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检索条件"机构=Quebec Inst Learning Algorithms"
16 条 记 录,以下是11-20 订阅
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Two types of human TCR differentially regulate reactivity to self and non-self antigens
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ISCIENCE 2022年 第9期25卷 104968页
作者: Trofimov, Assya Brouillard, Philippe Larouche, Jean-David Seguin, Jonathan Laverdure, Jean-Philippe Brasey, Ann Ehx, Gregory Roy, Denis-Claude Busque, Lambert Lachance, Silvy Lemieux, Sebastien Perreault, Claude Univ Montreal Inst Res Immunol & Canc IRIC Montreal PQ H3C 3J7 Canada Univ Montreal Dept Comp Sci & Res Operat Montreal PQ H3C 3J7 Canada Quebec Inst Learning Algorithms Mila Montreal PQ H2S 3H1 Canada Univ Montreal Dept Med Montreal PQ H3C 3J7 Canada Maisonneuve Rosemt Hosp Montreal PQ H1T 2M4 Canada Univ Liege Currently Interdisciplinary Cluster Appl Geno Pro B-4000 Liege Belgium Fred Hutchinson Canc Ctr Seattle WA 98109 USA Univ Washington Dept Phys Seattle WA 98195 USA Univ Montreal Dept Biochem Montreal PQ H3C 3J7 Canada
Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations i... 详细信息
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Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease
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CELL REPORTS MEDICINE 2024年 第2期5卷 101379-101379页
作者: Cheng, Feixiong Wang, Fei Tang, Jian Zhou, Yadi Fu, Zhimin Zhang, Pengyue Haines, Jonathan L. Leverenz, James B. Gan, Li Hu, Jianying Rosen-Zvi, Michal Pieper, Andrew A. Cummings, Jeffrey Cleveland Clin Genom Med Inst Lerner Res Inst Cleveland OH 44195 USA Cleveland Clin Lerner Res Inst Genome Ctr Cleveland OH 44195 USA Case Western Reserve Univ Cleveland Clin Dept Mol Med Lerner Coll Med Cleveland OH 44195 USA Cornell Univ Dept Populat Hlth Sci Weill Cornell Med Coll New York NY 10065 USA HEC Montreal Mila Quebec Inst Learning Algorithms Montreal PQ H3T 2A7 Canada HEC Montreal CIFAR AI Res Chair Montreal PQ H3T 2A7 Canada Northeast Ohio Med Univ Coll Pharm Rootstown OH 44272 USA Indiana Univ Dept Biostat & Hlth Data Sci Indianapolis IN 46037 USA Case Western Reserve Univ Cleveland Inst Computat Biol Cleveland OH 44106 USA Case Western Reserve Univ Dept Populat & Quantitat Hlth Sci Cleveland OH 44106 USA Cleveland Clin Neurol Inst Lou Ruvo Ctr Brain Hlth Cleveland OH 44195 USA Weill Cornell Med Helen & Robert Appel Alzheimers Dis Res Inst Brain & Mind Res Inst New York NY 10021 USA IBM Res Yorktown Hts NY 10598 USA IBM Res Labs AI Accelerated Healthcare & Life Sci Discovery IL-3498825 Haifa Israel Hebrew Univ Jerusalem Fac Med IL-9190500 Jerusalem Israel Univ Hosp Cleveland Harrington Discovery Inst Brain Hlth Med Ctr Med Ctr Cleveland OH 44106 USA Case Western Reserve Univ Dept Psychiat Cleveland OH 44106 USA Louis Stokes Cleveland VA Med Ctr Geriatr Psychiat GRECC Cleveland OH 44106 USA Case Western Reserve Univ Sch Med Inst Transformat Mol Med Cleveland OH 44106 USA Case Western Reserve Univ Sch Med Dept Pathol Cleveland OH 44106 USA Case Western Reserve Univ Sch Med Dept Neurosci Cleveland OH 44106 USA UNLV Sch Integrated Hlth Sci Dept Brain Hlth Chambers Grundy Ctr Transformat Neurosci Las Vegas NV 89154 USA
The high failure rate of clinical trials in Alzheimer's disease (AD) and AD-related dementia (ADRD) is due to a lack of understanding of the pathophysiology of disease, and this deficit may be addressed by applyin...
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HOW TRANSFERABLE ARE FEATURES IN CONVOLUTIONAL NEURAL NETWORK ACOUSTIC MODELS ACROSS LANGUAGES?  44
HOW TRANSFERABLE ARE FEATURES IN CONVOLUTIONAL NEURAL NETWOR...
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44th IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
作者: Thompson, Jessica A. F. Schoenwiesner, Marc Bengio, Yoshua Willett, Daniel Univ Montreal Int Lab Brain Mus & Sound Res BRAMS Montreal PQ Canada Quebec Inst Learning Algorithms Mila Montreal PQ Canada CRBLM Montreal PQ Canada Univ Leipzig Inst Biol Leipzig Germany Nuance Commun Aachen Germany
Characterization of the representations learned in intermediate layers of deep networks can provide valuable insight into the nature of a task and can guide the development of well-tailored learning strategies. Here w... 详细信息
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Unimodal Probability Distributions for Deep Ordinal Classification  34
Unimodal Probability Distributions for Deep Ordinal Classifi...
