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HdAC6 inhibitor loaded bimetallene nanosheets with antagonizing thermoresistance for augmented mild photothermal therapy

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Chinese Chemical Letters 2023年第9期34卷 235-242页

作者： Lingyu Qiu Shan Lei Jing Zhang ruhan Yan Wansi Chen Jing Lin Wei-Guo Zhu Peng Huang Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University Medical SchoolShenzhen 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Medical SchoolShenzhen 518055China Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China

Photothermal therapy(PTT)induces thermoresistance through cellular heat shock response,which impairs the therapeutic efficacy of the *** resolve this problem,we developed a photothermal theranostics(denoted as PMH),which integrated the photothermal conversion agent of PdMo bimetallene with histone deacetylase 6(HdAC6)selected inhibitor(ACY-1215),showing the synergistic antitumor effect both in vitro and in ***,under the photoacoustic imaging(PA)navigation,the released ACY-1215 triggered by NIr laser irradiation decrease the heat shock proteins(HSPs)expression and weaken the HdAC6-regulated HSP90 deacetylation,thus hindering the degradation of PTT-induced misfolded or unfold proteins through proteasome dependent ***,mild photothermal therapy(mPTT)treatment compromised the autophagy,which induced by HdAC6 inhibition,leading to mPTTinduced misfolded or unfold proteins further *** that inhibition of HdAC6 plus m PTT contribute to tumor *** study develops a promising combination strategy based on m PTT for future cancer treatment.

关键词： Mild photothermal therapy Thermoresistance Histone deacetylase 6 Heat shock proteins Autophagy

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rateless Coding for Multi-Hop Broadcast Transmission in Wireless IoT Networks

Rateless Coding for Multi-Hop Broadcast Transmission in Wire...

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2023 IEEE International Symposium on Information Theory, ISIT 2023

作者： Guo, Jianlin Koike-Akino, Toshiaki Wang, Pu Parsons, Kieran Orlik, Philip Shanmuga Sundaram, Jothi Prasanna Sumi, Takenori Nagai, Yukimasa CambridgeMA02139 United States Mitsubishi Electric Corporation Information Technology R&d Center Kanagawa Kamakura2478501 Japan University of California Electrical Engineering and Computer Science MercedCA95343 United States

ISBN: (纸本)9781665475549

The software distribution in advanced IoT networks is inevitable. However, distributing software in multi-hop wireless networks consumes enormous communication bandwidth and can also suffer from reliability challenge. This paper proposes an innovative dynamic relay point (drP) protocol to reduce the number of software packet transmissions. It also introduces a network condition based rateless coding scheme to improve the packet transmission reliability. The NS3 simulator is employed for performance evaluation. The proposed drP protocol outperforms multi-point relay (MPr) baseline by reducing the software packet transmissions and improving the effective throughput. © 2023 IEEE.

关键词： Wireless networks

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Electric Machine Inverse design with Variational Auto-Encoder (VAE)

Electric Machine Inverse Design with Variational Auto-Encode...

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2023 IEEE Energy Conversion Congress and Exposition, ECCE 2023

作者： Xu, Yihao Wang, Bingnan Sakamoto, Yusuke Yamamoto, Tatsuya Nishimura, Yuki Koike-Akino, Toshiaki Wang, Ye Northeastern University Mechanical and Industrial Engineering BostonMA02120 United States CambridgeMA02139 United States Advanced Technology R&d Center Mitsubishi Electric Corporation Amagasaki Hyogo661-8661 Japan

ISBN: (纸本)9798350316445

Machine learning and deep learning techniques have been proposed to facilitate the design optimization of electric machines. Most of the existing research focuses on the development of surrogate models, while iterative optimization is still needed. Inverse design approach, on the other hand, can directly provide design candidates with trained deep learning model without iteration. One major challenge in deep learning based inverse design is the so-called one-to-many mapping problem. In this paper, we propose an intelligent inverse design approach for electric machines based on a variational autoencoder (VAE), which can effectively address the problem and provide desired motor design candidates for multiple design targets at the same time. We demonstrate the feasibility of the proposed strategy with multi-objective design task of a surface-mount permanent magnet motor, and show that it is generally applicable for different types of electric motors. © 2023 IEEE.

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Introduction of a Trusted Whitelist Mechanism for ddOS Attack Early Warning Optimization 20

Introduction of a Trusted Whitelist Mechanism for DDOS Attac...

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20th International Computer Conference on Wavelet Active Media technology and Information Processing, ICCWAMTIP 2023

作者： Haoran, Luo Shuisong, H.U. Wenyong, Wang Yu, Miao Jun, deng Yubo, L.I. University of Electronic Science and Technology of China Sichuan Cloud Network Integration Engineering Laboratory SICHUAN CHENGDU610000 China NSFOCUS R&D Center Building C5 of the XINCHUAN Information Technology Incubation Park SICHUAN CHENGDU610000 China

ISBN: (纸本)9798350318982

distributed denial of Service (ddoS) attacks pose a significant threat to modern networks, leading to substantial computational resource consumption and economic losses. Many mature defense technologies exist to block malicious traffic and deploy honeypots for traffic monitoring, enabling early detection and mitigation of attacks. However, these defenses can disrupt normal client services, especially during peak network usage, due to over-blocking and inaccurate attack situation assessments. This paper introduces an optimized mechanism involving a trusted whitelist, which filters legitimate clients in advance during the ddoS attack Early warning stage, addressing potential misjudgments during peak network times. Experimental results show that this mechanism can more effectively and accurately discern ddoS situations, reducing the likelihood of false positives. © 2023 IEEE.

