检索结果-内蒙古大学图书馆

arXiv 2023年

作者： Dang, Lauren E. Gruber, Susan Lee, Hana Dahabreh, Issa Stuart, Elizabeth A. Williamson, Brian D. Wyss, Richard Díaz, Iván Ghosh, Debashis Kıcıman, Emre Alemayehu, Demissie Hoffman, Katherine L. Vossen, Carla Y. Huml, Raymond A. Ravn, Henrik Kvist, Kajsa Pratley, Richard Shih, Mei-Chiung Pennello, Gene Martin, David Waddy, Salina P. Barr, Charles E. Akacha, Mouna Buse, John B. van der Laan, Mark Petersen, Maya Department of Biostatistics University of California BerkeleyCA United States TL Revolution CambridgeMA United States Office of Biostatistics Office of Translational Sciences Center for Drug Evaluation and Research U.S. Food and Drug Administration Silver SpringMD United States Department of Epidemiology Harvard T.H. Chan School of Public Health BostonMA United States Department of Mental Health Johns Hopkins Bloomberg School of Public Health BaltimoreMD United States Biostatistics Division Kaiser Permanente Washington Health Research Institute SeattleWA United States Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women’s Hospital Harvard Medical School BostonMA United States Division of Biostatistics Department of Population Health New York University Grossman School of Medicine New YorkNY United States Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Microsoft Research RedmondWA United States Global Biometrics and Data Management Pfizer Inc. New YorkNY United States Department of Epidemiology Mailman School of Public Health Columbia University New YorkNY United States Syneos Health Clinical Solutions Amsterdam Netherlands Syneos Health Clinical Solutions MorrisvilleNC United States Novo Nordisk Søborg Denmark AdventHealth Translational Research Institute OrlandoFL United States Cooperative Studies Program Coordinating Center VA Palo Alto Health Care System Palo AltoCA United States Department of Biomedical Data Science Stanford University StanfordCA United States Division of Imaging Diagnostics and Software Reliability Office of Science and Engineering Laboratories Center for Devices and Radiological Health U.S. Food and Drug Administration Silver SpringMD United States Global Real World Evidence Group Moderna CambridgeMA United States National Center for Advancing Translational Sciences BethesdaMD United States G

Increasing emphasis on the use of real-world evidence (RWE) to support clinical policy and regulatory decision-making has led to a proliferation of guidance, advice, and frameworks from regulatory agencies, academia, professional societies, and industry. A broad spectrum of studies use real-world data (RWD) to produce RWE, ranging from randomized controlled trials with outcomes assessed using RWD to fully observational studies. Yet many RWE study proposals lack sufficient detail to evaluate adequacy, and many analyses of RWD suffer from implausible assumptions, other methodological flaws, or inappropriate interpretations. The Causal Roadmap is an explicit, itemized, iterative process that guides investigators to pre-specify analytic study designs;it addresses a wide range of guidance within a single framework. By requiring transparent evaluation of causal assumptions and facilitating objective comparisons of design and analysis choices based on pre-specified criteria, the Roadmap can help investigators to evaluate the quality of evidence that a given study is likely to produce, specify a study to generate high-quality RWE, and communicate effectively with regulatory agencies and other stakeholders. This paper aims to disseminate and extend the Causal Roadmap framework for use by clinical and translational researchers, with companion papers demonstrating application of the Causal Roadmap for specific use cases. Copyright © 2023, The Authors. All rights reserved.

关键词： Decision making

来源：评论

学校读者我要写书评

暂无评论

Residual Nanoscale Strain in Cesium Lead Bromide Perovskite Reduces Stability and Alters Local Band Gap

arXiv

引用

arXiv 2018年

作者： Li, Xueying Luo, Yanqi Holt, Martin Cai, Zhonghou Fenning, David P. Materials Science & Engineering Program University of California San Diego La JollaCA92093 United States Department of Nanoengineering University of California San Diego La JollaCA92093 United States

Using nanoprobe X-ray diffraction microscopy, we investigate the relationship between residual strains from crystal growth in CsPbBr3 thin film crystals, their stability, and local bandgap. We find that out-of-plane compressive strain that arises from cooldown from crystallization is detrimental to material stability under X-ray irradiation. We also find that the optical photoluminescence red shifts as a result of the out-of-plane compressive strain. The sensitivity of bandgap to strain suggests possible applications such as stress-sensitive sensors. Mosaicity, the formation of small misorientations in neighboring crystalline domains we observe in some CsPbBr3 single crystals, indicates the significant variations in crystal quality that can occur even in single-crystal halide perovskites. The nano-diffraction results suggest that reducing local strains is a necessary path to enhance the stability of perovskite optoelectronic materials and devices from light-emitting diodes to high-energy detectors. Copyright © 2018, The Authors. All rights reserved.

