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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Valley-selective optical Stark effect probed by Kerr rotation

arXiv

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arXiv 2017年

作者： LaMountain, Trevor Bergeron, Hadallia Balla, Itamar Stanev, Teodor K. Hersam, Mark C. Stern, Nathaniel P. Applied Physics Program Northwestern University EvanstonIL60208 United States Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Department of Physics and Astronomy Northwestern University EvanstonIL60208 United States Department of Chemistry Northwestern University EvanstonIL60208 United States Department of Electrical Engineering and Computer Science Northwestern University EvanstonIL60208 United States

The ability to monitor and control distinct states is at the heart of emerging quantum technologies. The valley pseudospin in transition metal dichalcogenide (TMDC) monolayers is a promising degree of freedom for such control, with the optical Stark effect allowing for valley-selective manipulation of energy levels in WS2 and WSe2 using ultrafast optical pulses. Despite these advances, understanding of valley-sensitive optical Stark shifts in TMDCs has been limited by reflectance-based detection methods where the signal is small and prone to background effects. More sensitive polarization-based spectroscopy is required to better probe ultrafast Stark shifts for all-optical manipulation of valley energy levels. Here, we show time-resolved Kerr rotation to be a more sensitive probe of the valley-selective optical Stark effect in monolayer TMDCs. Compared to the established time-resolved reflectance methods, Kerr rotation is less sensitive to background effects. Kerr rotation provides a five-fold improvement in the signal-to-noise ratio of the Stark effect optical signal and a more precise estimate of the energy shift. This increased sensitivity allows for observation of an optical Stark shift in monolayer MoS2 that exhibits both valley- and energy-selectivity, demonstrating the promise of this method for investigating this effect in other layered materials and heterostructures. Copyright © 2017, The Authors. All rights reserved.

关键词： Landforms

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A Precise Description of Inorganic Nanoparticles in HRTEM Micrographs

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Microscopy and Microanalysis 2016年第S3期22卷 548-549页

作者： D. Groom S. Rasouli K. Yu A. Bovik P.J. Ferreira Chemical Engineering University of Texas at Austin Austin TX Materials Science and Engineering Program University of Texas at Austin Austin TX Electrical and Computer Engineering University of Texas at Austin Austin TX

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Augmented Reality Based Brain Tumor 3D Visualization

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Procedia computer Science 2017年 113卷 400-407页

作者： Qian Shan Thomas E. Doyle Reza Samavi Mona Al-Rei Department of Computing and Software McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada Department of Electrical and Computer Engineering School of Biomedical Engineering McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada eHealth Graduate Program McMaster University 1280 Main St. W Hamilton ON L8S 4L8 Canada

In this paper we present an augmented reality system for mobile devices that facilitates 3D brain tumor visualization in real time. The system uses facial features to track the subject in the scene. The system performs camera calibration based on the face size of the subject, instead of the common approach of using a number of chessboard images to calibrate the camera every time the application is installed on a new device. Camera 3D pose estimation is performed by finding its position and orientation based on a set of 3D points and their corresponding 2D projections. According to the estimated camera pose, a reconstructed brain tumor model is displayed at the same location as the subject’s real anatomy. The results of our experiment show the system was successful in performing the brain tumor augmentation in real time with a reprojection accuracy of 97%.

关键词： Augmented reality 3D visualization Tumor visualization Markerless tracking Mobile device

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N-Queens solving algorithm by sets and backtracking

N-Queens solving algorithm by sets and backtracking

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IEEE Southeastcon

作者： Serkan Güldal Veronica Baugh Saleh Allehaibi Interdisciplinary Engineering Program University of Alabama in Birmingham Birmingham USA Department of Electric and Computer Engineering University of Alabama in Birmingham Birmingham USA

The N-Queens problem has been studied for over a century. The N-Queens problem may be solved using a variety of methods including backtracking algorithms and mathematical equations such as magic squares. We propose a more efficient approach to the most used technique, backtracking, by removing the threatened cells in order to decrease the number of trial and error steps.

关键词： Algorithm design and analysis computers Runtime Operating systems Optimization Central Processing Unit Classification algorithms

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A Model Predictive Control technique for utility-scale grid connected battery systems using packed U cells multilevel inverter

A Model Predictive Control technique for utility-scale grid ...

