Background: Polycystic ovary syndrome (PCOS), also known as the Stein-Leventhal syndrome is one of the most common causes of anovulation, infertility and hyperandrogenism in women, affecting between 5–10 % of women o...
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Background: Polycystic ovary syndrome (PCOS), also known as the Stein-Leventhal syndrome is one of the most common causes of anovulation, infertility and hyperandrogenism in women, affecting between 5–10 % of women of reproductive age (12–35 years) worldwide. Despite substantial effort to define the cause of PCOS, its pathophysiology remains poorly understood. Consequently, determining the mechanisms of PCOS and the possible treatment is the major goal of medical research in endocrine and reproductive physiology. Aim: To investigate the mechanism of ovarian metabolic changes in dehydroepiandrosterone (DHEA)-induced polycystic ovary in Wistar rats treated with vitamin C. Methods: Twenty-eight immature female Wistar rats weighing (16–21 g) were randomly divided into four groups (n = 7/group): group I served as control and was given water, group II were injected with DHEA (6 mg/100 g in 0.2 ml corn oil subcutaneously to induce PCOS condition), group III received 150 mg/kg BW of Vitamin C orally, group IV were co-administered with 6 mg/kg BW DHEA in 0.2 ml of corn oil subcutaneously and 150 mg/kg BW of Vitamin C orally. All treatments lasted for 15 days. Twenty-four hours after the last administration, the rats were sacrificed by cervical dislocation. Blood samples and ovaries were collected for reproductive hormonal analysis, biochemical and histopathological analysis. The expressions of mRNA androgen receptor gene in the ovary were determined by real-time reverse transcriptase polymerase chain reaction. All data were analysed using one-way ANOVA. Results: There was a significant decrease (p < 0.05) in the antioxidant and metabolic enzyme activity in the DHEA treated group compared with the control group. DHEA co-administration with Vitamin C showed a significant decrease in Malondialdehyde, cytokines and Estrogen and a significant increase (p < 0.05) in antioxidant and metabolic enzymes compared with DHEA treated group only. The histopathological evaluation demonstrat
Within the visual programming paradigm there is a vast range of potential for creating program representations. To benefit by these possibilities, it could be worthwhile to make the program representation open-ended, ...
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Within the visual programming paradigm there is a vast range of potential for creating program representations. To benefit by these possibilities, it could be worthwhile to make the program representation open-ended, i.e. modifiable to the specific needs of the user. The authors elucidate the tentative result of their research in this field around the iconic programming environment. An initially developed prototype framework is described, followed by a discussion on the current more open-ended system.< >
In this paper, based on the homotopy continuation method and the interval Newton method, an efficient algorithm is introduced to isolate the real roots of semi-algebraic system. Tests on some random examples and a var...
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In this paper, we combine the Euler scheme with the block group preserving methods to obtain the high accuracy block group preserving techniques. High index differential algebraic equations (DAEs) may have hidden alge...
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This paper presents bulk-synchronous parallel (BSP) algorithms for linear system solving through QR and QZ factorisation. The two new algorithms are analysed in terms of the BSP cost model, and portable implementation...
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This paper presents bulk-synchronous parallel (BSP) algorithms for linear system solving through QR and QZ factorisation. The two new algorithms are analysed in terms of the BSP cost model, and portable implementations of the QR and QZ decomposition methods are devised using the Oxford BSP Library. The experimental results obtained on a shared-memory multiprocessor accurately match the theoretical predictions, permitting a thorough comparison of the two algorithms.
On large-scale clusters, tens to hundreds of applications can simultaneously access a parallel file system, leading to contention and in its wake to degraded application performance. However, the degree of interferenc...
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On large-scale clusters, tens to hundreds of applications can simultaneously access a parallel file system, leading to contention and in its wake to degraded application performance. However, the degree of interference depends on the specific file access pattern. On the basis of synchronized time-slice profiles, we compare the interference potential of different file access patterns. We consider both micro-benchmarks, to study the effects of certain patterns in isolation, and realistic applications to gauge the severity of such interference under production conditions. In particular, we found that writing large files simultaneously with small files can slow down the latter at small chunk sizes but the former at larger chunk sizes. We further show that such effects can seriously affect the runtime of real applications-up to a factor of five in one instance. In the future, both our insights and profiling techniques can be used to automatically classify the interference potential between applications and to adjust scheduling decisions accordingly.
An overview of existing urban software mobile applications of the transport and economic direction is given. A model of a functional rationalizer of consumer behavior is being built. The software model of the function...
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The next phase of LHC Operations-High Luminosity LHC (HL-LHC), which is aimed at ten-fold increase in the luminosity of proton-proton collisions at the energy of 14 TeV, is expected to start operation in 2027-2028 and...
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