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101. Tandem high-dose 131I-mIBG therapy in paediatrics: Dosimetry-based treatment and radiation exposure monitoring of family caregivers

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Physica Medica 2018年 56卷 124-124页

作者： E. Genovese M. Longo B. Cassano S. Donatiello T. Insero M.F. Villani M. Pizzoferro M.C. Garganese V. Cannatà IRCCS Bambino Gesù Children’s Hospital Medical Physics Unit Rome Italy Sapienza University of Rome Ph.D. Program in Morphogenesis & Tissue Engineering Curriculum Biophysics Rome Italy IRCCS Bambino Gesù Children’s Hospital Nuclear Medicine Unit Imaging Department Rome Italy

Purpose Tandem high-dose based on two administrations of 131I-meta iodobenzylguanidine (131I-mIBG) is the treatment of choice for children with neuroblastoma (NB) with the aim to improve palliation and progression-free survival rates, especially in patients who have undergone a large amount of prior chemotherapy treatments. The present study aims to report the results of in vivo patient’s dosimetry as well as of radiation exposure to family caregivers. Methods Five children with relapsed/refractory NB were treated with 131I-mIBG between 2016 and 2017. Absorbed doses to whole body (WB) and red marrow (RM) were calculated according to MIRD and EANM guidelines. The calculation of WB absorbed dose for the first administration was used to determine the second activity to be administered to reach a total WB absorbed dose of 4 Gy. During patient’s isolation and the following hospitalization, the family members received an electronic personal dosimeter for monitoring their exposure. Results A dosimetry-based high-dose 131I-mIBG therapy of children with NB has been successfully established and routinely performed in our institution. The injected activity by administration was from 6610 to 10870 MBq (median: 8491 MBq), resulting in WB doses ranging from 0.79 to 2.40 Gy (median: 1.38 Gy) and in RM doses from 0.59 to 2.44 Gy (median: 0.88 Gy). Radiation dose to family caregivers ( H p [10]) varied from 0.4 to 16.6 mSv, with a mean WB exposure of 0.4 μSv/MBq. Conclusions For treatment of neuroblastoma, the WB absorbed doses could be prescribed individually in order to perform an adequate treatment and avoid hematologic toxicity. This is especially true in paediatrics where a highly heterogeneous and heavily pretreated patient population has to be treated. Radiation doses to family caregivers should be accurately evaluated considering the effective dose values established by the European Union regulation.

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[P182] Dosimetric study of radioactive esophageal stents for the treatment of advanced esophageal cancer

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Physica Medica 2018年 52卷 153-153页

作者： Payman Rafiepour Shahab Sheibani Daryiush Rezaey Uchbelagh Hossein Poorbaygi Mojtaba Arjmand Akbar Beiki-Ardakani Amirkabir University of Technology Department of Energy Engineering and Physics Tehran Iran Nuclear Science and Technology Research Institute Applied Radiation Research School Tehran Iran Tehran University of Medical Sciences Ocular Oncology Service Farabi Eye Hospital Tehran Iran Radiation Medicine Program Princess Margaret Cancer Centre University Health Network Department of Radiation Physics Toronto Canada

Purpose Perform a comprehensive dosimetric investigation of photon- and beta-emitting esophageal stents for the treatment of advanced esophageal cancer. Methods Using Geant4 toolkit, esophageal stents carrying 125 I, 103 Pd and 131 Cs brachytherapy seeds as well as esophageal stents coated with 166 Ho and 188 Re radioisotopes were simulated and their dose distributions were investigated. The effects of stent material, the presence of a magnetic field and the arrangement of the seeds on dose distributions were investigated. For validation, radiochromic EBT3 film dosimetry was performed for 125 I seed-loaded and 166 Ho impregnated esophageal stents. Furthermore, the accumulated dose of each radioactive stent (at the dose reference points), was calculated for different activities. Results Peak to valley dose (PVD) ratio is defined as a measure of dose uniformity for esophageal stents loaded with brachytherapy seeds to show the difference of dose intensity between the location of the presence of a radioactive seed and the adjacent vacant place. Due to the short penetration depth of beta particles in tissue, only palliative treatment is expected for beta-emitting esophageal stents. 103 Pd and 131 Cs seed-loaded stents cannot deliver the sufficient dose at the reference point, due to their short half-lives. It is shown that the edge restenosis in beta-emitting esophageal stents is more probable than in photon-emitters due to their rapid dose falloff on the stent edges. The presence of a magnetic field (>1.5 Tesla) along the stent axis, has a significant effect on dose distributions of beta-emitting stents. Conclusions The interval distance between two adjacent seeds (center to center) should not exceed 15 mm, due to the presence of cold spots in the spaces between seeds that are the locations of the tumor recurrence and it is more critical for 103 Pd seeds. Since the radioactive esophageal stents are permanent implants, 125 I with 28.4 keV mean energy and 59.4 days half-l

