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Author Correction: RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

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Nature communications 2021年第1期12卷 3128页

作者： Alessandro Bonetti Federico Agostini Ana Maria Suzuki Kosuke Hashimoto Giovanni Pascarella Juliette Gimenez Leonie Roos Alex J Nash Marco Ghilotti Christopher J F Cameron Matthew Valentine Yulia A Medvedeva Shuhei Noguchi Eneritz Agirre Kaori Kashi Joachim Luginbühl Riccardo Cazzoli Saumya Agrawal Nicholas M Luscombe Mathieu Blanchette Takeya Kasukawa Michiel de Hoon Erik Arner Boris Lenhard Charles Plessy Gonçalo Castelo-Branco Valerio Orlando Piero Carninci RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. alessandro.bonetti@riken.jp. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. alessandro.bonetti@riken.jp. The Francis Crick Institute 1 Midland Road London NW1 1AT UK. RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa 230-0045 Japan. Department of Medicine (H7) Karolinska Institutet Stockholm 141 86 Sweden. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. Faculty of Medicine Imperial College London Institute of Clinical Sciences London W12 0NN UK. MRC London Institute of Medical Sciences London W12 0NN UK. School of Computer Science McGill University Montréal QC Canada. Department of Biochemistry and Goodman Cancer Research Centre McGill University Montréal QC Canada. Institute of Bioengineering Research Centre of Biotechnology Russian Academy of Science 117312 Moscow Russia. Department of Computational Biology Vavilov Institute of General Genetics Russian Academy of Science 119991 Moscow Russia. Department of Biological and Medical Physics Moscow Institute of Physics and Technology 141701 Dolgoprudny Moscow Region Russia. Laboratory of Molecular Neurobiology Department Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy. UCL Genetics Institute University College London London WC1E 6BT UK. Okinawa Institute of Science and Technology Graduate University 1919-1 Tancha Onna-son Kunigami-gun Okinawa 904-0495 Japan. Sars International Centre for Marine Molecular Biology University of Bergen 5008 Bergen Norway. Epigenetics and Genome Reprogramming Laboratory IRCCS Fondazione Santa Lucia Rome Italy. valerio.orlando@kaust.edu.sa. KAUST Environmental Epigenetics Program King Abdullah University of Science and Technology (KAUS

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Constraints on Cosmic Strings Using Data from the Third Advanced LIGO–Virgo Observing Run

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Physical Review Letters 2021年第24期126卷 241102-241102页

作者： R. Abbott T. D. Abbott S. Abraham F. Acernese K. Ackley A. Adams C. Adams R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu K. M. Aleman G. Allen A. Allocca P. A. Altin A. Amato S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koya Arai Koji Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson H. Asada Y. Asali G. Ashton Y. Aso S. M. Aston P. Astone F. Aubin P. Auclair P. Aufmuth K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer M. Bals A. Balsamo G. Baltus S. Banagiri D. Bankar R. S. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo S. Barnum F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser R. Bhandare A. V. Bhandari D. Bhattacharjee S. Bhaumik J. Bidler I. A. Bilenko G. Billingsley R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn J. Blackman C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant A. Buikema T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic L. Cadonati M. Caesar G. Cagnoli C. Cahillane H. W. Cain, III J. Calderón Bustillo J. D LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Inter-University Centre for Astronomy and Astrophysics Pune 411007 India Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S.Angelo I-80126 Napoli Italy OzGrav School of Physics and Astronomy Monash University Clayton 3800 Victoria Australia Christopher Newport University Newport News Virginia 23606 USA LIGO Livingston Observatory Livingston Louisiana 70754 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom Gran Sasso Science Institute (GSSI) I-67100 L’Aquila Italy INFN Laboratori Nazionali del Gran Sasso I-67100 Assergi Italy INFN Sezione di Pisa I-56127 Pisa Italy Università di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan California State University Fullerton Fullerton California 92831 USA NCSA University of Illi

We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 dataset. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks, and, for the first time, kink-kink collisions. A template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension Gμ as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models. Additionally, we develop and test a third model that interpolates between these two models. Our results improve upon the previous LIGO–Virgo constraints on Gμ by 1 to 2 orders of magnitude depending on the model that is tested. In particular, for the one-loop distribution model, we set the most competitive constraints to date: Gμ≲4×10−15. In the case of cosmic strings formed at the end of inflation in the context of grand unified theories, these results challenge simple inflationary models.

