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Harmonized-Multinational qEEG norms (HarMNqEEG)

NEUROIMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, Carlos Hu, Shiang Reyes, Ronaldo Cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini Ismafairus Abd Evans, Alan C. Savostyanov, Alexander N. Calzada-Reyes, Ana Villringer, Arno Tobon-Quintero, Carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-Chacon, Lilia Valdes-Sosa, Mitchell J. Trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, Thomas Virues-Alba, Trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio [a]The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China [b]Cuban Center for Neurocience La Habana Cuba [c]McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada [d]Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [e]Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [f]Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [g]Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia [h]Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia [i]Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia [j]University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba [k]Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany [l]Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany [m]Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany [n]Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia [o]Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia [p]The Cuban center aging longevity and health Havana Cuba [q]Research Unit of NeuroInformation Chinese Academy of Medical Sciences Chengdu 2019RU035 China [r]School of Electrical Engineering Zhengzhou University Zhengzhou 4500

This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition Covid induced brain dysfunction Developmental Brain Chart

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Radio detection of an elusive millisecond pulsar in the Globular Cluster NGC 6397

arXiv

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arXiv 2022年

作者： Zhang, Lei Ridolfi, Alessandro Blumer, Harsha Freire, Paulo C.C. Manchester, Richard N. McLaughlin, Maura Kremer, Kyle Cameron, Andrew D. Zhang, Zhiyu Behrend, Jan Burgay, Marta Buchner, Sarah Champion, David J. Chen, Weiwei Dai, Shi Feng, Yi Fu, Xiaoting Guo, Meng Hobbs, George Keane, Evan F. Kramer, Michael Levin, Lina Li, Xiangdong Ni, Mengmeng Pan, Jingshan Padmanabh, Prajwal V. Possenti, Andrea Ransom, Scott M. Tsai, Chao-Wei Krishnan, Vivek Venkatraman Wang, Pei Zhang, Jie Zhi, Qijun Zhang, Yongkun Li, Di National Astronomical Observatories Chinese Academy of Sciences A20 Datun Road Chaoyang District Beijing100101 China Centre for Astrophysics and Supercomputing Swinburne University of Technology P.O. Box 218 HawthornVIC3122 Australia SelargiusI-09047 Italy Department of Physics and Astronomy West Virginia University MorgantownWV26506 United States Max-Planck Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany CSIRO Space and Astronomy Australia Telescope National Facility PO Box 76 EppingNSW1710 Australia TAPIR California Institute of Technology PasadenaCA91125 United States The Observatories of the Carnegie Institution for Science PasadenaCA91101 United States Swinburne University of Technology Mail H74 PO Box 218 VIC3122 Australia School of Astronomy and Space Science Nanjing University Nanjing210023 China Ministry of Education Nanjing210093 China South African Radio Astronomy Observatory Fir Street Black River Park Cape Town7925 South Africa School of Science Western Sydney University Locked Bag 1797 PenrithNSW2751 Australia Research Center for Intelligent Computing Platforms Zhejiang Laboratory Hangzhou311100 China Purple Mountain Observatory Chinese Academy of Sciences Nanjing210023 China National Supercomputing Center in Jinan Qilu University of Technology 28666 East Jingshi Road Licheng Distrist Jinan250103 China Jinan Institute of Supercomputing Technology 28666 East Jingshi Road Licheng Distrist Jinan250103 China School of Physics Trinity College Dublin College Green Dublin Ireland Jodrell Bank Centre for Astrophysics Department of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom HannoverD-30167 Germany MonserratoI-09042 Italy NRAO 520 Edgemont Road CharlottesvilleVA22903 United States College of Physics and Electronic Engineering Qilu Normal University 2 Wenbo Road Zhangqiu District Jinan250200 China Guizhou Provincial Key Laboratory of Radio

