检索结果-内蒙古大学图书馆

Two and a half years of country-wide rainfall maps using radio links from commercial cellular telecommunication networks

引用

WATEr rESOUrCES rESEArCH 2016年第10期52卷 8039-8065页

作者： Overeem, A. Leijnse, H. Uijlenhoet, r. Royal Netherlands Meteorol Inst KNMI R&D Observat & Data Technol De Bilt Netherlands Wageningen Univ Hydrol & Quantitat Water Management Grp Wageningen Netherlands

Although rainfall estimation employing microwave links from cellular telecommunication networks is recognized as a new promising measurement technique, its potential for long-term large-scale operational rainfall monitoring remains to be demonstrated. This study contributes to this endeavor by deriving a continuous series of rainfall maps from a large 2.5 year microwave link data set of, on average, 3383 links (2044 link paths) covering Netherlands (approximate to 3.5 x 10(4) km(2)), a midlatitude country (approximate to 5 degrees E, approximate to 52 degrees N) with a temperate climate. Maps are extensively verified against an independent gauge-adjusted radar rainfall data set for different temporal (15 min, 1 h, 1 day, 1 month) and spatial (0.9, 74 km(2)) scales. The usefulness of different steps in the rainfall retrieval algorithm, i.e., a wet-dry classification method and a filter to remove outliers, is systematically assessed. A novel dew filter is developed to correct for dew-induced wet antenna attenuation, which, although a relative underestimation of 6% to 9% is found, generally yields good results. The microwave link rainfall estimation technique performs well for the summer months (June, July, August), even outperforming interpolation of automatic rain gauge data (with a density of approximate to 1 gauge per 1000 km(2)), but large deviations are found for the winter months (december, January, February). These deviations are generally expected to be related to frozen or melting precipitation. Hence, our results show the potential of commercial microwave links for long-term large-scale operational rainfall monitoring.

关键词： precipitation remote sensing microwave links measurement

来源：评论

学校读者我要写书评

暂无评论

Avoiding the Pitfalls of reverse Innovation Lessons Learned from Essilor

引用

rESEArCH-TECHNOLOGY management 2017年第3期60卷 40-47页

作者： Hadengue, Marine de Marcellis-Warin, Nathalie von Zedtwitz, Max Warin, Thierry Polytech Montreal Innovat Management Montreal PQ Canada Polytech Montreal Management Sci Montreal PQ Canada CIRANO Montreal PQ Canada Harvard Ctr Risk Anal Cambridge MA USA Harvard Univ Harvard T Chan Sch Publ Hlth Dept Environm Hlth Cambridge MA 02138 USA Kaunas Univ Technol Kaunas Lithuania GLORAD Ctr Global R&D Innovat St Gallen Switzerland IMD Margate FL USA Peking Univ Beijing Peoples R China PRTM Management Consultants Global Innovat Shanghai Peoples R China HEC Montreal Int Business Montreal PQ Canada Harvard Univ Weatherhead Ctr Int Affairs Cambridge MA 02138 USA Mondo Int Data Project Montreal PQ Canada

OVErVIEW: The economic benefits of reverse innovation are intuitively compelling, but this new innovation strategy presents several challenges to established firms, ranging from fears of product cannibalization to not-invented-here syndrome. French ophthalmic lens maker Essilor has experimented with reverse innovation over several projects;an examination of its experiences suggests how the specific challenges of reverse innovation may be anticipated and overcome to allow companies to better leverage the results of their global innovation efforts.

