Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depen...
详细信息
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes and alleles require specific evidence and data types, but the discovery landscape is rapidly changing. To exploit the potential of emerging data, and to provide the field with improved state-of-the-art germline sets, an intermediate approach is needed that will allow the rapid publication of consolidated sets derived from these emerging sources. These sets must use a consistent naming scheme and allow refinement and consolidation into genes as new information emerges. Name changes should be minimised, but, where changes occur, the naming history of a sequence must be traceable. Here we outline the current issues and opportunities for the curation of germline IG/TR genes and present a forward-looking data model for building out more robust germline sets that can dovetail with current established processes. We describe interoperability standards for germline sets, and an approach to transparency based on principles of findability, accessibility, interoperability, and reusability.
A complete emotional expression typically contains a complex temporal course in a natural conversation. Related research on utterance-level, segment-level and multi-level processing lacks understanding of the underlyi...
详细信息
ISBN:
(纸本)9781538656280;9781538656273
A complete emotional expression typically contains a complex temporal course in a natural conversation. Related research on utterance-level, segment-level and multi-level processing lacks understanding of the underlying relation of emotional speech. In this work, a convolutional neural network (CNN) with audio word-based embedding is proposed for emotion modeling. In this study, vector quantization is first applied to convert the low level features of each speech frame into audio words using k-means algorithm. Word2vec is adopted to convert an input speech utterance into the corresponding audio word vector sequence. Finally, the audio word vector sequences of the training emotional speech data with emotion annotation are used to construct the CNN- based emotion model. The NCKU-ES database, containing seven emotion categories: happiness, boredom, anger, anxiety, sadness, surprise and disgust, was collected and five-fold cross validation was used to evaluate the performance of the proposed CNN-based method for speech emotion recognition. Experimental results show that the proposed method achieved an emotion recognition accuracy of 82.34%, improving by 8.7% compared to the Long Short Term Memory (LSTM)- based method, which faced the challenging issue of long input sequence. Comparing with raw features, the audio word-based embedding achieved an improvement of 3.4% for speech emotion recognition.
The learners' needs are an important factor in designing syllabus and materials design, this research deals with the syllabus and material design based on the professional's needs. It is expected that the syll...
详细信息
Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that can recognize patterns in data and us...
详细信息
This study explores the influence of trust and risk in the use of FinTech in Indonesian society. This exploration is based on findings from previous studies that suggest that trust and risk are important aspects in co...
详细信息
ISBN:
(纸本)9781538674086;9781538674079
This study explores the influence of trust and risk in the use of FinTech in Indonesian society. This exploration is based on findings from previous studies that suggest that trust and risk are important aspects in considering the use of FinTech. The focus of this research is to develop and validate the research instruments that will be used next. The basic theory of model development uses the theory of Technology Acceptance Model (TAM) developed by Davis. The models and instruments developed will be through pilot studies involving 133 communities as respondents. This Study is quantitative research and data obtained were analyzed using smart pls v3.0. This analysis is conducted to ensure the level of reliability and validity of the instrument. The results of this analysis find 31 instruments that are stated reliable and validity. So it can be used for collecting data from a survey in accordance with the research.
Background: Physicians invest hours creating patient notes, which are rich in information but difficult for computers to analyze due to their unstructured format. GPT-4 reshaped our ability to process text, yet it is ...
详细信息
Background: Physicians invest hours creating patient notes, which are rich in information but difficult for computers to analyze due to their unstructured format. GPT-4 reshaped our ability to process text, yet it is unknown how well this model can handle medical notes. This project aims to compare GPT-4’s ability to annotate medical notes against experienced physicians across three different languages at multiple institutions and countries. Methods: This study included eight sites from four countries - the United States, Colombia, Singapore, and Italy. Each site contributed seven de-identified notes (admission, progress, or consult) from hospitalized patients. GPT-4 assessed each note by answering 14 questions, including demographic information, clinical judgments, data quality, and patients’ eligibility for a hypothetical study enrollment. For validation, two physicians from each site independently evaluated GPT-4's responses. Findings: Overall, 56 medical notes, written in English, Italian, and Spanish, were analyzed. A total of 784 responses from GPT-4 were generated. Both physicians agreed with GPT-4’s response 79% of the time (622/784, 95%CI 76-82%). Only one of the two physicians agreed with GPT-4’s response 10% of the time (82/784, 95%CI 8-13%). Neither physician agreed with GPT-4’s response 10% of the time (80/784, 95%CI 8-13%). Both physicians agreed with GPT-4 more often in notes written in Spanish and Italian than in English, with agreement rates of 88% (86/98, 95%CI 79-93%), 84% (82/98, 95%CI 75-90%), and 77% (454/588, 95%CI 74-80%), respectively. Hallucinations were rare (10/784, 95%CI 0-2%). GPT-4 correctly selected patients for a hypothetical study enrollment based on three criteria 90% of the time (95%CI 81-98%). Interpretation: The findings indicate that GPT-4 annotations demonstrated a high agreement rate with physicians across all languages. We also demonstrate GPT-4's potential to assist in patient selection for studies. Funding: None. Declarati
In clinical diagnosis of mood disorder, a large portion of bipolar disorder patients (BDs) are misdiagnosed as unipolar depression (UDs). Clinicians have confirmed that BDs generally show "reduced affect''...