We report the discovery of a new 5.78 ms-period millisecond pulsar (MSP), PSR J1740−5340B (NGC 6397B), in an eclipsing binary system discovered with the Parkes radio telescope (now also known as Murriyanga), Australia, and confirmed with the MeerKAT radio telescope in South Africa. The measured orbital period, 1.97 days, is the longest among all eclipsing binaries in globular clusters (GCs) and consistent with that of the coincident X-ray source U18, previously suggested to be a ‘hidden MSP’. Our XMM-Newton observations during NGC 6397B’s radio quiescent epochs detected no X-ray flares. NGC 6397B is either a transitional MSP or an eclipsing binary in its initial stage of mass transfer after the companion star left the main sequence. The discovery of NGC 6397B potentially reveals a subgroup of extremely faint and heavily obscured binary pulsars, thus providing a plausible explanation to the apparent dearth of binary neutron stars in core-collapsed GCs as well as a critical constraint on the evolution of GCs. Copyright © 2022, The Authors. All rights reserved.

关键词： Mass transfer

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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Correction to: Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial

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Critical care (London, England) 2022年第1期26卷 115页

作者： Lu Ke Jiajia Lin Gordon S Doig Arthur R H van Zanten Yang Wang Juan Xing Zhongheng Zhang Tao Chen Lixin Zhou Dongpo Jiang Qindong Shi Jiandong Lin Jun Liu Aibin Cheng Yafeng Liang Peiyang Gao Junli Sun Wenming Liu Zhenyu Yang Rumin Zhang Wei Xing An Zhang Zhigang Zhou Tingfa Zhou Yang Liu Fei Tong Qiuhui Wang Aijun Pan Xiaobo Huang Chuming Fan Weihua Lu Dongwu Shi Lei Wang Wei Li Liming Gu Yingguang Xie Rongqing Sun Feng Guo Lin Han Lihua Zhou Xiangde Zheng Feng Shan Jianbo Liu Yuhang Ai Yan Qu Liandi Li Hailing Li Zhiguo Pan Donglin Xu Zhiqiang Zou Yan Gao Chunli Yang Qiuye Kou Xijing Zhang Jinglan Wu Chuanyun Qian Weixing Zhang Minjie Zhang Yuan Zong Bingyu Qin Fusen Zhang Zhe Zhai Yun Sun Ping Chang Bo Yu Min Yu Shiying Yuan Yijun Deng Liyun Zhao Bin Zang Yuanfei Li Fachun Zhou Xiaomei Chen Min Shao Weidong Wu Ming Wu Zhaohui Zhang Yimin Li Qiang Guo Zhiyong Wang Yuanqi Gong Yunlin Song Kejian Qian Yongjian Feng Baocai Fu Xueyan Liu Zhiping Li Chuanyong Gong Cheng Sun Jian Yu Zhongzhi Tang Linxi Huang Biao Ma Zhijie He Qingshan Zhou Rongguo Yu Zhihui Tong Weiqin Li Department of Critical Care Medicine Jinling Hospital Medical School of Nanjing University No. 305 Zhongshan East Road Nanjing 210000 Jiangsu Province China. National Institute of Healthcare Data Science Nanjing University Nanjing China. Northern Clinical School Royal North Shore Hospital University of Sydney Sydney Australia. Department of Intensive Care Medicine Gelderse Vallei Hospital Willy Brandtlaan 10 6716 RP Ede The Netherlands. Department of Medical Research and Biometrics Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Benq Medical Center Nanjing China. Department of Emergency Medicine Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China. Tropical Clinical Trials Unit Department of Clinical Sciences Liverpool School of Tropical Medicine Liverpool L3 5QA UK. First People's Hospital of Foshan Foshan China. Daping Hospital Army Medical University Chongqing China. First Affiliated Hospital of Xi'an Jiao Tong University Xi'an China. First Affiliated Hospital of Fujian Medical University Fuzhou China. Suzhou Municipal Hospital Suzhou China. North China University of Science and Technology Affiliated Hospital Tangshan China. Qindao University Medical College Affiliated Yantai Yuhuangding Hospital Yantai China. Chengdu University of Traditional Chinese Medicine Affiliated Hospital Chengdu China. Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China. Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University Changzhou China. The Second Affiliated Hospital of Harbin Medical University Harbin China. Zibo Central Hospital Zibo China. Department of Intensive Care Medicine The Third Xiangya Hospital of Central South University Changsha China. The Second Affiliated Hospital of Chongqing Medical University Chongqing China. First People's Hospita

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