关键词： Cosmic strings & domain walls Gravitational waves

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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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Nature communications 2020年第1期11卷 6232页

作者： Matthew H Bailey William U Meyerson Lewis Jonathan Dursi Liang-Bo Wang Guanlan Dong Wen-Wei Liang Amila Weerasinghe Shantao Li Yize Li Sean Kelso Gordon Saksena Kyle Ellrott Michael C Wendl David A Wheeler Gad Getz Jared T Simpson Mark B Gerstein Li Ding The McDonnell Genome Institute at Washington University St. Louis MO 63108 USA. Division of Oncology Department of Medicine Washington University School of Medicine St. Louis MO 63108 USA. Alvin J. Siteman Cancer Center Washington University School of Medicine St. Louis MO 63108 USA. Yale School of Medicine Yale University New Haven CT 06520 USA. Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 USA. Computational Biology Program Ontario Institute for Cancer Research Toronto ON M5G 0A3 Canada. The Hospital for Sick Children Toronto ON M5G 1X8 Canada. Broad Institute of MIT and Harvard Cambridge MA 02142 USA. Biomedical Engineering Oregon Health and Science University Portland OR 97239 USA. Department of Mathematics Washington University in St. Louis St. Louis MO 63130 USA. Department of Genetics Washington University School of Medicine St.Louis MO 63110 USA. Human Genome Sequencing Center Baylor College of Medicine Houston TX 77030 USA. Department of Molecular and Human Genetics Baylor College of Medicine Houston TX 77030 USA. Harvard Medical School Boston MA 02115 USA. Center for Cancer Research Massachusetts General Hospital Boston MA 02114 USA. Department of Pathology Massachusetts General Hospital Boston MA 02114 USA. Department of Computer Science University of Toronto Toronto ON M5S Canada. Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 USA. mark.gerstein@yale.edu. Department of Computer Science Yale University New Haven CT 06520 USA. mark.gerstein@yale.edu. Department of Molecular Biophysics and Biochemistry Yale University New Haven CT 06520 USA. mark.gerstein@yale.edu. The McDonnell Genome Institute at Washington University St. Louis MO 63108 USA. lding@wustl.edu. Division of Oncology Department of Medicine Washington University School of Medicine St. Louis MO 63108 USA. lding@wustl.edu. Alvin J. Siteman Cancer Center Wash

Correction to this paper has been published: https://***/10.1038/s41467-020-20128-w.

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Effect of climate on traits of dominant and rare tree species in the world’s forests

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Nature Communications 2025年第1期16卷 1-15页