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SciPy 1.0—Fundamental algorithms for scientific computing in python

arXiv

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arXiv 2019年

作者： Virtanen, Pauli Gommers, Ralf Oliphant, Travis E. Haberland, Matt Reddy, Tyler Cournapeau, David Burovski, Evgeni Peterson, Pearu Weckesser, Warren Bright, Jonathan van der Walt, Stéfan J. Brett, Matthew Wilson, Joshua Millman, K. Jarrod Mayorov, Nikolay Nelson, Andrew R.J. Jones, Eric Kern, Robert Larson, Eric Carey, C.J. Polat, Ilhan Feng, Yu Moore, Eric W. VanderPlas, Jake Laxalde, Denis Perktold, Josef Cimrman, Robert Henriksen, Ian Quintero, E.A. Harris, Charles R. Archibald, Anne M. Ribeiro, Antônio H. Pedregosa, Fabian van Mulbregt, Paul University of Jyväskylä University of Jyväskylä FI-40014 Finland Quansight LLC AustinTX United States Ultrasound Imaging Mayo Clinic RochesterMN55902 United States Electrical Engineering Brigham Young University ProvoUT84604 United States Enthought Inc. AustinTX78701 United States Anaconda Inc AustinTX78701 United States BioResource and Agricultural Engineering Department California Polytechnic State University San Luis ObispoCA93407 United States Department of Mathematics University of California Los AngelesCA90025 United States Los Alamos National Laboratory Los AlamosNM87544 United States Independent Researcher Higher School of Economics Myasnitskaya 20 Moscow101000 Russia Independent Researcher Saue Estonia Department of Mechanics and Applied Mathematics Institute of Cybernetics Tallinn Technical University Akadeemia Rd 21 Tallinn Estonia Independent Researcher NY United States Berkeley Institute for Data Science University of California BerkeleyCA94720 United States School of Psychology University of Birmingham Edgbaston BirmighamB15 2TT United Kingdom Division of Biostatistics University of California BerkeleyCA94720 United States WayRay LLC Skolkovo Innovation Center Moscow143026 Russia Australian Nuclear Science and Technology Organisation Locked Bag 2001 Kirrawee DCNSW2232 Australia Institute for Learning and Brain Sciences University of Washington SeattleWA98195 United States College of Information and Computing Sciences University of Massachusetts Amherst AmherstMA01002 United States Berkeley Center for Cosmological Physics University of California BerkeleyCA94720 United States Bruker Biospin Corp. 15 Fortune Drive BillericaMA01821 United States University of Washington SeattleWA98195 United States New Technologies - Research Centre University of West Bohemia Univerzitní 8 Plzeň306 14 Czech Republic Oden Institute for Computational Engineering and Sciences University of Texas at Austin AustinTX7

SciPy is an open source scientific computing library for the Python programming language. SciPy 1.0 was released in late 2017, about 16 years after the original version 0.1 release. SciPy has become a de facto standard for leveraging scientific algorithms in the Python programming language, with more than 600 unique code contributors, thousands of dependent packages, over 100,000 dependent repositories, and millions of downloads per year. This includes usage of SciPy in almost half of all machine learning projects on GitHub, and usage by high profile projects including LIGO gravitational wave analysis and creation of the first-ever image of a black hole (M87). The library includes functionality spanning clustering, Fourier transforms, integration, interpolation, file I/O, linear algebra, image processing, orthogonal distance regression, minimization algorithms, signal processing, sparse matrix handling, computational geometry, and statistics. In this work, we provide an overview of the capabilities and development practices of the SciPy library and highlight some recent technical developments. Copyright © 2019, The Authors. All rights reserved.

