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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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Proceedings of the 3rd IPLeiria's International Health Congress Abstracts

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BMC HEALTH SERVICES RESEARCH 2016年第3期16卷 111-242页

作者： [Anonymous] Health Sciences Research Unit: Nursing Collegue of College of Health Technology of Coimbra Coimbra Portugal Sisters Hospitallers of the Sacred Heart of Jesus Casa de Saúde Rainha Santa Isabel Coimbra Portugal Research Unit for Sport and Physical Activity Faculty of Sport Sciences and Physical Education University of Coimbra Coimbra Portugal Complementary Sciences- INESCC Coimbra Portugal CUF Hospitals Lisbon Portugal Breast Unit Champalimaud Clinical Center Lisbon Portugal Swiss Centre for Medical Simulation & Swiss Association of Simulation in Healthcare Basel Switzerland Basel University Hospital Basel Switzerland HELPO Association Cascais Portugal Centro de Linguística Universidade de Lisboa Lisboa Portugal Centro Superior de Estudios Universitarios La Salle Madrid Spain Universidade da Madeira Funchal Portugal Serviço de Saúde da Região Autónoma da Madeira E.P.E. Funchal Portugal Escola Superior de Enfermagem de Lisboa Lisboa Portugal Instituto Superior Miguel Torga Coimbra Portugal Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental Universidade de Coimbra Coimbra Portugal Escola Superior de Saúde de Leiria & Unidade de Investigação em Saúde Instituto Politécnico de Leiria Leiria Portugal National School of Public Health & Centro de Investigação em Saúde Pública Universidade Nova de Lisboa Lisboa Portugal Agrarian Superior School Polytechnic Institute of Viseu Viseu Portugal Laboratory of Microbiology Department of Biological Sciences Faculty of Pharmacy University of Porto Porto Portugal Unit for Multidisciplinary Biomedical Research Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal Agrupamento de Centros de Saúde (ACES) Baixo Mondego Figueira da Foz Portugal Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Centro de Salud La Paz Badajoz España Centro de Salud San Fernando Badajoz España Complejo Hospitalario Universitario de Badajoz Badajoz España Hospital Don Beni

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region of Príncipe, São Tomé and Príncipe Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Bonfim, Carina Silva S6 Safety culture of the patient: a reflexion about the therapeutic approach on the patient with vocal pathology Débora Franco S7 About wine, fortune cookies and patient experience Jesús Alcoba González O1 The psychological impact on the emergency crews after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto O4 Optimal age to give the first dose of measles vaccine in Portugal João G. Frade, Carla Nunes, João R. Mesquita, Maria S. Nascimento, Guilherme Gonçalves O5 Functional assessment of elderly in primary care Conceição Castro, Alice Mártires, Mª João Monteiro, Conceição Rainho O6 Smoking and coronary events in a population of Spanish health-care centre: An observational study Francisco P. Caballero, Fatima M. Monago, Jose T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco B. Ramirez O7 Prevalence of musculoskeletal injuries in Por

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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

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Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

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Corrigendum to “environmental contaminants and human health in the Canadian Arctic” [Sci. Total Environ. 408 (2010) 5165–5234]

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Science of The Total environment 2012年 431卷 437-438页

作者： S.G. Donaldson J. Van Oostdam C. Tikhonov M. Feeley B. Armstrong P. Ayotte O. Boucher W. Bowers L. Chan F. Dallaire R. Dallaire É. Dewailly J. Edwards G.M. Egeland J. Fontaine C. Furgal T. Leech E. Loring R.G. Shearer Chemicals Surveillance Bureau HECSB Health Canada 269 Laurier Ave West Ottawa ON Canada K1A 0K9 Carleton University 1125 Colonel By Drive Ottawa ON Canada K1S 5B6 Research and Monitoring FNIHB Health Canada 200 Eglantine Driveway Tunney's Pasture Ottawa ON Canada K1A 0K9 Toxicological Evaluation Section HPFB Health Canada 251 Sir Frederick Banting Driveway Tunney's Pasture Ottawa ON Canada K1A 0K9 Inuvik and Stanton Regional/Territorial Health Authorities and Inuvialuit Regional Corporation Canada Centre de Recherche du CHUQ and Université Laval 2875 Boulevard Laurier Édifice Delta 2 bureau 600 Québec QC Canada G1V 2M2 École de psychologie Université Laval Pavillon Félix-Antoine-Savard 2325 rue des Bibliothèques Local 1116 QC Canada G1V 0A6 Environmental Health Sciences and Research Bureau Health Canada 50 Columbine Driveway Rm 236A Ottawa ON Canada K1A 0K9 University of Northern British Columbia Community Health Sciences Program 3333 University Way Prince George BC Canada V2N4Z9 Department of Social and Preventive Medicine and the Department of Pediatrics Faculty of Medicine Laval University Québec QC Canada Department of Indian and Northern Development Northern Science and Contaminants Research Directorate 10 Wellington St Gatineau Quebec Canada K1A 0H4 Centre for Indigenous Peoples' Nutrition and Environment (CINE) and School of Dietetics and Human Nutrition McGill University Macdonald Campus 21111 Lakeshore Rd. Ste.Anne-de-Bellevue QC Canada H9X 3V9 Office of Community Medicine FNIHB Health Canada 200 Eglantine Driveway Ottawa ON Canada K1A 0K9 Department of Environmental and Resources Studies/Science and Department of Indigenous Studies Trent University 1600 West Bank Dr Peterborough ON Canada K9J 7B8 Inuit Tapiriit Kanatami Health and Environment 75 Albert Street Suite 1101 Ottawa ON Canada K1P 5E7

