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Proposing plant-derived extracellular vesicles as sustainable and safe bioactive nanocarriers for target-specific human skin transdermal therapeutics strategies

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Sustainable Materials and Technologies 2025年 45卷

作者： Mulyani, Rizka Adi, Prakoso Yudhistira, Bara Chang, Chao-Kai Gavahian, Mohsen Hsu, Hsien-Yi Chen, Yeh Hsieh, Chang-Wei International Doctoral Program in Agriculture National Chung Hsing University Taichung City402202 Taiwan Department of Agricultural Product Technology Sebelas Maret University Central Java Surakarta City57126 Indonesia Department of Food Science and Technology Sebelas Maret University Central Java Surakarta City57126 Indonesia Department of Food Science and Biotechnology National Chung Hsing University Taichung City402202 Taiwan Department of Food Science National Pingtung University of Science and Technology Pingtung Neipu912301 Taiwan School of Energy and Environment Department of Materials Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Food Science National Ilan University Shennong Road Yilan City260007 Taiwan Department of Medical Research China Medical University Hospital Taichung City40447 Taiwan

Plant-derived extracellular vesicles (PDEVs) as bioactive nanocarriers are promising alternatives to mammalian-derived extracellular vesicles (MDEVs) in therapeutic applications. Specifically, the richness in secondary metabolites, such as polyphenols and flavonoids, allows PDEVs to replicate the anti-inflammatory, antioxidative, anti-cancer, and wound-healing properties of MDEVs. In addition, PDEVs also served as cost-effective resources with ethical benefits by avoiding animal use. This characteristic aligns with consumer demand for sustainable and animal-free skin therapeutic solutions. The widespread availability of plants as food sources also provides a foundation for large-scale PDEVs production. However, further research on efficient isolation and characterization methods is essential to enhance the practicality and efficacy of PDEVs production. In addition, future research could benefit from re-engineering PDEVs to improve stability, targeting specificity, and loading capacity for therapeutic agents. This improvement is important for the reliability and efficacy of PDEVs in skin therapy applications. Despite the current potential, applications and mechanisms of PDEVs in skin therapy remain underexplored. Thus, this review highlights the key characteristics of PDEVs that underpin the potential application in skin transdermal. Furthermore, this review addresses core aspects such as isolation, characterization methods, functional assessment, and mechanisms of action of PDEVs while outlining current regulations, challenges, and future trends. Ultimately, this review will deliver insights into the applications and potential efficient production methods of PDEVs for skin therapeutic purposes. PDEVs were identified as safer, sustainable options for skin treatment, capable of driving innovative developments in skin therapeutic applications. © 2025

关键词： Rats

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Effect of bean maturity and roasting temperature on chemical content of robusta coffee

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IOP Conference Series: Materials Science and engineering 2020年第2期830卷

作者： N L E Wahyuni R Rispiandi T Hariyadi Chemical Engineering Department Politeknik Negeri Bandung Jl. GegerkalongHilir Ds. Ciwaruga Bandung 40559 Indonesia Doctoral Program in Agricultural Sciences Faculty of Agriculture Padjadjaran University Jl Bandung-Sumedang KM 21 Bandung Indonesia

This study aims to determine the effect of roasting temperature on chemical content of coffee beans at various fruit maturity. Robusta coffee was obtained from Karawang Regency, West Java. After picking, sortation, and drying in the sun to 10% moisture content, the coffee beans were roasted at 190°C, 200°C, 210°C for 12 minutes. Physical properties observed were weight loss during the roasting. The chemical content observed were water, caffeine, fat, chlorogenic acid and ash before and after roasting. Chemical content analysis was performed using gravimetric methods, soxhlet extraction, and UV-Vis spectrophotometry. The color, aroma and flavor of roasted bean were conducted by organoleptic test. The results obtained, the ripe coffee bean with roasting temperature of 210°C is the best, which gives the lowest yield. The unripe green beans have the highest water content. The roasting temperature did not provide a significant difference in fat, caffeine, chlorogenic acid, and ash content. Organoleptic test results (color and aroma) showed that the mature beans with roasting temperature of 200-210°C were the most preferred, while the coffee brew most preferred was overripe bean with the roasting temperature of 200°C.