关键词： Open source software

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Optimization of a Spherical Active Coded Mask Gamma-Ray Imager

Optimization of a Spherical Active Coded Mask Gamma-Ray Imag...

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IEEE nuclear Science Symposium

作者： Daniel Hellfeld Paul Barton Donald Gunter Lucian Mihailescu Kai Vetter Nuclear Engineering Department University of California Berkeley Berkeley CA USA Applied Nuclear Physics Program Lawrence Berkeley National Laboratory Berkeley CA USA Nuclear Engineering Department University of California Berkeley

Gamma-ray imaging allows for efficient detection, characterization, and localization of compact radioactive sources in cluttered environments. Fieldable detector systems employing active planar coded masks demonstrate broad energy sensitivity via both coded aperture and Compton imaging modalities. Because planar configurations suffer from a limited field-of-view, we introduce a novel design by rearranging the detectors into an active coded spherical configuration, thereby facilitating an isotropic 4π field-of-view with both coded aperture and Compton imaging. This report focuses on the low-energy coded aperture modality and the optimization techniques used to determine the optimal number and configuration of 1 cm~3 CdZnTe coplanar grid detectors on the inner surface of a ～14 cm outer diameter sphere with 192 available detector locations. We also explore the improvements in image reconstruction with the addition of depth-of-interaction information in each detector.

关键词： Detectors Imaging Optimization Apertures Sensitivity Image reconstruction

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Search for Gravitational Waves Emitted from SN2023ixf

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Astrophysical Journal 2025年第2期985卷 183-183页

