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8th International Conference on Medical and Health informatics, ICMHI 2024

作者： Peng, Kang-Syuan Chang, Hsiao-Huang Hsu, Ying-Kai Chien, Ting-Ying Department of Computer Science and Engineering Yuan Ze University Taoyuan City Taiwan Cardiovascular Surgery Department Taipei Veterans General Hospital Taipei City TaiwanTaipei Medical University Taipei City Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan TaiwanInnovation Center for Big Data and Digital Convergence Yuan Ze University Taoyuan City Taiwan

ISBN: (纸本)9798400716874

Narrowing of the coronary arteries is an important indicator of the severity of coronary artery disease (CAD) in patients. Previous research using deep learning to identify narrowed vessels has primarily been based on object detection, but this approach has several problems, such as the inability to detect multivessel narrowing, calculate the actual rate of narrowing, and determine the exact location of occurrence. Therefore, we believe that the determination of narrowing should return to the original method, namely, calculating the maximum and minimum diameters around the vessel. However, to automate this task, a preprocessing step for separating each vessel is needed, especially for the complex structure of the left coronary artery. We designed a deep learning model capable of analyzing an entire coronary angiography (CAG) image for the separation and tracking of vessels. This not only serves as a preprocessing step for calculating narrowing but also allows for the analysis of different vessel flow directions, providing doctors with comprehensive assessment indicators. © 2024 Copyright ACM.

关键词： Image segmentation

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An Analysis of Fluid Intake Assessment Approaches for Fluid Intake Monitoring System

Biosensors

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Biosensors 2024年第1期14卷 14页

作者： Hsieh, Chia-Yeh Huang, Hsiang-Yun Chan, Chia-Tai Chiu, Li-Tzu Bachelor’s Program in Medical Informatics and Innovative Applications Fu Jen Catholic University New Taipei City24205 Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei City11221 Taiwan

Monitoring fluid intake is essential to help people manage their individual fluid intake behaviors and achieve adequate hydration. Previous studies of fluid intake assessment approaches based on inertial sensors can be categorized into wrist-worn-based and smart-container-based approaches. This study aims to analyze wrist-worn-based and smart-container-based fluid intake assessment approaches using inertial sensors. The comparison of these two approaches should be analyzed according to gesture recognition and volume estimation. In addition, the influence of the fill level and sip size information on the performance is explored in this study. The accuracy of gesture recognition with postprocessing is 92.89% and 91.8% for the wrist-worn-based approach and smart-container-based approach, respectively. For volume estimation, sip-size-dependent models can achieve better performance than general SVR models for both wrist-worn-based and smart-container-based approaches. The improvement of MAPE, MAD, and RMSE can reach over 50% except MAPE for small sip sizes. The results demonstrate that the sip size information and recognition performance are important for fluid intake assessment approaches. © 2023 by the authors.

关键词： Containers

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DCGAN-based Medical Image Augmentation to Improve ELM Classification Performance 11

DCGAN-based Medical Image Augmentation to Improve ELM Classi...

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11th IEEE International Conference on Communication, Networks and Satellite, COMNETSAT 2022

作者： Rando Setiawan, Noor Akhmad Permanasari, Adhistya Erna Rulaningtyas, Riries Suksmono, Andriyan Bayu Sitanggang, Imas Sukaesih Universitas Gadjah Mada Dept. of Electrical and Information Engineering Yogyakarta Indonesia Biomedical Engineering Program Dept. of Physics Universitas Airlangga Surabaya Indonesia Institut Teknologi Bandung School of Electrical Engineering and Informatics Bandung Indonesia Ipb University Department of Computer Science Bogor Indonesia

ISBN: (纸本)9781665460309

Cervical cancer is one of the deadliest diseases in women. One of the cervical cancer screening methods is pap smear method. However, using a pap smear method to detect cervical cancer takes a long time for a pathologist to diagnose. Hence, a rapid development of medical computerization for early detection to get the results quickly is needed. This paper proposes synthetic data augmentation by using Deep Convolutional Generative Adversarial Network (DCGAN) to increase number of pap smear samples in dataset. Gray Level Co-occurrence Matrix (GLCM) is employed to extract features from dataset. Classification of 3 classes which are Adenocarcinoma, High-Grade Squamous Intraepithelial Lesion (HSIL), and Squamous Cell Carcinoma (SCC) is conducted using Extreme Learning Machine (ELM). The result shows that the addition of synthetic data improves the performance of ELM with the accuracy of 90%. This accuracy is better than the accuracy of ELM using only the original dataset which is 85%. © 2022 IEEE.