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Purchasing Strategy of Small-sized Contractors for Building Projects in The Greater Bandung Areas

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IOP Conference Series: Materials Science and engineering 2019年第1期650卷

作者： R Irfanto F S C S Maisarah M Abduh Postgraduate student in Civil Engineering Masters Program Faculty of Civil and Environmental Engineering Institut Teknologi Bandung Bandung Doctoral student in Civil Engineering Doctoral Program Faculty of Civil and Environmental Engineering Institut Teknologi Bandung Bandung Lecturer in Civil Engineering Faculty of Civil and Environmental Engineering Institut Teknologi Bandung Bandung

The purchasing strategy of commodities in a construction project is one of the things that determine the success of a project. Commodities in construction projects are very diverse, thus the commodity purchasing strategy will be focused on strategic commodities. Important strategic commodities are determined by contractors in managing logistics to support the implementation of the projects they are working on. This paper discusses the purchasing strategy for small-sized contractors who are usually working on building projects in Greater Bandung areas. The methodology used for this study were identifying strategic commodities by conducting a survey of 10 small-sized contractors in Greater Bandung areas, getting an assessment of strategic commodities, and to trace the historical data of the project, confirming the value of purchasing strategic commodities, then analyze the appropriate purchasing strategy by doing literature review while considering the nature of strategic commodities. The results of the study show that strategic commodities in buildings are sand, cement, concrete, reinforcing steel, brick, and glass.

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Implementation of Fuzzy-based Model for Prediction of Prostate Cancer

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Journal of Physics: Conference Series 2021年第1期1751卷

作者： Rusliyawati Kurnia Muludi Admi Syarif Agus Wantoro Doctoral Program of Mathematics and Science Faculty Lampung University Jl. Sumantri Brojonegoro No 1 Bandar Lampung Indonesia. Faculty of Engineering and Computer Science Universitas Teknokrat Indonesia J. ZA. Pagaralam No. 9-11 Bandar Lampung Indonesia. Department of Computer Science Faculty of Mathematics and Science University of Lampung Jl. Sumantri Brojonegoro No 1 Bandar Lampung Indonesia

Cancer is one of the leading causes of death worldwide. One type of cancer that causes death in the male population is prostate cancer. This disease occurs only in men because in women they do not have a prostate appearance. The aim of this study was to compare the accuracy of the model with the predictions of prostate cancer specialists. Prediction is made based on prostate specific antigen data, age, and patient prostate volume. The independent variables in this study were prostate specific antigen, age, and prostate volume. The dependent variable is the risk of prostate cancer using a fuzzy model. The novelty of this study is that the model has a low, moderate, high, and very high prostate cancer risk level output. In the previous article only PCR values were produced. The results show that the proposed fuzzy model provides a PCR value that is within the PCR interval predicted by a specialist doctor can be used properly to help diagnose and analyze the possibility of prostate cancer and is one of the considerations for doctors to decide whether or not a biopsy is needed for these patients.

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Electrolysis results in a comparison of metformin using aluminum, zinc, and iron (as the anode) as well as used carbon (as the cathode)

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Journal of Physics: Conference Series 2020年第1期1524卷

作者： S Suhartana P Purwanto A Darmawan Doctoral Program in Environmental Science School of Postgraduate Studies Universitas Diponegoro Semarang Indonesia Departement of Chemistry Faculty of Engineering Universitas Diponegoro Semarang Indonesia Inorganic Chemistry Laboratory Departement of Chemistry Faculty of Sciences and Mathematics Universitas Diponegoro Semarang Indonesia

Metformin is an antidiabetic drug that can be obtained easily in pharmacies/on the market, because it is traded freely, so people can easily buy and consume it. Ferrous metal, aluminum metal, and zinc metals are metal quite easy to find and are often used by the public. Metformin and Ferrous metal, aluminum metal and zinc metals are metal are quite familiar in the community. This research aims to deconcentrate metformin which can be obtained easily in pharmacies / on the market by electrolysis method, using ferrous metal, aluminum metal, and zinc metals are as an anode and carbon as the cathode. Electrolysis of metformin has been carried out using ferrous metal, aluminum metal, and zinc metal as an anode. The success of the electrolysis process was seen with a decrease in the sample COD index. In the case without the addition of electrolytes using ferrous metals, the COD index of the sample reduction was very low (9-17%). This research aims to increase the success of the electrolysis process, by adding various kinds of electrolytes, such as acetic acid (weak electrolytes), hydrochloric acid (strong electrolytes), sodium chloride and Fenton reagents. The addition of electrolytes can increase electrolysis yield significantly. The interaction between metformin during electrolysis is traced to the possibility of changes in the chromophore group (with UV-Visible spectra) and the functional group (with FTIR spectra) of the sample. From the research data obtained information that there is a decrease and shift in UV-Visible spectra and changes in functional groups after the electrolysis process occurs. The best electrolysis percentage is obtained, after adding NaCl solution and Fenton's reagent in the range of 50 -66%.