作者： Abac, A.G. Abbott, R. Abouelfettouh, I. Acernese, F. Ackley, K. Adhicary, S. Adhikari, N. Adhikari, R.X. Adkins, V.K. Agarwal, D. Agathos, M. Aghaei Abchouyeh, M. Aguiar, O.D. Aguilar, I. Aiello, L. Ain, A. Akutsu, T. Albanesi, S. Alfaidi, R.A. Al-Jodah, A. Alléné, C. Allocca, A. Al-Shammari, S. Altin, P.A. Alvarez-Lopez, S. Amato, A. Amez-Droz, L. Amorosi, A. Amra, C. Ananyeva, A. Anderson, S.B. Anderson, W.G. Andia, M. Ando, M. Andrade, T. Andres, N. Andrés-Carcasona, M. Andrić, T. Anglin, J. Ansoldi, S. Antelis, J.M. Antier, S. Aoumi, M. Appavuravther, E.Z. Appert, S. Apple, S.K. Arai, K. Araya, A. Araya, M.C. Areeda, J.S. Argianas, L. Aritomi, N. Armato, F. Arnaud, N. Arogeti, M. Aronson, S.M. Ashton, G. Aso, Y. Assiduo, M. Assis de Souza Melo, S. Aston, S.M. Astone, P. Attadio, F. Aubin, F. AultONeal, K. Avallone, G. Babak, S. Badaracco, F. Badger, C. Bae, S. Bagnasco, S. Bagui, E. Baier, J.G. Baiotti, L. Bajpai, R. Baka, T. Ball, M. Ballardin, G. Ballmer, S.W. Banagiri, S. Banerjee, B. Bankar, D. Baral, P. Barayoga, J.C. Barish, B.C. Barker, D. Barneo, P. Barone, F. Barr, B. Barsotti, L. Barsuglia, M. Barta, D. Bartoletti, A.M. Barton, M.A. Bartos, I. Basak, S. Basalaev, A. Bassiri, R. Basti, A. Bates, D.E. Bawaj, M. Baxi, P. Bayley, J.C. Baylor, A.C. Baynard, P.A. Bazzan, M. Bedakihale, V.M. Beirnaert, F. Bejger, M. Belardinelli, D. Bell, A.S. Benedetto, V. Benoit, W. Bentley, J.D. Ben Yaala, M. Bera, S. Berbel, M. Bergamin, F. Berger, B.K. Bernuzzi, S. Beroiz, M. Bersanetti, D. Bertolini, A. Betzwieser, J. Beveridge, D. Bevins, N. Bhandare, R. Bhardwaj, U. Bhatt, R. Bhattacharjee, D. Bhaumik, S. Bhowmick, S. Bianchi, A. Bilenko, I.A. Billingsley, G. Binetti, A. Bini, S. Birnholtz, O. Biscoveanu, S. Bisht, A. Bitossi, M. Bizouard, M.-A. Blackburn, J.K. Blagg, L.A. Blair, C.D. Blair, D.G. Bobba, F. Bode, N. Boileau, G. Boldrini, M. Bolingbroke, G.N. Bolliand, A. Bonavena, L.D. Bondarescu, R. Bondu, F. Bonilla, E. Bonilla, M.S. Bonino, A. Bonnand, R. Booker, P. Borchers, A. Boschi, V. Bose, S. Bossilkov, V. Max Planck Institute for Gravitational Physics (Albert Einstein Institute) Potsdam D-14476 Germany LIGO Laboratory California Institute of Technology Pasadena 91125 CA United States LIGO Hanford Observatory Richland 99352 WA United States Dipartimento di Farmacia Università di Salerno Fisciano Salerno I-84084 Italy INFN Sezione di Napoli Napoli I-80126 Italy University of Warwick Coventry CV4 7AL United Kingdom The Pennsylvania State University University Park 16802 PA United States University of Wisconsin-Milwaukee Milwaukee 53201 WI United States Louisiana State University Baton Rouge 70803 LA United States Université catholique de Louvain Louvain-la-Neuve B-1348 Belgium Inter-University Centre for Astronomy and Astrophysics Pune 411007 India Queen Mary University of London London E1 4NS United Kingdom Department of Physics and Astronomy Sejong University 209 Neungdongro Gwangjin-gu Seoul 143-747 South Korea Instituto Nacional de Pesquisas Espaciais São José dos Campos São Paulo 12227-010 Brazil Stanford University Stanford 94305 CA United States Università di Roma Tor Vergata Roma I-00133 Italy INFN Sezione di Roma Tor Vergata Roma I-00133 Italy Cardiff University Cardiff CF24 3AA United Kingdom Universiteit Antwerpen Antwerpen 2000 Belgium Gravitational Wave Science Project National Astronomical Observatory of Japan Mitaka City 2-21-1 Osawa Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan Mitaka City 2-21-1 Osawa Tokyo 181-8588 Japan INFN Sezione di Torino Torino I-10125 Italy Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena Jena D-07743 Germany Dipartimento di Fisica Università degli Studi di Torino Torino I-10125 Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom OzGrav University of Western Australia Crawley 6009 WA Australia University Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules IN2P3 Annecy F-7

We present the results of a search for gravitational-wave transients associated with core-collapse supernova SN 2023ixf, which was observed in the galaxy Messier 101 via optical emission on 2023 May 19, during the LIGO–Virgo–KAGRA 15th engineering Run. We define a five-day on-source window during which an accompanying gravitational-wave signal may have occurred. No gravitational waves have been identified in data when at least two gravitational-wave observatories were operating, which covered ∼14% of this five-day window. We report the search detection efficiency for various possible gravitational-wave emission models. Considering the distance to M101 (6.7 Mpc), we derive constraints on the gravitational-wave emission mechanism of core-collapse supernovae across a broad frequency spectrum, ranging from 50 Hz to 2 kHz, where we assume the gravitational-wave emission occurred when coincident data are available in the on-source window. Considering an ellipsoid model for a rotating proto-neutron star, our search is sensitive to gravitational-wave energy 1 × 10⁻⁴ M_⊙c² and luminosity 2.6 × 10⁻⁴ M_⊙c² s⁻¹ for a source emitting at 82 Hz. These constraints are around an order of magnitude more stringent than those obtained so far with gravitational-wave data. The constraint on the ellipticity of the proto-neutron star that is formed is as low as 1.08, at frequencies above 1200 Hz, surpassing past results. © 2025. The Author(s).