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The U.S. proposed carbon tariffs, WTO scrutiny and China's responses

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International Economics and Economic Policy 2010年第2期7卷 203-225页

作者： Zhang, ZhongXiang Research Program East-West Center Honolulu HI 96848-1601 1601 East-West Road United States Center for Energy Economics and Strategy Studies Fudan University Shanghai China Institute of Policy and Management Chinese Academy of Sciences Beijing China China Centre for Urban and Regional Development Research Peking University Beijing China Center for Environment and Development Chinese Academy of Social Sciences Beijing China

With governments from around the world trying to hammer out a post-2012 climate change agreement, no one would disagree that a U. S. commitment to cut greenhouse gas emissions is essential to such a global pact. However, despite U. S. president Obama's announcement to push for a commitment to cut U. S. greenhouse gas emissions by 17% by 2020, in reality it is questionable whether U. S. Congress will agree to specific emissions cuts, although they are not ambitious at all from the perspectives of both the EU and developing countries, without the imposition of carbon tariffs on Chinese products to the U. S. market, even given China's own announcement to voluntarily seek to reduce its carbon intensity by 40-45% over the same period. This dilemma is partly attributed to flaws in current international climate negotiations, which have been focused on commitments on the two targeted dates of 2020 and 2050. However, if the international climate change negotiations continue on their current course without extending the commitment period to 2030, which would really open the possibility for the U. S. and China to make the commitments that each wants from the other, the inclusion of border carbon adjustment measures seems essential to secure passage of any U. S. legislation capping its own greenhouse gas emissions. Moreover, the joint WTO-UNEP report indicates that border carbon adjustment measures might be allowed under the existing WTO rules, depending on their specific design features and the specific conditions for implementing them. Against this background, this paper argues that, on the U. S. side, there is a need to minimize the potential conflicts with WTO provisions in designing such border carbon adjustment measures. The U. S. also needs to explore, with its trading partners, ccooperative sectoral approaches to advancing low-carbon technologies and/or concerted mitigation efforts in a given sector at the international level. Moreover, to increase the prospects for a s

关键词： Border carbon adjustments Cap-and-trade regime Carbon tariffs China Emissions allowance requirements Kyoto protocol Lieberman-Warner bill Post-2012 climate negotiations United States Waxman-Markey bill World trade organization

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China's hunt for oil in Africa in perspective

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Energy and environment 2007年第1期18卷 87-92页

作者： Zhang, Zhongxiang Research Program East-West Center 1601 East-West Road Honolulu HI 96848-1601 United States Institute of Policy and Management Chinese Academy of Sciences Beijing China Centre for Environment and Development Chinese Academy of Social Sciences Beijing China China Centre for Regional Economic Research Peking University Beijing China

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From Durban to Ahmedabad: Some Practical Conference Reflections

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Journal of Education for Sustainable development 2007年第2期1卷 189 - 190页

作者： Jim Taylor Jim Taylor is Director of Southern African Development Community – Regional Environmental Education Program (SADC-REEP) and Wildlife and Environment Society of South Africa (WESSA EE). Email:

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Trade and the environment in North America

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International environmental Agreements: Politics, Law and Economics 2007年第2期7卷 105-107页

作者： Zhang, Zhongxiang Carpentier, Chantal Line Research Program East-West Center Honolulu HI 96848-1601 1601 East-West Road United States Institute of Policy and Management Chinese Academy of Sciences Beijing China Centre for Environment and Development Chinese Academy of Social Sciences Beijing China China Centre for Regional Economic Research Peking University Beijing China Trade and Environment Program NAFTA Commission for Environmental Cooperation Montreal Que. H2Y 1N9 393 St-Jacques O Canada

environmental assessments of trade agreements remain in its infancy, and demonstrate that trade in itself will not green our economies. By examining various aspects of the environmental effects of trade in North America, this special issue not only contributes to deepening our understanding of the key issues in the trade and environment debate, but also helps to formulate mutually supportive trade and environmental policies. © Springer Science+Business Media B.V. 2007.