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A Study of Place Attachment to Mosques as an Evacuation Shelter Building

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IOP Conference Series: Materials Science and engineering 2020年第1期931卷

作者： L Vivita Husaini R Anggraini C Dewi Student of Engineering Doctoral Program Universitas Syiah Kuala Darussalam Banda Aceh Indonesia Mechaninal and Industrial Engineering Department Universitas Syiah Kuala Darussalam Banda Aceh Indonesia Civil Engineering Department Universitas Syiah Kuala Darussalam Banda Aceh Indonesia Architecture Engineering Department Universitas Syiah Kuala Darussalam Banda Aceh Indonesia

The city of Banda Aceh has a geological location that is prone to earthquakes and tsunamis. In 2004, the tsunami damaged the city structure, and many victims died. When the tsunami struck the area, a mosque was used as an evacuation building. Its scatter existence in residential areas made it easy to reach, but several mosques could not be used as an evacuation building. The purpose of this study was to explore the function of mosques as tsunami evacuation building through place attachment studies using qualitative methods and depth interviews to identify public attachment factors. To measure place attachment, this research used three variables, i.e. socio-demographic, environmental experience, and familiarity with the place. This study also used the space forming variables, which include meaning, function, and form to see the public attachment to a mosque as an evacuation shelter building. The results showed that place attachment to a mosque was influenced by its meaning as a sacred place. The majority of people in Banda Aceh are Muslim and have Islamic cultural backgrounds. People's routine activities form strong bonds to a mosque. Acehnese culture to glorify guests is reflected in mosque building design by exploring open walls, ease of accessibility, and spread presence in residential areas. These cultural characteristics strengthen the opportunity to make mosques as tsunami evacuation shelter buildings in Banda Aceh.

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The Effect of Mangrove on Fish Catch Using Belat at Teluk Pemedas and Sanipah of Kutai Kartanegara Regency, East Kalimantan Province, Indonesia 2

The Effect of Mangrove on Fish Catch Using Belat at Teluk Pe...

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2nd International Conference on Energy, Environmental and Information System, ICENIS 2017

作者： Sulaiman, Bustam Bambang, Azis Nur Purnaweni, Hartuti Lutfi, Mohammad Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Faculty of Fishery and Ocean Diponegoro University Semarang50275 Indonesia Master Program of Environmental Science School of Post Graduate Studies Diponegoro University Semarang50275 Indonesia Faculty of Social Science and Political Science Diponegoro University Semarang50275 Indonesia Department of Oil and Gas Processing Engineering STT MIGAS Balikpapan76127 Indonesia Department of Petroleum Engineering STT MIGAS Balikpapan76127 Indonesia

The increasing population at Teluk Pemedas and Sanipah coastal areas of Kutai Kartanegara Regency, East Kalimantan Province, has led to coastal degradation. The problem was mainly caused by conversion of mangrove into aquaculture, agriculture, plantation industrial, and residential areas. This research was a study case, used descriptive analysis to describe the local fishermen activity using belat traditional device to catch fish. The results revealed that there were many fishermen still did not know the benefits of mangrove for economy growth, ecological, ecotourism etc. This condition affects to the decline of the mangrove function. Fisherman who used belat often move from one location to another location in order to find places that have many catches. The belat which are placed in good environment mangrove areas produces lots of catches that greatly benefit the fisherman, therefore mangrove ecosystem must be well preserved for the sustainability of fishermen's efforts to earn a living. © 2018 The Authors, published by EDP Sciences.