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Light, the universe, and everything-12 Herculean tasks for quantum cowboys and black diamond skiers

arXiv

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arXiv 2018年

作者： Agarwal, Girish Allen, Roland E. Bezdìková, Iva Boyd, Robert W. Chen, Goong Hanson, Ronald Hawthorne, Dean L. Hemmer, Philip Kim, Moochan B. Kocharovskaya, Olga Lee, David M. Lidström, Sebastian K. Lidström, Suzy Losert, Harald Maier, Helmut Neuberger, John W. Padgett, Miles J. Raizen, Mark Rajendran, Surjeet Rasel, Ernst Schleich, Wolfgang P. Scully, Marlan O. Shchedrin, Gavriil Shvets, Gennady Sokolov, Alexei Svidzinsky, Anatoly Walsworth, Ronald L. Weiss, Rainer Wilczek, Frank Willner, Alan E. Yablonovich, Eli Zheludev, Nikolay Department of Physics and Astronomy Texas A&M University College StationTX77843 United States Department of Physics Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague Brehova 7 Praha 1-Staré mìsto11519 Czech Republic Department of Physics Technical University of Ostrava 17 Listopadu 15 Ostrava-Poruba70833 Czech Republic Department of Physics School of Electrical Engineering and Computer Science University of Ottawa OttawaONK1N6N5 Canada Institute of Optics Department of Physics and Astronomy University of Rochester RochesterNY14627 United States School of Physics and Astronomy University of Glasgow GlasgowG128QQ United Kingdom Department of Mathematics Texas A&M University College StationTX77843 United States Science Program Texas A&M University at Qatar Education City Doha Qatar Texas A&M University College StationTX77843 United States QuTech and Kavli Institute of Nanoscience Delft University of Technology P.O. Box 5046 Delft2600 GA Netherlands Cornell Laboratory of Ornithology Cornell University IthacaNY14850 United States Laboratory of Atomic and Solid State Physics Cornell University IthacaNY14853 United States Department of Electrical & Computer Engineering Texas A&M Energy Institute Texas A&M University TX77843 United States Department of Physics Strathclyde University GlasgowG11XJ United Kingdom Physica Scripta Royal Swedish Academy of Sciences StockholmSE-10405 Sweden Universität Ulm Albert-Einstein-Allee 11 Ulm89081 Germany Institut für Zahlentheorie und Wahrscheinlichkeitstheorie Universität Ulm Albert-Einstein-Allee 11 Ulm89081 Germany Department of Mathematics University of North Texas DentonTX76203-5017 United States College of Natural Sciences University of Texas AustinTX78712 United States Department of Physics University of California BerkeleyCA94720-7300 United States Institut fuer Quantenoptik QUEST-LFS Welfengarten 1 Hannover30167 Germany Hagler Insti

The Winter Colloquium on the physics of Quantum Electronics (PQE) has been a seminal force in quantum optics and related areas since 1971. It is rather mindboggling to recognize how the concepts presented at these conferences have transformed scientific understanding and human society. In January, 2017, the participants of PQE were asked to consider the equally important prospects for the future, and to formulate a set of questions representing some of the greatest aspirations in this broad field. The result is this multi-authored paper, in which many of the world's leading experts address the following fundamental questions: (1) What is the future of gravitational wave astronomy? (2) Are there new quantum phases of matter away from equilibrium that can be found and exploited-such as the time crystal? (3) Quantum theory in uncharted territory: What can we learn? (4) What are the ultimate limits for laser photon energies? (5) What are the ultimate limits to temporal, spatial, and optical resolution? (6) What novel roles will atoms play in technology? (7) What applications lie ahead for nitrogen-vacancy centers in diamond? (8) What is the future of quantum coherence, squeezing, and entanglement for enhanced superresolution and sensing? (9) How can we solve (some of) humanity's biggest problems through new quantum technologies? (10) What new understanding of materials and biological molecules will result from their dynamical characterization with free electron lasers? (11) What new technologies and fundamental discoveries might quantum optics achieve by the end of this century? (12) What novel topological structures can be created and employed in quantum optics? Copyright © 2018, The Authors. All rights reserved.