作者： Hordijk, Iris Poorter, Lourens Liang, Jingjing Reich, Peter B. de-Miguel, Sergio Nabuurs, Gert-Jan Gamarra, Javier G. P. Chen, Han Y. H. Zhou, Mo Wiser, Susan K. Pretzsch, Hans Paquette, Alain Picard, Nicolas Hérault, Bruno Bastin, Jean-Francois Alberti, Giorgio Abegg, Meinrad Adou Yao, Yves C. Almeyda Zambrano, Angelica M. Alvarado, Braulio V. Alvarez-Davila, Esteban Alvarez-Loayza, Patricia Alves, Luciana F. Amaral, Iêda Ammer, Christian Antón-Fernández, Clara Araujo-Murakami, Alejandro Arroyo, Luzmila Avitabile, Valerio Aymard C, Gerardo A. Baker, Timothy Banki, Olaf Barroso, Jorcely Bastian, Meredith L. Birigazzi, Luca Birnbaum, Philippe Bitariho, Robert Boeckx, Pascal Bongers, Frans Bouriaud, Olivier Brancalion, Pedro H. S. Brandl, Susanne Brearley, Francis Q. Brienen, Roel Broadbent, Eben N. Bruelheide, Helge Cazzolla Gatti, Roberto Cesar, Ricardo G. Cesljar, Goran Chazdon, Robin L. Chisholm, Chelsea Cienciala, Emil Clark, Connie J. Clark, David B. Colletta, Gabriel Coomes, David Cornejo Valverde, Fernando Corral-Rivas, Jose J. Crim, Philip Cumming, Jonathan Dayanandan, Selvadurai de Gasper, André L. Decuyper, Mathieu Derroire, Géraldine DeVries, Ben Djordjevic, Ilija Dourdain, Aurélie Dolezal, Jiri Engone Obiang, Nestor Laurier Enquist, Brian Eyre, Teresa Fandohan, Adandé Belarmain Fayle, Tom M. Ferreira, Leandro V. Feldpausch, Ted R. Finér, Leena Fischer, Markus Fletcher, Christine Frizzera, Lorenzo Gianelle, Damiano Glick, Henry B. Harris, David Hector, Andrew Hemp, Andreas Herbohn, John Hillers, Annika Honorio Coronado, Eurídice N. Hui, Cang Cho, Hyunkook Ibanez, Thomas Jung, Ilbin Imai, Nobuo Jagodzinski, Andrzej M. Jaroszewicz, Bogdan Johannsen, Vivian Joly, Carlos A. Jucker, Tommaso Karminov, Viktor Kartawinata, Kuswata Kearsley, Elizabeth Kenfack, David Kennard, Deborah Kepfer-Rojas, Sebastian Keppel, Gunnar Khan, Mohammed Latif Killeen, Timothy Kim, Hyun Seok Kitayama, Kanehiro Köhl, Michael Korjus, Henn Kraxner, Florian Laarmann, Diana Lang, Mait Lewis, Simon Lu, Huicui Lukina, Natalia Maitner, Br Institute of Integrative Biology ETH Zurich (Swiss Federal Institute of Technology) Zurich Switzerland Wageningen University and Research Wageningen Netherlands Department of Forestry and Natural Resources Purdue University West Lafayette IN United States Department of Forest Resources University of Minnesota St Paul MN United States Hawkesbury Institute for the Environment Western Sydney University Penrith NSW Australia Department of Agricultural and Forest Sciences and Engineering University of Lleida Lleida Spain Forest Science and Technology Centre of Catalonia (CTFC) Solsona Spain Forestry Division Food and Agriculture Organization of the United Nations Rome Italy Faculty of Natural Resources Management Lakehead University Thunder Bay ON Canada Manaaki Whenua–Landcare Research Lincoln New Zealand Chair for Forest Growth and Yield Science TUM School for Life Sciences Technical University of Munich Munich Germany Centre for Forest Research Université du Québec à Montréal Montréal QC Canada GIP ECOFOR Paris France CIRAD Forêts et Sociétés Montpellier France Forêts et Sociétés Univ Montpellier CIRAD Montpellier France Gembloux Agro Bio-Tech University of Liege Liege Belgium Faculty of Science and Technology Free University of Bolzano Bolzano Italy Department of Agricultural Food Environmental and Animal Sciences University of Udine Udine Italy Swiss Federal Institute for Forest Snow and Landscape Research WSL Birmensdorf Switzerland UFR Biosciences University Félix Houphouët-Boigny Abidjan Cote d'Ivoire Spatial Ecology and Conservation Laboratory Center for Latin American Studies University of Florida Gainesville FL United States Forestry School Tecnológico de Costa Rica TEC Cartago Costa Rica Fundacion ConVida Universidad Nacional Abierta y a Distancia UNAD Medellin Colombia Field Museum of Natural History Chicago IL United States Center for Tropical Research Institute of the Environment and Sustainability UCLA Los Angeles CA

