Cancers have emerged as a significant concern due to their impact on public health and society. The examination and interpretation of tissue sections stained with Hematoxylin and Eosin (H&E) play a crucial role in...
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Cancers have emerged as a significant concern due to their impact on public health and society. The examination and interpretation of tissue sections stained with Hematoxylin and Eosin (H&E) play a crucial role in disease assessment, particularly in cases like gastric cancer. Microsatellite instability (MSI) is suggested to contribute to the carcinogenesis of specific gastrointestinal tumors. However, due to the nonspecific morphology observed in H&E-stained tissue sections, MSI determination often requires costly evaluations through various molecular studies and immunohistochemistry methods in specialized molecular pathology laboratories. Despite the high cost, international guidelines recommend MSI testing for gastrointestinal cancers. Thus, there is a pressing need for a new diagnostic modality with lower costs and widespread applicability for MSI detection. This study aims to detect MSI directly from H&E histology slides in gastric cancer, providing a cost-effective alternative. The performance of well-known deep convolutional neural networks (DCNNs) and a proposed architecture are compared. Medical image datasets are typically smaller than benchmark datasets like ImageNet, necessitating the use of off-the-shelf DCNN architectures developed for large datasets through techniques such as transfer learning. Designing an architecture proportional to a custom dataset can be tedious and may not yield desirable results. In this work, we propose an automatic method to extract a lightweight and efficient architecture from a given heavy architecture (e.g., well-known off-the-shelf DCNNs) proportional to a specific dataset. To predict MSI instability, we extracted the MicroNet architecture from the Xception network using the proposed method and compared its performance with other well-known architectures. The models were trained using tiles extracted from whole-slide images, and two evaluation strategies, tile-based and whole-slide image (WSI)-based, were employed and comp
This study employs advanced radar imaging techniques to conduct a comprehensive analysis of a volcanic terrain, unraveling its geological intricacies through the lenses of lithology, geomorphology, and structural feat...
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Contemporary attackers,mainly motivated by financial gain,consistently devise sophisticated penetration techniques to access important information or *** growing use of Internet of Things(IoT)technology in the contemp...
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Contemporary attackers,mainly motivated by financial gain,consistently devise sophisticated penetration techniques to access important information or *** growing use of Internet of Things(IoT)technology in the contemporary convergence environment to connect to corporate networks and cloud-based applications only worsens this situation,as it facilitates multiple new attack vectors to emerge *** such,existing intrusion detection systems suffer from performance degradation mainly because of insufficient considerations and poorly modeled detection *** address this problem,we designed a blended threat detection approach,considering the possible impact and dimensionality of new attack surfaces due to the aforementioned *** collectively refer to the convergence of different technology sectors as the internet of blended *** proposed approach encompasses an ensemble of heterogeneous probabilistic autoencoders that leverage the corresponding advantages of a convolutional variational autoencoder and long short-term memory variational *** extensive experimental analysis conducted on the TON_IoT dataset demonstrated 96.02%detection ***,performance of the proposed approach was compared with various single model(autoencoder)-based network intrusion detection approaches:autoencoder,variational autoencoder,convolutional variational autoencoder,and long short-term memory variational *** proposed model outperformed all compared models,demonstrating F1-score improvements of 4.99%,2.25%,1.92%,and 3.69%,respectively.
Next-generation sequencing is producing data at an exponential rate, which creates immense computation hurdles for reliably and efficiently storing, transmitting, and analysing the data. Compression plays a vital role...
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ISBN:
(数字)9798350383409
ISBN:
(纸本)9798350383416
Next-generation sequencing is producing data at an exponential rate, which creates immense computation hurdles for reliably and efficiently storing, transmitting, and analysing the data. Compression plays a vital role in managing the challenges associated with the growing volume of genomic data. Direct analysis over the compressed representations of DNA sequences can facilitate scalability, enabling the analysis of larger datasets within reasonable computational resources. The proposed scheme develops a methodology to extract meaningful features from compressed DNA sequences that maintain a high correlation with features from the original sequences. We employed deep learning techniques to maximize feature correlation between original and compressed sequence representations. This approach ensures that the features derived from compressed sequences are as informative and representative as those from the original sequences. We evaluated the proposed method with various state-of-the-art approaches for genomic sequence analysis using a dataset that includes genome sequences of different viruses. According to the results, the features extracted from compressed sequences are discriminative for the classification task; thus, downstream analysis of genomic sequences is possible without decompression.
In offline reinforcement learning, weighted regression is a common method to ensure the learned policy stays close to the behavior policy and to prevent selecting out-of-sample actions. In this work, we show that due ...
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Wireless federated learning (FL) is envisioned as a promising paradigm of distributed learning in wireless networks without disclosing users' data privacy. However, radio channel leads to a potential risk of eaves...
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Ultrasound (US) technology has revolutionized prenatal care by offering noninvasive, real-time visualization of maternal-fetal anatomy. The accurate classification of maternal-fetal US planes is a critical segment of ...
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Simulating vehicle trajectories at intersections is one of the challenging tasks in traffic simulation. Existing methods are often ineffective due to the complexity and diversity of lane topologies at intersections, a...
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This paper proposes a joint design of probabilistic constellation shaping (PCS) and precoding to enhance the sum-rate performance of multi-user visible light communications (VLC) broadcast channels subject to signal a...
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The volume of genomic data being generated is growing due to the technological breakthroughs in genome sequencing and the economic affordability of sequencing. Consequently, the need for compression techniques that ar...
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ISBN:
(数字)9798350385922
ISBN:
(纸本)9798350385939
The volume of genomic data being generated is growing due to the technological breakthroughs in genome sequencing and the economic affordability of sequencing. Consequently, the need for compression techniques that are specifically designed for genomic data is rising. Deep learning provides robust methods for reducing the data size and unlocking the full potential of genomic information. The proposed method minimizes storage requirements by applying a 2-D convolutional neural network autoencoder, which learns spatial and sequential redundancies in the sequence to compress the data losslessly. In contrast to conventional compression methods, which handle data as a one-dimensional sequence, the proposed approach uses the spatial structure of the data to produce more compact representations. We evaluated the proposed method with various compression approaches, including state-of-the-art DNA sequence compression algorithms, on two homo sapiens genomes. Experimental results indicate that the proposed method can compress the genomic data effectively, with an improvement of 31.3% compression over the best existing method.
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