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检索条件"机构=Protein Structure-Function and Research Laboratory"
11 条 记 录,以下是1-10 订阅
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Structural and supramolecular insights into crystalline multicomponent systems of 2,4-diamino-6-phenyl-1,3,5-triazine with various carboxylic acids
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Acta Crystallographica Section C: Structural Chemistry 2025年 第Pt 4期81卷 212-223页
作者: Nidhishree, Murugan Gomathi, Sundaramoorthy Nirmalram, Jeyaraman Selvaraj Yasien, Sayed Ramesh, Pandian Department of Chemistry Periyar Maniammai Institute of Science & Technology Tamilnadu Thanjavur613403 India Department of Chemistry Research and Development Cell PRIST Deemed to be University Tamilnadu Thanjavur613403 India Protein Structure Function Research Laboratory School of Molecular and Cell Biology University of the Witwatersrand Johannesburg2050 South Africa
Three multicomponent systems, namely, 2,4-diamino-6-phenyl-1,3,5-triazine-nicotinic acid (DAPT-NA), C9H9N5·C6H5NO2, (I), 2,4-diamino-6-phenyl-1,3,5-triazin-1-ium hydrogen malonate (DAPT-MMA), C9H10N5+·C3H3O4... 详细信息
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Crystal enigma: Understanding diverse protein conformational dynamics, ligand selectivity and interaction in multi-space group crystals using computational modelling
Results in Chemistry
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Results in Chemistry 2025年 16卷
作者: Mfeka, Mbalenhle Onisuru, Olalekan Pandian, Ramesh Sayed, Yasien Khoza, Thandeka Achilonu, Ikechukwu Department of Biochemistry School of Life Sciences College of Agriculture Engineering & Science University of KwaZulu-Natal Pietermaritzburg 3209 South Africa Protein Structure-Function and Research Laboratory School of Molecular and Cell Biology Faculty of Science University of the Witwatersrand Braamfontein Johannesburg 2000 South Africa
Empirical structural methods have been instrumental in drug design, but they often fall short of capturing protein dynamics. To address this limitation, computer-aided drug design (CADD) is essential. Given that Schis... 详细信息
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DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases
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Nature Communications 2025年 第1期16卷 1-15页
作者: Ge, Ruixin Chen, Miao Wu, Sijin Huang, Sirui Zhou, Ping Cao, Minghui Zhang, Fan Zang, Jinzhi Zhu, Yigao Li, Jingrui Ni, Guilin Yang, Zhihao Li, Qingchao Pan, Wei Zhang, Liang Liu, Min Xuan, Chenghao Yu, Haiyang Zhou, Jun Xie, Songbo Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of Shandong College of Life Sciences Shandong Normal University Jinan China School of Life Sciences and Medicine Shandong University of Technology Zibo China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool University Suzhou China Jiangsu Province Higher Education Key Laboratory of Cell Therapy Nanoformulation (Construction) Xi’an Jiaotong-Liverpool University Suzhou China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Department of Biochemistry and Molecular Biology Tianjin Medical University Tianjin China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical University Jinan China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell Ecosystem Tianjin China Department of Neuroscience Genentech South San Francisco San Francisco CA United States State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein Science College of Life Sciences Nankai University Tianjin China Department of Ophthalmology Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma Ministry of Education International Joint Laboratory of Ocular Diseases Tianjin Institute of Eye Health and Eye Diseases China-UK “Belt and Road” Ophthalmology Joint Laboratory Tianjin Medical University General Hospital Tianjin China
Oligonucleotide-based medicine faces challenges in efficiently crossing the blood-brain barrier and rapidly reducing toxic proteins. To address these challenges, here we establish an integrated modality, brain-pe...
