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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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P2.02-026 Impact of PD-L1 Expression on 18F-FDG-PET in Pulmonary Squamous Cell Carcinoma

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Journal of Thoracic Oncology 2017年第11期12卷 S2108-S2108页

作者： N. Kasahara K. Kaira B. Alatan T. Higuachi Y. Arisaka E. Bilguun N. Sunaga T. Oyama T. Yokobori T. Asao M. Nishiyama K. Shimizu A. Mogi H. Kuwano Department of Respiratory Medicine Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Department of Oncology Clinical Development Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Oncology Center Gunma University Hospital Maebashi Gunma Japan/JP Department of Diagnostic Pathology Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Research Program for Omics-Based Medical Science Division of Integrated Oncology Research Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Big Data Center for Integrative Analysis Gunma University Initiative for Advance Research Maebashi Gunma Japan/JP Department of Molecular Pharmacology and Oncology Gunma University Graduate School of Medicine Maebashi Gunma Japan/JP Division of General Thoracic Surgery Integrative Center of General Surgery Gunma University Hospital Maebashi/JP Integrative Center of General Surgery Gunma University Hospital Maebashi Gunma Japan/JP

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Cosmic-ray electron-positron spectrum from 7 GeV to 2 TeV with the Fermi Large Area Telescope

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Physical Review D 2017年第8期95卷 082007-082007页

作者： S. Abdollahi M. Ackermann M. Ajello W. B. Atwood L. Baldini G. Barbiellini D. Bastieri R. Bellazzini E. D. Bloom R. Bonino T. J. Brandt J. Bregeon P. Bruel R. Buehler R. A. Cameron R. Caputo M. Caragiulo D. Castro E. Cavazzuti C. Cecchi A. Chekhtman S. Ciprini J. Cohen-Tanugi F. Costanza A. Cuoco S. Cutini F. D’Ammando F. de Palma R. Desiante S. W. Digel N. Di Lalla M. Di Mauro L. Di Venere P. S. Drell A. Drlica-Wagner C. Favuzzi W. B. Focke S. Funk P. Fusco F. Gargano D. Gasparrini N. Giglietto F. Giordano M. Giroletti D. Green L. Guillemot S. Guiriec A. K. Harding T. Jogler G. Jóhannesson T. Kamae M. Kuss G. La Mura L. Latronico F. Longo F. Loparco P. Lubrano S. Maldera D. Malyshev A. Manfreda M. N. Mazziotta P. F. Michelson N. Mirabal W. Mitthumsiri T. Mizuno A. A. Moiseev M. E. Monzani A. Morselli I. V. Moskalenko M. Negro E. Nuss E. Orlando D. Paneque J. S. Perkins M. Pesce-Rollins F. Piron G. Pivato T. A. Porter G. Principe S. Rainò R. Rando M. Razzano A. Reimer O. Reimer C. Sgrò D. Simone E. J. Siskind F. Spada G. Spandre P. Spinelli H. Tajima J. B. Thayer L. Tibaldo D. F. Torres E. Troja M. Wood A. Worley G. Zaharijas S. Zimmer Department of Physical Sciences Hiroshima University Higashi-Hiroshima Hiroshima 739-8526 Japan Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics Clemson South Carolina 29634-0978 USA Santa Cruz Institute for Particle Physics Department of Physics and Department of Astronomy and Astrophysics University of California at Santa Cruz Santa Cruz California 95064 USA Università di Pisa and Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica e Astronomia “G. Galilei ” Università di Padova I-35131 Padova Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford California 94305 USA Istituto Nazionale di Fisica Nucleare Sezione di Torino I-10125 Torino Italy Dipartimento di Fisica Università degli Studi di Torino I-10125 Torino Italy NASA Goddard Space Flight Center Greenbelt Maryland 20771 USA Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 F-34095 Montpellier France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 F-91128 Palaiseau France Dipartimento di Fisica “M. Merlin” dell’Università e del Politecnico di Bari I-70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari I-70126 Bari Italy Agenzia Spaziale Italiana (ASI) Science Data Center I-00133 Roma Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia I-06123 Perugia Italy Dipartimento di Fisica Università degli Studi di Perugia I-06123 Perugia Italy College of Science

We present a measurement of the cosmic-ray electron+positron spectrum between 7 GeV and 2 TeV performed with almost seven years of data collected with the Fermi Large Area Telescope. We find that the spectrum is well fit by a broken power law with a break energy at about 50 GeV. Above 50 GeV, the spectrum is well described by a single power law with a spectral index of 3.07±0.02(stat+syst)±0.04(energy measurement). An exponential cutoff lower than 1.8 TeV is excluded at 95% CL.