关键词： Generative adversarial networks

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A Computationally Efficient Algorithm for Estimating Respiratory Rate from Seismocardiogram

SSRN

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SSRN 2024年

作者： Ku, Tienhsiung Lin, Yue-Der Department of Anesthesiology Changhua Christian Hospital Changhua50051 Taiwan Artificial Intelligence Development Center Changhua Christian Hospital Changhua50051 Taiwan Department of Automatic Control Engineering Feng Chia University Taichung40724 Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung40724 Taiwan

Respiratory rate (RR) monitoring is crucial in clinical and healthcare settings. With the advancements in microelectromechanical system (MEMS) technology, monitoring respiration using seismocardiogram (SCG) is emerging as a promising approach. This study presents a computationally efficient algorithm for estimating RR from SCG signal. The proposed algorithm consists of two primary steps: firstly applying Gaussian averaging filter for pre-processing and next computing the averaged spectrum from the scalogram based on complex Morlet wavelet within the specified frequency range. RR is then estimated from the dominant frequency appeared in the averaged spectrum. This study also establishes the analytical relationship between the parameters of Gaussian averaging filter and the sampling frequency of SCG signal, which serves as the design criterion for pre-processing filter. The proposed algorithm undergoes testing on two SCG datasets and has demonstrated its feasibility for estimating RR from SCG signal. Furthermore, the algorithm is also tested on both finger and wrist PPG datasets for RR estimation. The test results present high agreement between the RR estimations from SCG (or PPG) signal and those from respiration signal. Based on these testing results, the proposed algorithm shows significant potential in clinical and healthcare applications. © 2024, The Authors. All rights reserved.

关键词： Computational efficiency

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Deep Learning-based Fall Detection Algorithm Using Ensemble Model of Coarse-fine CNN and GRU Networks

Deep Learning-based Fall Detection Algorithm Using Ensemble ...

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2023 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2023

作者： Liu, Chien-Pin Li, Ju-Hsuan Chu, En-Ping Hsieh, Chia-Yeh Liu, Kai-Chun Chan, Chia-Tai Tsao, Yu National Yang Ming Chiao Tung University Department of Biomedical Engineering Taipei City112 Taiwan Fu Jen Catholic University Bachelor's Program in Medical Informatics and Innovative Applications New Taipei City242062 Taiwan Research Center for Information Technology Innovation Academia Sinica Taipei City115 Taiwan

ISBN: (纸本)9781665493840

Falls are the public health issue for the elderly all over the world since the fall-induced injuries are associated with a large amount of healthcare cost. Falls can cause serious injuries, even leading to death if the elderly suffers a 'long-lie.' Hence, a reliable fall detection (FD) system is required to provide an emergency alarm for first aid. Due to the advances in wearable device technology and artificial intelligence, some fall detection systems have been developed using machine learning and deep learning methods to analyze the signal collected from accelerometer and gyroscopes. In order to achieve better fall detection performance, an ensemble model that combines a coarse-fine convolutional neural network and gated recurrent unit is proposed in this study. The parallel structure design used in this model restores the different grains of spatial characteristics and capture temporal dependencies for feature representation. This study applies the FallAllD public dataset to validate the reliability of the proposed model, which achieves a recall, precision, and F-score of 92.54%, 96.13%, and 94.26%, respectively. The results demonstrate the reliability of the proposed ensemble model in discriminating falls from daily living activities and its superior performance compared to the state-of-the-art convolutional neural network long short-term memory (CNN-LSTM) for FD. © 2023 IEEE.