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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats
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Heliyon 2025年 第2期11卷 e41624页
作者: Agbara, Amaka Cecilia Eze, Ejike Daniel Offor, Christian Emeka Afodun, Adam Moyosore Ekpono, Ezebuilo Ugbala Agu, Peter Chinedu Aloke, Chinyere Ezeani, Nkeiru Nwaamaka Ikuomola, Emmanuel Orire Etukudo, Ekom Monday Fasogbon, Ilemobayo Victor Musyoka, Angela Mumbua Aja, Patrick Maduabuchi Department of Biochemistry Faculty of Science Ebonyi State University Abakaliki Nigeria Department of Biochemistry Faculty of Biomedical Sciences Kampala International University Uganda Department of Physiology School of Medicine Kabale University Kabale Uganda Department of Anatomy and Cell Biology Faculty of Health Sciences Busitema University Uganda Department of Science Laboratory Technology Biochemistry Option Federal Polytechnic Oko Anambra State Nigeria Department of Medical Biochemistry Faculty of Basic Medical Sciences College of Medicine Alex-Ekwueme Federal University Ndufu-Alike Ikwo Ebonyi State Nigeria Protein Structure-Function and Research Unit School of Molecular and Cell Biology Faculty of Science University of the Witwatersrand Braamfontein Johannesburg 2050 South Africa Department of Physiology Faculty of Biomedical Sciences Kampala International University Uganda Department of Human Anatomy Faculty of Biomedical Sciences Kampala International University Uganda
This study aimed to determine whether C. mannii seed oil (CMSO) could shield rats from cyclophosphamide-induced hepatorenal toxicity. The focus was on its antioxidant and anti-inflammatory properties. We randomly assi... 详细信息
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High yield and efficient expression and purification of the human 5-HT3A receptor
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中国药理学报(英文版) 2015年 第8期36卷 1024-1032页
作者: Zhong-shan WU Zhi-cheng CUI Hao CHENG Chen FAN Karsten MELCHER Yi JIANG Cheng-hai ZHANG Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China VARI-SIMM Center Center for Structure and Function of Drug Targets CAS-Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201210 China VARI-SIMM Center Center for Structure and Function of Drug Targets CAS-Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Laboratory of Structural Sciences Van Andel Research Institute Grand Rapids MI 49503 USA
Aim:To establish a method for efficient expression and purification of the human serotonin type 3A receptor (5-HT3A) that is suitable for structural studies.
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Crystallization scale purification of α7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system
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中国药理学报(英文版) 2015年 第8期36卷 1013-1023页
作者: Hao CHENG Chen FAN Si-wei ZHANG Zhong-shan WU Zhi-cheng CUI Karsten MELCHER Cheng-hai ZHANG VARI-SIMM Center Center for Structure and Function of Drug Targets CAS-Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201210 China VARI-SIMM Center Center for Structure and Function of Drug Targets CAS-Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Laboratory of Structural Sciences Van Andel Research Institute Grand Rapids MI 49503 USA
Aim:To report our methods for expression and purification of α7 nicotinic acetylcholine receptor (α7-nAChR), a ligand-gated pentameric ion channel and an important drug target.
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Variation in Polyamine Content among 12 Pollinated Wheat Genotypes under Drought Stress Condition
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Open Journal of Geology 2017年 第8期7卷 1094-1109页
作者: Mahdi Seyedsalehi Parisa Sharifi Ombretta Paladino Gassan Hodaifa Elba C. Villegas Randa M. Osman Department of Environmental Engineering Science and Research Branch Islamic Azad University Tehran Iran Department of Agronomy Faculty of Agriculture Urmia University Urmia Iran Department of Civil Chemical and Environmental Engineering Università di Genova Genoa Italy Department of Molecular Biology and Biochemical Engineering Chemical Engineering Area University of Pablo de Olavide Seville Spain Laboratory of Function-Structure and Protein Engineering Center for Research on Biotechnology Autonomous University of Morelos State (UAEM) Cuernavaca Mexico Department of Chemical Engineering and Pilot Plant National Research Centre Cairo Egypt
The present work aims to study the drought stress effects on polyamine content and its relationship with growth and development in seeds, during cell division (from the beginning and until 17 days after pollination) a... 详细信息