Species’ traits and environmental conditions determine the abundance of tree species across the globe. The extent to which traits of dominant and rare tree species differ remains untested across a broad environmental range, limiting our understanding of how species traits and the environment shape forest functional composition. We use a global dataset of tree composition of >22,000 forest plots and 11 traits of 1663 tree species to ask how locally dominant and rare species differ in their trait values, and how these differences are driven by climatic gradients in temperature and water availability in forest biomes across the globe. We find three consistent trait differences between locally dominant and rare species across all biomes;dominant species are taller, have softer wood and higher loading on the multivariate stem strategy axis (related to narrow tracheids and thick bark). The difference between traits of dominant and rare species is more strongly driven by temperature compared to water availability, as temperature might affect a larger number of traits. Therefore, climate change driven global temperature rise may have a strong effect on trait differences between dominant and rare tree species and may lead to changes in species abundances and therefore strong community reassembly. © The Author(s) 2025.

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A non-Gaussian spatio-temporal model for daily wind speeds based on a multivariate skew-t distribution

arXiv

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arXiv 2017年

作者： Tagle, Felipe Castruccio, Stefano Crippa, Paola Genton, Marc G. Department of Applied and Computational Mathematics and Statistics University of Notre Dame Notre DameIN46556 United States Department of Civil and Environmental Engineering and Earth Sciences University of Notre Dame Notre DameIN46556 United States Statistics Program King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia

Facing increasing domestic energy consumption from population growth and industrialization, Saudi Arabia is aiming to reduce its reliance on fossil fuels and to broaden its energy mix by expanding investment in renewable energy sources, including wind energy. A preliminary task in the development of wind energy infrastructure is the assessment of wind energy potential, a key aspect of which is the characterization of its spatio-temporal behavior. In this study we examine the impact of internal climate variability on seasonal wind power density uctuations over Saudi Arabia using 30 simulations from the Large Ensemble Project (LENS) developed at the National Center for Atmospheric Research. Furthermore, a spatio-temporal model for daily wind speed is proposed with neighbor-based cross-temporal dependence, and a multivariate skewt distribution to capture the spatial patterns of higher order moments. The model can be used to generate synthetic time series over the entire spatial domain that adequately reproduce the internal variability of the LENS dataset. Copyright © 2017, The Authors. All rights reserved.

关键词： Wind power

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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Nature Communications 2022年第1期13卷 1-14页

作者： Reiner, Robert C. Welgan, Catherine A. Troeger, Christopher E. Baumann, Mathew M. Weiss, Daniel J. Deshpande, Aniruddha Blacker, Brigette F. Miller-Petrie, Molly K. Earl, Lucas Bhatt, Samir Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adekanmbi, Victor Adetokunboh, Olatunji O. Aghaali, Mohammad Aji, Budi Alahdab, Fares Al-Aly, Ziyad Alhassan, Robert Kaba Ali, Saqib Alizade, Hesam Aljunid, Syed Mohamed Almasi-Hashiani, Amir Al-Mekhlafi, Hesham M. Altirkawi, Khalid A. Alvis-Guzman, Nelson Amare, Azmeraw T. Amini, Saeed Amugsi, Dickson A. Ancuceanu, Robert Andrei, Catalina Liliana Ansari, Fereshteh Anvari, Davood Appiah, Seth Christopher Yaw Arabloo, Jalal Aremu, Olatunde Atout, Maha Moh’d Wahbi Ausloos, Marcel Ausloos, Floriane Ayanore, Martin Amogre Aynalem, Yared Asmare Azene, Zelalem Nigussie Badawi, Alaa Baig, Atif Amin Banach, Maciej Bedi, Neeraj Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bijani, Ali Birhanu, Tesega Tesega Mengistu Bitew, Zebenay Workneh Boloor, Archith Brady, Oliver J. Butt, Zahid A. Car, Josip Carvalho, Felix Casey, Daniel C. Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Coelho, Camila H. Cook, Aubrey J. Damiani, Giovanni Daoud, Farah Gela, Jiregna Darega Darwish, Amira Hamed Daryani, Ahmad Das, Jai K. Davis Weaver, Nicole Deribe, Kebede Desalew, Assefa Dharmaratne, Samath Dhamminda Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Dorostkar, Fariba Dubljanin, Eleonora Duko, Bereket Dwyer-Lindgren, Laura Effiong, Andem El Sayed Zaki, Maysaa El Tantawi, Maha Enany, Shymaa Fattahi, Nazir Feigin, Valery L. Fernandes, Eduarda Ferrara, Pietro Fischer, Florian Foigt, Nataliya A. Folayan, Morenike Oluwatoyin Foroutan, Masoud Frostad, Joseph Jon Fukumoto, Takeshi Gaidhane, Abhay Motiramji Gebrekrstos, Hailemikael Gebrekidan G. K. Gebremeskel, Leake Gebreslassie, Assefa Ayalew Gething, Peter W. Gezae, Kebede Embaye Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Gubar Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Malaria Atlas Project University of Oxford Oxford United Kingdom Imperial College London London United Kingdom Department of Laboratory Medicine Karolinska University Hospital Huddinge Sweden Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Debre Berhan University Debre Berhan Ethiopia Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Population Health Sciences King’s College London London United Kingdom Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Stellenbosch South Africa Department of Global Health Stellenbosch University Cape Town South Africa Department of Epidemiology and Biostatistics Qom University of Medical Sciences Qom Iran Faculty of Medicine and Public Health Jenderal Soedirman University Purwokerto Indonesia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T. Milliken Department of Internal Medicine Washington University in St. Louis St. Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Institute of Health Research University of Health and Allied Sciences Ho Ghana Department of Information Systems College of Economics and Political Science Sultan Qaboos University Muscat Oman Infectious and Tropical Disease Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Health Policy and Management Kuwait University Safat Kuwait International Centre for Casemix and Clinical Coding National University of Malaysia Bandar Tun Razak Malaysia Department of Epidemiology Arak University of Medical Sciences Arak Iran Medical Research Center