关键词： denial-of-service attack

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Fast-Settling Onboard Electrochemical Impedance Spectroscopy System Adopting Two-Stage Hilbert Transform 49

Fast-Settling Onboard Electrochemical Impedance Spectroscopy...

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49th Annual Conference of the IEEE Industrial Electronics Society, IECON 2023

作者： Lee, Young-Nam Jung, Min Jae Jo, Seong-Won rahim, Gul Lee, Sang-Gug Choi, Kyung-Sik Daejeon34141 Korea Republic of Autosilicon Co. Ltd. Daejeon R&d Center Daejeon34050 Korea Republic of Eth Zürich Department of Information Technology and Electrical Engineering Zürich Switzerland

ISBN: (纸本)9798350331820

Electrochemical impedance spectroscopy (EIS) is a non-invasive method for analyzing battery states based on impedance measurements. With the widespread use of high-capacity lithium-ion batteries in the range of mΩ impedance, achieving highly accurate impedance measurements becomes crucial for precise battery examination. EIS systems frequently utilize a digital lock-in amplifier (dLIA) to achieve ultra-precision impedance readings, but it requires a long settling time. This study proposes an innovative EIS architecture with a two-stage Hilbert transform that significantly reduces the measurement time by widening the bandwidth of noise suppression low-pass filter while maintaining high accuracy. It achieves a substantial 66% reduction in the estimated settling time at the lower bound frequency of 1 Hz and a 57% reduction in the total measurement time across the frequency range of 1-to-1k Hz. © 2023 IEEE.

关键词： Electrochemical impedance spectroscopy

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Compensating the impurities on the Cu surface by MOFs for enhanced hydrocarbon production in the electrochemical reduction of carbon dioxide

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Journal of Energy Chemistry 2022年第3期31卷 68-73,I0003页

作者： Shin Joon Kang Jong Ho Won Hansaem Choi Woohyeong Sim Mun Kyoung Kim Siraj Sultan Youngkook Kwon Hyung Mo Jeong School of Mechanical Engineering and Department of Smart Fab.Technology Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea Department of Chemistry Kookmin University77 Jeongneung-roSeongbuk-guSeoul 02707Republic of Korea School of Energy and Chemical Engineering Emergent Hydrogen Technology R&D CenterUlsan National Institute of Science and Technology50 UNIST-gilUlsan 44919Republic of Korea

Copper(Cu)provides a cost-effective means of producing value-added fuels through the electrochemical reduction of carbon dioxide(CO_(2)rr).However,we observed the production of hydrocarbons via CO_(2)rr on commercial Cu films is less efficient because of the surface impurities,i.e.,*** monoxide(CO),a reaction intermediate of CO_(2)rr to hydrocarbons,binds strongly to the Fe sites and interrupts the production of hydrocarbons,resulting in an active hydrogen evolution reaction(HEr).Herein,we report a method of blocking the effect of Fe impurities on the Cu surface through the preferential growth of nano-sized metal-organic frameworks(MOFs)on Fe *** zirconium(Zr)-based MOFs(UiO-66)forms a compensating layer on Cu film via the terephthalic acid(TPA)-Fe coordination bond,the Ui O-66 coated Cu film(UiO-66@Cu)presents significantly improved hydrocarbon Faradaic efficiency(FE)of 37.59%compared to 14.68%FE on commercial Cu film(99.9%purity)by suppressing *** to X-ray photoelectron spectroscopy(XPS)analysis,the UiO-66 ligand binds to entire metallic Fe site on the Cu surface,while metallic Cu is ***,UiO-66@Cu provides active sites of Cu for CO_(2)rr and leads to highly efficient and selective production of hydrocarbons.

关键词： Impurity on Cu film Zr-based MOFs Electrocatalysts CO_(2)reduction Hydrocarbon

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Experimental demonstration of multiparty reference-frame-independent QKd

Experimental demonstration of multiparty reference-frame-ind...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Lee, donghwa Shin, Kyujin Kim, Yosep Lim, Hyang-Tag Kim, Yong-Su Seoul02792 Korea Republic of Division of Nano & Information Technology KIST School Korea University of Science and Technology Seoul02792 Korea Republic of Materials Research & Engineering Center R&D Division Hyundai Motor Company Uiwang16082 Korea Republic of

We report that rFI-QKd protocol can be extended to multiparty system using Greenberger-Horne-Zeilinger (GHZ) state. We derive the asymptotic key rate and perform proof-of-principle experiment to verify the feasibility...