关键词： reverse innovation Emerging markets Case study

来源：评论

学校读者我要写书评

暂无评论

POS0591 TrEATMENTS TO PrEVENT rHEUMATOId ArTHrITIS IN FIrST dEGrEE rELATIVES: dEMOGrAPHIC ANd PSYCHOLOGICAL PrEdICTOrS OF rISK TOLErANCES

引用

Annals of the rheumatic diseases 2022年 81卷 562-562页

作者： G. Simons E. Janssen J. Veldwijk r. disantostefano M. Englbrecht C. radawski L. Valor J. Humphreys I.N. Bruce B. Hauber K. raza M. Falahee University of Birmingham Rheumatology Research Group Institute of Inflammation and Ageing Queen Elizabeth Hospital United Kingdom Janssen R&D NJ United States of America Erasmus University Rotterdam Erasmus School of Health Policy and Management and Erasmus Choice Modelling Centre Rotterdam Netherlands Freelance data scientist Eckental Germany Eli Lilly & Company Indianapolis United States of America Friedrich-Alexander-University Erlangen Erlangen Germany University of Manchester Centre for Epidemiology Versus Arthritis Centre for Musculoskeletal Research Manchester Academic Health Science Centre Manchester United Kingdom Manchester University NHS Foundation Trust Kellgren Centre for Rheumatology Manchester United Kingdom Manchester University NHS Foundation Trust Manchester Academic Health Science Centre NIHR Manchester Biomedical Research Centre Manchester United Kingdom University of Manchester Division of Musculoskeletal and Dermatological Sciences School of Biological Sciences Faculty of Biology Medicine and Health Manchester United Kingdom Pfizer Inc. New York United States of America University of Birmingham Rheumatology Research Group Institute of Inflammation and Ageing Birmingham United Kingdom University of Birmingham Research into Inflammatory Arthritis Centre Versus Arthritis and MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research Birmingham United Kingdom Sandwell and West Birmingham NHS Trust Rheumatology Department Birmingham United Kingdom

Background There is a growing research focus on the development of interventions to reduce risk of rheumatoid arthritis (rA) in at-risk groups.(1) rA patients' first-degree relatives (Fdrs) have an elevated risk of developing rA and are potential candidates for preventive interventions. recent studies have quantified the preferences of at risk groups for preventive treatments.(2-4) Little is known about predictors of preference heterogeneity in this context. Objectives Assess the extent to which Fdr characteristics and beliefs predict risk tolerances for preventive treatments. Methods Adult Fdrs of patients with confirmed rA in the UK were invited to take part in a web-based survey. Fdrs enrolled in a UK prospective cohort (PrEVeNT-rA) were also invited. Survey development, including attribute selection and presentation, was informed by qualitative research, ranking surveys, literature review, and expert opinion including patient research partners. respondents received information about rA, questions to check comprehension, and an introduction to the survey. Participants were asked to imagine they were experiencing arthralgia and had positive autoantibody tests indicating a 60% chance of developing rA within two years. Using a probabilistic threshold technique, participants made choices between no treatment (no benefit and no risks) or a preventive treatment option. Treatment options were defined by a fixed level of benefit (reduction in risk of rA from 60% to 20%) and varying levels of risks ( Table 1 ). For each treatment risk, participants made a series of choices where the risk was systematically increased or decreased until they switched their choice. This procedure was repeated for each of the remaining risks. Participants also completed items assessing demographics, perceived risk of developing rA, health literacy, subjective numeracy, the Brief Illness Perception Questionnaire (IPQ) and the Beliefs about Medicines Questionnaire General (BMQ-G). The maximum a

关键词：

来源：评论

学校读者我要写书评

暂无评论

Provable convex co-clustering of tensors

arXiv

引用

arXiv 2018年

作者： Chi, Eric C. Gaines, Brian r. Sun, Will Wei Zhou, Hua Yang, Jian Department of Statistics North Carolina State University RaleighNC27695 United States Advanced Analytics R&D SAS Institute Inc. CaryNC27513 United States Krannert School of Management Purdue University West LafayetteIN47907 United States Department of Biostatistics University of California Los AngelesCA90095 United States Advertising Sciences Yahoo Research SunnyvaleCA94089 United States