关键词： Agriculture Arbitration Electronic industry environmental standards Foreign investor Investment NAFTA Scale Technique and composition effects Trade and environment linkages

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State of the Climate in 2008

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BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY 2009年第8期90卷 S13-+页

作者： Peterson, T. C. Baringer, M. O. Thorne, P. W. Menne, M. J. Kennedy, J. J. Christy, J. Seidel, D. Mears, C. Haimberger, L. Wang, Junhong Zhang, L. Levinson, D. H. Hilburn, K. A. Kruk, M. C. Robinson, D. A. Foster, M. J. Ackerman, S. A. Bennartz, R. Heidinger, A. K. Maddux, B. C. Rossow, W. B. Macdonald, A. M. Fekete, B. M. Bowling, L. C. Lammers, R. B. Lawford, R. Allan, R. Wong, Takmeng Stackhouse, P. W., Jr. Kratz, D. P. Wilber, A. C. Schnell, R. C. Dlugokencky, E. J. Montzka, S. A. Elkins, J. W. Dutton, G. S. Haywood, J. Bellouin, N. Jones, A. Weber, M. Pelto, M. S. Belward, A. S. Bartholome, E. Achard, F. Brink, A. B. Gobron, N. Belward, A. S. Levy, J. M. Xue, Y. Reynolds, R. W. Johnson, G. C. Lyman, J. M. Willis, J. K. Levitus, S. Boyer, T. Antonov, J. Schmid, C. Goni, G. J. Yu, L. Weller, R. A. Goni, G. J. Knaff, J. A. Johnson, G. C. Lyman, J. M. Lumpkin, R. Goni, G. Dohan, K. Baringer, M. O. Meinen, C. S. Johnson, G. C. Kanzow, T. O. Cunningham, S. A. Johns, W. E. Beal, L. M. Hirschi, J. J. -M. Rayner, D. Longworth, H. R. Bryden, H. L. Marotzke, J. Merrifield, M. A. Nerem, R. S. Mitchum, G. T. Miller, L. Leuliette, E. Gill, S. Feely, R. A. Sabine, C. L. Feely, R. A. Wanninkhof, R. Takahashi, T. Behrenfeld, M. J. Siegel, D. A. O'Malley, R. T. Maritorena, S. Dickson, A. G. Feely, R. A. Dickson, A. G. Diamond, H. J. L'Heureux, M. Bell, G. Halpert, M. Bell, G. D. Blake, E. Goldenberg, S. B. Kimberlain, T. Landsea, C. W. Pasch, R. Schemm, J. Kruk, M. C. Levinson, D. H. Weyman, J. Camargo, S. J. Gleason, K. L. Kruk, M. C. Salinger, M. J. Trewin, B. Watkins, A. B. Luo, J. J. Richter-Menge, J. Overland, J. Wang, M. Walsh, J. Perovich, D. K. Meier, W. Nghiem, S. V. Walker, D. A. Bhatt, U. S. Raynolds, M. K. Comiso, J. E. Epstein, H. E. Jia, G. J. Romanovsky, V. Oberman, N. Drozdov, D. Malkova, G. Kholodov, A. Marchenko, S. Derksen, C. Brown, R. Wang, Lei Sharp, M. Wolken, G. Box, J. E. Bai, L. -S. Benson, R. Bhattacharya, I. Bromwich, D. H. Cappelen, J. Decker, D. DiGirolamo, N. Fettweis, X. Hall, D. Hanna, E. Mote, Universidad de Chile Santiago Chile Institute for Environment and Sustainability Joint Research Centre Ispra Italy Earth Sciences Centre University of Gothenburg Gothenburg Sweden Cimss University of Wisconsin-Madison Madison WI United States Center for Geophysical Research University of Costa Rica San José Costa Rica Met Office Hadley Centre Devon Exeter United Kingdom NOAA/NESDIS National Ocean Data Center Silver Spring MD United States Arctic and Antarctic Research Institute St. Petersburg Russian Federation Ministry of Agriculture and Land Reclamation Cairo Egypt DMH-DINAC/CTA-UCA Asunción Paraguay Byrd Polar Research Center Department of Geography The Ohio State University Columbus OH United States NOAA/NWS Honolulu HI United States NOAA/Atlantic Oceanographic and Meteorological Laboratory Physical Oceanography Division Miami FL United States Argentine Naval Hydrographic Service Buenos Aires Argentina Centro de Geofísica da Universidade de Lisboa Lisbon Portugal Rosenstiel School of Marine and Atmospheric Science Division of Meteorology and Physical Oceanography Miami FL United States Oregon State University Corvallis OR United States International Institute for Climate and Society Palisades NY United States Department of Atmospheric and Oceanic Sciences University of Wisconsin-Madison Madison WI United States Geophysical Institute University of Alaska-Fairbanks Fairbanks AK United States Instituto de Fisica Montevideo Uruguay German Meteorological Service Offenbach Germany NOAA/NWS/NCEP National Hurricane Center Miami FL United States Institute of Meteorology of Cuba La Habana Cuba Department of Agronomy Purdue University West Lafayette IN United States Climate Research Division Environment Canada Downsview ON Canada Ocean Observing and Climate Research Group National Oceanography Centre Southampton United Kingdom All-Russian Research Institute of Hydrological Information Obninsk Russian Federation Lamont Doherty Earth Observa

