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Potential targeting of the tumor microenvironment to improve cancer virotherapy

Pharmacology and Therapeutics 2023年第1期250卷 108521页

作者： Liao, Zi-Xian Hsu, Shan-hui Tang, Shiue-Cheng Kempson, Ivan Yang, Pan-Chyr Tseng, S. Ja Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 80424 Taiwan Institute of Polymer Science and Engineering National Taiwan University Taipei 10051 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan Department of Medical Science National Tsing Hua University Hsinchu Taiwan Future Industries Institute University of South Australia Mawson Lakes 5095 SA Australia Department of Internal Medicine National Taiwan University College of Medicine Taipei 10051 Taiwan Graduate Institute of Oncology National Taiwan University College of Medicine Taipei 10051 Taiwan National Taiwan University YongLin Institute of Health National Taiwan University Taipei 10051 Taiwan Program in Precision Health and Intelligent Medicine Graduate School of Advanced Technology National Taiwan University Taipei 10051 Taiwan

In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant adeno-associated virus (AAV) delivery was also approved. However, systemic administration remains challenging due to the limited number of viruses that successfully reach the target site. Although the US Food and Drug Administration (FDA) permits the use of higher doses of AAV to achieve greater rates of transduction, most AAV still accumulates in the liver, potentially leading to toxicity there and elsewhere. Targeting the tumor microenvironment is a promising strategy for cancer treatment due to the critical role of the tumor microenvironment in controlling tumor progression and influencing the response to therapies. Newly discovered evidence indicates that administration routes focusing on the tumor microenvironment can promote delivery specificity and transduction efficacy within the tumor. Here, we review approaches that involve modifying viral surface features, modulating the immune system, and targeting the physicochemical characteristics in tumor microenvironment to regulate therapeutic delivery. Targeting tumor acidosis presents advantages that can be leveraged to enhance virotherapy outcomes and to develop new therapeutic approaches that can be integrated with standard treatments. © 2023 Elsevier Inc.

关键词： Adeno-associated virus Intratumoral injection Oncolytic virotherapy Systemic circulation Tumor acidosis Tumor microenvironment

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Synthesis, properties, and applications of graphene oxide/reduced graphene oxide and their nanocomposites

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Nano Materials science 2019年第1期1卷 31-47页

作者： Andrew T. Smith Anna Marie LaChance Songshan Zeng Bin Liu Luyi Sun Polymer Program Institute of Materials Science University of Connecticut Storrs Connecticut 06269 United States Department of Chemical and Biomolecular Engineering University of Connecticut Storrs Connecticut 06269 United States of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Department of Biomedical Engineering University of Connecticut Storrs Connecticut 06269 United States

Thanks to their remarkable mechanical, electrical, thermal, and barrier properties, graphene-based nanocomposites have been a hot area of research in the past decade. Because of their simple top-down synthesis, graphene oxide (GO) and reduced graphene oxide (rGO) have opened new possibilities for gas barrier, membrane separation, and stimuli-response characteristics in nanocomposites. Herein, we review the synthesis techniques most commonly used to produce these graphene derivatives, discuss how synthesis affects their key material properties, and highlight some examples of nanocomposites with unique and impressive properties. We specifically highlight their performances in separation applications, stimuli-responsive materials, anti-corrosion coatings, and energy storage. Finally, we discuss the outlook and remaining challenges in the field of practical industrial-scale production and use of graphene-derivative-based polymer nanocomposites.

关键词： Graphene oxide Reduced graphene oxide Graphene quantum dots polymer Nanocomposites Synthesis Properties of graphene and graphene oxide Applications

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Dynamic Covalent Bonds Enabled Carbon Fiber Reinforced polymers Recyclability and Material Circularity

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Angewandte Chemie 2024年第40期136卷

作者： Xiaotong Fan Jie Zheng Jayven Chee Chuan Yeo Sheng Wang Ke Li Joseph Kinyanjui Muiruri Nikos Hadjichristidis Zibiao Li Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science Technology and Research (A*STAR) 1 Pesek Road Jurong Island Singapore 627833 Republic of Singapore Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR) 2 Fusionopolis Way Innovis #08-03 Singapore 138634 Republic of Singapore Polymer Synthesis Laboratory Chemistry Program KAUST Catalysis Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Saudi Arabia Department of Materials Science & Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Republic of Singapore

Due to their remarkable features of lightweight, high strength, stiffness, high-temperature resistance, and corrosion resistance, carbon fiber reinforced polymers (CFRPs) are extensively used in sports equipment, vehicles, aircraft, windmill blades, and other sectors. The urging need to develop a resource-saving and environmentally responsible society requires the recycling of CFRPs. Traditional CFRPs, on the other hand, are difficult to recycle due to the permanent covalent crosslinking of polymer matrices. The combination of covalent adaptable networks (CANs) with carbon fibers (CFs) marks a new development path for closed-loop recyclable CFRPs and polymer resins. In this review, we summarize the most recent developments of closed-loop recyclable CFRPs from the unique paradigm of dynamic crosslinking polymers, CANs. These sophisticated materials with diverse functions, oriented towards CFs recycling and resin sustainability, are further categorized into several active domains of dynamic covalent bonds, including ester bonds, imine bonds, disulfide bonds, boronic ester bonds, and acetal linkages, etc. Finally, the possible strategies for the future design of recyclable CFPRs by combining dynamic covalent chemistry innovation with materials interface science are proposed.