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Annual Conference of Industrial Electronics Society

作者： Shunlong Xiao Morcos Metry Mohamed Trabelsi Robert S. Balog Haitham Abu-Rub Department of Electrical and Computer Engineering Texas A&M University College Station TX USA Electrical & Computer Engineering Program Texas A&M University at Qatar Doha Qatar

Grid-connected energy storage systems have been implemented in ac power systems as uninterruptable power supplies (UPS). Batteries and bi-directional power converters provide electrical power when off-grid and recharge when grid-connected. In this paper, a packed U cells (PUC) seven-level inverter has been selected as the grid-interface due to the lower cost and fewer number of components compared to other bi-directional topologies. Additionally, the PUC has higher power quality when compared to the traditional H-bridge. Compared to the traditional PI controller, Model Predictive Control (MPC) is attracting more interest due to its good dynamic response and high accuracy of reference tracking. Through the minimization of a user-defined cost function, the proposed MPC technique can simultaneously achieve unity power factor, low total harmonics distortion of the grid-side current and balance the PUC capacitor's voltages at the grid side, and control bi-directional power flow in the batteries-PUC system. The presented topology and proposed control technique are verified by simulating a 600 W reduced-scale prototype. The theoretical principles are validated by implementing the controller on the prototype using dSPACE 1007 platform.

关键词： Batteries Voltage control Inverters Cost function Capacitors Switches Predictive control

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Femtosecond photonic viral inactivation probed using solid-state nanopores

arXiv

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arXiv 2018年

作者： Nazari, Mina Li, Xiaoqing Alibakhshi, Mohammad Amin Yang, Haojie Souza, Kathleen Gillespie, Christopher Gummuluru, Suryaram Reinhard, Björn M. Korolev, Kirill S. Ziegler, Lawrence D. Zhao, Qing Wanunu, Meni Erramilli, Shyamsunder Department of Electrical and Computer Engineering Boston University BostonMA02115 United States Department of Physics Boston University BostonMA02115 United States Department of Chemistry Boston University BostonMA02115 United States Photonics Center Boston University BostonMA02115 United States Bioinformatics Program Boston University BostonMA02115 United States Department of Microbiology Boston University School of Medicine BostonMA02118 United States Department of Physics Northeastern University BostonMA02115 United States Next Generation Bioprocessing MilliporeSigma BedfordMA01730 United States School of Physics Peking University Beijing China Department of Mechanics Southeast University Nanjing China

We report on the detection of inactivation of virus particles using femtosecond laser radiation by measuring the conductance of a solid state nanopore designed for detecting single virus particles. Conventional methods of assaying for viral inactivation based on plaque forming assays require 24-48 hours for bacterial growth. Nanopore conductance measurements provide information on morphological changes at a single virion level. We show that analysis of a time series of nanopore conductance can quantify the detection of inactivation, requiring only a few minutes from collection to analysis. Morphological changes were verified by Dynamic Light Scattering (DLS). Statistical analysis maximizing the information entropy provides a measure of the Log-reduction value. Taken together, our work provides a rapid method for assaying viral inactivation with femtosecond lasers using solid-state nanopores. Copyright © 2018, The Authors. All rights reserved.

关键词： Femtosecond lasers

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Quantum annealing versus classical machine learning applied to a simplified computational biology problem

arXiv

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arXiv 2018年

作者： Li, Richard Di Felice, Rosa Rohs, Remo Lidar, Daniel Department of Chemistry University of Southern California Los AngelesCA90089 United States Computational Biology and Bioinformatics Program Department of Biological Sciences University of Southern California Los AngelesCA90089 United States Center for Quantum Information Science & Technology University of Southern California Los AngelesCA90089 United States Department of Physics and Astronomy University of Southern California Los AngelesCA90089 United States Center S3 CNR Institute of Nanoscience Via Campi 213/A Modena41125 Italy Department of Computer Science University of Southern California Los AngelesCA90089 United States Department of Electrical Engineering University of Southern California Los AngelesCA90089 United States

Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the ability of a quantum machine learning approach to predict binding specificity. Using simplified datasets of a small number of DNA sequences derived from actual binding affinity experiments, we trained a commercially available quantum annealer to classify and rank transcription factor binding. The results were compared to state-of-the-art classical approaches for the same simplified datasets, including simulated annealing, simulated quantum annealing, multiple linear regression, LASSO, and extreme gradient boosting. Despite technological limitations, we find a slight advantage in classification performance and nearly equal ranking performance using the quantum annealer for these fairly small training data sets. Thus, we propose that quantum annealing might be an effective method to implement machine learning for certain computational biology problems. Copyright © 2018, The Authors. All rights reserved.

关键词： Simulated annealing

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Model predictive control for PV maximum power point tracking of single-phase subMultilevel Inverter

Model predictive control for PV maximum power point tracking...

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IEEE Power and Energy Conference at Illinois, PECI 2016

作者： Metry, Morcos Bayhan, Sertac Balog, Robert S. Rub, Haitham Abu Renewable Energy and Advanced Power Electronics Research Laboratory United States Department of Electrical and Computer Engineering Texas AandM University College StationTX United States Department of Electronics and Automation Gazi University Ankara Turkey Electrical and Computer Engineering Program Texas AandM University at Qatar Doha Qatar Qatar Environment and Energy Research Institute Hamad Bin Khalifa University Qatar Foundation Doha Qatar

ISBN: (纸本)9781509002610

Dynamic behavior of solar energy resource entails the need of robust controllers that can converge to the maximum power point (MPP) to maximize energy harvest. This paper explores an improved Perturb and Observe (P&O) technique that combines a fixed step model predictive controller (MPC), to speed up the control loop, applied to a boost converter. The proposed MPC Maximum Power Point Tracking (MPPT) technique is of higher efficacy and robustness over conventional MPPT. The improved MPCMPPT is tested for the first time on an MPC strategy of sevenlevel subMultilevel Inverter (sMI) using three power arms cascaded with the H-bridge inverter. Such topology brings about many sizable benefits such as reduced number of power switches and their gate drivers when compared to the traditional multilevel inverter. MPC is also used as the control strategy for the sMI to eliminate complexities in the space vector pulse width modulation (SVPWM) and overcome the weaknesses of the inner control loop performance. © 2016 IEEE.

关键词： Model predictive control

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Management of intellectual capital in a system of management accounting information 6

Management of intellectual capital in a system of management...

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6th International Conference on computers Communications and Control, ICCCC 2016

作者： Piontkewicz, Regiane Freitas, Maria Do Carmo D. Kemczinski, Avanilde Martin, Claudia Duran San Department of Industrial Engineering Federal University of Paraná Curitiba Brazil Department of Science and Information Management Faculty of Information Management Federal University of Paraná Curitiba Brazil Graduate Program in Applied Computing Computer Science Department Santa Catarina State University Joinville Brazil Department of Industrial Engineering Faculty of Engineering University of Santiago de Chile Santiago Chile

ISBN: (纸本)9781509017355

The recognition of Intellectual Capital as a source of competitive advantage and differentiation element for organizations requires an application of new management strategies that include this feature. Considering the importance of the Accounting Information System (AIS) in organizations, the research has the main objective to investigate the contributions of accounting as Management Information System in management of Intellectual Capital in an organization. Therefore, it was adopted a single case study as research strategy, applied in a Brazilian industry of consumption goods, on the market for over 85 years. The results obtained in the documentary analysis, questionnaires, interviews and literature show that the Accounting Management Information System (AMIS) contributes to the management of Intellectual Capital. In the investigated organization, AMIS is widely used and shows similarities with the specifications found in the literature, possessing the ability of adaptation to receive indicators or variables that enable the management of Intellectual Capital. It was found that the incorporation of the variables of Intellectual Capital in AMIS could be accomplished by adopting the method proposed by López-Ruiz and Nevado-Pena, that uses both traditional financial indicators and indicators of Intellectual Capital, not conflicting with the traditional AMIS, but complementing it. Inserting variables of Intellectual Capital in AMIS also allows uniformity of understanding on the subject by all company managers. © 2016 IEEE.

关键词： Competition

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