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).

关键词： Biogeography Epidemiology Infectious diseases Malaria

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Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration

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Cell reports 2025年第6期44卷 115750页

作者： Macsue Jacques Shanie Landen Adam P Sharples Andrew Garnham Ralf Schittenhelm Joel Steele Aino Heikkinen Elina Sillanpää Miina Ollikainen James Broatch Navabeh Zarekookandeh Ola Hanson Ola Ekström Olof Asplund Séverine Lamon Sarah E Alexander Cassandra Smith Carlie Bauer Mary N Woessner Itamar Levinger Andrew E Teschendorff Linn Gillberg Ida Blom Jørn Wulff Helge Nicholas R Harvey Larisa M Haupt Lyn R Griffiths Atul S Deshmukh Kirsi H Pietiläinen Päivi Piirilä Robert A E Seaborne Marie Klevjer Anja Bye Ulrik Wisløff Bernadette Jones-Freeman Nir Eynon Australian Regenerative Medicine Institute Monash University Clayton VIC Australia Institute for Health and Sport (iHeS) Victoria University Footscray VIC Australia. Centre for Endocrinology and Metabolism Hudson Institute of Medical Research Melbourne VIC Australia. Institute of Physical Performance Norwegian School of Sport Sciences Oslo Norway. Monash Proteomics & Metabolomics Platform Monash Biomedicine Discovery Institute Monash University Melbourne VIC Australia. Institute for Molecular Medicine Finland (FIMM) Helsinki University Helsinki Finland. Faculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland Wellbeing Services County of Central Finland Jyväskylä Finland. Institute for Molecular Medicine Finland (FIMM) Helsinki University Helsinki Finland Minerva Foundation Institute for Medical Research Helsinki Finland. Department of Clinical Sciences Translational Muscle Research Unit Lund University Diabetes Center Lund University Lund Sweden. Institute for Physical Activity and Nutrition (IPAN) School of Exercise and Nutrition Sciences Deakin University 221 Burwood Highway Burwood VIC 3125 Australia. Cardiometabolic Health and Exercise Physiology Laboratory Baker Heart and Diabetes Institute 75 Commercial Road Melbourne VIC 3004 Australia. Nutrition & Health Innovation Research Institute Edith Cowan University Joondalup WA Australia Medical School The University of Western Australia Perth WA Australia. Institute for Health and Sport (iHeS) Victoria University Footscray VIC Australia Australian Institute for Musculoskeletal Science (AIMSS) Victoria University Melbourne VIC Australia. CAS Key Lab of Computational Biology Shanghai Institute of Nutrition and Health Shanghai China. Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark. Faculty of Health Sciences and Medicine Bond University Gold Coast QLD Australia Genomics Research Centre Centre for Genomics and Personalised Health School of