关键词： dynamic covalent bonds carbon fiber reinforced polymers recyclability materials circularity

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Correction to: Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024 (Photochemical & Photobiological sciences, (2025), 24, 3, (357-392), 10.1007/s43630-025-00687-x)

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Photochemical and Photobiological sciences 2025年第5期24卷 863-865页

作者： Neale, Patrick J. Hylander, Samuel Banaszak, Anastazia T. Häder, Donat-P. Rose, Kevin C. Vione, Davide Wängberg, Sten-Åke Jansen, Marcel A. K. Busquets, Rosa Andersen, Mads P. Sulbæk Madronich, Sasha Hanson, Mark L. Schikowski, Tamara Solomon, Keith R. Sulzberger, Barbara Wallington, Timothy J. Heikkilä, Anu M. Pandey, Krishna K. Andrady, Anthony L. Bruckman, Laura S. White, Christopher C. Zhu, Liping Bernhard, Germar H. Bais, Alkiviadis Aucamp, Pieter J. Chiodo, Gabriel Cordero, Raúl R. Petropavlovskikh, Irina Neale, Rachel E. Olsen, Catherine M. Hales, Simon Lal, Aparna Lingham, Gareth Rhodes, Lesley E. Young, Antony R. Robson, T. Matthew Robinson, Sharon A. Barnes, Paul W. Bornman, Janet F. Harper, Anna B. Lee, Hanna Calderón, Roy Mackenzie Ossola, Rachele Paul, Nigel D. Revell, Laura E. Wang, Qing-Wei Zepp, Richard G. Environmental Research Center Smithsonian Institution EdgewaterMD United States Centre for Ecology and Evolution in Microbial Model Systems Linnaeus University Kalmar Sweden Unidad Académica de Sistemas Arrecifales Universidad Nacional Autónoma de México Puerto Morelos Mexico Erlangen Germany Department of Biological Sciences and Department of Civil and Environmental Engineering Rensselaer Polytechnic Institute TroyNY United States Department of Chemistry University of Turin Turin Italy Department of Marine Sciences University of Gothenburg Gotheburg Sweden School of Biological Earth and Environmental Sciences Environmental Research Institute University College Cork Cork Ireland Chemical and Pharmaceutical Sciences Kingston University London Kingston Upon Thames United Kingdom Civil Environmental & Geomatic Engineering University College London London United Kingdom Department of Chemistry and Biochemistry California State University NorthridgeCA United States Atmospheric Chemistry Observations and Modeling National Center for Atmospheric Research BoulderCO United States USDA UV-B Monitoring and Research Program Colorado State University Fort. CollinsCO United States Department of Environment and Geography University of Manitoba WinnipegMB Canada Working Group Environmental Epidemiology IUF-Leibniz Research Institute for Environmental Medicine Düsseldorf Germany Department of Environment and Health School of Public Health University of Bielefeld Bielefeld Germany School of Environmental Sciences University of Guelph GuelphON Canada Retired From Eawag Swiss Federal Institute of Aquatic Science and Technology Dübendorf Switzerland Center for Sustainable Systems School for Environment and Sustainability University of Michigan Ann ArborMI United States Climate Research Finnish Meteorological Institute Helsinki Finland Indian Academy of Wood Science Bengaluru India Chemical and Biomolecular Engineering North Carolina State University RaleighN

This work is not a product of the U.S. Government or the U.S. Environmental Protection Agency, and the author is not doing this work in any governmental capacity. This research was not performed or funded by EPA and was not subject to EPA’s quality system requirements. The views expressed in this journal article are those of the author(s) and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency. The original article has been corrected. © The Author(s), under exclusive licence to the European Photochemistry Association, European Society for Photobiology 2025.

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Spatially regulated water-heat transport by fluidic diode membrane for efficient solar-powered desalination and electricity generation

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Nature communications 2025年第1期16卷 5050页

作者： Yuanhang Cao Jiemin Wang Weixin Guan Meng An Peng Yan Zhengtong Li Changsheng Zhao Guihua Yu College of Biomedical Engineering Sichuan University Chengdu China. College of Biomedical Engineering Sichuan University Chengdu China. jiemin@***. Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at Austin Austin TX USA. Yangtze Delta Region Academy in Jiaxing Beijing Institute of Technology JiaXing China. anmeng@photon.t.u-tokyo.ac.jp. College of Mechanical and Electrical Engineering Shaanxi University of Science and Technology Xi'an China. State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing China. College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu China. zhaochsh70@***. Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at Austin Austin TX USA. ghyu@austin.utexas.edu.

