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(CSMR) European Conference on Software Maintenance and Reengineering

作者： K. Mens A. Kellens Département dIngénierie Informatique Université catholique de Louvain Louvain-la-Neuve Belgium Programming Technology Laboratory Vrije Universiteit Brussel Brussels Belgium

As size and complexity of software systems increase, preserving the design and specification of their implementation structure gains importance in order to maintain the evolvability of the system. However, due to constant changes, the implementation structure and its documentation tend to dilute over time. To address this problem, we developed IntensiVE: a toolsuite for documenting and checking structural source-code regularities. Building on the underlying models of intensional views and relations, the toolsuite helps a developer in documenting structural source-code regularities, verifying them and offering fine-grained feedback when the source-code does not satisfy those regularities. By illustrating our tools on a Smalltalk application, we show that violations of the source code against the structural regularities can be detected easily and that our toolsuite provides useful feedback for a developer to refine the regularities or to fix the code so that it does satisfy the regularities

关键词： Documentation Feedback Software systems Object oriented modeling Software maintenance Application software Buildings Scholarships Technological innovation Packaging

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A dynamic accelerator-cluster architecture

A dynamic accelerator-cluster architecture

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41st International Conference on Parallel Processing Workshops, ICPPW 2012

作者： Rinke, Sebastian Becker, Daniel Lippert, Thomas Prabhakaran, Suraj Westphal, Lidia Wolf, Felix Laboratory for Parallel Programming German Research School for Simulation Sciences 52062 Aachen Germany Department of Computer Science RWTH Aachen University 52062 Aachen Germany Corporate Technology Siemens AG 81739 München Germany Jülich Supercomputing Centre 52428 Jülich Germany MAGMA Giessereitechnologie GmbH 52072 Aachen Germany

ISBN: (纸本)9780769547954

Accelerators such as graphics processing units (GPUs) provide an inexpensive way of improving the performance of cluster systems. In such an arrangement, the individual nodes of the cluster are directly connected to one or more accelerator devices via PCI Express. This results in a static mapping of accelerators onto compute nodes, where each accelerator can only be accessed from exactly one compute node. While this static mapping enables efficient data transfers between a given accelerator and the compute node it belongs to, differing computational demands across jobs may, however, produce either underutilized accelerators or nodes whose computational demands cannot be satisfied with the number of accelerators available to them. In particular, smaller numbers of GPUs available per node may enforce explicit MPI parallelism across compute nodes where it is not necessary. To address this limitation, we propose a novel accelerator-cluster architecture in which network-attached accelerators are dynamically assigned to compute nodes. This allows not only their optimal utilization but also a more precise match between application requirements and accelerator hardware. We outline the general concept of our dynamic architecture and show that it can offer substantial benefits to certain classes of applications without significantly harming the performance of others. © 2012 IEEE.

关键词： Memory architecture

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Data envelopment analysis for optimal generators start-up strategy

Data envelopment analysis for optimal generators start-up st...

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8th International Conference on Advances in Power System Control, Operation and Management (APSCOM 2009)

作者： Q. Liu L. B. Shi Y. X. Ni L. Zh. Yao M. Bazargan Programming Research Center CPECC China National Key Laboratory of Power Systems in Shenzhen Tsinghua University China Technology Centre AREVA T and D Inc. UK

An optimal strategy involving the corresponding model and approach to the generators start-up during power system restoration is presented. The aim of the method is to maximize the total power generation capability (MWh) over an optimization time period whilst considering the corresponding constraints. The Data Envelopment Analysis (DEA) method is employed to get an effective assessment towards each generator (to be cranked) by the newly introduced indices derived from the objective function together with its constraints. As a result, the relative efficiency of each generator to be started can be evaluated comprehensively and objectively. On the other hand, the priority for each generator start-up can be determined as well. The proposed method, to some extent, can make the trade off between the simulation precision and the computing efforts much better. Case study based on a 12-generator modified real-sized system illustrate that the proposed strategy could provide more comprehensive and objective decision reference.