关键词： Quantum optics

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Author Correction: Federated learning enables big data for rare cancer boundary detection

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Nature communications 2023年第1期14卷 436页

作者： Sarthak Pati Ujjwal Baid Brandon Edwards Micah Sheller Shih-Han Wang G Anthony Reina Patrick Foley Alexey Gruzdev Deepthi Karkada Christos Davatzikos Chiharu Sako Satyam Ghodasara Michel Bilello Suyash Mohan Philipp Vollmuth Gianluca Brugnara Chandrakanth J Preetha Felix Sahm Klaus Maier-Hein Maximilian Zenk Martin Bendszus Wolfgang Wick Evan Calabrese Jeffrey Rudie Javier Villanueva-Meyer Soonmee Cha Madhura Ingalhalikar Manali Jadhav Umang Pandey Jitender Saini John Garrett Matthew Larson Robert Jeraj Stuart Currie Russell Frood Kavi Fatania Raymond Y Huang Ken Chang Carmen Balaña Jaume Capellades Josep Puig Johannes Trenkler Josef Pichler Georg Necker Andreas Haunschmidt Stephan Meckel Gaurav Shukla Spencer Liem Gregory S Alexander Joseph Lombardo Joshua D Palmer Adam E Flanders Adam P Dicker Haris I Sair Craig K Jones Archana Venkataraman Meirui Jiang Tiffany Y So Cheng Chen Pheng Ann Heng Qi Dou Michal Kozubek Filip Lux Jan Michálek Petr Matula Miloš Keřkovský Tereza Kopřivová Marek Dostál Václav Vybíhal Michael A Vogelbaum J Ross Mitchell Joaquim Farinhas Joseph A Maldjian Chandan Ganesh Bangalore Yogananda Marco C Pinho Divya Reddy James Holcomb Benjamin C Wagner Benjamin M Ellingson Timothy F Cloughesy Catalina Raymond Talia Oughourlian Akifumi Hagiwara Chencai Wang Minh-Son To Sargam Bhardwaj Chee Chong Marc Agzarian Alexandre Xavier Falcão Samuel B Martins Bernardo C A Teixeira Flávia Sprenger David Menotti Diego R Lucio Pamela LaMontagne Daniel Marcus Benedikt Wiestler Florian Kofler Ivan Ezhov Marie Metz Rajan Jain Matthew Lee Yvonne W Lui Richard McKinley Johannes Slotboom Piotr Radojewski Raphael Meier Roland Wiest Derrick Murcia Eric Fu Rourke Haas John Thompson David Ryan Ormond Chaitra Badve Andrew E Sloan Vachan Vadmal Kristin Waite Rivka R Colen Linmin Pei Murat Ak Ashok Srinivasan J Rajiv Bapuraj Arvind Rao Nicholas Wang Ota Yoshiaki Toshio Moritani Sevcan Turk Joonsang Lee Snehal Prabhudesai Fanny Morón Jacob Mandel Konstantinos Kamnitsas Ben Glocker Luke V M Dixon Matthew Williams Peter Zamp Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA. Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Informatics Technical University of Munich Munich Bavaria Germany. Intel Corporation Santa Clara CA USA. Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany. Clinical Cooperation Unit Neuropathology German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ) Heidelberg Germany. Department of Neuropathology Heidelberg University Hospital Heidelberg Germany. Division of Medical Image Computing German Cancer Research Center Heidelberg Germany. Pattern Analysis and Learning Group Department of Radiation Oncology Heidelberg University Hospital Heidelberg Germany. Neurology Clinic Heidelberg University Hospital Heidelberg Germany. Department of Radiology & Biomedical Imaging University of California San Francisco San Francisco CA USA. Symbiosis Center for Medical Image Analysis Symbiosis International University Pune Maharashtra India. Department of Neuroimaging and Interventional Radiology National Institute of Mental Health and Neurosciences Bangalore Karnataka India. Department of Radiology School of Medicine and Public Health University of Wisconsin Madison WI USA. Department of Medical Physics School of Medicine and Public Health University of Wisconsin Madison WI USA. Leeds Teaching Hospitals Trust Department of Radiology Leeds UK. Department of Radiology Brigham and Women's Hospital Harvard Medical School Boston MA USA. Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA USA. Catalan Institute of Oncology Badalona Spain. Consorci MAR Parc de Salut de Barcelona Catalonia Spain. Department of Radiology (IDI