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Cover Image, Volume 88, Issue 4
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proteins: structure, function, and Bioinformatics 2020年 第4期88卷
作者: Lan Lan Minli Xing Maithri Kashipathy Justin Douglas Philip Gao Kevin Battaile Robert Hanzlik Scott Lovell Liang Xu Department of Molecular Biosciences The University of Kansas Lawrence Kansas Bio-NMR Core Facility NIH COBRE in Protein Structure and Function The University of Kansas Lawrence Kansas Protein Structure Laboratory NIH COBRE in Protein Structure and Function The University of Kansas Lawrence Kansas Protein Production Group NIH COBRE in Protein Structure and Function The University of Kansas Lawrence Kansas IMCA-CAT Hauptman Woodward Medical Research Institute Argonne Illinois Department of Medicinal Chemistry The University of Kansas Lawrence Kansas Department of Radiation Oncology The University of Kansas Cancer Center Kansas City Kansas
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structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex
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Nature 2021年 第7843期589卷 620-626页
作者: Yu-Qi Ping Chunyou Mao Peng Xiao Ru-Jia Zhao Yi Jiang Zhao Yang Wen-Tao An Dan-Dan Shen Fan Yang Huibing Zhang Changxiu Qu Qingya Shen Caiping Tian Zi-Jian Li Shaolong Li Guang-Yu Wang Xiaona Tao Xin Wen Ya-Ni Zhong Jing Yang Fan Yi Xiao Yu H Eric Xu Yan Zhang Jin-Peng Sun CAS Key Laboratory of Receptor Research Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China. Department of Physiology and Pathophysiology School of Basic Medical Sciences Peking University Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing China. Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Shandong China. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China. Zhejiang Laboratory for Systems and Precision Medicine Zhejiang University Medical Center Hangzhou China. Key Laboratory Experimental Teratology of the Ministry of Education Department of Physiology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Shandong China. State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences Beijing Beijing Institute of Lifeomics Beijing China. School of Medicine Tsinghua University Beijing China. Key Laboratory of Molecular Cardiovascular Science Ministry of Education Peking University Beijing China. The Key Laboratory of Infection and Immunity of Shandong Province Department of Pharmacology School of Basic Medical Sciences Shandong University Shandong China. CAS Key Laboratory of Receptor Research Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China. eric.xu@***. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China. zhang_yan@***. Zhejiang Laboratory for Systems and Precision Medicine Zhejiang University Medical Center Hangzhou China. zhang_yan@zju.edu.cn. Zhejiang Provincial Key Laboratory of Immu
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available. Here we report that glucocorticoid stress hormones activate adhesio...
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Correction to: Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin
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Biomolecular NMR assignments 2018年 第2期12卷 365-367页
作者: Donald Gagné Chitra Narayanan Khushboo Bafna Laurie-Anne Charest Pratul K Agarwal Nicolas Doucet INRS-Institut Armand-Frappier Université du Québec 531 Boulevard des Prairies Laval QC H7V 1B7 Canada. Structural Biology Initiative CUNY Advanced Science Research Center New York NY 10031 USA. Graduate School of Genome Science and Technology University of Tennessee Knoxville TN 37996 USA. Computational Biology Institute and Computer Science and Mathematics Division Oak Ridge National Laboratory 1 Bethel Valley Road Oak Ridge TN 37830 USA. Department of Biochemistry Cellular and Molecular Biology University of Tennessee Knoxville TN 37996 USA. INRS-Institut Armand-Frappier Université du Québec 531 Boulevard des Prairies Laval QC H7V 1B7 Canada. nicolas.doucet@iaf.inrs.ca. PROTEO The Québec Network for Research on Protein Function Engineering and Applications Université Laval 1045 Avenue de la Médecine Quebec QC G1V 0A6 Canada. nicolas.doucet@iaf.inrs.ca. GRASP The Groupe de recherche Axé sur la Structure des Protéines McGill University 3649 Promenade Sir William Osler Montreal QC H3G 0B1 Canada. nicolas.doucet@iaf.inrs.ca.
After publication of this article, the authors noticed that a N-C dimension error was unwillingly coded in the 3D NMR spectrum "***" processing script used to perform backbone assignments for this enzyme. Th...
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