关键词： Lead compounds

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Development of a functional salivary gland tissue chip with potential for high-content drug screening

Communications biology

引用

Communications biology 2022年第1期5卷 315页

作者： Yuanhui Song Hitoshi Uchida Azmeer Sharipol Lindsay Piraino Jared A Mereness Matthew H Ingalls Jonathan Rebhahn Shawn D Newlands Lisa A DeLouise Catherine E Ovitt Danielle S W Benoit Department of Biomedical Engineering University of Rochester Rochester NY USA. Center for Oral Biology University of Rochester Medical Center Rochester NY USA. Department of Biomedical Genetics University of Rochester Medical Center Rochester NY USA. Department of Dermatology University of Rochester Medical Center Rochester NY USA. Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA. David H. Smith Center for Vaccine Biology and Immunology University of Rochester Medical Center Rochester NY USA. Department of Otolaryngology University of Rochester Medical Center Rochester NY USA. Wilmot Cancer Institute University of Rochester Medical Center Rochester NY USA. Department of Neuroscience University of Rochester Medical Center Rochester NY USA. Materials Science Program University of Rochester Rochester NY USA. Department of Biomedical Engineering University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Center for Oral Biology University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Department of Biomedical Genetics University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Wilmot Cancer Institute University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu. Materials Science Program University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Department of Chemical Engineering University of Rochester Rochester NY USA. benoit@bme.rochester.edu. Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA. benoit@bme.rochester.edu.

来源：评论

学校读者我要写书评

暂无评论

A unified theory of grain growth in polycrystalline materials

arXiv

引用

arXiv 2018年

作者： Hu, Jianfeng Wang, Xianhao Zhang, Junzhan Shen, Zhijian Luo, Jun Luo, Jian School of Materials Science and Engineering Shanghai University Shanghai200444 China Carl Zeiss Co. Shanghai 60 Meiyue road Shanghai200131 China Department of Materials and Environmental Chemistry Arrhenius Laboratory Stockholm University StockholmS-106 91 Sweden College of Materials and Mineral Resources Xi'an University of Architecture and Technology 13 Yanta Road Xi'an710055 China Materials Genome Institute Shanghai University Shanghai200444 China Department of Nano Engineering Program of Materials Science and Engineering University of California San Diego San diegoCA92093 United States

Grain growth is a ubiquitous and fundamental phenomenon observed in the cellular structures with the grain assembly separated by a network of grain boundaries, including metals and ceramics. However, the underlying mechanism of grain growth has remained ambiguous for more than 60 years. The models for grain growth, based on the classically linear relationship between the grain boundary migration and capillary driving force, generally predict normal grain growth. Quantitative model for abnormal grain growth is lacking despite decades of efforts. Here, we present a unified model to reveal quantitatively how grain growth evolves, which predicts the normal, abnormal and stagnant behaviors of grain growth in polycrystalline materials. Our model indicates that the relationship between grain boundary migration and capillary driving force is generally nonlinear, but will switch to be the classically linear relationship in a specific case. Furthermore, the grain growth experiments observed in polycrystalline SrTiO3 demonstrates the validity of the unified model. Our study provides a unified, quantitative model to understand and predict grain growth in polycrystalline materials, and thus offers helpful guides for the microstructural design to optimize the properties of polycrystalline materials. © 2018, CC BY.

关键词： Grain growth

来源：评论

学校读者我要写书评

暂无评论

Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii

Microbe (Netherlands)

引用

Microbe (Netherlands) 2025年 7卷

作者： Yonpiam, Manta Wannigama, Dhammika Leshan Shein, Aye Mya Sithu Liao, Tingting Hurst, Cameron Monk, Peter N. Amarasiri, Mohan Phattharapornjaroen, Phatthranit Ounjai, Puey Saethang, Thammakorn Badavath, Vishnu Nayak Luk-in, Sirirat Nilgate, Sumanee Rirerm, Ubolrat Srisakul, Sukrit Ngamwongsatit, Natharin Leelahavanichkul, Asada Ragupathi, Naveen Kumar Devanga Kanjanabuch, Talerngsak Narkban, Phurin Miyanaga, Kazuhiko Cui, Longzhu Boontaveeyuwat, Einapak Higgins, Paul G. Kicic, Anthony Hamamoto, Hiroshi Abe, Shuichi Hongsing, Parichart Chatsuwan, Tanittha Department of Microbiology Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Research Faculty of Medicine Chulalongkorn University Bangkok Thailand Dual degree Medical Science program Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan School of Medicine Faculty of Health and Medical Sciences The University of Western Australia Nedlands WA Australia Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield United Kingdom Pathogen Hunter's Research Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit 10120 Thailand Department of Infection Immunity & Cardiovascular Disease University of Sheffield Medical School United Kingdom Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Miyagi Japan Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok 10210 Thailand HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok 10210 Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand Department of Computer Science Faculty of Science Kasetsart University Bangkok Thailand School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad 509301 India Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veteri