关键词： Cosmic ray & astroparticle detectors Cosmic ray composition & spectra Cosmic ray sources Particle astrophysics

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Integrating knowledge tracing and item response theory: A tale of two frameworks 22

Integrating knowledge tracing and item response theory: A ta...

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Workshop of the 22nd Conference on User Modeling, Adaptation, and Personalization, UMAP 2014 - Co-located with the 22nd Conference on User Modeling, Adaptation, and Personalization, UMAP 2014

作者： Khajah, Mohammad M. Huang, Yun González-Brenes, José P. Mozer, Michael C. Brusilovsky, Peter Department of Computer Science Institute of Cognitive Science University of Colorado BoulderCO80309-0430 United States Intelligent Systems Program University of Pittsburgh PittsburghPA15260 United States Digital Data Analytics and Adaptive Learning Pearson Research and Innovation Network PhiladelphiaPA19103 United States

Traditionally, the assessment and learning science commu-nities rely on different paradigms to model student performance. The assessment community uses Item Response Theory which allows modeling different student abilities and problem difficulties, while the learning science community uses Knowledge Tracing, which captures skill acquisition. These two paradigms are complementary - IRT cannot be used to model student learning, while Knowledge Tracing assumes all students and problems are the same. Recently, two highly related models based on a principled synthesis of IRT and Knowledge Tracing were introduced. However, these two models were evaluated on different data sets, using different evaluation metrics and with different ways of splitting the data into training and testing sets. In this paper we reconcile the models' results by presenting a unified view of the two models, and by evaluating the models under a common evaluation metric. We find that both models are equivalent and only differ in their training procedure. Our results show that the combined IRT and Knowledge Tracing models offer the best of assessment and learning sciences - high prediction accuracy like the IRT model, and the ability to model student learning like Knowledge Tracing.

关键词： Students

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Search for extended sources in the galactic plane using 6 years of Fermi-Large area telescope pass 8 data above 10 GeV

arXiv

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arXiv 2017年

作者： Ackermann, M. Ajello, M. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Bloom, E.D. Bonino, R. Bottacini, E. Brandt, T.J. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caragiulo, M. Caraveo, P.A. Castro, D. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Cheung, C.C. Chiaro, G. Ciprini, S. Cohen, J.M. Costantin, D. Costanza, F. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Favuzzi, C. Fegan, S.J. Ferrara, E.C. Franckowiak, A. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Green, D. Grenier, I.A. Grondin, M.-H. Guillemot, L. Guiriec, S. Harding, A.K. Hays, E. Hewitt, J.W. Horan, D. Hou, X. Jóhannesson, G. Kamae, T. Kuss, M. la Mura, G. Larsson, S. Lemoine-Goumard, M. Li, J. Longo, F. Loparco, F. Lubrano, P. Magill, J.D. Maldera, S. Malyshev, D. Manfreda, A. Mazziotta, M.N. Michelson, P.F. Mitthumsiri, W. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Omodei, N. Orienti, M. Orlando, E. Ormes, J.F. Paliya, V.S. Paneque, D. Perkins, J.S. Persic, M. Pesce-Rollins, M. Petrosian, V. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Razzaque, S. Reimer, A. Reimer, O. Reposeur, T. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Suson, D.J. Tak, D. Thayer, J.B. Thompson, D.J. Torres, D.F. Tosti, G. Troja, E. Vianello, G. Wood, K.S. Wood, M. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia PerugiaI-06123 Italy Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy College of Science George Mason University Fairfax VA22030 United States Naval Research Laboratory Washi

The spatial extension of a γ-ray source is an essential ingredient to determine its spectral properties as well as its potential multi-wavelength counterpart. The capability to spatially resolve γ-ray sources is greatly improved by the newly delivered Fermi-Large Area Telescope (LAT) Pass 8 event-level analysis which provides a greater acceptance and an improved point spread function, two crucial factors for the detection of extended sources. Here, we present a complete search for extended sources located within 7◦ from the Galactic plane, using 6 years of Fermi-LAT data above 10 GeV. We find 46 extended sources and provide their morphological and spectral characteristics. This constitutes the first catalog of hard Fermi-LAT extended sources, named the Fermi Galactic Extended Source Catalog, which allows a thorough study of the properties of the Galactic plane in the sub-TeV domain. Copyright © 2017, The Authors. All rights reserved.