We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. Finally, we created a webtool, OMAx, featuring our individual omics and integration analysis. These findings provide a comprehensive multi-omics framework for understanding exercise-induced molecular adaptations, offering insights into muscle health, cardiorespiratory fitness, and their roles in aging and disease prevention.

关键词： CP: Metabolism DNA methylation Multi Omics VO(2 max) epigenetics exercise gene expression proteomic skeletal muscle transcriptomic

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Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

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Nature 2022年第7909期605卷 E3页

作者： Jill E Moore Michael J Purcaro Henry E Pratt Charles B Epstein Noam Shoresh Jessika Adrian Trupti Kawli Carrie A Davis Alexander Dobin Rajinder Kaul Jessica Halow Eric L Van Nostrand Peter Freese David U Gorkin Yin Shen Yupeng He Mark Mackiewicz Florencia Pauli-Behn Brian A Williams Ali Mortazavi Cheryl A Keller Xiao-Ou Zhang Shaimae I Elhajjajy Jack Huey Diane E Dickel Valentina Snetkova Xintao Wei Xiaofeng Wang Juan Carlos Rivera-Mulia Joel Rozowsky Jing Zhang Surya B Chhetri Jialing Zhang Alec Victorsen Kevin P White Axel Visel Gene W Yeo Christopher B Burge Eric Lécuyer David M Gilbert Job Dekker John Rinn Eric M Mendenhall Joseph R Ecker Manolis Kellis Robert J Klein William S Noble Anshul Kundaje Roderic Guigó Peggy J Farnham J Michael Cherry Richard M Myers Bing Ren Brenton R Graveley Mark B Gerstein Len A Pennacchio Michael P Snyder Bradley E Bernstein Barbara Wold Ross C Hardison Thomas R Gingeras John A Stamatoyannopoulos Zhiping Weng University of Massachusetts Medical School Program in Bioinformatics and Integrative Biology Worcester MA USA. The Broad Institute of Harvard and MIT Cambridge MA USA. Department of Genetics School of Medicine Stanford University Palo Alto CA USA. Cold Spring Harbor Laboratory Functional Genomics Cold Spring Harbor NY USA. Altius Institute for Biomedical Sciences Seattle WA USA. Department of Medicine University of Washington School of Medicine Seattle WA USA. Department of Cellular and Molecular Medicine Institute for Genomic Medicine Stem Cell Program Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA. Program in Computational and Systems Biology Massachusetts Institute of Technology Cambridge MA USA. Center for Epigenomics Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA. Ludwig Institute for Cancer Research University of California San Diego La Jolla CA USA. Institute for Human Genetics Department of Neurology University of California San Francisco San Francisco CA USA. Genomics Analysis Laboratory The Salk Institute for Biological Studies La Jolla CA USA. HudsonAlpha Institute for Biotechnology Huntsville AL USA. Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA. Department of Developmental and Cell Biology University of California Irvine Irvine CA USA. Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA USA. Environmental Genomics and Systems Biology Division Lawrence Berkeley National Laboratory Berkeley CA USA. Department of Genetics and Genome Sciences Institute for Systems Genomics UConn Health Farmington CT USA. Département de Biochimie et Médecine Moléculaire Université de Montréal Montréal Quebec Canada. Division of Experimental Medicine McGill University Montreal Quebec Canada. Institut de Recherches Cliniques de Montréal (IR

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Search for anisotropic gravitational-wave backgrounds using data from Advanced LIGO and Advanced Virgo’s first three observing runs

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Physical Review D 2021年第2期104卷 022005-022005页