Cluster analysis is a fundamental tool for pattern discovery of complex heterogeneous data. Prevalent clustering methods mainly focus on vector or matrix-variate data and are not applicable to general-order tensors, which arise frequently in modern scientific and business applications. Moreover, there is a gap between statistical guarantees and computational efficiency for existing tensor clustering solutions due to the nature of their non-convex formulations. In this work, we bridge this gap by developing a provable convex formulation of tensor co-clustering. Our convex co-clustering (CoCo) estimator enjoys stability guarantees and its computational and storage costs are polynomial in the size of the data. We further establish a non-asymptotic error bound for the CoCo estimator, which reveals a surprising "blessing of dimensionality" phenomenon that does not exist in vector or matrix-variate cluster analysis. Our theoretical findings are supported by extensive simulated studies. Finally, we apply the CoCo estimator to the cluster analysis of advertisement click tensor data from a major online company. Our clustering results provide meaningful business insights to improve advertising effectiveness. Copyright © 2018, The Authors. All rights reserved.

关键词： Cluster analysis

来源：评论

学校读者我要写书评

暂无评论

On-tissue polysulfide visualization by surface-enhanced raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity

引用

rEdOX BIOLOGY 2021年 41卷 101926-101926页

作者： Honda, Kazufumi Hishiki, Takako Yamamoto, Sohei Yamamoto, Takehiro Miura, Nami Kubo, Akiko Itoh, Mai Chen, Wei-Yu Takano, Masashi Yoshikawa, Tomoyuki Kasamatsu, Takahiro Sonoda, Shinichiro Yoshizawa, Hirotoshi Nakamura, Seigo Itai, Yuichiro Shiota, Megumi Koike, daisuke Naya, Masayuki Hayakawa, Noriyo Naito, Yoshiko Matsuura, Tomomi Iwaisako, Keiko Masui, Toshihiko Uemoto, Shinji Nagashima, Kengo Hashimoto, Yoshinori Sakuma, Tomohiro Matsubara, Osamu Huang, Wilber Ida, Tomoaki Akaike, Takaaki Masugi, Yohei Sakamoto, Michiie Kato, Tomoyasu Ino, Yoshinori Yoshida, Hiroshi Tsuda, Hitoshi Hiraoka, Nobuyoshi Kabe, Yasuaki Suematsu, Makoto Natl Canc Ctr Dept Biomarkers Early Detect Canc Res Inst Tokyo Japan Keio Univ Dept Biochem Sch Med Tokyo Japan Anjo Kosei Hosp Dept Diagnost Pathol Anjo Aichi Japan Taipei Med Univ Coll Med Sch Med Dept Pathol Taipei Taiwan Taipei Med Univ Wan Fang Hosp Dept Pathol Taipei Taiwan Natl Def Med Coll Dept Obstet & Gynecol Saitama Japan Natl Def Med Coll Hosp Dept Clin Oncol Saitama Japan Tokyo Metropolitan Bokutoh Hosp Dept Obstet & Gynecol Tokyo Japan FUJIFILM Corp Frontier Core Technol Labs R&D Management Headquarters Odawara Kanagawa Japan FUJIFILM Business Expert Corp Odawara Kanagawa Japan Kyoto Univ Dept Surg Div HepatoBiliary Pancreat Surg & Transplantat 54 Shogoin Kawaracho Sakyo Kyoto Japan Doshisha Univ Fac Life & Med Sci Dept Med Life Syst 1-3 Tatara Miyakodani Kyotanabe Kyoto Japan Res Ctr Med & Hlth Data Sci Inst Stat Math Tokyo Japan Sci Imaging Scanner Dept Syst Div Hamamatsu Photon Hamamatsu Shizuoka Japan Mitsui Knowledge Ind Corp Ltd Biosci Div Tokyo Japan Hiratsuka Kyosai Hosp Canc Inst Dept Pathol Hiratsuka Kanagawa Japan Abnova Corp Taipei Taiwan Tohoku Univ Dept Environm Med & Mol Toxicol Grad Sch Med Sendai Miyagi Japan Keio Univ Dept Pathol Sch Med Keio Japan Natl Canc Ctr Div Gynecol Tokyo Japan Natl Canc Ctr Div Mol Pathol Tokyo Japan Natl Canc Ctr Dept Diagnost Pathol Tokyo Japan Natl Def Med Coll Dept Basic Pathol Saitama Japan Japan Agcy Med Res & Dev AMED AMED CREST Tokyo Japan Grad Sch Med Nippon Med Sch Dept Bioregulat Tokyo Japan Keio Univ Clin & Translat Res Ctr Sch Med Keio Japan

Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed with high-throughput automated immunohistochemistry which identified cystathionine gamma-lyase (CSE) as an independent marker distinguishing non-responders from responders to post-operative platinum-based chemotherapy. We aimed to identify CSE-derived metabolites responsible for chemoresistant mechanisms: gold-nanoparticle (AuN)-based surface-enhanced raman spectroscopy (SErS) was used to enhance electromagnetic fields which enabled to visualize multiple sulfur-containing metabolites through detecting scattering light from Au-S vibration two-dimensionally. Clear cell carcinoma (CCC) who turned out less sensitive to cisplatin than serous adenocarcinoma was classified into two groups by the intensities of SErS intensities at 480 cm(-1);patients with greater intensities displayed the shorter overall survival after the debulking surgery. The SErS signals were eliminated by topically applied monobromobimane that breaks sulfane-sulfur bonds of polysulfides to result in formation of sulfodibimane which was detected at 580 cm(-1), manifesting the presence of polysulfides in cancer tissues. CCC-derived cancer cell lines in culture were resistant against cisplatin, but treatment with ambroxol, an expectorant degrading polysulfides, renders the cells CddP-susceptible. Co-administration of ambroxol with cisplatin significantly suppressed growth of cancer xenografts in nude mice. Furthermore, polysulfides, but neither glutathione nor hypotaurine, attenuated cisplatin-induced disturbance of dNA supercoiling. Polysulfide detection by on-tissue SErS thus enables to predict prognosis of cisplatin-based chemotherapy. The current findings suggest polysulfide degradation as a

关键词： 3-Mercaptopyruvate sulfotransferase Cancer stroma Ambroxol Imaging metabolomics

来源：评论

学校读者我要写书评

暂无评论

Cover Image, Volume 5, Issue 4

引用

WIrEs Water 2018年第4期5卷

作者： remko Uijlenhoet Aart Overeem Hidde Leijnse Hydrology and Quantitative Water Management Group Wageningen University & Research Wageningen The Netherlands R&D Observations and Data Technology Royal Netherlands Meteorological Institute (KNMI) De Bilt The Netherlands

The cover image, by remko Uijlenhoet et al, is based on Primer Opportunistic remote sensing of rainfall using microwave links from cellular communication networks , dOI: 10.1002/wat2.1289 . Image courtesy of identim/S...