The global mean temperature in 2008 was slightly cooler than that in 2007; however, it still ranks within the 10 warmest years on record. Annual mean temperatures were generally well above average in South America, northern and southern Africa, Iceland, Europe, Russia, South Asia, and Australia. In contrast, an exceptional cold outbreak occurred during January across Eurasia and over southern European Russia and southern western Siberia. There has been a general increase in land-surface temperatures and in permafrost temperatures during the last several decades throughout the Arctic region, including increases of 1° to 2°C in the last 30 to 35 years in Russia. Record setting warm summer (JJA) air temperatures were observed throughout *** year 2008 was also characterized by heavy precipitation in a number of regions of northern South America, Africa, and South Asia. In contrast, a prolonged and intense drought occurred during most of 2008 in northern Argentina, Paraguay, Uruguay, and southern Brazil, causing severe impacts to agriculture and affecting many *** year began with a strong La Niña episode that ended in June. Eastward surface current anomalies in the tropical Pacific Ocean in early 2008 played a major role in adjusting the basin from strong La Niña conditions to ENSO-neutral conditions by July–August, followed by a return to La Niña conditions late in December. The La Niña conditions resulted in far-reaching anomalies such as a cooling in the central tropical Pacific, Arctic Ocean, and the regions extending from the Gulf of Alaska to the west coast of North America; changes in the sea surface salinity and heat content anomalies in the tropics; and total column water vapor, cloud cover, tropospheric temperature, and precipitation patterns typical of a La Niña. Anomalously salty ocean surface salinity values in climatologically drier locations and anomalously fresh values in rainier locations observed in recent years generally persisted

关键词： Storms

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A Report on the International Conference on Climate Policy after Marrakech: Towards Global Participation

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Mitigation and Adaptation Strategies for Global Change 2006年第2期12卷 203-217页

作者： Zhang, Zhongxiang Research Program East-West Center Honolulu USA Centre for Environment and Development Chinese Academy of Social Sciences Beijing China China Centre for Regional Economic Research Peking University Beijing China

The East-West Center convened the international conference on climate policy in Honolulu, Hawaii, on September 4–6, 2003. Sponsored by the Dutch Ministry of Housing, Spatial Planning and the environment, the Japanese Ministry of the environment, Industrial Technology Research Institute (Taiwan), and Institute for Global environmental Strategies (Japan), this major event covered almost every important issue and featured perspectives from the most important parties and stakeholders in formulating and implementing climate policies and taking international climate negotiations further. It brought together a remarkable cross-section of world opinion on climate policy after Kyoto. This report provides a summary of each presentation and highlights discussions organized under the following six session headings: Session 1: Climate Change in Focus – From Science to Policy; Session 2: U.S. Climate Policy and Perspectives; Session 3: European Union Climate Policy and Perspectives; Session 4: Challenges for other Major Industrialized Countries; Session 5: Issues Related to Developing Countries; and Session 6: Panel Discussions: Where Do We Go from Here?.

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