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Z16b,a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia

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中国药理学报（英文版） 2022年第9期43卷 2340-2350页

作者： Jiang-fan Wan Gang Wang Fu-ying Qin Dan-ling Huang Yan Wang Ai-ling Su Hai-ping Zhang Yang Liu Shao-yin Zeng Chao-liang Wei Yong-xian Cheng Jie Liu Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhen 518000China Center for Translation Medicine Research and Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Guangdong Provincial key laboratory of South China Structure Heart Disease Department of Pediatric CardiologyGuangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China

Catecholaminergic polymorphic ventricular tachycardia(CPVT)is an inherited,lethal ventricular arrhythmia triggered by *** in genes that encode cardiac ryanodine receptor(RyR2)and proteins that regulate RyR2 activity cause enhanced diastolic Ca2+release(leak)through the RyR2 channels,resulting in *** therapies for CPVT are *** found that Z16b,a meroterpenoid isolated from Ganoderma cochlear,inhibited Ca2+spark frequency(CaSF)in R2474S/+cardiomyocytes in a dose-dependent manner,with an IC50 of 3.2 μM.Z16b also dose-dependently suppressed abnormal post-pacing Ca2+release *** injection(i.p.)of epinephrine and caffeine stimulated sustained ventricular tachycardia in all R2474S/+mice,while pretreatment with Z16b(0.5 mg/kg,i.p.)prevented ventricular arrhythmia in 9 of 10 mice,and Z16b administration immediately after the onset of VT abolished sVT in 9 of 12 *** translational significance,Z16b significantly inhibited CaSF and abnormal Ca2+release events in human CPVT ***,Z16b interacts with RyR2,enhancing the"zipping"state of the N-terminal and central domains of RyR2.A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626,His1670,and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight"zipping"*** findings support that Z16b is a novel RyR2 stabilizer that can prevent *** may also serve as a lead compound with a new scaffold for the design of safer and more efficient drugs for treating CPVT.

关键词： arrhythmia catecholaminergic polymorphic ventricular tachycardia natural product ryanodine receptor induced pluripotent stem cell-derived cardiomyocytes

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Stable Learning via Triplex Learning

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2024年第10期5卷 5267-5276页

作者： Yang, Shuai Jiang, Tingting Dang, Qianlong Gu, Lichuan Wu, Xindong Anhui Agricultural University School of Information and Artificial Intelligence Hefei230036 China Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing Hefei230036 China Northwest A & F University College of Science Yangling712100 China Hefei University of Technology Key Laboratory of Knowledge Engineering with Big Data The Ministry of Education of China Hefei230601 China Hefei University of Technology School of Computer Science and Information Engineering Hefei230601 China

Stable learning aims to learn a model that generalizes well to arbitrary unseen target domain by leveraging a single source domain. Recent advances in stable learning have focused on balancing the distribution of confounders for each feature to eliminate spurious correlations. However, previous studies treat all features equally without considering the difficulties of confounder balancing associated with different features, and regard irrelevant features as confounders, deteriorating generalization performance. To tackle these issues, this article proposes a novel triplex learning (TriL) based stable learning algorithm, which performs sample reweighting, causal feature selection, and representation learning to remove spurious correlations. Specifically, first, TriL adaptively assigns weights to the confounder balancing term of each feature in accordance with the difficulties of confounder balancing, and aligns the confounder distribution of each feature by learning a group of sample weights. Second, TriL integrates the sample weights into a weighted cross-entropy model to compute causal effects of features for excluding irrelevant features from the confounder set. Finally, TriL relearns a set of sample weights and uses them to guide a new supervised dual-autoencoder containing two classifiers to learn feature representations. TriL forces the results of two classifiers to remain consistent for removing spurious correlations by using a cross-classifier consistency regularization. Extensive experiments on synthetic and two real-world datasets show the superiority of TriL compared with seven methods. © 2024 IEEE.

关键词： Feature Selection

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Task-Aware Dynamic Transformer for Efficient Arbitrary-Scale Image Super-Resolution 27

Task-Aware Dynamic Transformer for Efficient Arbitrary-Scale...