作者： R. Abbott T. D. Abbott S. Abraham F. Acernese K. Ackley A. Adams C. Adams R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu K. M. Aleman G. Allen A. Allocca P. A. Altin A. Amato S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koya Arai Koji Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson H. Asada Y. Asali G. Ashton Y. Aso S. M. Aston P. Astone F. Aubin P. Aufmuth K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer M. Bals A. Balsamo G. Baltus S. Banagiri D. Bankar R. S. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser R. Bhandare A. V. Bhandari D. Bhattacharjee S. Bhaumik J. Bidler I. A. Bilenko G. Billingsley R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn J. Blackman C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant A. Buikema T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic R. L. Byer L. Cadonati M. Caesar G. Cagnoli C. Cahillane H. W. Cain, III J. Calderón Bustillo J. LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Inter-University Centre for Astronomy and Astrophysics Pune 411007 India Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S.Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia Christopher Newport University Newport News Virginia 23606 USA LIGO Livingston Observatory Livingston Louisiana 70754 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom Gran Sasso Science Institute (GSSI) I-67100 L’Aquila Italy INFN Laboratori Nazionali del Gran Sasso I-67100 Assergi Italy INFN Sezione di Pisa I-56127 Pisa Italy Università di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan California State University Fullerton Fullerton California 92831 USA NCSA University of Illinois

We report results from searches for anisotropic stochastic gravitational-wave backgrounds using data from the first three observing runs of the Advanced LIGO and Advanced Virgo detectors. For the first time, we include Virgo data in our analysis and run our search with a new efficient pipeline called pystoch on data folded over one sidereal day. We use gravitational-wave radiometry (broadband and narrow band) to produce sky maps of stochastic gravitational-wave backgrounds and to search for gravitational waves from point sources. A spherical harmonic decomposition method is employed to look for gravitational-wave emission from spatially-extended sources. Neither technique found evidence of gravitational-wave signals. Hence we derive 95% confidence-level upper limit sky maps on the gravitational-wave energy flux from broadband point sources, ranging from Fα,Θ<(0.013–7.6)×10−8 erg cm−2 s−1 Hz−1, and on the (normalized) gravitational-wave energy density spectrum from extended sources, ranging from Ωα,Θ<(0.57–9.3)×10−9 sr−1, depending on direction (Θ) and spectral index (α). These limits improve upon previous limits by factors of 2.9–3.5. We also set 95% confidence level upper limits on the frequency-dependent strain amplitudes of quasimonochromatic gravitational waves coming from three interesting targets, Scorpius X-1, SN 1987A and the Galactic Center, with best upper limits range from h0<(1.7–2.1)×10−25, a factor of ≥2.0 improvement compared to previous stochastic radiometer searches.

关键词： Experimental studies of gravity General relativity Gravitational waves

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In situ characterization of nanoparticles using rayleigh scattering

arXiv

引用

arXiv 2017年

作者： Santra, Biswajit Shneider, Mikhail N. Car, Roberto Department of Chemistry Princeton University PrincetonNJ08544 United States Mechanical and Aerospace Engineering Department Princeton University PrincetonNJ08544 United States Princeton Institute for the Science and Technology of Materials Princeton University PrincetonNJ08544 United States Program in Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States

We report a theoretical analysis showing that Rayleigh scattering could be used to monitor the growth of nanoparticles under arc discharge conditions. We compute the Rayleigh scattering cross sections of the nanoparticles by combining light scattering theory for gas-particle mixtures with calculations of the dynamic electronic polarizability of the nanoparticles. We find that the resolution of the Rayleigh scattering probe is adequate to detect nanoparticles as small as C60 at the expected concentrations of synthesis conditions in the arc periphery. Larger asymmetric nanoparticles would yield brighter signals, making possible to follow the evolution of the growing nanoparticle population from the evolution of the scattered intensity. Observable spectral features include characteristic resonant behaviour, shape-dependent depolarization ratio, and mass-dependent line shape. Direct observation of nanoparticles in the early stages of growth with unobtrusive laser probes should give insight on the particle formation mechanisms and may lead to better-controlled synthesis protocols. Copyright © 2017, The Authors. All rights reserved.

关键词： Rayleigh scattering

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