关键词：

来源：评论

学校读者我要写书评

暂无评论

A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PrASTrO-I trial

引用

EXPErT OPINION ON PHArMACOTHErAPY 2018年第6期19卷 529-535页

作者： Nagao, Takehiko Toyoda, Kazunori Kitagawa, Kazuo Kitazono, Takanari Yamagami, Hiroshi Uchiyama, Shinichiro Tanahashi, Norio Matsumoto, Masayasu Minematsu, Kazuo Nagata, Izumi Nishikawa, Masakatsu Nanto, Shinsuke Abe, Kenji Ikeda, Yasuo Ogawa, Akira Nippon Med Sch Tama Nagayama Hosp Dept Neurol Tokyo Japan Natl Cerebral & Cardiovasc Ctr Dept Cerebrovasc Med Suita Osaka Japan Tokyo Womens Med Univ Dept Neurol Sch Med Tokyo Japan Kyushu Univ Grad Sch Med Sci Dept Med & Clin Sci Fukuoka Japan Int Univ Hlth & Welf Sanno Hosp Ctr Brain & Cerebral Vessels Tokyo Japan Int Univ Hlth & Welf Sanno Med Ctr Tokyo Japan Saitama Med Univ Dept Neurol Int Med Ctr Saitama Japan JCHO Hoshigaoka Med Ctr Dept Neurol Osaka Japan Kokura Mem Hosp Dept Neurosurg Fukuoka Japan Mie Univ Hosp Clin Res Support Ctr Tsu Mie Japan Nishinomiya Municipal Cent Hosp Nishinomiya Hyogo Japan Daiichi Sankyo Co Ltd R&D Div Biostat & Data Management Dept Tokyo Japan Waseda Univ Fac Sci & Engn Tokyo Japan Iwate Med Univ Dept Neurosurg Iwate Japan

Background: This comparison of PrAsugrel and clopidogrel in Japanese patients with ischemic STrOke (PrASTrO)-I trial investigates the noninferiority of prasugrel to clopidogrel sulfate in the prevention of recurrence of primary events (ischemic stroke, myocardial infarction, and death from other vascular causes), and the long-term safety of prasugrel in Japanese patients with non-cardioembolic *** design and methods: This was an active-controlled, randomized, double-blind, double-dummy, parallel-group study conducted between July 2011 and March 2016 at multiple centers around Japan. Patients had to meet eligibility criteria before receiving 3.75mg prasugrel or 75mg clopidogrel orally once daily for a period of ***: A total of 3747 patients were included in this trial;1598 in the 3.75mg prasugrel group and 1551 in the 75mg clopidogrel group completed the study. during the study period, 287 (15.2%) patients in the prasugrel group and 311 (16.7%) in the clopidogrel group discontinued treatment. Baseline characteristics, safety, and efficacy results are forthcoming and will be published ***: This article presents the study design and rationale for a trial investigating the noninferiority of prasugrel to clopidogrel sulfate with regards to the inhibitory effect on primary events in patients with non-cardioembolic stroke.

关键词： Antiplatelet ischemic event clopidogrel sulfate prasugrel non-cardioembolic stroke

来源：评论

学校读者我要写书评

暂无评论

Swift-BAT GUANO Follow-up of Gravitational-wave Triggers in the Third LIGO-Virgo-KAGrA Observing run