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27th European Conference on Artificial Intelligence, ECAI 2024

作者： Xu, Tianyi Zhou, Yijie Hu, Xiaotao Zhang, Kai Zhang, Anran Qiu, Xingye Xu, Jun School of Statistics and Data Science Nankai University Tianjin China College of Computer Science Nankai University Tianjin China School of Intelligence Science and Technology Nanjing University Suzhou China Tencent Data Platform Beijing China Zhejiang University Hangzhou China Systems Engineering Research Institute China State Shipbuilding Corporation Limited Beijing China Guangdong Provincial Key Laboratory of Big Data Computing The Chinese University of Hong Kong Shenzhen China

ISBN: (纸本)9781643685489

Arbitrary-scale super-resolution (ASSR) aims to learn a single model for image super-resolution at arbitrary magnifying scales. Existing ASSR networks typically comprise an off-the-shelf scale-agnostic feature extractor and an arbitrary scale upsampler. These feature extractors often use fixed network architectures to address different ASSR inference tasks, each of which is characterized by an input image and an upsampling scale. However, this overlooks the difficulty variance of super-resolution on different inference scenarios, where simple images or small SR scales could be resolved with less computational effort than difficult images or large SR scales. To tackle this difficulty variability, in this paper, we propose a Task-Aware Dynamic Transformer (TADT) as an input-adaptive feature extractor for efficient image ASSR. Our TADT consists of a multi-scale feature extraction backbone built upon groups of Multi-Scale Transformer Blocks (MSTBs) and a Task-Aware Routing Controller (TARC). The TARC predicts the inference paths within feature extraction backbone, specifically selecting MSTBs based on the input images and SR scales. The prediction of inference path is guided by a new loss function to trade-off the SR accuracy and efficiency. Experiments demonstrate that, when working with three popular arbitrary-scale upsamplers, our TADT achieves state-of-the-art ASSR performance when compared with mainstream feature extractors, but with relatively fewer computational costs. The code is available at https://***/Tillyhere/TADT. © 2024 The Authors.

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4K-Resolution Photo Exposure Correction at 125 FPS with ∼8K Parameters

arXiv

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arXiv 2023年

作者： Zhou, Yijie Li, Chao Liang, Jin Xu, Tianyi Liu, Xin Xu, Jun Nankai University China Tianjin University China Lappeenranta-Lahti University of Technology Finland Guangdong Provincial Key Laboratory of Big Data Computing CUHK Shenzhen China

The illumination of improperly exposed photographs has been widely corrected using deep convolutional neural networks or Transformers. Despite with promising performance, these methods usually suffer from large parameter amounts and heavy computational FLOPs on high-resolution photographs. In this paper, we propose extremely light-weight (with only ∼8K parameters) Multi-Scale Linear Transformation (MSLT) networks under the multi-layer perception architecture, which can process 4K-resolution sRGB images at 125 Frame-Per-Second (FPS) by a Titan RTX GPU. Specifically, the proposed MSLT networks first decompose an input image into high and low frequency layers by Laplacian pyramid techniques, and then sequentially correct different layers by pixel-adaptive linear transformation, which is implemented by efficient bilateral grid learning or 1 × 1 convolutions. Experiments on two benchmark datasets demonstrate the efficiency of our MSLTs against the state-of-the-arts on photo exposure correction. Extensive ablation studies validate the effectiveness of our contributions. The code is available at https://***/Zhou-Yijie/MSLTNet. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep neural networks

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FACOS: Enabling Privacy Protection Through Fine-Grained Access Control with On-chain and Off-chain System

arXiv

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arXiv 2024年

作者： Liu, Chao Hou, Cankun Jiang, Tianyu Ning, Jianting Qiao, Hui Wu, Yusen Fujian Provincial Key Laboratory of Data Intensive Computing the Key Laboratory of Intelligent Computing and Information Processing Fujian China The School of Computer Science and Technology Xidian University Shaanxi Xi’an710071 China The Department of Computer Science University of Miami MiamiFL33146 United States College of Computer and Cyber Security Fujian Normal University Fuzhou350007 China The Faculty of Data Science City University of Macau China

data-driven landscape across finance, government, and healthcare, the continuous generation of information demands robust solutions for secure storage, efficient dissemination, and fine-grained access control. Blockchain technology emerges as a significant tool, offering decentralized storage while upholding the tenets of data security and accessibility. However, on-chain and off-chain strategies are still confronted with issues such as untrusted off-chain data storage, absence of data ownership, limited access control policy for clients, and a deficiency in data privacy and auditability. To solve these challenges, we propose a permissioned blockchain-based privacy-preserving fine-grained access control on-chain and off-chain system, namely FACOS. We applied three fine-grained access control solutions and comprehensively analyzed them in different aspects, which provides an intuitive perspective for system designers and clients to choose the appropriate access control method for their systems. Compared to similar work that only stores encrypted data in centralized or non-fault-tolerant IPFS systems, we enhanced off-chain data storage security and robustness by utilizing a highly efficient and secure asynchronous Byzantine fault tolerance (BFT) protocol in the off-chain environment. As each of the clients needs to be verified and authorized before accessing the data, we involved the Trusted Execution Environment (TEE)-based solution to verify the credentials of clients. Additionally, our evaluation results demonstrated that our system1 offers better scalability and practicality than other state-of-the-art designs. We deployed our system on Alibaba Cloud and Tencent Cloud and conducted multiple evaluations. The results indicate that it takes about 2.79 seconds for a client to execute the protocol for uploading and about 0.96 seconds for downloading. Compared to other decentralized systems, our system exhibits efficient latency for both download and upload operations.