关键词： Gamma rays

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MB-94 IMMUNOLOGIC PROFILE OF PATIENTS WITH NEWLY-DIAGNOSED MEDULLOBLASTOMA AT INITIAL DIAGNOSIS AND DURING STANDARD RADIATION AND CHEMOTHERAPY (PBTC-N11)

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Neuro-Oncology 2016年第SUPPL_3期18卷 iii118-iii118页

作者： Sridharan Gururangan Elizabeth Reap Renee Reynolds Gerald Grant Arzu Onar-Thomas Mehmet Kodak Patricia Baxter Ian Pollack Peter Phillips James Boyett Maryam Fouladi Duane Mitchell Preston A. Wells Center for Brain Tumor Therapy University of Florida Gainesville FL USA Immunotherapy Program Duke University Medical Center Durham NC USA Department of Neurosurgery State University of New York at Buffalo Buffalo NY USA Department of Neurosurgery Stanford University Palo Alto CA USA Operations Biostatistics and Data Management Center The Pediatric Brain Tumor Consortium Memphis TN USA University of Tennessee Health Science Center Memphis TN USA Texas Children's Cancer Center Houston TX USA Department of Neurosurgery Children's Hospital of Pittsburgh Pittsburgh PA USA Neuro-Oncology Program Children's Hospital of Philadelphia Philadelphia PA USA Cincinnati Children's Hospital Medical Center Cincinnati OH USA

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Cosmic-ray electron+positron spectrum from 7 GeV to 2 TeV with the Fermi Large Area Telescope

arXiv

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arXiv 2017年

作者： Abdollahi, S. Ackermann, M. Ajello, M. Atwood, W.B. Baldini, L. Barbiellini, G. Bastieri, D. Bellazzini, R. Bloom, E.D. Bonino, R. Brandt, T.J. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caputo, R. Caragiulo, M. Castro, D. Cavazzuti, E. Cecchi, C. Chekhtman, A. Ciprini, S. Cohen-Tanugi, J. Costanza, F. Cuoco, A. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Drell, P.S. Drlica-Wagner, A. Favuzzi, C. Focke, W.B. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Green, D. Guillemot, L. Guiriec, S. Harding, A.K. Jogler, T. Jóhannesson, G. Kamae, T. Kuss, M. la Mura, G. Latronico, L. Longo, F. Loparco, F. Lubrano, P. Maldera, S. Malyshev, D. Manfreda, A. Mazziotta, M.N. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Moiseev, A.A. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Orlando, E. Paneque, D. Perkins, J.S. Pesce-Rollins, M. Piron, F. Pivato, G. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Reimer, A. Reimer, O. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Tajima, H. Thayer, J.B. Tibaldo, L. Torres, D.F. Troja, E. Wood, M. Worley, A. Zaharijas, G. Zimmer, S. Department of Physical Sciences Hiroshima University Higashi-HiroshimaHiroshima739-8526 Japan Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Santa Cruz Institute for Particle Physics Department of Physics Department of Astronomy and Astrophysics University of California at Santa Cruz Santa CruzCA95064 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia PerugiaI-06123 Italy Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy College of Science George Mason University Fairfax VA22

We present a measurement of the cosmic-ray electron+positron spectrum between 7 GeV and 2 TeV performed with almost seven years of data collected with the Fermi Large Area Telescope. We find that the spectrum is well fit by a broken power law with a break energy at about 50 GeV. Above 50 GeV, the spectrum is well described by a single power law with a spectral index of 3.07 ± 0.02 (stat+syst) ± 0.04 (energy measurement). An exponential cutoff lower than 1.8 TeV is excluded at 95% CL. Copyright © 2017, The Authors. All rights reserved.