引用

ASTrOPHYSICAL JOUrNAL 2025年第2期980卷 207-207页

作者： raman, Gayathri ronchini, Samuele delaunay, James Tohuvavohu, Aaron Kennea, Jamie A. Parsotan, Tyler Ambrosi, Elena Bernardini, Maria Grazia Campana, Sergio Cusumano, Giancarlo d'Ai, Antonino d'Avanzo, Paolo d'Elia, Valerio de Pasquale, Massimiliano dichiara, Simone Evans, Phil Hartmann, dieter Kuin, Paul Melandri, Andrea O'Brien, Paul Osborne, Julian P. Page, Kim Palmer, david M. Sbarufatti, Boris Tagliaferri, Gianpiero Troja, Eleonora Abac, A. G. Abbott, r. Abe, H. Abouelfettouh, I. Acernese, F. Ackley, K. Adamcewicz, C. Adhicary, S. Adhikari, N. Adhikari, r. X. Adkins, V. K. Adya, V. B. Affeldt, C. Agarwal, d. Agathos, M. Aguiar, O. d. Aguilar, I. Aiello, L. Ain, A. Akutsu, T. Albanesi, S. Alfaidi, r. A. Al-Jodah, A. Allene, C. Allocca, A. Al-Shammari, S. Altin, P. A. Alvarez-Lopez, S. Amato, A. Amez-droz, L. Amorosi, A. Amra, C. Anand, S. Ananyeva, A. Anderson, S. B. Anderson, W. G. Andia, M. Ando, M. Andrade, T. Andres, N. Andres-Carcasona, M. Andric, T. Anglin, J. Ansoldi, S. Antelis, J. M. Antier, S. Aoumi, M. Appavuravther, E. Z. Appert, S. Apple, S. K. Arai, K. Araya, A. Araya, M. C. Areeda, J. S. Aritomi, N. Armato, F. Arnaud, N. Arogeti, M. Aronson, S. M. Ashton, G. Aso, Y. Assiduo, M. Melo, S. Assis de Souza Aston, S. M. Astone, P. Aubin, F. AultONeal, K. Avallone, G. Babak, S. Badaracco, F. Badger, C. Bae, S. Bagnasco, S. Bagui, E. Bai, Y. Baier, J. G. Bajpai, r. Baka, T. Ball, M. Ballardin, G. Ballmer, S. W. Banagiri, S. Banerjee, B. Bankar, d. Baral, P. Barayoga, J. C. Barish, B. C. Barker, d. Barneo, P. Barone, F. Barr, B. Barsotti, L. Barsuglia, M. Barta, d. Barthelmy, S. d. Barton, M. A. Bartos, I. Basak, S. Basalaev, A. Bassiri, r. Basti, A. Bawaj, M. Baxi, P. Bayley, J. C. Baylor, A. C. Bazzan, M. Becsy, B. Bedakihale, V. M. Beirnaert, F. Bejger, M. Belardinelli, d. Bell, A. S. Benedetto, V. Beniwal, d. Benoit, W. Bentley, J. d. Ben Yaala, M. Bera, S. Berbel, M. Bergamin, F. Berger, B. K. Bernuzzi, S. Beroiz, M. Berry, C. P. L. Bersanetti, d. Bertolini, A. Betzwieser, J. Beveridge, d. Bevins, Penn State Univ Dept Astron & Astrophys Davey Lab 525 University Pk PA 16802 USA Univ Alabama Dept Phys & Astron Tuscaloosa AL 35487 USA Univ Toronto Dept Astron & Astrophys Toronto ON M5S 3H4 Canada Univ Toronto Dunlap Inst Astron & Astrophys Toronto ON M5S 3H4 Canada NASA Goddard Space Flight Ctr Astrophys Sci Div Greenbelt MD 20771 USA INAF IASF Palermo Via Ugo La Malfa 153 Palermo Pa Italy INAF Osservatorio Astron Brera Via E Bianchi 46 I-23807 Merate LC Italy Agenzia Spaziale Italiana ASI Space Sci Data Ctr SSDC I-00133 Rome Italy INAF Osservatorio Astron Roma Via Frascati 33 I-00040 Monte Porzio Catone Italy Univ Messina MIFT Dept Polo Papardo Viale Ferdinando Stagno Alcontres 31 I-98166 Messina Italy Univ Leicester Sch Phys & Astron Univ Rd Leicester LE1 7RH Leics England Clemson Univ Kinard Lab Phys Dept Phys & Astron Clemson SC 29634 USA Univ Coll London Mullard Space Sci Lab Dorking RH5 6NT Surrey England INAF Osservatorio Astron Roma Via Frascati 33 I-00040 Monte Porzio Catone RM Italy Los Alamos Natl Lab POB 1663 Los Alamos NM 87545 USA INAF Osservatorio Astron Brera Via E Bianchi 46 I-23807 Merate Italy Univ Roma Tor Vergata Via Cracovia 50 I-00100 Rome Italy Max Planck Inst Gravitat Phys Albert Einstein Inst D-14476 Potsdam Germany CALTECH LIGO Lab Pasadena CA 91125 USA Tokyo Inst Technol Grad Sch Sci 2-12-1 OokayamaMeguro Ku Tokyo 1528551 Japan LIGO Hanford Observ Richland WA 99352 USA Univ Salerno Dipartimento Farm Salerno Italy INFN Sez Napoli I-80126 Naples Italy Univ Warwick Coventry CV4 7AL W Midlands England Monash Univ Sch Phys & Astron OzGrav Clayton Vic 3800 Australia Penn State Univ University Pk PA 16802 USA Univ Wisconsin Milwaukee Milwaukee WI 53201 USA Louisiana State Univ Baton Rouge LA 70803 USA Australian Natl Univ OzGrav Canberra ACT 0200 Australia Max Planck Inst Gravitat Phys Albert Einstein Inst D-30167 Hannover Germany Leibniz Univ Hannover D-30167 Hannover Germany Inte