详细信息
ISBN:
(纸本)9781538653128
In clinical diagnosis of mood disorder, a large portion of bipolar disorder patients (BDs) are misdiagnosed as unipolar depression (UDs). Clinicians have confirmed that BDs generally show "reduced affect'' during clinical treatment. Thus, it is expected to build an objective and one-time diagnosis system for diagnosis assistance by using machine-learning techniques. In this study, facial expressions of BD, UD and control group (C) elicited by emotional video clips are collected for exploring temporal fluctuation characteristics of intensities of facial muscles expression among the three groups. The differences of facial expressions among mood disorders are investigated by observing macroscopic fluctuations. To deal with these problems, the corresponding methods for feature extraction and modeling are proposed. From the viewpoint of macroscopic facial expression, action unit (AU) is applied for describing the temporal transformation of muscles. Then, modulation spectrum is used for extracting short-term variation of AU. The multilayer perceptron (MLP)-based disorder prediction model is then applied to obtain the prediction results. For evaluation of the proposed method, 12 subjects for three group are included in the K-fold (K=12) cross validation experiments. The experiment results reached 61.1% classification accuracy, and outperformed the other baseline methods.
This study proposes a long-short term memory (LSTM)-based approach to text emotion recognition based on semantic word vector and emotional word vector of the input text. For each word in an input text, the semantic wo...
详细信息
ISBN:
(纸本)9781538653128
This study proposes a long-short term memory (LSTM)-based approach to text emotion recognition based on semantic word vector and emotional word vector of the input text. For each word in an input text, the semantic word vector is extracted from the word 2vec model. Besides, each lexical word is projected to all the emotional words defined in an affective lexicon to derive an emotional word vector. An autoencoder is then adopted to obtain the bottleneck features from the emotional word vector for dimensionality reduction. The autoencoder bottleneck features are then concatenated with the features in the semantic word vector to form the final textual features for emotion recognition. Finally, given the textual feature sequence of the entire sentence, the LSTM is used for emotion recognition by modeling the contextual emotion evolution of the input text. For evaluation, the NLPCC-MHMC-TE database containing seven emotion categories: anger, boredom, disgust, anxiety, happiness, sadness, and surprise was constructed and used. Five-fold cross-validation was employed to evaluate the performance of the proposed method. Experimental results show that the proposed LSTM-based method achieved a recognition accuracy of 70.66%, improving 5.33% compared with the CNN-based method. Besides, the proposed method based on integration of the semantic word vector and emotional word vector of the input text outperformed that using the individual feature vector.
Generative adversarial network (GAN) has achieved impressive success on cross-domain generation, but it faces difficulty in cross-modal generation due to the lack of a common distribution between heterogeneous data. M...
详细信息
Generative adversarial network (GAN) has achieved impressive success on cross-domain generation, but it faces difficulty in cross-modal generation due to the lack of a common distribution between heterogeneous data. Most existing methods of conditional based cross-modal GANs adopt the strategy of one-directional transfer and have achieved preliminary success on text-to-image transfer. Instead of learning the transfer between different modalities, we aim to learn a synchronous latent space representing the cross-modal common concept. A novel network component named synchronizer is proposed in this work to judge whether the paired data is synchronous/corresponding or not, which can constrain the latent space of generators in the GANs. Our GAN model, named as SyncGAN, can successfully generate synchronous data (e.g., a pair of image and sound) from identical random noise. For transforming data from one modality to another, we recover the latent code by inverting the mappings of a generator and use it to generate data of different modality. In addition, the proposed model can achieve semi-supervised learning, which makes our model more flexible for practical applications.
暂无评论