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Elemental changes in hemolymph and urine of Rhodnius prolixus induced by in-vivo exposure to mercury: A study using synchrotron radiation total reflection X-ray fluorescence

Elemental changes in hemolymph and urine of Rhodnius prolixu...

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作者： Mantuano, Andrea Pickler, Arissa Barroso, Regina C. De Almeida, André P. Braz, Delson Cardoso, Simone C. Gonzalez, Marcelo S. Figueiredo, Marcela B. Garcia, Eloi S. Azambuja, Patricia Physics Institute State University of Rio de Janeiro Sao Francisco Xavier 524/3007B 20550-900 Rio de Janeiro RJ Brazil Nuclear Engineering Program Federal University of Rio de Janeiro Brazil Physics Institute Federal University of Rio de Janeiro Brazil Department of General Biology Fluminense Federal University Brazil Laboratory of Biochemistry and Physiology of Insects Oswaldo Cruz Foundation Brazil

In recent years, the effects of pollution on the health of humans and other vertebrates were extensively studied. However, the effects on some invertebrates are comparatively unknown. Recent studies have demonstrated that toxic metals interfere with the reproduction, development and immune defenses of some terrestrial and marine invertebrates. Some environmental conditions including pollution produce chronic and acute effects on different animal's organs and systems. In this work, we investigated changes in the concentrations of Cl, K, Ca, Fe and Zn in Rhodnius prolixus as insect model. The elements were quantified using urine and hemolymph samples collected on different days after feeding the insects with blood containing HgCl2. The synchrotron radiation total reflection X-ray fluorescence measurements were carried at the X-ray fluorescence beamline facility in Brazilian Synchrotron Light Laboratory. The observation reveals that the calcium level was higher in the hemolymph than in urine. On the other hand, the urine collected from insects treated with HgCl2 showed higher level of Cl than hemolymph samples. Ca, Fe and Zn concentrations decrease drastically in urine samples collected after 2 days of HgCl2 treatment. The regulation of triatomines excretion was discussed pointing out the importance of trace elements. © 2012 Elsevier B.V.

关键词： Synchrotron radiation

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A new class of obese phantoms for radiation protection dosimetry

A new class of obese phantoms for radiation protection dosim...

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2011 ANS Annual Winter Meeting and Embedded Topical Meetings: 1st ANS SMR 2011 Conference and Young Professionals Congress 2011

作者： Ding, Aiping Mille, Matthew Caracappa, Peter F. Xu, X. George Nuclear Engineering and Engineering Physics Program Rensselaer Polytechnic Institute Troy NY 12180-3590 United States

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Rapid prototyping PET phantoms for partial volume correction

Rapid prototyping PET phantoms for partial volume correction

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2011 ANS Annual Meeting

作者： Mille, Matthew M. George Xu, X. Zimmerman, Brian E. Nuclear Engineering and Engineering Physics Program Rensselaer Polytechnic Institute Troy NY 12180 United States National Institute of Standards and Technology Gaithersburg MD 20899 United States

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A gadolinium doped superlattice GaN schottky diode for neutron detection

A gadolinium doped superlattice GaN schottky diode for neutr...

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2011 ANS Annual Meeting

作者： Wang, Jinghui Kandlakunta, Praneeth Kent, Thomas F. Carlin, John Hoy, Daniel R. Myers, Roberto C. Cao, Lei Nuclear Engineering Program Department of Mechanical and Aerospace Engineering Ohio State University Columbus OH 43210 United States Department of Materials Science and Engineering Ohio State University Columbus OH 43210 United States Department of Electrical and Computer Engineering Ohio State University Columbus OH 43210 United States Institute for Materials Research Ohio State University Columbus OH 43210 United States Department of Physics Ohio State University Columbus OH 43210 United States

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Method for experimental acquisition of hydraulic induced plastic and elastic test plate deformation

Method for experimental acquisition of hydraulic induced pla...

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2011 ANS Annual Winter Meeting and Embedded Topical Meetings: 1st ANS SMR 2011 Conference and Young Professionals Congress 2011

作者： Marcum, W.R. Phillips, A.M. Ambrosek, R.G. Spears, R.E. Wiest, J.D. Oregon State University Department of Nuclear Engineering and Radiation Health Physics 116 Radiation Center Corvallis OR 97331-5902 United States Idaho National Laboratory GTRI/RERTR Fuels Development Program 2525 Fremont Ave. Idaho Falls ID 83415-3720 United States

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Elemental quantification through gamma-stimulated spectroscopy: An NRF simulation in GEANT4

Elemental quantification through gamma-stimulated spectrosco...

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IEEE Symposium on nuclear Science (NSS/MIC)

作者： Anuj J. Kapadia Qiujian Ye Greeshma A. Agasthya Department of Radiology and the Medical Physics Graduate Program Duke University Durham NC USA Department of Physics and the Triangle Universities Nuclear Laboratory Duke University USA Department of Biomedical Engineering and the Department of Radiology Duke University USA

Since 2008, we have been developing a new method for the quantification of naturally occurring elements in the human body. The technique, called gamma-stimulated spectroscopy (GSS), uses high-energy, tuned gamma-ray beams to stimulate selected energy levels in specific stable isotopes in the body through nuclear resonance fluorescence (NRF). Such selective excitation can be used to detect a variety of human disorders that exhibit differences in element concentration between diseased and healthy tissue. In previous work, we have developed a prototype GSS device using the free-electron-laser (FEL) source at Duke University and demonstrated the selective excitation of iron in water. Here we describe the development of a GEANT4 simulation of the GSS system including the modeling of the NRF process. A monochromatic, collimated gamma source, virtual gamma-ray detectors, and an aqueous iron-copper phantom were simulated in GEANT4. The NRF process was modeled by creating a new NRF process class that calculated the interaction cross-section and the nuclear deexcitation data. The simulation was tested at two source energies (846.7 keV and 3448.41 keV) corresponding to excitable energy levels in natural iron. The resulting spectra showed accurate gamma energy response and emission patterns and exhibited excellent correlation between the simulated and the measured iron concentration. Following benchmarking against experimental data, the simulation will provide an accurate tool for modeling NRF processes in GEANT4 and will be used to guide the development of the clinical GSS system.