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34th International Conference on Machine learning
作者: Beckham, Christopher Pal, Christopher Montreal Inst Learning Algorithms Quebec City PQ Canada
Probability distributions produced by the cross-entropy loss for ordinal classification problems can possess undesired properties. We propose a straightforward technique to constrain discrete ordinal probability distr... 详细信息
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Deep generative molecular design reshapes drug discovery
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CELL REPORTS MEDICINE 2022年 第12期3卷 100794-100794页
作者: Zeng, Xiangxiang Wang, Fei Luo, Yuan Kang, Seung-Gu Tang, Jian Lightstone, Felice C. Fang, Evandro F. Cornell, Wendy Nussinov, Ruth Cheng, Feixiong Hunan Univ Coll Comp Sci & Elect Engn Changsha 410082 Hunan Peoples R China Cornell Univ Weill Cornell Med Coll Dept Populat Hlth Sci New York NY 10065 USA Northwestern Univ Feinberg Sch Med Dept Prevent Med Div Hlth & Biomed Informat Chicago IL 60611 USA Ibm TJ Watson Res Ctr Healthcare & Life Sci Res 1101 Kitchawan Rd Yorktown Hts NY 10598 USA HEC Montreal Mila Quebec Inst Learning Algorithms Montreal PQ H3T 2A7 Canada HEC Montreal CIFAR AI Res Chair Montreal PQ H3T 2A7 Canada Lawrence Livermore Natl Lab Biosci & Biotechnol Div Phys & Life Sci Directorate Livermore CA 94550 USA Univ Oslo Dept Clin Mol Biol N-1478 Oslo Norway Akershus Univ Hosp N-1478 Oslo Norway Norwegian Ctr Hlth NO Ageing Age Oslo Norway NCI Computat Struct Biol Sect Frederick Natl Lab Canc Res Lab Canc Immunometab Frederick MD 21702 USA Tel Aviv Univ Sackler Sch Med Dept Human Mol Genet & Biochem IL-69978 Tel Aviv Israel Cleveland Clin Lerner Res Inst Genom Med Inst Cleveland OH 44195 USA Case Western Reserve Univ Cleveland Clin Dept Mol Med Lerner Coll Med Cleveland OH 44195 USA Case Western Reserve Univ Case Comprehens Canc Ctr Sch Med Cleveland OH 44106 USA
Recent advances and accomplishments of artificial intelligence (AI) and deep generative models have established their usefulness in medicinal applications, especially in drug discovery and development. To correctly ap...
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Transparency and reproducibility in artificial intelligence
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NATURE 2020年 第7829期586卷 E14-U7页
作者: Haibe-Kains, Benjamin Adam, George Alexandru Hosny, Ahmed Khodakarami, Farnoosh Shraddha, Thakkar Kusko, Rebecca Sansone, Susanna-Assunta Tong, Weida Wolfinger, Russ D. Mason, Christopher E. Jones, Wendell Dopazo, Joaquin Furlanello, Cesare Waldron, Levi Wang, Bo McIntosh, Chris Goldenberg, Anna Kundaje, Anshul Greene, Casey S. Broderick, Tamara Hoffman, Michael M. Leek, Jeffrey T. Korthauer, Keegan Huber, Wolfgang Brazma, Alvis Pineau, Joelle Tibshirani, Robert Hastie, Trevor Ioannidis, John P. A. Quackenbush, John Aerts, Hugo J. W. L. Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada Univ Toronto Dept Med Biophys Toronto ON Canada Univ Toronto Dept Comp Sci Toronto ON Canada Ontario Inst Canc Res Toronto ON Canada Vector Inst Artificial Intelligence Toronto ON Canada Harvard Med Sch Brigham & Womens Hosp Artificial Intelligence Med AIM Program Boston MA 02115 USA Harvard Med Sch Radiat Oncol & Radiol Dana Farber Canc Inst Brigham & Womens Hosp Boston MA 02115 USA CUNY Grad Sch Publ Hlth & Hlth Policy Dept Epidemiol & Biostat New York NY 10021 USA CUNY Grad Sch Publ Hlth & Hlth Policy Inst Implementat Sci Populat Hlth New York NY 10021 USA Univ Hlth Network Peter Munk Cardiac Ctr Toronto ON Canada Univ Toronto Dept Lab Med & Pathobiol Toronto ON Canada SickKids Res Inst Toronto ON Canada CIFAR Child & Brain Dev Program Toronto ON Canada Stanford Univ Dept Genet Sch Med Stanford CA 94305 USA Stanford Univ Dept Comp Sci Stanford CA 94305 USA Univ Penn Perelman Sch Med Dept Syst Pharmacol & Translat Therapeut Philadelphia PA 19104 USA Alexs Lemonade Stand Fdn Childhood Canc Data Lab Philadelphia PA USA MIT Dept Elect Engn & Comp Sci Cambridge MA 02139 USA Johns Hopkins Bloomberg Sch Publ Hlth Dept Biostat Baltimore MD USA Univ British Columbia Dept Stat Vancouver BC Canada BC Childrens Hosp Res Inst Vancouver BC Canada European Mol Biol Lab Genome Biol Unit Heidelberg Germany EMBL EBI European Mol Biol Lab European Bioinformat Inst Hinxton England McGill Univ Montreal PQ Canada Montreal Inst Learning Algorithms Quebec City PQ Canada Stanford Univ Dept Stat Sch Humanities & Sci Stanford CA 94305 USA Stanford Univ Sch Med Dept Biomed Data Sci Stanford CA 94305 USA Stanford Univ Dept Med Sch Med Stanford CA 94305 USA Meta Res Innovat Ctr Stanford METRICS Stanford CA USA Stanford Univ Sch Med Dept Epidemiol & Populat Hlth Stanford CA 94305 USA Harvard TH Chan Sch Publ Hlth Dept Biostat Boston MA USA Brigham & Womens Hosp Channin
Scientific progress depends on the ability of independent researchers to scrutinize the results of a research study, to reproduce the study's main results using its materials, and to build on them in future studie... 详细信息
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