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A comparative analysis of load balancing algorithms applied to aweather forecast model

A comparative analysis of load balancing algorithms applied ...

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IEEE International Symposium on Computer Architecture and High Performance Computing

作者： Rodrigues, Eduardo R. Navaux, Philippe O. A. Panetta, Jairo Fazenda, Alvaro Mendes, Celso L. Kale, Laxmikant V. Institute of Informatics Federal University of Rio Grande do Sul Porto Alegre Brazil Center for Weather Forecast and Climate Studies INPE Cachoeira Paulista Brazil Science and Technology Department Federal University of Sao Paulo Sao Jose dos Campos Brazil Parallel Programming Laboratory University of Illinois at Urbana-Champaign Urbana United States

ISBN: (纸本)9780769542164

Among the many reasons for load imbalance in weather forecasting models, the dynamic imbalance caused by localized variations on the state of the atmosphere is the hardest one to handle. As an example, active thunderstorms may substantially increase load at a certain timestep with respect to previous timesteps in an unpredictable manner - after all, tracking storms is one of the reasons for running a weather forecasting model. In this paper, we present a comparative analysis of different load balancing algorithms to deal with this kind of load imbalance. We analyze the impact of these strategies on computation and communication and the effects caused by the frequency at which the load balancer is invoked on execution time. This is done with-out any code modification, employing the concept of processor virtualization, which basically means that the domain is over-decomposed and the unit of rebalance is a sub-domain. With this approach, we were able to reduce the execution time of a full, real-world weather model. © 2010 IEEE.

关键词： Weather forecasting

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Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3

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Gastroenterology Report 2021年第1期9卷 59-70,I0002页

作者： Ke-Wang Luo Jun Xia Bao-Hui Cheng Han-Chao Gao Li-Wu Fu Xin-Le Luo Key Laboratory People’s Hospital of LonghuaShenzhenGuangdongP.R.China Key Laboratory of Medical Programming Technology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Shenzhen Key Laboratory of ENT Longgang ENT Hospital and Institute of ENTShenzhenGuangdongP.R.China Department of Nephrology Shenzhen Longhua District Central HospitalAffiliated Central Hospital of Shenzhen Longhua DistrictGuangdong Medical UniversityShenzhenGuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China

Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate(EGCG)is the most bioactive polyphenol in green *** study aims to investigate the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480,SW620,and LS411N cells,and elucidate the underlying *** The in vitro anti-proliferation and anti-migration effects of EGCG against colon-cancer cells were evaluated using MTT,scratch-wound-healing,and transwell-migration *** effects of EGCG on apoptosis were assessed by Annexin V-FITC/PI double staining and JC-1 ***,Western blotting was employed to detect the protein-expression level and elucidate the underlying ***-time qPCR and dual-luciferase reporter assay were adopted to determine the mRNA level and promoter *** Our results demonstrated that treatment with EGCG resulted in significant inhibition of cell proliferation by the induction of *** also inhibited SW480 cell migration in a dose-dependent manner as assessed by wound-healing and transwell-migration *** blot confirmed that EGCG induced apoptosis by the activation of Caspase-3 and *** addition,both STAT3 and phosphorylated STAT3(p-STAT3)were downregulated significantly by EGCG in three selected colorectal-cancer cell *** treatment also resulted in a significant decrease in Bcl-2,MCL-1,and Vimentin,and an increase in *** STAT3 was inhibited,EGCG showed no obvious effect on cell proliferation and *** investigation by luciferase-reporter-activity assay showed that EGCG suppressed the promoter activity of STAT3 and downregulated the transcription of *** Our study presents evidence on the anti-proliferation and anti-migration effects of EGCG against colorectalcancer SW480,SW620,and LS411N cells by downregulating the expression of STAT3 and suggests that EGCG could be an effective and natural supplement for colon-cancer treatment.

关键词： EGCG colon cancer STAT3 SW480 SW620 LS411N

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Performance Characterization of SPEC CPU2006 Benchmarks on Intel and AMD Platform

Performance Characterization of SPEC CPU2006 Benchmarks on I...