The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii. In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm²) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro. In murine A. baumannii-associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm²) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii-associated wound infection. © 2025 The Authors

关键词： Acinetobacter baumannii Alternative therapy Biofilm eradication Chitosan Curcumin Multidrug-resistant (MDR) Photodynamic therapy (PDT) Wound infection

来源：评论

学校读者我要写书评

暂无评论

Tuning Internal Strain in Metal–Organic Frameworks via Vapor Phase Infiltration for CO2Reduction

引用

Angewandte Chemie 2020年第11期132卷

作者： Fan Yang Wenhui Hu Chongqing Yang Margaret Patrick Andrew L. Cooksy Jian Zhang Jeffery A. Aguiar Chengcheng Fang Yinghua Zhou Ying Shirley Meng Jier Huang Jing Gu Department of Chemistry and Biochemistry San Diego State University 5500 Campanile Drive San Diego USA Department of Chemistry Marquette University Milwaukee WI 53201 USA The Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Nuclear Materials Department Idaho National Laboratory 2525 Fremont Avenue Idaho Falls ID 83415 USA Materials Science and Engineering Program University of California San Diego La Jolla CA 92093 USA The Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Laboratory of Molecule-Based Materials College of Chemistry and Materials Science Anhui Normal University Wuhu 241000 China

A gas‐phase approach to form Zn coordination sites on metal–organic frameworks (MOFs) by vapor‐phase infiltration (VPI) was developed. Compared to Zn sites synthesized by the solution‐phase method, VPI samples revealed approximately 2.8 % internal strain. Faradaic efficiency towards conversion of CO 2 to CO was enhanced by up to a factor of four, and the initial potential was positively shifted by 200–300 mV. Using element‐specific X‐ray absorption spectroscopy, the local coordination environment of the Zn center was determined to have square‐pyramidal geometry with four Zn−N bonds in the equatorial plane and one Zn‐OH 2 bond in the axial plane. The fine‐tuned internal strain was further supported by monitoring changes in XRD and UV/Visible absorption spectra across a range of infiltration cycles. The ability to use internal strain to increase catalytic activity of MOFs suggests that applying this strategy will enhance intrinsic catalytic capabilities of a variety of porous materials.

关键词： CO2-Reduktion Interne Spannung Metallorganische Gerüste Dampfphaseninfiltration

来源：评论

学校读者我要写书评

暂无评论

The influence of micro plastic to Chlorella growth in difference aquatic systems

引用

AIP Conference Proceedings 2020年第1期2197卷

作者： Mohammad Muslihuddin Hadiyanto Fuad Muhammad Adian Khoironi Norma Afiati 1Center of Biomass and Renewable Energy Chemical Engineering Department Diponegoro University Indonesia 2Master Program of Environmental Sciences School of Postgraduate Studies Diponegoro University Indonesia 3Biology Department Faculty of Science and Mathematics Diponegoro University Indonesia 4Faculty of Fisheries and Marines Sciences Diponegoro University Indonesia

Plastic waste is harmful to human health and became climacteric problem for our environment. In year 2010, 275 million metric tons (MT) of plastic waste was emerge in 192 coastal countries. Micro plastic with size range around 1-5mm also affecting microorganism such as microalgae, Chlorella Pyrenoidosa which one of many species of microalgae is no exception. This microalga commonly used for foodstuff as the source of protein and lipid, also can be used as materials to make biodiesel since it also rich with lipid and can be processed with either esterification, trans-esterification or both. 500mg micro plastic of polyethylene terephthalate (PET) is added in 25ml Chlorella Pyrenoidosa on peak of its growth. Additional amount of diluted nutrients in 250ml freshwater and brackish also being added as controls with different salinity. Since control experiment also being made without the presence of PET micro plastic, the growth rate shown in Chlorella Pyrenoidosa which being add with PET micro plastic is more than the growth rate Chlorella Pyrenoidosa without micro plastic. This difference could be due utilization of micro plastic as carbon source by Chlorella Pyrenoidosa.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Publisher's Note: “Mechanical properties of stabilized nanocrystalline FCC metals” [J. Appl. Phys. 126, 110901 (2019)]

