The creation of novel materials with high mechanical qualities necessitates the use of advanced machining techniques. Non-conventional machining processes alter the entire manufacturing scenario. Non-conventional mach...
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The miniaturization of portable electronic devices has driven the demand for smaller electronic components. Traditional inductors limited by conventional manufacturing processes was hard to achieve both small size and...
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Biomanufacturing,which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals,has long been regarded as a production model that replaces the unsustainable fossil *** co...
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Biomanufacturing,which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals,has long been regarded as a production model that replaces the unsustainable fossil *** construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green *** methods that rely on experience are difficult to support the realization of this ***,with the rapiddevelopment of information technology,the intelligence of biomanufacturing has brought hope to achieve this *** and computational enzyme design,as two of the main technologies in intelligent biomanufacturing,have developedrapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may *** achieve the final integration of the two fields,it is necessary to examine the information,methods and tools from a bird’s-eye view,and to find a feasible idea and solution for establishing a connection *** this purpose,this article briefly reviewed the main ideas,methods and tools of the two fields,and put forward views on how to achieve the integration of the two fields.
Age-related maculardegeneration (AMd) anddiabetic macular edema (dME) affect the macula of the retina for the person above 50 years. Accurate diagnosis of eye diseases in the initial stages prevents blindness. Manua...
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Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SArS-Co V-2 *** this study,we developed a tetravalent COVI...
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Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SArS-Co V-2 *** this study,we developed a tetravalent COVId-19 vaccine SCTV01E,based on the trimeric Spike protein of SArS-Co V-2 variants Alpha,Beta,delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant *** the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(d614G,Alpha,Beta,anddelta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with d614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the d614G booster ***,SCTV01E vaccination elicited na?ve and central memory T cell responses to SArS-Co V-2 ancestral strain and Omicron spike ***,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVId-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 ***01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m rNA vaccines(NCT05323461).
Internet of Things (IoT) and Information Technology (IT) are integrated andreleased as many browser-based applications that can fulfil the needs of people in this smart world. Especially, these technologies are used ...
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The study introduces a deep learning model, CCNN, developed to identify and classify eight types of breast cancer: normal adenosis, normal fibroadenoma, normal phyllodes tumor, normal tubular adenoma, malignant ductal...
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diabetic retinopathy (dr) is a prevalent retinal vascular condition that can lead to significant visual impairment. The early classification of dr and precise grading of dr are essential for maintaining eyesight and p...
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This study developed a modern autonomous navigation system using proximity and accelerometer sensors, along with deep reinforcement learning algorithms. The system ensures safety by providing real-time data on obstacl...
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This Paper presents an analysis of landlord land price prediction utilizing machine learning techniques. The objective is to develop a predictive model that can accurately forecast land prices, aiding landlords in mak...
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