关键词： Access control

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Rapid Maize Seedling Detection Based on Receptive-Field and Cross-Dimensional Information Interaction

Rapid Maize Seedling Detection Based on Receptive-Field and ...

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2024 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2024

作者： Hao, Fengqi Zhu, Shulei Ma, Dexin Dong, Xiangjun Kong, Hoiio Liu, Xia Mu, Chunhua Key Laboratory of Computing Power Network and Information Security Ministry of Education Jinan250014 China City University of Macau Faculty of Data Science 999078 China Shandong Fundamental Research Center for Computer Science Shandong Provincial Key Laboratory of Computer Networks Jinan250014 China Communication College Qingdao Agricultural University Qingdao266109 China Maize Research Institute Shandong Academy of Agricultural Sciences National Engineering Laboratory of Wheat and Maize Key Laboratory of Biology and Genetic Improvement of Maize in Northern Yellow-huai River Plain Ministry of Agriculture Jinan250100 China

ISBN: (纸本)9781665410205

The seedling stage is important in the growth and development of maize, and it is also a critical period that affects maize yield and quality. Accurately recognizing this stage of maize is challenging, as current maize seedling detection methods struggle with small sizes and complex environments. This paper proposes a rapid maize seedling detection method that emphasizes spatial feature extraction in the receptive field and cross-dimensional interaction - receptive field triplet attention YOLO (RFT-YOLO). First, we design a convolutional module for cross-dimensional information interaction within the receptive field. Second, we introduce an advanced selective fusion network, which boosts the multi-scale fusion capability of small object features while reducing the GFLOPs of the model. Additionally, we employ Inner-IoU to diminish sensitivity to positional biases of small objects and expedite the convergence of the loss function. Finally, we create a dataset of maize seedlings to conduct our experiments. Experimental results demonstrate that the RFT-YOLO significantly enhances performance, reducing the number of parameters by 35.3% and GFLOPs by 14.24%, compared to the baseline model. Moreover, the mean average precision (mAP) improves from 89.6% to 91.5%. These improvements confirm the model's effectiveness in detecting maize seedlings. © 2024 IEEE.

关键词： Deep learning Maize seedling detection Object detection UAV

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A Parallelizable Counterfactual Generation Method Based on Gradient Optimization 29

A Parallelizable Counterfactual Generation Method Based on G...

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29th IEEE International Conference on Parallel and Distributed Systems, ICPADS 2023

作者： Ding, Haorun Jiang, Xuesong Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Qilu University of Technology Shandong Academy of Sciences Jinan China Shandong Engineering Research Center of Big Data Applied Technology Faculty of Computer Science and Technology Qilu University of Technology Shandong Academy of Sciences Jinan China Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer Science Jinan China Quan Cheng Laboratory Jinan China State Key Laboratory of High-end Server and Storage Technology Jinan China

ISBN: (纸本)9798350330717

Post-hoc explanations are important for people to understand the predictions of explanation models. One class of methods in post-hoc explanation is the generation of counterfactuals, where a hypothetical example is obtained by perturbing the inputs to show how one could obtain a different prediction from the decision model. Counter-factual explanations should satisfy several properties: One is that counterfactuals generated under specific scenarios and constraints should be feasible for users, i.e., they should accommodate different causal constraints. The other is that it is more desirable for users to have a wider variety of viable examples, i.e., counterfactual diversity. To this end, we propose a parallelizable method based on gradient optimization. We partition the input feasible domains, perform counterfactual generation independently for each feasible domain, and then parallelize the counterfactual generation process for each feasible domain. Experimental results show that our approach effectively improves the diversity, sparsity, and proximity of the generated counterfactual instances on the public datasets Adult-Income, Lending-Club, German-Credit, and COMPAS compared to other models. © 2023 IEEE.

关键词： counterfactual explanation machine learning parallel computing

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LDVNet: Lightweight and Detail-Aware Vision Network for Image Recognition Tasks in Resource-Constrained Environments 29

LDVNet: Lightweight and Detail-Aware Vision Network for Imag...