Interfacial solar-driven evaporation has attracted great research interests, given its high conversion efficiency of solar energy and transformative industrial potential for desalination. However, current evaporators with porous volume remain critical challenges by inherently balancing efficient fluid transport and effective heat localization. Herein, we propose the strategy and design of lightweight, flexible and monolayered fluidic diode membrane-based evaporators, featuring regularly arrayed macropores and dense nanopores on each side. Such a delicate microstructure offers universality in establishing asymmetric channels along macroporous-to-nanoporous to enable the diode-like directional water transport as well as facilitate the heat localization on the nanopores side. Consequently, a high evaporation rate of a maximum 3.82 kg m h can be achieved under 1 sun illumination, exceeding most 2D and 3D evaporators. Besides, the durability and practicability of our evaporators are validated through salt resistance tests, purification experiments among various contaminants, and outdoor evaluations. Moreover, the structure engineering and water-transport optimization of fluidic diode membranes also offer potentials for hydrovoltaic applications, with over 1.6 V generated by tandem devices at the ambient environment. This work provides a concept for designing high-performance monolayered membranes applicable in environmental and energy-related realms.

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Synthesis of α,ω-End Functionalized Polydienes: Allylic-Bearing Heteroleptic Aluminums for Selective Alkylation and Transalkylation in Coordinative Chain Transfer polymerization

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Angewandte Chemie 2023年第5期136卷

作者： Dr. Pibo Liu Xiao Yang Dr. He Li Dr. Songbo Zhang Prof. Yanming Hu Prof. Guangyuan Zhou Prof. Nikos Hadjichristidis Division of Energy Materials Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 China Physical Sciences and Engineering Division KAUST Catalysis Center Chemistry Program Polymer Synthesis Laboratory King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Kingdom of Saudi Arabia

There are still challenges in the preparation of difunctional stereoregular polydienes, especially for the construction of initiating chain-end functionalization. Coordinative chain transfer polymerization (CCTP) provides a way to achieve the goal but usually requires sophisticated functionalized catalysts as well as expensive chain transfer agents (CTAs). In this work, heteroleptic aluminum with oligo(dienyl) substituents (oligo-Al agents) were readily prepared by living anionic polymerization (LAP) technique. The oligo-Al agents used in Nd-mediated CCTPs of dienes exhibit highly selective alkylation and transalkylation features. Kinetics and transfer efficiency studies using 1 H NMR, 13 C NMR, 1 H- 13 C HSQC, and Dosy NMR analyses revealed that the resulting polydienes possess substituents at the initiating chain-end that have transferred from the oligo-Al agents. The functionalization efficiency of the initiating chain-end is up to 99 %, and the molar mass regulation efficiency of heteroleptic aluminum is higher than that of the traditional CTA Al i Bu 2 H (0.608 vs. 0.410). Based on the experimental results and density functional theory (DFT) calculations, we propose a mechanism in which allylic-Al acts as an efficient alkylating moiety in catalyst preformation and also as an effective transfer agent in polymerization. Taking advantage of these features, di-functionalized polyisoprene, polybutadiene, and poly(isoprene-co-butadiene) can be facilely synthesized.

关键词： Aluminum Chain Transfer polymerization End-Functionalization Neodymium Polydiene

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Correction: N-doped carbon nanoparticles on highly porous carbon nanofiber electrodes for sodium ion batteries

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RSC advances 2025年第8期15卷 6370页

作者： Meltem Yanilmaz Bülin Atıcı Jiadeng Zhu Ozan Toprakci Juran Kim Nano-Science and Nano-Engineering Program Graduate School of Science Engineering and Technology Istanbul Technical University Istanbul 34469 Turkey yanilmaz@itu.edu.tr. Textile Engineering Istanbul Technical University Istanbul 34469 Turkey. Smart Devices Brewer Science Inc. Springfield MO 65806 USA. Department of Polymer Materials Engineering Yalova University 77200 Yalova Turkey. Advanced Textile R&D Department Korea Institute of Industrial Technology (KITECH) Ansan 15588 Korea jkim0106@kitech.re.kr.

[This corrects the article DOI: 10.1039/D3RA00635B.].