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International Workshop on Education technology and Computer Science, ETCS

作者： Shengmei Li Buqi Cheng Xingyu Gao Lin Qiao Zhizhong Tang Department of Computer Science and Technology Tsinghua University Beijing China Programming Systems Laboratory Intel China Research Center Limited Beijing China Chinese Academy and Sciences Beijing China

For understanding the performance differences caused by different computer architectures and optimization technologies, the paper characterizes performance of SPEC CPU2006 benchmarks both on Intel and AMD platform. Using the performance events collected by Performance Monitor Unit, we compare their performance differences and analyze the causes from the features of architectures and the optimization technologies. Our results and analysis help the programmers better understand the memory performance and branch prediction performance which are caused by architectures and guide them in the optimization. The analysis also help the processor architects better balance among the key architecture factors such as memory disambiguation and hardware prefetch when doing architecture design decision.

关键词： Microarchitecture Decoding Educational technology Paper technology programming profession Performance analysis Computer science Computer architecture Hardware Prefetching

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Automated early warning for ATM safety risks based on fuzzy reasoning

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Information technology Journal 2013年第17期12卷 4188-4191页

作者： Heng, Xiang Man, Liang Sino-European Institution of Aviation Engineering Civil Aviation University of China Tianjin 300300 China Tianj in Key Laboratory of Operation Programming and Safety Technology of Air Traffic Management Civil Aviation University of China Tianjin 300300 China

The establishment of an automated risk early warning mechanism closely linked to the air traffic flow management system and information management system plays a positive role in ATM risk management. In this study, a fuzzy reasoning-based approach was proposed to effectively extract the key ATM risk factors for establishing a rapid early warning mechanism. The fuzzy IF-THEN rules were used to build up a fuzzy rule base on the base of experts' knowledge and then through a multi-input fuzzy logic, the different kinds of the unsafe models were ranked. Finally, an extraction of key attributes for ATM safety risks early warning was realized. The result is that the most important attribute is weather conditions, followed by controller's ability in handling large flows and the influences from military activities rank in the third place. The use of this approach is an exploration in the intelligent warning technology for ATM safety risks. © 2013 Asian Network for Scientific Information.

关键词： Extraction

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Aspect-oriented programming workshop report

Aspect-oriented programming workshop report

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Workshops on Object-Oriented technology, ECOOP 1997

作者： Mens, Kim Lopes, Cristina Tekinerdogan, Bedir Kiczales, Gregor Department of Computer Science Programming Technology Lab Vrije Universiteit Brussel Pleinlaan 2 BrusselB-1050 Belgium Systems and Practices Laboratory Xerox PARC 3333 Coyote Hill Rd Palo AltoCA94304 United States Department of Computer Science Software Engineering University of Twente P.O. Box 217 Enschede7500 AE Netherlands

ISBN: (纸本)3540640398

Whereas it is generally acknowledged that code tangling reduces the quality of software and that aspect-oriented programming (AOP) is a means of addressing this problem, there is — as yet — no clear definition or characterisation of AOP. Therefore, the main goal of the ECOOP’97 AOP workshop was to identify the "good questions" for exploring the idea of AOP. © Springer-Verlag Berlin Heidelberg 1998.

关键词： Aspect oriented programming

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How File-access Patterns Inuence the Degree of I/O Interference between Cluster Applications

Supercomputing Frontiers and Innovations

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Supercomputing Frontiers and Innovations 2019年第2期6卷 29-55页

作者： Shah, Aamer Kuo, Chih-Song Nomura, Akihiro Matsuoka, Satoshi Wolf, Felix Laboratory for Parallel Programming Technische Universita•t Darmstadt Darmstadt Germany Taiwan Semiconductor Manufacturing Company Limited Hsinchu Taiwan Global Scientic Information and Computing Center Tokyo Institute of Technology Tokyo Japan Department of Mathematical and Computing Science Tokyo Institute of Technology Tokyo Japan

