanghai 200433China Department of Genetics Development and Cell BiologyProgram of Bioinformatics and Computational BiologyIowa State UniversityAmesIA 50011USA
Side effects from targeted drugs remain a serious conccrn. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which arc highly homologous in sequences and have similar struct... 详细信息
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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
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Science (New York, N.Y.) 2025年 第6735期387卷 eadn2337页
作者: Fagerberg, Eric Attanasio, John Dien, Christine Singh, Jaiveer Kessler, Emily A. Abdullah, Leena Shen, Jian Hunt, Brian G. Connolly, Kelli A. De Brouwer, Edward He, Jiaming Iyer, Nivedita R. Buck, Jessica Borr, Emily R. Damo, Martina Foster, Gena G. Giles, Josephine R. Huang, Yina H. Tsang, John S. Krishnaswamy, Smita Cui, Weiguo Joshi, Nikhil S. Department of Immunobiology Yale University School of Medicine New Haven CT United States Program in Computational Biology & Bioinformatics Yale University New Haven CT United States Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth NH United States Department of Pathology Feinberg School of Medicine at Northwestern University Chicago IL United States Department of Genetics and Computer Science Yale University School of Medicine New Haven CT United States Department of Medicine University of Chicago Chicago IL United States Section of Hematology Department of Internal Medicine Yale University School of Medicine New Haven CT United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Philadelphia PA United States Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Parker Institute for Cancer Immunotherapy Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Yale Center for Systems and Engineering Immunology Yale University School of Medicine New Haven CT United States New Haven CT United States Department of Biomedical Engineering Yale University New Haven CT United States Computational Biology and Bioinformatics Program Yale University CT USA New Haven United States Applied Math Program Yale University New Haven CT United States
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiati...
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Variable importance-weighted Random Forests
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Frontiers of Electrical and Electronic Engineering in China 2017年 第4期5卷 338-351页
作者: Yiyi Liu Hongyu Zhao Department of Biostatistics School of Public Health Yale University New Haven CT 06511 USA Program of Computational Biology and Bioinformatics Yale University New Haven CT 06511 USA
Background: Random Forests is a popular classification and regression method that has proven powerful for various prediction problems in biological studies. However, its performance often deteriorates when the number... 详细信息
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