关键词： Cosmology

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Personalized medicine and Hispanic health: improving health outcomes and reducing health disparities - a National Heart, Lung, and Blood Institute workshop report

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BMC proceedings 2017年第SUPPL 11期11卷 11页

作者： M Larissa Avilés-Santa John Heintzman Nangel M Lindberg Rafael Guerrero-Preston Kenneth Ramos Ana L Abraído-Lanza Jonca Bull Adolph Falcón Mary Ann McBurnie Ernest Moy George Papanicolaou Ileana L Piña Jennifer Popovic Shakira F Suglia Miguel A Vázquez Division of Cardiovascular Sciences National Heart Lung and Blood Institute 6701 Rockledge Drive Room 10188 Bethesda MD 20892-7936 USA. Department of Family Medicine Oregon Health and Science University 318 SW Sam Jackson Park Rd Portland OR 97239 USA. Kaiser Permanente Northwest Center for Health Research 3800 N. Interstate Ave Portland OR 97227 USA. Johns Hopkins University School of Medicine 1550 Orleans Street CRB2 Room 5M Baltimore MD 21231 USA. University of Arizona Health Sciences 1295 North Martin Avenue PO Box 210202 Tucson AZ 86721 USA. Columbia University Mailman School of Public Health 722 West 168th Street New York NY 10032 USA. Office of Minority Health U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring MD 20993 USA. National Alliance for Hispanic Health 1600 P St NW Washington DC 20009 USA. National Center for Health Statistics 3311 Toledo Road Hyattsville MD 20782 USA. Albert Einstein College of Medicine Montefiore Heart and Vascular Center 111 East 210th Street Bronx NY 10467-2401 USA. Program for Health Data and Standardized Methods Center for Health Data Analytics | eHealth Quality & Analytics Division RTI International | 307 Waverley Oaks Road Suite 101 Waltham MA 02452 USA. Rollins School of Public Health Emory University 1518 Clifton Rd Rm 4005 Atlanta GA 30322 USA. Department of Internal Medicine University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard Dallas TX 75390-8856 USA.

Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U.S., thus leading to new strategies that improve health care outcomes. However, there are major gaps in our current knowledge about how personalized medicine can shape health outcomes among Hispanics/Latinos and address the potential factors that may explain the observed differences within this heterogeneous group, and between this group and other U.S. demographic groups. For that purpose, the National Heart, Lung, and Blood Institute (NHLBI), in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Food and Drug Administration (FDA), held a workshop in which experts discussed (1) potential approaches to study medical treatments and health outcomes among Hispanics/Latinos and garner the necessary evidence to fill gaps of efficacy, effectiveness and safety of therapies for heart, lung, blood and sleep (HLBS) disorders and conditions--and their risk factors; (2) research opportunities related to personalized medicine to improve knowledge and develop effective interventions to reduce health disparities among Hispanics/Latinos in the U.S.; and (3) the incorporation of expanded sociocultural and socioeconomic data collection and genetic/genomic/epigenetic information of Hispanic/Latino patients into their clinical assessments, to account for individual variability in ancestry; physiology or disease risk; culture; environment; lifestyle; and socioeconomic determinants of health. The experts also provided recommendat

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NGS-Based Copy Number Analysis in 1,185 Patients with Myeloid Neoplasms

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BLOOD 2016年第22期128卷 955-955页

作者： Saiki, Ryunosuke Shiozawa, Yusuke Yoshizato, Tetsuichi Yoshida, Kenichi Shiraishi, Yuichi Tanaka, Hiroko Chiba, Kenichi Atsuta, Yoshiko Onizuka, Makoto Itonaga, Hidehiro Kanda, Yoshinobu Sekeres, Mikkael A. Guinta, Kathryn M. Miyawaki, Shuichi Nakamaki, Tsuyoshi Chiba, Shigeru Shih, Lee-Yung Miyazaki, Yasushi Miyano, Satoru Makishima, Hideki Maciejewski, Jaroslaw P. Ogawa, Seishi Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Department of Pediatrics Graduate School of Medicine The University of Tokyo Tokyo Japan Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Laboratory of DNA information Analysis & Laboratory of Sequence Analysis Human Genome Center The University of Tokyo Tokyo Japan Japanese Data Center for Hematopoietic Cell Transplantation Nagoya Japan Nagoya University Graduate School of Medicine Nagoya Japan Department of Hematology and Oncology Tokai University School of Medicine Isehara Japan Department of Hematology Atomic Bomb Disease and Hibakusha Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan Division of Hematology Saitama Medical Center Jichi Medical University Saitama Japan Department of Translational Hematology and Oncology Research Taussig Cancer Institute Cleveland Clinic Cleveland OH Leukemia Program Department of Hematology and Medical Oncology Cleveland Clinic Cleveland OH Division of Hematology Tokyo Metropolitan Ohtsuka Hospital Tokyo Japan Department of Hematology Showa University School of Medicine Tokyo Japan Department of Hematology Faculty of Medicine University of Tsukuba Tsukuba Japan Division of Hematology-Oncology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Taoyuan Taiwan