ISBN: (纸本)9781957171258

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A feasible route to produce 1.1 GPa ferritic-based low-Mn lightweight steels with ductility of 47%

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Journal of Materials Science & technology 2022年第22期117卷 225-237页

作者： Kwang Kyu Ko Hyo Ju Bae Eun Hye Park Hyeon-Uk Jeong Hyoung Seok Park Jae Seok Jeong Jung Gi Kim Hyokyung Sung Nokeun Park Jae Bok Seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea School of Materials Science and Engineering Yeungnam UniversityGyeongbuk 38541South Korea Materials Research Team R&D Hyundai MobisYongin 16891South Korea Materials Technology Development Team Doosan Heavy Industries&ConstructionChangwon 51711South Korea

High- and medium-Mn (H/M-Mn) base lightweight steels are a class of ultrastrong structural materials with high ductility compared to their low-Mn counterparts with low strength and poor ***, producing these H/M-Mn materials requires the advanced or high-tech manufacturing techniques, which can unavoidably provoke labor and cost concerns. Herein, we have developed a facilestrategy that circumvents the strength–ductility trade-off in low-Mn ferritic lightweight steels, by employing low-temperature tempering-induced partitioning (LTP). This LTP treatment affords a typical Fe-2.8Mn-5.7Al-0.3C (wt.%) steel with a heterogeneous size-distribution of metastable austenite embeddedin a ferrite matrix for partitioning more carbon into smaller austenite grains than into the larger austenite ones. This size-dependent partitioning results in slip plane spacing modification and lattice strain,which act through dislocation engineering. We ascribe the simultaneous improvement in strength andtotal elongation to both the size-dependent dislocation movement in austenite grains and the controlleddeformation-induced martensitic transformation. The low-carbon-partitioned large austenite grains increase the strength and ductility as a consequence of the combined martensitic transformation andhigh dislocation density-induced hardening and by interface strengthening. Additionally, high-carbonpartitioned small austenite grains enhance the strength and ductility by planar dislocation glide (inthe low strain regime) and by cross-slipping and delayed martensitic transformation (in the high strainregime). The concept of size-dependent dislocation engineering may provide different pathways for developing a wide range of heterogeneous-structured low-Mn lightweight steels, suggesting that LTP maybe desirable for broad industrial applications at an economic cost.

关键词： Low-Mn lightweight steel Carbon partitioning Metastable austenite dislocation movement

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The appearance of cytoplasmic cytochrome C precedes apoptosis during drosophila salivary gland degradation

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Insect Science 2024年第1期31卷 157-172页

作者： Shihui Long Wenxin Cao Yongyu Qiu ruohan deng Jiali Liu Lidan Zhang renke dong Fengxin Liu Sheng Li Haigang Zhao Na Li Kang Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina ChemPartner PharmaTech Co. LtdJiangmenGuangdong ProvinceChina

Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during *** mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the ***,whether this process is conserved in the fruit fly,drosophila melanogaster,remains *** this study,we discovered that during the degradation of drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding *** proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland ***,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the ***,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,*** research provides evidence that cytoplasmic Cyt-c appears before apoptosis during drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals.

关键词： active caspase 3 apoptosis Cyt-c drosophila salivary gland

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The characteristics of temperature-responsive ionic liquids on the integrated operational effectiveness of water reclamation from semiconductor wastewater using forward osmosis

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Chemosphere 2025年 371卷 144059页

作者： Shih, Cheng-En Kuan, Wen-Hui Department of Safety Health and Environmental Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Center for Sustainability and Energy Technologies Chang Gung University Taoyuan33323 Taiwan Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City243303 Taiwan Chronic Diseases and Health Promotion Research Center Chang Gung University of Science and Technology Chiayi61363 Taiwan

Large amounts of wastewater are produced from semiconductor manufacturing, and the production energy consumption has skyrocketed with its global demand in recent years. Forward osmosis (FO) provides unique merits in reclaiming the wastewater if suitable draw solutes with high water flux, low leakage, and limited energy requirement in regeneration are available. Two lower critical solution temperature-ionic liquids (LCST-ILs), tetrabutylphosphonium trimethylbenzensulfonate ([P4444][TMBS]) and tetrabutylphosphonium maleate ([P4444][Mal]) were synthesized and systematically assessed as recycled draw solutes in FO for the water reclamation from the wastewater of Si-ingot sawing. The water flux of [P4444][TMBS] and [P4444][Mal] was 4.12 and 2.67 LMH in the FO for the authentic sawing wastewater, respectively. The characteristics of relatively higher hydrophobic and the structure configuration ensure the lower thermal-stimulus separation energy (Ets) of the spent [P4444][Mal] solution and its relative ease in recycling because of the higher regeneration ratio. The more hydrophilic [P4444][TMBS] based draw solution (dS) exhibits higher osmotic pressure, which is beneficial for water filtration but leads to higher Ets. The estimated energy required for the integrated processes, including FO filtration for the sawing wastewater, thermal separation of draw solute, and the reclaimed water polishing, for the system with [P4444][Mal] as draw solutes is 14.22 kWh m−3. The value significantly reduced to 1.33 kWh m−3 if low-grade waste heat ( © 2024

关键词： Water filtration

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