关键词： Fish

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Extraction and characteristic of Dioscorea alata mucilage

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IOP Conference Series: Earth and Environmental Science 2020年第1期542卷

作者： D Fortuna S S Mardjan T C Sunarti E Darmawati S M Widayati N Purwanti Doctoral Program in Agricultural Engineering Science Department of Mechanical and Biosystem Engineering Bogor Agricultural University Bogor Indonesia Department of Mechanical and Biosystem Engineering Bogor Agricultural University Bogor Indonesia Department of Agricultural Industry Technology Bogor Agricultural University Bogor Indonesia Indonesia Center for Agricultural Postharvest Research and Development (ICAPRD) Bogor Indonesia

Dioscorea alata (DA) mucilage is classified as water-soluble polysaccharides, which has potential as a source of hydrocolloid. This research was conducted to investigate effects of salt types on water to tuber ratio to produce the most optimal mucilage yield. This research was conducted using Completely Randomized Factorial Design 3 x 5. The DA mucilage was extracted using two factors, i.e., types of salt (without salt, sodium chloride, and calcium chloride) and water to tuber ratios (2:1, 4:1, 6:1, 8:1, and 10:1). The results showed that the types of salt significantly affect (P<0.05) on starch content, but did not have a significant effect on mucilage yield and water content of the mucilage. The water to tuber ratios significantly affected (p<0.05) the mucilage yield and starch content of the mucilage, however it did not affect the water content. Addition of calcium chloride when water to tuber ratio was 4:1 was recommended to produce the optimal mucilage yield (1.58%) with relatively low starch content (7.86%).

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Improving student's complex problem solving through LAPS-Talk-Ball learning integrated with interactive games

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Journal of Physics: Conference Series 2021年第1期1722卷

作者： A M I T Asfar A M I A Asfar S Sulastri Department of Mathematics Education STKIP Muhammadiyah Bone Abu Dg. Pasolong Street No.62 Watampone Indonesia Doctoral Program Science Education Universitas Negeri Makassar Bonto Langkasa street Makassar Indonesia Department of Chemical Engineering State Polytechnic of Ujung Pandang Tamalanrea Makassar Indonesia Department of Economics Education STKIP Muhammadiyah Bone Abu Dg. Pasolong Street No.62 Watampone Indonesia

One of the competencies needed currently is non-routine competency in solving a complex problem. Students with complex problem solving will be able to identify the complex problem, understand to review related information, and create solutions for the problems. However, the improvement of complex problem-solving abilities lacks attention. This phenomenon occurs when students are given problem-solving, students have not been able to understand the problem, plan solutions, and provide solutions to problems. To overcome these problems, the LAPS-Talk-Ball learning model integrated with interactive games that guide the students in solving problems was implemented by using interactive games and speech balloons to stimulate each student to express their ideas. This research is quantitative experimental research to determine the success of the LAPS-Talk-Ball learning model integrated with android-based interactive games in training complex problem-solving students using saturated sampling and non-equivalent control group research designs. From the results of gain test results high improvement category, which means that the LAPS-Talk-Ball learning model integrated with android-based interactive games can train the complex problem-solving abilities of students.

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Freshwater microalgae-mediated engineered nanoparticles: Sustainable approach for heavy metals remediation

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Bioresource Technology 2025年 132761页

作者： Manish Sutradhar Raju Kumar Sharma Gobinda Dey Uttara Sukul Koyeli Das Md. Taharia Pin-Yun Lin Shafiqa Ali Chin-Wen Wang Chien-Yen Chen Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan You-Cheng Engineering & Technology Co. Ltd 168 University Road Min-Hsiung Chiayi Country 62102 Taiwan

Recently, convergence of nanotechnology and sustainable approaches has emerged as promising strategy for advanced remediation of heavy metals (HMs) from water. However, engineered nanoparticles (ENPs)-derived from freshwater microalgae gained attention as viable alternative, owing their inherent metal tolerance, rapid-growth rates, and versatile metabolic capabilities. This review predominantly focuses on freshwater microalgae-mediated-ENPs, highlighting intracellular/extracellular pathways induced by biomolecules such as polysaccharides, proteins, lipids, reductases etc., which govern nanoparticle nucleation, stabilization, and functionalization. Subsequently, the review discusses significant types of ENPs including iron, silver, gold, cadmium-sulfide, iron-oxide, nanocomposites, and bio-nano-hybrids nanoparticles, which reported removal efficiency from 21 to 100% of different HMs (lead, cadmium, chromium, copper, zinc, etc.). Despite ENPs exhibit significant potential, their large-scale implementation is constrained by challenges such as scaling-up, nutrient-variability, and high turbidity of wastewater. Future research recommended to focus on optimizing biosynthesis parameters, investigating diverse microalgal-strains, incorporating hybrid nano-materials to enhance their stability, reusability, and scalability for sustainable green-technology.

关键词： Bio-nanotechnology Bioremediation efficiency Environmental nano-materials Green synthesis Heavy metal removal Phytoremediation

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