955

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OBSERVATIONS OF M31 AND M33 WITH THE FERMI LARGE AREA TELESCOPE: A GALACTIC CENTER EXCESS IN ANDROMEDA?

arXiv

引用

arXiv 2017年

作者： Ackermann, M. Ajello, M. Albert, A. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Bloom, E.D. Bonino, R. Bottacini, E. Brandt, T.J. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caputo, R. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Chiaro, G. Ciprini, S. Costanza, F. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Favuzzi, C. Funk, S. Fusco, P. Gargano, F. Giglietto, N. Giordano, F. Giroletti, M. Glanzman, T. Green, D. Grenier, I.A. Guillemot, L. Guiriec, S. Hayashi, K. Hou, X. Jóhannesson, G. Kamae, T. Knödlseder, J. Kong, A.K.H. Kuss, M. la Mura, G. Larsson, S. Latronico, L. Li, J. Longo, F. Loparco, F. Lubrano, P. Maldera, S. Malyshev, D. Manfreda, A. Martin, P. Mazziotta, M.N. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Omodei, N. Orlando, E. Ormes, J.F. Paneque, D. Persic, M. Pesce-Rollins, M. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Reimer, O. Sánchez-Conde, M. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Tanaka, K. Tibaldo, L. Torres, D.F. Troja, E. Uchiyama, Y. Wang, J.C. Wood, K.S. Wood, M. Zaharijas, G. Zhou, M. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Los Alamos National Laboratory Los AlamosNM87545 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Santa Cruz Institute for Particle Physics Department of Physics Department of Astronomy and Astrophysics University of California at Santa Cruz Santa CruzCA95064 United States Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fi

The Fermi Large Area Telescope (LAT) has opened the way for comparative studies of cosmic rays (CRs) and high-energy objects in the Milky Way (MW) and in other, external, star-forming galaxies. Using 2 yr of observations with the Fermi LAT, Local Group galaxy M31 was detected as a marginally extended gamma-ray source, while only an upper limit has been derived for the other nearby galaxy M33. We revisited the gamma-ray emission in the direction of M31 and M33 using more than 7 yr of LAT Pass 8 data in the energy range 0.1−100 GeV, presenting detailed morphological and spectral analyses. M33 remains undetected, and we computed an upper limit of 2.0×10−12 erg cm−2 s−1 on the 0.1−100 GeV energy flux (95% confidence level). This revised upper limit remains consistent with the observed correlation between gamma-ray luminosity and star-formation rate tracers and implies an average CR density in M33 that is at most half of that of the MW. M31 is detected with a significance of nearly 10σ. Its spectrum is consistent with a power law with photon index Γ = 2.4±0.1stat+syst and a 0.1−100 GeV energy flux of (5.6±0.6stat+syst)×10−12 erg cm−2 s−1. M31 is detected to be extended with a 4σ significance. The spatial distribution of the emission is consistent with a uniform-brightness disk with a radius of 0◦.4 and no offset from the center of the galaxy, but nonuniform intensity distributions cannot be excluded. The flux from M31 appears confined to the inner regions of the galaxy and does not fill the disk of the galaxy or extend far from it. The gamma-ray signal is not correlated with regions rich in gas or star-formation activity, which suggests that the emission is not interstellar in origin, unless the energetic particles radiating in gamma rays do not originate in recent star formation. Alternative and nonexclusive interpretations are that the emission results from a population of millisecond pulsars dispersed in the bulge and disk of M31 by disrupted globular clusters or from

关键词： Galaxies

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