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29th IEEE International Conference on Parallel and Distributed Systems, ICPADS 2023

作者： Liu, Yuchen Liang, Hu Qiu, Ran Zhao, Shengrong Qilu University of Technology Shandong Academy of Sciences Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Jinan China Qilu University of Technology Shandong Academy of Sciences Shandong Engineering Research Center of Big Data Applied Technology Faculty of Computer Science and Technology Jinan China Shandong Fundamental Research Center for Computer Science Shandong Provincial Key Laboratory of Computer Networks Jinan China

ISBN: (纸本)9798350330717

In many underwater application scenarios, recognition tasks need to be executed promptly on computationally limited platforms. However, models designed for this field often exhibit spatial locality, and existing works lack the ability to capture crucial details in images. Therefore, a lightweight and detail-aware vision network (LDVNet) for resource-constrained environments is proposed to overcome the limitations of these approaches. Firstly, in order to enhance the accuracy of target image recognition, we introduce transformer modules to acquire global information, thus addressing the issue of spatial locality inherent in traditional convolutional neural networks (CNNs). Secondly, to maintain the network's lightweight nature, we integrate the transformer module with convolutional operations, thereby mitigating the substantial parameter and floating point operations (FLOPs) overhead. Thirdly, for the efficient extraction of crucial fine-grained details from feature maps, we have devised a channel and spatial attention module (C&SA). This module aids in recognizing intricate and fine-grained visual tasks and enhances image understanding. It is seamlessly integrated into LDVNet with nearly negligible parameter overhead. The experimental results demonstrate that LDVNet outperforms other lightweight networks and hybrid networks in different recognition tasks, while being suitable for resource-constrained environments. © 2023 IEEE.

关键词： Detail-aware Image recognition Lightweight

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A Defense Framework for Backdoor Attacks in Federated Learning Based on Client-Server Detection 4

A Defense Framework for Backdoor Attacks in Federated Learni...

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4th International Conference on Industrial Automation, Robotics and Control Engineering, IARCE 2024

作者： Chen, Ding Li, Tianrui Yu, Cai Al-Huthaifi, Rasha Huang, Wei School of Computing and Artificial Intelligence Southwest Jiaotong University Chengdu611756 China School of Cybersecurity Chengdu University of Information Technology Sichuan Provincial Key Laboratory of Cyberspace Security Chengdu610225 China School of Cybersecurity Chengdu University of Information Technology Chengdu610225 China College of Computer and Data Science Fuzhou University Fuzhou350108 China

ISBN: (纸本)9798350380323

Addressing the challenge of backdoor attacks in federated learning (FL), various defense schemes are examined, resulting in the proposal of a comprehensive strategy that incorporates both client-side and server-side measures. This defense strategy is based on Dropout and LOF (Local Outlier Factor) outlier detection techniques. The model's resilience against data poisoning is enhanced by applying the Dropout technique on the client side. At the same time, the LOF outlier detection algorithm is utilized on the server side to identify potential abnormal model updates. Experimental results highlight the effectiveness of the proposed strategy, demonstrating a significant reduction in the Attack Success Rate (ASR) from 88.11% to 1.62% on the FMNIST dataset, and from 95.45% to only 0.25% on the EMNIST dataset. The success rate of backdoor attacks is notably diminished, confirming the strategy's strong backdoor defense capabilities. © 2024 IEEE.

关键词： Federated learning

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PNRITR:Research on Positive and Negative Entity Region Perception Methods for Image-Text Retrieval 36

PNRITR:Research on Positive and Negative Entity Region Perce...

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36th International Conference on Software Engineering and Knowledge Engineering, SEKE 2024

作者： Zhang, Zhiping Sun, Tao Zheng, Hongyan Liu, Hao Liu, Gengchen Yang, Zhi Wang, Xiaoyu Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Qilu University of Technology Shandong Academy of Sciences Jinan China Shandong Engineering Research Center of Big Data Applied Technology Faculty of Computer Science and Technology Qilu University of Technology Shandong Academy of Sciences Jinan China Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer Science Jinan China

ISBN: (纸本)1891706594

The aim of cross-modal image-text retrieval is to heighten comprehension and to create robust associations between visual and textual content. This process entails a mutual querying and synchronization across various data formats. While conventional techniques have seen enhancements via attention-based approaches, they frequently miss the dynamics between corresponding and non-corresponding entity areas within image-text pairs. These techniques, often fixated on aligning image entities with textual terms, can overlook the congruence of entity characteristics, leading to less accurate localization. This research introduces PNRITR, an innovative strategy for cross-modal retrieval that leverages label learning to discern attributes absent from images, broadening the scope beyond just positive entity areas. PNRITR has delivered notable advancements on the Flickr30K and MS-COCO datasets. © 2024 Knowledge Systems Institute Graduate School. All rights reserved.

关键词： Knowledge based systems

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