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[P216] Dosimetric study of several beta-emitting ophthalmic plaques with different plaque materials, by Monte Carlo simulation

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Physica Medica 2018年 52卷 163-163页

作者： Mojtaba Arjmand Fariba Ghassemi Payman Rafiepour Hossein Poorbaygi Akbar Beiki-Ardakani Tehran University of Medical Sciences Ocular Oncology Service Farabi Eye Hospital Tehran Iran Tehran University of Medical Sciences Retina & Vitreous Service – Ocular Oncology Service Farabi Eye Hospital Tehran Iran Amirkabir University of Technology Department of Energy Engineering and Physics Tehran Iran Nuclear Science and Technology Research Institute Applied Radiation Research School Tehran Iran Radiation Medicine Program Princess Margaret Cancer Centre University Health Network Department of Radiation Physics Toronto Canada

Purpose Dosimetric investigation of brachytherapy eye plaques (based on CCB, COB and CIB models) for different coated radionuclides and different plaque materials for the treatment of uveal melanoma . Methods An eye model (including cornea, lens, optic nerve and tumor) and a plaque (with 0.1 mm window, 0.2 mm radionuclide coated foil and 0.7 mm backing), were simulated in a spherical water phantom, using Geant4.10.4. Dose-depth profiles were plotted for Ru-106, Sr-90, Ho-166, Re-188 and Pr-142 plaques. The dose deposited in the tumor and behind the plaque’s backing was calculated for the silver, gold and stainless steel plaques. For validation, dosimetry of CCB, COB and CIB plaques were performed using radiochromic EBT3 film and Plaque Simulator software, and the obtained dose rates were compared with Geant4.10.4 and the manufacturer’s (BEBIG) results. Results The ratio of dose at a point behind the silver backing to the reference point (2 mm depth) was 1.56%, 0.13%, 0.28%, 0.39% and 0.18% for Ru-106, Sr-90, Ho-166, Re-188 and Pr-142 CCB model plaques, respectively. The dose rate at the reference point was 66.4%, 50.7%, 34.8%, 41.87% and 47.1% of the dose rate at a depth of 0.5 mm for the mentioned plaques, respectively. With the same activity, Ho-166 plaque delivered the highest dose to the scleral, while Ru-106 plaque delivered the lowest. The dose per decay at the tumor apex (5 mm depth) was 3.59e−11 Gy, 5.27e−12 Gy, 7.96e−13 Gy, 2.24e−12 Gy and 3.36e-12 Gy for the mentioned plaques, respectively. The deposited dose in the tumor decreased by 50% for gold Ru-106 plaques and increased by 20% for stainless steel ones. Conclusions From the perspective of dose distribution, Ru-106 plaques can be replaced by Sr-90 or Pr-142 plaques for the tumor apex up to 3 mm. The dose fall-off for Ho-166 and Re-188 plaques are more severe, which limits their use only for superficial lesions. Gold plaques show more attenuation and can be made thinner. They may be used in COB and CIB

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Scientific data 2021年第1期8卷 242页