关键词： Fall detection

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The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net

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European Radiology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, Shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi Shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background: To evaluate the effect of the weighting of input imaging combo and ADC threshold on the performance of the U-Net and to find an optimized input imaging combo and ADC threshold in segmenting acute ischemic stroke (AIS) lesion. Methods: This study retrospectively enrolled a total of 212 patients having AIS. Four combos, including ADC-ADC-ADC (AAA), DWI-ADC-ADC (DAA), DWI-DWI-ADC (DDA), and DWI-DWI-DWI (DDD), were used as input images, respectively. Three ADC thresholds including 0.6, 0.8 and 1.8 × 10^–3 mm²/s were applied. Dice similarity coefficient (DSC) was used to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used for comparison. A p <.05 was considered statistically significant. Results: The DSC significantly varied among different combos of images and different ADC thresholds. Hybrid U-Nets outperformed uniform U-Nets at ADC thresholds of 0.6 × 10^–3 mm²/s and 0.8 × 10^–3 mm²/s (p <.001). The U-Net with imaging combo of DDD had segmentation performance similar to hybrid U-Nets at an ADC threshold of 1.8 × 10^–3 mm²/s (p =.062 to 1). The U-Net using the imaging combo of DAA at the ADC threshold of 0.6 × 10^–3 mm²/s achieved the highest DSC in the segmentation of AIS lesion. Conclusions: The segmentation performance of U-Net for AIS varies among the input imaging combos and ADC thresholds. The U-Net is optimized by choosing the imaging combo of DAA at an ADC threshold of 0.6 × 10^–3 mm²/s in segmentating AIS lesion with highest DSC. Key Points: • Segmentation performance of U-Net for AIS differs among input imaging combos. • Segmentation performance of U-Net for AIS differs among ADC thresholds. • U-Net is optimized using DAA with ADC = 0.6 × 10^–3mm²/s. © 2023, The Author(s), under exclusive licence to European Society of Radiology.

关键词： Deep Learning Diffusion Magnetic Resonance Imaging Ischemic Stroke Neural Networks, Computer Retrospective Study

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ATP_mCNN: Predicting ATP binding sites through pretrained language models and multi-window neural networks

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Computers in Biology and Medicine 2025年 185卷 109541-109541页

作者： Le, Van-The Malik, Muhammad-Shahid Lin, Yi-Jing Liu, Yu-Chen Chang, Yan-Yun Ou, Yu-Yen Department of Computer Science and Engineering Yuan Ze University Chung-Li32003 Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Chung-Li32003 Taiwan Department of Computer Sciences Karakoram International University Gilgit-Baltistan 15100 Pakistan

Adenosine triphosphate plays a vital role in providing energy and enabling key cellular processes through interactions with binding proteins. The increasing amount of protein sequence data necessitates computational methods for identifying binding sites. However, experimental identification of adenosine triphosphate-binding residues remains challenging. To address the challenge, we developed a multi-window convolutional neural network architecture taking pre-trained protein language model embeddings as input features. In particular, multiple parallel convolutional layers scan for motifs localized to different window sizes. Max pooling extracts salient features concatenated across windows into a final multi-scale representation for residue-level classification. On benchmark datasets, our model achieves an area under the ROC curve of 0.95, significantly improving on prior sequence-based models and outperforming convolutional neural network baselines. This demonstrates the utility of pre-trained language models and multi-window convolutional neural networks for advanced sequence-based prediction of adenosine triphosphate-binding residues. Our approach provides a promising new direction for elucidating binding mechanisms and interactions from primary structure. © 2024 Elsevier Ltd

关键词： Convolutional neural networks

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Development of Automated Detection Methods for Calculating Blood Vessel Width and Stenosis Rate in Cardiac Catheterization Imaging 24

Development of Automated Detection Methods for Calculating B...

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8th International Conference on Medical and Health informatics, ICMHI 2024

作者： Huang, Hsien-Cheng Chang, Hsiao-Huang Ke, Xiang-Wei Chien, Ting-Ying Department of Computer Science and Engineering Yuan Ze University Taoyuan City Taiwan Cardiovascular Surgery Department Taipei Veterans General Hospital Taipei City Taiwan Taipei Medical University Taipei City Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan Innovation Center for Big Data and Digital Convergence Yuan Ze University Taoyuan City Taiwan