引用

Journal of Applied Physics 2019年第14期126卷

作者： Douglas E. Spearot Garritt J. Tucker Ankit Gupta Gregory B. Thompson 1Department of Mechanical and Aerospace Engineering University of Florida Gainesville Florida 32611 USA 2Department of Mechanical Engineering Materials Science Program Colorado School of Mines Golden Colorado 80401 USA 3Department of Metallurgical and Materials Engineering University of Alabama Tuscaloosa Alabama 35487 USA

This article was originally published online on 17 September 2019 with a minor change corrected. All online versions of the article were corrected on 20 Septemb

关键词：

来源：评论

学校读者我要写书评

暂无评论

Preparation of Nanocellulose-Alginate Nanocomposites for Chlorhexidine Digluconate Drug Carrier

引用

IOP Conference Series: materials science and engineering 2019年第1期547卷

作者： Angela Evelyna Tiara Khumaira Astifanni Imelda Ruth Lia Asri Bambang Sunendar Purwasasmita Faculty of Dentistry Maranatha Christian University Indonesia Materials Science and Engineering Bandung Institute of Technology Indonesia Advanced Materials Processing Group Engineering Physics Study Program Bandung Institute of Technology Indonesia Research Center for Nanosciences and Nanotechnology Bandung Institute of Technology Indonesia.

Root canal treatment failures generally caused by microorganisms that have ability to invade dentinal tubules. Chlorhexidine is widely known to effectively eradicate broad spectrum bacteria that infected dentinal tubules. The delivery of chlorhexidine to the infected site of root canal still becomes an issue. In order to increase the stability and to regulate the release of chlorhexidine, encapsulation of chlorhexidine digluconate was conducted by employing nanocellulose and alginate nanocomposites. Nanocellulose was prepared from palm kernel cake using acid hydrolysis method. Transmission electron microscopy images showed the formation of whisker and fiber nanocellulose with the average diameter of 20 nm. Resulting nanocellulose was combined with alginate in the presence of Ca2+ crosslinker. Scanning electron microscopy images displayed sphere and oval morphologies of microcapsules with diameter of 500 nm. The microcapsules were further loaded with chlorhexidine digluconate 2% (w/v). In vitro drug release properties were evaluated in PBS at pH 7.4 (normal tooth environment) and at pH 5.5 (infected tooth environment). The UV-VIS results showed that chlorhexidine digluconate has higher release rate at pH 5.5 than at pH 7.4, suggesting that the microcapsule is a good candidate for the delivery of chlorhexidine digluconate to the infected root canal tooth environment.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Fluorescent phenylthiazoles: Application as latent fingermark and their cytotoxicity against NOK-SI cell line

引用

Chemical Data Collections 2021年 33卷

作者： Bruno Nunes da Rosa Kristiane de Cássia Mariotti Bruna Silveira Pacheco Caroline Carapina da Silva Neftalí Lenin Villarreal Carreño Caroline Nicolodi Tais Poletti Allison Carlos Assunção Silva Adriana Fernandes da Silva Janice Luehring Giongo Rodrigo de Almeida Vaucher Tiago Franco de Oliveira Claudio Martin Pereira de Pereira Laboratory of Lipidomics and Bioorganic Bioforensics Research Group Federal University of Pelotas 96010 900 Pelotas RS Brazil National Institute of Forensic Science and Technology (INCT Forensic) Porto Alegre (RS) Pelotas (RS) Brazil Identification Group Brazilian Federal Police 90610-093 Porto Alegre RS Brazil Materials Science and Engineering Technology Development Center Federal University of Pelotas 96010-000 Pelotas RS Brazil Post-Graduate Program in Dentistry Department of Restorative Dentistry Dental School Federal University of Pelotas 96010 Pelotas RS Brazil Laboratory of Biochemistry Research and Molecular Biology of Microorganisms (LaPeBBiOM) Federal University of Pelotas 96010-900 Pelotas RS Brazil Pharmacosciences Department Federal University of Health Sciences of Porto Alegre Porto Alegre RS Brazil

Fingerprints are unique to each individual who contributes to human identification in forensic cases. In this sense, the present work aimed to synthesize 1H-pyrazol-1-yl-4-phenylthiazoles and apply them as powder agents to reveal latent finger marks as an alternative and low cost related to powders found on the market. The compounds were characterized by infrared; fluorescence; 1H NMR; 13C NMR; laser diffractometer and SEM. In addition, cytotoxicity was also evaluated in oral keratinocytes showing high cell viability. The result of the hemolytic assay revealed that compound 2a does not present red cell cytotoxicity. The prepared powders were applied to fingermarks deposited on different surfaces providing quality visualization at level three so that human identification is possible.

关键词： Forensic chemistry Fingermark Thiazoles Cytotoxicity Development powder

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：