作者： Julien Cohen-Adad Eva Alonso-Ortiz Mihael Abramovic Carina Arneitz Nicole Atcheson Laura Barlow Robert L Barry Markus Barth Marco Battiston Christian Büchel Matthew Budde Virginie Callot Anna J E Combes Benjamin De Leener Maxime Descoteaux Paulo Loureiro de Sousa Marek Dostál Julien Doyon Adam Dvorak Falk Eippert Karla R Epperson Kevin S Epperson Patrick Freund Jürgen Finsterbusch Alexandru Foias Michela Fratini Issei Fukunaga Claudia A M Gandini Wheeler-Kingshott Giancarlo Germani Guillaume Gilbert Federico Giove Charley Gros Francesco Grussu Akifumi Hagiwara Pierre-Gilles Henry Tomáš Horák Masaaki Hori James Joers Kouhei Kamiya Haleh Karbasforoushan Miloš Keřkovský Ali Khatibi Joo-Won Kim Nawal Kinany Hagen H Kitzler Shannon Kolind Yazhuo Kong Petr Kudlička Paul Kuntke Nyoman D Kurniawan Slawomir Kusmia René Labounek Maria Marcella Laganà Cornelia Laule Christine S Law Christophe Lenglet Tobias Leutritz Yaou Liu Sara Llufriu Sean Mackey Eloy Martinez-Heras Loan Mattera Igor Nestrasil Kristin P O'Grady Nico Papinutto Daniel Papp Deborah Pareto Todd B Parrish Anna Pichiecchio Ferran Prados Àlex Rovira Marc J Ruitenberg Rebecca S Samson Giovanni Savini Maryam Seif Alan C Seifert Alex K Smith Seth A Smith Zachary A Smith Elisabeth Solana Y Suzuki George Tackley Alexandra Tinnermann Jan Valošek Dimitri Van De Ville Marios C Yiannakas Kenneth A Weber Ii Nikolaus Weiskopf Richard G Wise Patrik O Wyss Junqian Xu NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. jcohen@polymtl.ca. Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada. jcohen@polymtl.ca. Mila - Quebec AI Institute Montreal QC Canada. jcohen@polymtl.ca. NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland. Centre for Advanced Imaging The University of Queensland Brisbane Australia. Department of Radiology University of British Columbia Vancouver BC Canada. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown MA USA. Department of Radiology Harvard Medical School Boston MA USA. Harvard-Massachusetts Institute of Technology Health Sciences & Technology Cambridge MA USA. School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia. NMR Research Unit Queen Square MS Centre UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany. Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA. Aix-Marseille Univ CNRS CRMBM Marseille France. APHM Hopital Universitaire Timone CEMEREM Marseille France. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA. Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada. CHU Sainte-Justine Research Centre Montreal QC Canada. Centre de Recherche CHUS CIMS Sherbrooke Canada. Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science department Université de Sherbrooke Sherbrooke Canada. Université de Strasbourg CNRS ICube Strasbourg France. UHB - University Hospital Brno and Masaryk University Department of Radiology and Nuclear

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Time dependence of fission energy deposition in nuclear thermal rockets

Time dependence of fission energy deposition in nuclear ther...

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2015 nuclear and Emerging Technologies for Space, NETS 2015

作者： Eades, Michael J. Caffrey, Jarvis A. Nuclear Engineering Program Ohio State University ColumbusOH43201 United States Department of Nuclear Engineering and Radiation Health Physics Oregon State University CorvallisOR97301 United States

ISBN: (纸本)9781510843424

Presented is a time dependent estimate of the effective energy absorbed in a reactor from a fission or Qfeff (X) for a nuclear thermal rocket (NTR). An estimate of Qfeff (t) is required for many aspects of reactor analyses as a value for Qfeff(t) is needed to calculate fission rate in a reactor. Fission rate in a reactor has a direct impact on thermal, shielding, burn up, and decay heat analysis calculations and Qfeff(t) serves as normalization constants to scale effects based upon reactor power. The Qfeff(t) for a reactor is dependent on many factors such as faction of energy leaking out of the system, energy released from radiative capture of neutrons, energy released from the activated material in the core, and the decay of the current inventory of fission products. A NTR operates in a unique regime where decay emissions from fission products are not in equilibrium with fission product production. Decay of fission products account for ∼7% of all energy produced in a nuclear reactor in steady state operation. Because the decay of fission products contribute a sizeable portion of the total energy deposited in the core and the inventory of fission products is not in equilibrium a static estimate of Qfeffis not well suited for NTR reactor analysis. Estimates of Qfeff(t) in a representative NTR concept over a 30 minute burn were produced using a time-dependent MCNP6 model and an analytical model derived from information readily available in literature. The required fission rate to achieve the power profile of a representative 30 minute NTR burn was calculated with each model and compared against the default steady state assumption in MCNP6. The time-dependent MCNP6 and analytical models agreed very closely. It was found that over a representative 30 minute NTR burn the time-dependent MCNP6 model predicts a fission rate ranging from 0.99 to 1.07 times the value determined using the default steady state assumption for Qfeff in MCNP6 burnup calculations.

关键词： Fission products

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