We present results from a search for X-ray/gamma-ray counterparts of gravitational-wave (GW) candidates from the third observing run (O3) of the LIGO-Virgo-KAGrA network using the Swift Burst Alert Telescope (Swift-BAT). The search includes 636 GW candidates received with low latency, 86 of which have been confirmed by the offline analysis and included in the third cumulative Gravitational-Wave Transient Catalogs (GWTC-3). Targeted searches were carried out on the entire GW sample using the maximum-likelihood Non-imaging Transient reconstruction and Temporal Search pipeline on the BAT data made available via the GUANO infrastructure. We do not detect any significant electromagnetic emission that is temporally and spatially coincident with any of the GW candidates. We report flux upper limits in the 15-350 keV band as a function of sky position for all the catalog candidates. For GW candidates where the Swift-BAT false alarm rate is less than 10(-3) Hz, we compute the GW-BAT joint false alarm rate. Finally, the derived Swift-BAT upper limits are used to infer constraints on the putative electromagnetic emission associated with binary black hole mergers.

关键词：

来源：评论

学校读者我要写书评

暂无评论

INTrOdUCTION

引用

Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. dunn, r.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–december) having each been record warm. Over land, the globally averaged temperature was also record high. dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. due to rapid volume loss beginning in 2021, St. A

关键词：

来源：评论

学校读者我要写书评

暂无评论

147P Pharmacokinetics, safety, and efficacy of trastuzumab deruxtecan (T-dXd) with OATP1B/CYP3A inhibitors in patients with HEr2-expressing advanced solid tumours

引用

Annals of Oncology 2020年 31卷 S68-S69页

作者： M. Takahashi Y-J. Bang M. Karayama J. Watanabe H. Minami N. Yamamoto I. Kinoshita C.C. Lin Y-H. Im T. Fujiki I. Achiwa E. Kamiyama Y. Okuda C. Lee S. Takahashi Department of Breast Surgery National Hospital Organization Hokkaido Cancer Center Sapporo Japan Internal Medicine (Medical Oncology) Seoul National University Hospital Seoul Republic of Korea Clinical Oncology Department Hamamatsu University School of Medicine Hamamatsu Japan Breast Oncology Department Shizuoka Cancer Center Shizuoka Japan Kobe University Hospital Kobe Japan Thoracic National Cancer Center Hospital Tokyo Japan Department of Medical Oncology Hokkaido University Sapporo Japan Department of Oncology National Taiwan University Hospital (NTUH) Taipei Taiwan Department of Medicine Division of Hematology/Medical Oncology Samsung Medical Center (SMC) - Sungkyunkwan University School of Medicine Seoul Republic of Korea Oncology Medical Science Department Daiichi Sankyo Co Ltd Tokyo Japan Clinical Development Department Daiichi Sankyo Co Ltd Tokyo Japan Clinical Pharmacology Department Daiichi Sankyo Co Ltd Tokyo Japan Biostatistics and Data Management Department Daiichi Sankyo Co Ltd Tokyo Japan Global Oncology R&D Daiichi Sankyo Inc Basking Ridge NJ USA Medical Oncology The Cancer Institute Hospital of JFCR Tokyo Japan

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：