ISBN: (纸本)9798400716874

Coronary artery disease is the most prevalent type of heart disease and has a considerable mortality rate. In diagnosing and assessing coronary artery disease, physicians must integrate a variety of clinical information and test results to evaluate the degree of coronary artery obstruction and continually learn and improve their skills in clinical practice to ensure the most accurate assessment of patients. Currently, the use of information technology to assist medical staff allows more effective and accurate analysis of symptoms. This approach not only serves as an auxiliary standard for physician diagnosis, thereby reducing the possibility of misdiagnosis, but also significantly improves patient treatment outcomes and medical quality while reducing the time burden on physicians for diagnosing patients. This study utilized image processing techniques and thinning algorithms to automate the detection of coronary artery width and, following the recommended methods of physicians in related fields, used specific vessel widths to calculate the degree of coronary artery narrowing. This provides a more accurate and efficient assessment method for evaluating the degree of vascular constriction in patients with coronary artery disease. © 2024 Copyright ACM.

关键词： Patient treatment

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A VAE-Based Data Augmentation Method for Fall Detection System using Wearable Sensor

A VAE-Based Data Augmentation Method for Fall Detection Syst...

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International Conference on Applied System Innovation (ICASI)

作者： Yu-Chen Tu Hsuan-Chih Wang Chien-Pin Liu Chia-Yeh Hsieh Chia-Tai Chan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei City Taiwan Bachelor's Program in Medical Informatics and Innovative Applications Fu Jen Catholic University New Taipei City Taiwan

ISBN: (数字)9798350394924

ISBN: (纸本)9798350394931

Fall incidents among the elderly represent a significant global concern, often resulting in physical injuries and psychological distress. It is crucial to develop reliable fall detection systems which are capable of identifying fall events immediately and triggering alerts for assistance. However, real-world fall occurrences are infrequent, leading to a highly imbalanced class situation. Training a model with imbalanced datasets may result in biased models with poor performance in fall detection. To address this challenge, various techniques such as data transformation and Synthetic Minority Oversampling Technique (SMOTE) have been proposed. However, these methods are constrained by issues such as limitations in input data size or sensitivity to outliers. Compared to other methods, variational autoencoder (VAE) can generate data with a similar probability distribution to the original input data while constraining the latent representation in a Gaussian distribution. This study proposes a VAE-based data augmentation method for wearable-based fall detection system. The proposed method is validated on the FallAllD public dataset, achieving a F-score of 99.46%. The performance has been increased by 2.21%. The results demonstrate the effectiveness of VAE-based data augmentation technique in enhancing fall detection systems and its superior performance compared with other traditional data augmentation methods.

关键词： Training Technological innovation Sensitivity Psychology Data augmentation Probability distribution Reliability

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Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains

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Computational and Structural Biotechnology Journal 2024年 23卷 1864-1876页

作者： Do, Duyen Thi Yang, Ming-Ren Vo, Tran Nam Son Le, Nguyen Quoc Khanh Wu, Yu-Wei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Business Administration College of Management Lunghwa University of Science and Technology Taoyuan City Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan

In current genomic research, the widely used methods for predicting antimicrobial resistance (AMR) often rely on prior knowledge of known AMR genes or reference genomes. However, these methods have limitations, potentially resulting in imprecise predictions owing to incomplete coverage of AMR mechanisms and genetic variations. To overcome these limitations, we propose a pan-genome-based machine learning approach to advance our understanding of AMR gene repertoires and uncover possible feature sets for precise AMR classification. By building compacted de Brujin graphs (cDBGs) from thousands of genomes and collecting the presence/absence patterns of unique sequences (unitigs) for Pseudomonas aeruginosa, we determined that using machine learning models on unitig-centered pan-genomes showed significant promise for accurately predicting the antibiotic resistance or susceptibility of microbial strains. Applying a feature-selection-based machine learning algorithm led to satisfactory predictive performance for the training dataset (with an area under the receiver operating characteristic curve (AUC) of > 0.929) and an independent validation dataset (AUC, approximately 0.77). Furthermore, the selected unitigs revealed previously unidentified resistance genes, allowing for the expansion of the resistance gene repertoire to those that have not previously been described in the literature on antibiotic resistance. These results demonstrate that our proposed unitig-based pan-genome feature set was effective in constructing machine learning predictors that could accurately identify AMR pathogens. Gene sets extracted using this approach may offer valuable insights into expanding known AMR genes and forming new hypotheses to uncover the underlying mechanisms of bacterial AMR. © 2024 The Authors

关键词： Genes

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