On large-scale clusters, tens to hundreds of applications can simultaneously access a parallel le system, leading to contention and, in its wake, to degraded application performance. In this article, we analyze the inuence of le-access patterns on the degree of interference. As it is by experience most intrusive, we focus our attention on write-write contention. We observe considerable dierences among the interference potentials of several typical write patterns. In particular, we found that if one parallel program writes large output les while another one writes small checkpointing les, then the latter is slowed down when the checkpointing les are small enough and the former is vice versa. Moreover, applications with a few processes writing large output les already can signicantly hinder applications with many processes from checkpointing small les. Such eects can seriously impact the runtime of real applications|up to a factor of ve in one instance. Our insights and measurement techniques oer an opportunity to automatically classify the interference potential between applications and to adjust scheduling decisions accordingly. © The Authors 2019. This paper is published with open access at ***

关键词： Benchmarking

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Automated CRISPR/Cas9-based genome editing of human pluripotent stem cells using the StemCellFactory

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Cytotherapy 2025年第5期27卷 S36-S37页

作者： Nießing, B. Breitkreuz, Y. Elanzew, A. de Toledo, M.A.S. Vajs, P. Nolden, M. Erkens, F. Wanek, P. Yeung, S. Au Haupt, S. Koenig, N. Peitz, M. Schmitt, R. Zenke, M. Brustle, O. Bioadaptive Production Fraunhofer Institute for Production Technology IPT Aachen Germany Cellomics Unit LIFE&BRAIN GmbH Bonn Germany Institute of Reconstructive Neurobiology University of Bonn Medical Faculty and University Hospital Bonn Bonn Germany Institute for Biomedical Engineering Cell Biology Faculty of Medicine RWTH Aachen University Aachen Germany Helmholtz Institute for Biomedical Engineering RWTH Aachen University Aachen Germany Department of Medicine IV Hematology Oncology and Stem Cell Transplantation RWTH Aachen University Hospital Aachen Germany Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD) Aachen Germany Fraunhofer Institute for Production Technology IPT Aachen Germany Cell Programming Core Facility University of Bonn Medical Faculty Bonn Germany Laboratory for Machine Tools and Production RWTH Aachen University Aachen Germany

Background & AimCRISPR/Cas9 technology is a leading method for efficient gene editing, enabling the creation of isogenic pairs of mutant and control human induced pluripotent stem cells (hiPSCs). While hiPSCs provide valuable opportunities for disease modeling and personalized medicine, challenges remain in distinguishing specific mutation effects from genetic backgrounds. Manual genome editing processes often face scalability and standardization limitations. The StemCellFactory, a modular robotic system, has been developed to automate the reprogramming, expansion, and differentiation of hiPSCs, enhancing the application of CRISPR/Cas9 in research. MethodologyHiPSCs were cultured in StemMACS iPS-Brew XF medium, with daily medium changes and mycoplasma testing. For CRISPR/Cas9 editing, target gene-specific CRISPR-RNA and tracrRNA formed ribonucleoprotein complexes, utilizing an optimized nucleofection protocol. HiPSCs were dissociated, counted, and nucleofected through manual and automated processes. The automated StemCellFactory workflow included cell preparation, nucleofection, and cell seeding, managed by the COPE software for data visualization. Genotyping of polyclonal hiPSCs was performed via Sanger sequencing to assess editing efficiency, with automated isolation of monoclonal colonies conducted using an integrated CellCelector. ResultsThe StemCellFactory successfully integrated a 4D-Nucleofector with a 96-well shuttle device for automated CRISPR/Cas9 editing. Adjustments replaced manual consumables with scalable formats, enhancing efficiency. The CM150 electroporation program yielded high cell viability (83.5%) and indel rates (81.7%). Optimal culture conditions combined Laminin 521 with CloneR-supplemented iPS-Brew medium, supporting hiPSC survival and colony formation. The automated system allowed parallel processing of up to 24 conditions, demonstrating high editing efficiencies, with indel rates exceeding 80% across all tested cell lines, comparable to ma

关键词： Standardization Personalized Medicine COPE

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