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Enhanced properties of PBAT by incorporating CNC

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AIP Conference Proceedings 2023年第1期2607卷

作者： Emre Vatansever Dogan Arslan Deniz Sema Sarul Ali Durmus Mohammadreza Nofar Polymer Science and Technology Program Istanbul Technical University Maslak Istanbul 34469 Turkey Metallurgical & Materials Engineering Department Faculty of Chemical and Metallurgical Engineering Istanbul Technical University Maslak Istanbul 34469 Turkey Department of Chemical Engineering Faculty of Engineering Istanbul University-Cerrahpasa Avcılar Istanbul 34320 Turkey

In this study, cellulose nanocrystal (CNC) dispersion within polybutylene adipate terephthalate (PBAT) was investigated. PBAT/CNC nanocomposites with various CNC contents were prepared through solution casting as well as dilution of a solution casted masterbatch using a twin screw extruder. The efficiency of two different preparation approaches on CNC dispersion was assessed by transmission electron microscopic and rheological analysis. It was found that solution casted PBAT/CNC nanocomposites had a much better CNC dispersion compared to that of their melt processed counterparts. This was while the diluted melt processed cases also revealed a good level of CNC dispersion. As a result, CNC was able to form a percolation network within PBAT at CNC contents of around 2 and 4 wt% in the two approaches, respectively.

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Correction: NaCMC-decorated ZnO nanocomposite polymer membranes for the separation of reactive dyes from textile water

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New Journal of Chemistry 2023年第3期48卷 1443-1443页

作者： R. Robin Vinoth Kumar Raja R. Sathish Kumar G. Arthanareeswaran Wirach Taweepreda Membrane Research Laboratory Department of Chemical Engineering National Institute of Technology Tiruchirappalli 620015 India Department of Chemical Engineering National Institute of Technology Andhra Pradesh Tadepalligudem Andhra Pradesh 534101 India Polymers & Composites Lab Department of Biomaterials Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai 600077 India Polymer Science Program Division of Physical Science Faculty of Science Prince of Songkla University Hat-Yai Songkhla 90110 Thailand

Correction for ‘NaCMC-decorated ZnO nanocomposite polymer membranes for the separation of reactive dyes from textile water’ by R. Robin et al., New J. Chem., 2023, 47, 20517–20526, https://***/10.1039/D3NJ03783E.

Correction for ‘NaCMC-decorated ZnO nanocomposite polymer membranes for the separation of reactive dyes from textile water’ by R. Robin et al., New J. Chem., 2023, 47, 20517–20526, https://***/10.1039/D3NJ03783E.

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Effect of particle size, solvent to sludge ratio and solvent temperature on the extraction of lipids from sewage sludge cake using methanol

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AIP Conference Proceedings 2024年第1期2923卷

作者： Nor Afifah Khalil Aiman Danial Azri Aida Syafiqah Abd. Rahman Mohd Faizar Banjar Ahmad Noor Syimir Fizal Norkhairihairi Ahmad Muzafar Zulkifli Wirach Taweepreda Md. Sohrab Hossain Ahmad Naim Ahmad Yahaya Green Chemistry and Sustainability Cluster Universiti Kuala Lumpur Branch Campus Malaysian Institute of Chemical and BioEngineering Technology 78000 Alor Gajah Melaka Malaysia Student Development Section Branch Campus Malaysian France Institute Universiti Kuala Lumpur 43650 Bandar Baru Bangi Selangor Malaysia Aero Composite Cluster Universiti Kuala Lumpur Branch Campus Malaysian Institute of Aviation Technology Jalan Jenderam Hulu 43800 Dengkil Selangor Malaysia Polymer Science Program Division of Physical Science Faculty of Science Prince of Songkla University Hat-Yai Songkhla 90110 Thailand School of Industrial Technology Universiti Sains Malaysia Gelugor 11800 Penang Malaysia

Municipal wastewater treatment plant generates a large amount of sludge each year with a generation rate of up to 30.8 kg per population equivalent per year. These sewage sludge cakes contain an abundant amount of lipids that can be extracted, and their compound can be utilized in the production of value-added products. The separation of lipids subsequently reduces the volume of sludge to be managed and disposed of. Lipids can be separated using the conventional Soxhlet extractor, and the yield depends on process parameters such as solvent to sludge ratio, temperature, extraction time, and particle size. Among these parameters, particle size was scarcely studied while extraction time shows an insignificant effect on lipids yield. Therefore, this paper focuses on the impact of the particle size as effective extraction size as well as significant extraction parameters; temperature and sludge-to-solvent ratio on the lipids yield of extraction from the sewage sludge cake using methanol as solvent. Four sludge particle size ranges (x) were selected as the effective extraction size (x≤0.425mm, 0.4254.00mm), five solvents to sludge ratio (7, 8, 10, 13, and 20mL/g) and solvent temperature ranging from 60 to 90℃ were studied with the percentage of lipids yield as the response. The results show that the fine treatment region of x≤2.00mm resulted in higher lipids output compared to the coarse treatment region of x>2.00mm. The highest lipid of 9.70% was obtained at an effective size range of 1.00

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