关键词： Signal resolution Energy measurement Iron

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Observation of exclusively He-induced H emission in cooled laser plasma

Observation of exclusively He-induced H emission in cooled l...

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作者： Lie, Z.S. Niki, H. Kagawa, K. Tjia, May On Hedwig, R. Pardede, M. Jobiliong, E. Suliyanti, M.M. Abdulmadjid, S.N. Kurniawan, K.H. Program of Nuclear Power and Energy Safety Engineering Graduate School of Engineering Fukui University Fukui 910-8507 Japan Department of Physics Faculty of Education and Regional Studies Fukui University 9-1 bunkyo 3-chome Fukui 910-8507 Japan Physics of Magnetism and Photonics Research Group Faculty of Mathematics and Natural Sciences Bandung Institute of Technology 10 Ganesha Bandung 40132 Indonesia Department of Computer Engineering Bina Nusantara University 9 K.H. Syahdan Jakarta 14810 Indonesia Department of Electrical Engineering University of Pelita Harapan 1100 M.H. Thamrin Boulevard Lippo Vilage Tangerang 15811 Indonesia Industrial Engineering Department University of Pelita Harapan 1100 M.H. Thamrin Boulevard Lippo Vilage Tangerang 15811 Indonesia Research Center for Physics Indonesian Institute of Sciences Kawasan PUSPIPTEK Serpong Tangerang Selatan 15314 Banten Indonesia Research Center of Maju Makmur Mandiri Foundation 40/80 Srengseng Raya Jakarta 11630 Indonesia

An experiment was performed for the observation of H emission induced in a cooled laser-induced atmospheric pressure gas plasma of He atoms in their metastable excited state. The strong H emission detected clearly established, to the exclusion of other well known major excitation processes, the exclusive contribution of the He-induced excitation (HIE) mechanism. The process is suggested to take place by means of energy transfer from the excited He atoms to the H atoms via Penning collision induced ionization involving electron exchange. The result further shows that this mechanism may also work for elements other than H and thereby strongly suggests the use of ambient He gas to broaden and complement the applications of standard laser-induced breakdown spectroscopy. © 2011 American Institute of physics.

关键词： Laser induced breakdown spectroscopy

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Quantitative computed microtomography for evaluation of radiotherapy effects on bone microstructure

Quantitative computed microtomography for evaluation of radi...

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IEEE Symposium on nuclear Science (NSS/MIC)

作者： Liebert P. Nogueira Regina C. Barroso Christiano J.G. Pinheiro Delson Braz Carlos E. de Almeida Cherley B. Andrade Nuclear Engineering Program Federal University of Rio de Janeiro Brazil Physics Institute State University of Rio de Janeiro Brazil Laboratory of Radiological Sciences State University of Rio de Janeiro Brazil

In this work we investigated the consequences of irradiation in the femur of rats to a radiation dose of 5 Gy. Three different sites in femur specimens were imaged using synchrotron radiation computed microtomography to assess trabecular bone microarchitecture: femur head, distal metaphysis and distal epiphysis. Histomorphometric quantification was extracted directly from the 3D tomographic images using synchrontron radiation. The 3D tomographic images were obtained at the SYRMEP (SYnchrotron Radiation for MEdical physics) beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. A better understanding of the biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. Results showed significant differences between irradiated and non-irradiated mostly in head and distal metaphysis bone sites.

关键词： Head Irrigation Microstructure

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Application of X-ray synchrotron microscopy instrumentation in biology

Application of X-ray synchrotron microscopy instrumentation ...

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2nd International Conference on Advancements in nuclear Instrumentation, Measurement Methods and their Applications, ANIMMA 2011

作者： Gasperini, F.M. Pereira, G.R. Granjeiro, J.M. Calasans-Maia, M.D. Rossi, A.M. Perez, C.A. Lopes, R.T. Lima, I. Medical Science Program Fluminense Federal University Niterói Brazil Department of Metallurgical and Materials Engineering Federal University of Rio de Janeiro Brazil Molecular and Cell Biology Department Fluminense Federal University Niterói Rio de Janeiro Brazil Oral Surgery Department Fluminense Federal University Niterói Rio de Janeiro Brazil Biomaterials Laboratory Brazilian Center of Physics Research Rio de Janeiro Brazil Brazilian Synchrotron Laboratory Campinas São Paulo Brazil Nuclear Engineering Laboratory Federal University of Rio de Janeiro Brazil

ISBN: (纸本)9781457709265

X-ray microfluorescence imaging technique has been used as a significant tool in order to investigate minerals contents in some kinds of materials. The aim of this study was to evaluate the elemental distribution of calcium and zinc in bone substitute materials (nanohydroxyapatite spheres) and cortical bones through X-Ray Microfluorescence analysis with the increment of Synchrotron Radiation in order to evaluate the characteristics of the newly formed bone and its interface, the preexisting bone and biomaterials by the arrangement of collagen fibers and its birefringence. The elemental mapping was carried out at Brazilian Synchrotron Light Laboratory, Campinas - Sao Paulo, Brazil working at D09-XRF beam line. Based on this study, the results suggest that hydroxyapatite-based biomaterials are biocompatible, promote osteoconduction and favored bone repair. © 2011 IEEE.

关键词： Bone

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